DNA immobilization on electrode surfaces has been widely used for fabricating sensors since DNA can interact with a wide variety of biomolecules. Recendy, DNA has been demonstrated as an electronic super conductor... DNA immobilization on electrode surfaces has been widely used for fabricating sensors since DNA can interact with a wide variety of biomolecules. Recendy, DNA has been demonstrated as an electronic super conductor and become the most promising biomolecule for application of chemical sensing in biological system. Calf thymus DNA (ct-DNA) is a most popularly used native DNA in many applications. An electrochemical deposition on carbon fiber micro electrode can provide sensitive detection of dopamine in presence of large amount of ascorbic acid.……展开更多
Objective To evaluate the effects of simvastatin combined with omega-3 fatty acids on high sensitive C-reactive protein(HsCRP), lipidemia, and fibrinolysis in coronary heart disease (CHD) and CHD risk equivalent patie...Objective To evaluate the effects of simvastatin combined with omega-3 fatty acids on high sensitive C-reactive protein(HsCRP), lipidemia, and fibrinolysis in coronary heart disease (CHD) and CHD risk equivalent patients with mixed dyslipi-demia. Methods A randomized, double-blind placebo controlled and parallel group trial was conducted. Patients with CHD and CHD risk equivalents with mixed dyslipidemia were treated with 10 or 20 mg simvastatin for 6-12 weeks. Following with the treatment of patients whose low-density lipoprotein cholesterol (LDL-ch) reaching goal level (< 100 mg/dL) or close to the goal (< 130 mg/dL), while triglyceride (TG) ≥200 mg/dL and < 500 mg/dL, was combined with omega-3 fatty acids (3 g/d) or a placebo for 2 months. The effects of the treatment on HsCRP, total cholesterol (TC), LDL-ch, high-density lipoprotein cholesterol (HDL-ch), TG, lipoprotein (a) [LP (a)], apolipoprotein A1 (apoA1), apolipoprotein B (apoB), plasminogen activator inhibitor-1 (PAI-1), and tissue plasminogen activator (tPA) were investigated. Forty patients finished the study with each group consisting of twenty patients. Results (1) There were significant reductions of HsCRP, TG, TC, and TC/HDL-ch, which decreased by 2.16 ±2.77 mg/L (38.5%), 94.0 ±65.4 mg/dL (31.1%), 13.3 ±22.3 mg/dL (6.3%), 0.78 ±1.60 respectively in the omega-3 fatty acids group (P< 0.01, < 0.001, < 0.05, < 0.05) compared to the baseline. HsCRP and triglyceride reduction were more significant in omega-3 fatty acids group compared to the placebo group (P=0.021 and 0.011 respectively). (2) In the omega-3 fatty acids group, the values and percentage of TG reduction had a significantly positive relation with HsCRP reduction (r=0.51 and 0.45, P=0.021 and 0.047 respectively). Conclusion In CHD and CHD risk equivalent patients with mixed dyslipidemia, dyslipidemia’s therapeutic effect using simvastatin and omega-3 fatty acids may result from not only the combination of lipid adjustment, but also enhancement of their own nonlipid influences.展开更多
A novel method of correlation function for analyzing cross-sensitivity between strain and temperature is reported for the first time in this paper. Using the new method,the correlative characteristics between strain a...A novel method of correlation function for analyzing cross-sensitivity between strain and temperature is reported for the first time in this paper. Using the new method,the correlative characteristics between strain and temperature of fiber Bragg grating sensors are studied both theoretically and experimentally The experimental results accord with the theoretical calculations.展开更多
A series of 1-D polymer ternary composites based on poly(styrene-butadiene-styrene)(SBS)/carbon nanotubes(CNTs)/few-layer graphene(FLG) conductive fibers(SCGFs)were prepared via wet-spinning. Employed as ultra-high st...A series of 1-D polymer ternary composites based on poly(styrene-butadiene-styrene)(SBS)/carbon nanotubes(CNTs)/few-layer graphene(FLG) conductive fibers(SCGFs)were prepared via wet-spinning. Employed as ultra-high stretchable and super-sensitive strain sensors, the ternary composite fiber materials’ interaction, percolation behaviors and mechanism were systematically explored. The resultant SCGFs-based strain sensors simultaneously exhibited high sensitivity, superior stretchability(with a gauge factor of 5,467 under 600% deformation) and excellent durability under different test conditions due to excellent flexibility of SBS, the synergistic effect of hybrid conductive nanofibers and the strong π-π interaction. Besides, the conductive networks in SBS matrix were greatly affected by the mass ratio of CNTs and FLG, and thus the piezoresistive performances of the strain sensors could be controlled by changing the content of hybrid conductive fillers. Especially, the SCGFs with 0.30 wt.%CNTs(equal to their percolation threshold 0.30 wt.%) and 2.7 wt.% FLG demonstrated the highest sensitivity owing to the bridge effect of FLG between adjacent CNTs. Whereas, the SCGFs with 1.0 wt.% CNTs(higher than their percolation threshold) and 2.0 wt.% FLG showed the maximum strain detection range(600%) due to the welding connection caused by FLG between the contiguous CNTs. To evaluate the fabricated sensors, the tensile and the cyclic mechanical recovery properties of SCGFs were tested and analyzed. Additionally, a theoretical piezoresistive mechanism of the ternary composite fiber was investigated by the evolution of conductive networks according to tunneling theory.展开更多
