大学生思想道德修养课感化式教学八探

认真改革传统的单一的教学方式和方法,积极倡导感化式教学,以平等、民主、和谐的课堂气氛,多种多样的教学手段,引导学生“亲其师、信其道”,各自发挥独特的才能,塑造完美的人格,自觉具备优良的心理健康标准,培养知行统一的良好的道德品质,同传统的错误观念做最彻底的决裂。

广告风格与产品生命周期

广告风格是广告作品在创作过程中所表现出来的艺术特色和创作个性。把握产品在生命周期不同阶段上所面临的不同营销特征,并在广告创作中依从和反映这些特征,则是广告风格形成机制的决定性因素。产品导入期,规则式广告风格是必须考虑和追求的;产品成长期,呼唤和决定了感化式广告风格的出现和盛行;论证式风格的广告,则是结合产品生命周期不同阶段的营销特征而灵活采用。

Inhibition of Telomerase with hTERT Antisense Increases Susceptibility of Leukemic Cells to CDDP-induced Apoptosis

Objective: To investigated the e?ect of inhibition of telomerase with hTERT antisense on leukemic cells (HL-60 and K562) to CDDP-induced apoptosis. Methods: Antisense phosphorothioate oligodeoxynucleotide (AS PS-ODN) was synthesized and puri?ed. Telomerase activity was detected by Telomerase PCR ELASA kit and cell apoptosis was observed by morphological method and determined by ?owcytometry. Results: AS PS-ODN could signi?cantly inhibit telomerase activity by down regulat- ing the hTERT expression, and increase the susceptibility of leukemic cells to CDDP-induced apoptosis. Conclusion: Inhibition of telomerase with hTERT antisense can increases the susceptibility of leukemic cells to CDDP-induced apoptosis.

rAd-p53 enhances the sensitivity of human gastric cancer cells to chemotherapy

AIM： To investigate potential antitumor effects of rAd-p53 by determining if it enhanced sensitivity of gastric cancer cells to chemotherapy. METHODS： Three gastric cancer cell lines with distinct levels of differentiation were treated with various doses of rAd-p53 alone, oxaliplatin （OXA） alone, or a combination of both. Cell growth was assessed with an 3-（4,5）-dimethylthiahiazo （-z-yl）-3,5-diphenytetrazoli- umromide assay and the expression levels of p53, Bax and Bcl-2 were determined by immunohistochemistry. The presence of apoptosis and the expression of caspase-3 were determined using flow cytometry. RESULTS： Treatment with rAd-p53 or OXA alone inhibited gastric cancer cell growth in a time- and dose- dependent manner; moreover, significant synergistic effects were observed when these treatments were combined. Immunohistochemical analysis demonstrated that treatment with rAd-p53 alone, OXA alone or combined treatment led to decreased Bcl-2 expression and increased Bax expression in gastric cancer cells.Furthermore, flow cytometry showed that rAd-p53 alone, OXA alone or combination treatment induced apoptosis of gastric cancer cells, which was accompa- nied by increased expression of caspase-3. CONCLUSION： rAd-p53 enhances the sensitivity of gastric cancer cells to chemotherapy by promoting apoptosis. Thus, our results suggest that p53 gene therapy combined with chemotherapy represents a novel avenue for gastric cancer treatment.

Energy-Efficient Distributed Lifetime Optimizing Scheme for Wireless Sensor Networks

In this paper, a sensing model for the coverage analysis of wireless sensor networks is provided. Using this model and Monte Carlo method, the ratio of private range to sensing range required to obtain the desired coverage can be derived considering the scale of deployment area and the number of sensor nodes. Base on the coverage analysis, an energy-efficient distributed node scheduling scheme is proposed to prolong the network lifetime while maintaining the desired sensing coverage, which does not need the geographic or neighbor information of nodes. The proposed scheme can also handle uneven distribution, and it is robust against node failures. Theoretical and simulation results demonstrate its efficiency and usefulness.

MIMO Soft-sensor Model of Nutrient Content for Compound Fertil- izer Based on Hybrid Modeling Technique

In compound fertilizer production, several quality variables need to be monitored and controlled simultaneously. It is very diifficult to measure these variables on-line by existing instruments and sensors. So, soft-sensor technique becomes an indispensable method to implement real-time quality control. In this article, a new model of multi-inputs multi-outputs （MIMO） soft-sensor, which is constructed based on hybrid modeling technique, is proposed for these interactional variables. Data-driven modeling method and simplified first principle modelingmethod are combined in this model. Data-driven modeling method based on limited memory partial least squares（LM-PLS） al.gorithm is used to build soft-senor models for some secondary variables.then, the simplified first principle model is used to compute three primary variables on line. The proposed model has been used in practicalprocess; the results indicate that the proposed model is precise and efficient, and it is possible to realize on line quality control for compound fertilizer process.

Economic management and innovation strategies of enterprises under market economy conditions

Under the highly competitive market economy management system, economic management of Chinese enterprises tends to be diversity. With the continuous development of market economy, enterprises need choose the appropriate management methods according to the actual situation, which is to help enterprises to survive in the highly competitive environment. However, due to a variety of external factors, economic management situation is not optimistic. And it increases their sense of crisis. This article will make a systematic analysis of management strategies as the point of the enterprise management mode and innovation strategy under market economy.

Analytical investigation for stress measurement with the rheological stress recovery method in deep soft rock

Due to the difficulty and weakness of current stress measurement methods in deep soft rock, a new rheological stress recovery method of the determination of the three-dimensional(3D) stress tensor is proposed. It is supposed that rock stresses will recovery gradually with time and can be measured by embedding transducers into the borehole. In order to explore the applicability and accuracy of this method, analytical solutions are developed for stress measurement with the rheological stress recovery method in a viscoelastic surrounding rock, the rheological properties of which are depicted as both the Burger's model and a 3-parameter solid model. In such conditions, explicit analytical expressions for predicting time-dependent pressures on the transducer are derived. A parametric analysis is then adopted to investigate the influences of the grout solidification time and the mechanical properties of the grout layer. The results indicate that this method is suitable for stress measurement in deep soft rock, the characteristics of which are soft, fractured and subjected to high geo-stress.

Guidelines on common cold for Traditional Chinese Medicine based on pattern differentiation

OBJECTIVE: To establish the guidelines on common cold treated with Traditional Chinese Medicine (TCM) in terms of pattern identification. METHODS: The guidelines were formulated by using the basic patterns of common cold in ChinaPharmacopeia integrated with findings from systematic literature review and the experts' consensus on the issue in question. RESULTS: Common cold was divided into four patterns in the guidelines. The medications were recommended respectively: Ganmaoqingre granule for wind-cold exterior syndrome,Yinqiaojiedu granule for wind-heat exterior syndrome, Huoxiangzhengqi Wan for summer-heat dampness exterior syndrome and Shensu Wan for wind-cold exterior syndrome accompanied with Qi deficiency. CONCLUSION: The guidelines were primarily derived from the practice experience of TCM and the experts' consensus. The process was not strictly evidence-based because of lacking enough clinical studies. Further refinement of the guidelines should be needed as more studies are available.

SENSITIVITY ANALYSIS FOR PARAMETERIZED VARIATIONAL INEQUALITY PROBLEMS

This paper presents sensitivity analysis for parameterized variational inequality problems (VIP). Under appropriate assumption, it is shown that the perturbed solution to parameterized VIP is existent, unique, continuous and differentiable with respect to perturbation parameter. In the case of differentiability, we derive the equations for calculating the derivative of solution variables with respect to the perturbation parameters.