目的本研究旨在直观分析近20年来感官障碍在阿尔茨海默病(AD)中作用的相关文献,系统识别协作网络,跟踪研究趋势,突出当前热点并且预测该领域的未来前沿。方法以Web of Science Core Collection(WOSCC)为检索库,运用CiteSpace软件分析该...目的本研究旨在直观分析近20年来感官障碍在阿尔茨海默病(AD)中作用的相关文献,系统识别协作网络,跟踪研究趋势,突出当前热点并且预测该领域的未来前沿。方法以Web of Science Core Collection(WOSCC)为检索库,运用CiteSpace软件分析该领域最具影响力的国家、作者和机构,以及期刊和参考文献的共被引情况,对关键词进行聚类、突现分析,绘制可视化知识图谱。结果共纳入322篇外文文献。近年来感官障碍在AD中作用的相关研究逐年增加,美国在该领域具有绝对的权威性与影响力,中国在该领域发文量位于第二,有待提高论文的发表量与质量。听力损伤与嗅觉损伤研究较多,且与Aβ、APOE等位基因等的关联研究一直是该领域的研究热点,近年来味觉等器官失灵影响大脑以致认知下降等成为新兴问题。未来研究方向将朝着探究哪些感官障碍能够在识别早期AD中发挥作用方面发展,并且找出嗅觉、听觉等损伤可作为检测早期AD生物标志物的证据。结论我国在该领域的高质量论文较少,感官障碍与AD的关系研究已深入分子水平,建议我国研究者结合疾病的发病机制深入研究,不断开拓思路,为通过识别感官障碍预防或治疗AD途径提供依据。展开更多
Objective： To quantitatively identify and grade trigeminal sensory functions after 3 major surgical procedures of trigeminal neuralgia using a newly developed quantitative sensory testing technique, current perceptio...Objective： To quantitatively identify and grade trigeminal sensory functions after 3 major surgical procedures of trigeminal neuralgia using a newly developed quantitative sensory testing technique, current perception threshold measurement （CPTM）. Methods： In the current study, there were 48 trigeminal neuralgia patients without history of prior surgical treatment. These patients received one of the following 3 surgical procedures, microvascular decompression （MVD）, peripheral nerve block with alcohol （PNB）, or percutaneous radiofrequency thermocoagulation （PRFT）. The quantitative sensory testing measurement, CPTM, and conventional qualitative sensory testing measurements were performed preoperatively and postoperatively to evaluate and grade the trigeminal sensory functions All 3 major cutaneous sensory fiber types, large myelinated fibers （A beta）, small myelinated fibers （A delta） and unmyelinated fibers（C） were allowed to quantitatively evaluate and grade by CPTM. The results of the measurements were statistically analyzed using a one-way analysis of variance （single factor）. Each subject was his/her own control for comparison of the preoperative to postoperative state on the asymptomatic and symptomatic sides. Subjects were tested 48 h preoperatively and 4 weeks postoperatively. Results： PNB with alcohol and PRFT caused significant sensory dysfunction postoperatively in every fiber type, indicating damage to all fibers. On the contrary, the sensory function in all 3 fiber types was unchanged after MVD management. Conclusion： Among the 3 major surgical procedures tested, only MVD preserves sensory function in trigeminal system. CPTM is of quantitative nature on the evaluation of sensory functions of nerve fibers展开更多
文摘目的本研究旨在直观分析近20年来感官障碍在阿尔茨海默病(AD)中作用的相关文献,系统识别协作网络,跟踪研究趋势,突出当前热点并且预测该领域的未来前沿。方法以Web of Science Core Collection(WOSCC)为检索库,运用CiteSpace软件分析该领域最具影响力的国家、作者和机构,以及期刊和参考文献的共被引情况,对关键词进行聚类、突现分析,绘制可视化知识图谱。结果共纳入322篇外文文献。近年来感官障碍在AD中作用的相关研究逐年增加,美国在该领域具有绝对的权威性与影响力,中国在该领域发文量位于第二,有待提高论文的发表量与质量。听力损伤与嗅觉损伤研究较多,且与Aβ、APOE等位基因等的关联研究一直是该领域的研究热点,近年来味觉等器官失灵影响大脑以致认知下降等成为新兴问题。未来研究方向将朝着探究哪些感官障碍能够在识别早期AD中发挥作用方面发展,并且找出嗅觉、听觉等损伤可作为检测早期AD生物标志物的证据。结论我国在该领域的高质量论文较少,感官障碍与AD的关系研究已深入分子水平,建议我国研究者结合疾病的发病机制深入研究,不断开拓思路,为通过识别感官障碍预防或治疗AD途径提供依据。
文摘Objective： To quantitatively identify and grade trigeminal sensory functions after 3 major surgical procedures of trigeminal neuralgia using a newly developed quantitative sensory testing technique, current perception threshold measurement （CPTM）. Methods： In the current study, there were 48 trigeminal neuralgia patients without history of prior surgical treatment. These patients received one of the following 3 surgical procedures, microvascular decompression （MVD）, peripheral nerve block with alcohol （PNB）, or percutaneous radiofrequency thermocoagulation （PRFT）. The quantitative sensory testing measurement, CPTM, and conventional qualitative sensory testing measurements were performed preoperatively and postoperatively to evaluate and grade the trigeminal sensory functions All 3 major cutaneous sensory fiber types, large myelinated fibers （A beta）, small myelinated fibers （A delta） and unmyelinated fibers（C） were allowed to quantitatively evaluate and grade by CPTM. The results of the measurements were statistically analyzed using a one-way analysis of variance （single factor）. Each subject was his/her own control for comparison of the preoperative to postoperative state on the asymptomatic and symptomatic sides. Subjects were tested 48 h preoperatively and 4 weeks postoperatively. Results： PNB with alcohol and PRFT caused significant sensory dysfunction postoperatively in every fiber type, indicating damage to all fibers. On the contrary, the sensory function in all 3 fiber types was unchanged after MVD management. Conclusion： Among the 3 major surgical procedures tested, only MVD preserves sensory function in trigeminal system. CPTM is of quantitative nature on the evaluation of sensory functions of nerve fibers