To measure the pulsed neutron of a pulsed fission source, an organic scintillation fiber （OSF） detector with separation structure has been designed. The proposed detector employs UV optical fibers as the light guide...To measure the pulsed neutron of a pulsed fission source, an organic scintillation fiber （OSF） detector with separation structure has been designed. The proposed detector employs UV optical fibers as the light guide, and the sensitive region of the detector is composed of a linear array of OSFs, which are individually connected to the optical fibers. The other end of the light guide is coupled to a photomultiplier tube. The key properties of the device including the energy response, time response, neutron sensitivity, and radiation effect of the optical fiber were studied. The detector has a relatively high n/γ sensitivity ratio, which increases as the diameter of the OSF decreases, and ratios greater than 10 could be achieved when the diameter of the OSF is less than 0.3 nun. The sensitivity of the detector to neutrons ranges from 10-14 to 10-20 C cm2/n, and has a response time of 3 ns （FWHM）. The proposed detector is also highly flexible. For instance, the probe can be set close to the source, while the PMT can be placed far away from radiation, allowing easy shielding. Due to these characteristics, pulsed fission neutrons in the vicinity of the source can be accurately measured.展开更多
文摘 DNA immobilization on electrode surfaces has been widely used for fabricating sensors since DNA can interact with a wide variety of biomolecules. Recendy, DNA has been demonstrated as an electronic super conductor and become the most promising biomolecule for application of chemical sensing in biological system. Calf thymus DNA (ct-DNA) is a most popularly used native DNA in many applications. An electrochemical deposition on carbon fiber micro electrode can provide sensitive detection of dopamine in presence of large amount of ascorbic acid.……
文摘Objective To evaluate the effects of simvastatin combined with omega-3 fatty acids on high sensitive C-reactive protein(HsCRP), lipidemia, and fibrinolysis in coronary heart disease (CHD) and CHD risk equivalent patients with mixed dyslipi-demia. Methods A randomized, double-blind placebo controlled and parallel group trial was conducted. Patients with CHD and CHD risk equivalents with mixed dyslipidemia were treated with 10 or 20 mg simvastatin for 6-12 weeks. Following with the treatment of patients whose low-density lipoprotein cholesterol (LDL-ch) reaching goal level (< 100 mg/dL) or close to the goal (< 130 mg/dL), while triglyceride (TG) ≥200 mg/dL and < 500 mg/dL, was combined with omega-3 fatty acids (3 g/d) or a placebo for 2 months. The effects of the treatment on HsCRP, total cholesterol (TC), LDL-ch, high-density lipoprotein cholesterol (HDL-ch), TG, lipoprotein (a) [LP (a)], apolipoprotein A1 (apoA1), apolipoprotein B (apoB), plasminogen activator inhibitor-1 (PAI-1), and tissue plasminogen activator (tPA) were investigated. Forty patients finished the study with each group consisting of twenty patients. Results (1) There were significant reductions of HsCRP, TG, TC, and TC/HDL-ch, which decreased by 2.16 ±2.77 mg/L (38.5%), 94.0 ±65.4 mg/dL (31.1%), 13.3 ±22.3 mg/dL (6.3%), 0.78 ±1.60 respectively in the omega-3 fatty acids group (P< 0.01, < 0.001, < 0.05, < 0.05) compared to the baseline. HsCRP and triglyceride reduction were more significant in omega-3 fatty acids group compared to the placebo group (P=0.021 and 0.011 respectively). (2) In the omega-3 fatty acids group, the values and percentage of TG reduction had a significantly positive relation with HsCRP reduction (r=0.51 and 0.45, P=0.021 and 0.047 respectively). Conclusion In CHD and CHD risk equivalent patients with mixed dyslipidemia, dyslipidemia’s therapeutic effect using simvastatin and omega-3 fatty acids may result from not only the combination of lipid adjustment, but also enhancement of their own nonlipid influences.
基金This work is supported by the National Natural Science Founda-tion of China (Grant No. 60577018 and No. 10674075.)
文摘A novel method of correlation function for analyzing cross-sensitivity between strain and temperature is reported for the first time in this paper. Using the new method,the correlative characteristics between strain and temperature of fiber Bragg grating sensors are studied both theoretically and experimentally The experimental results accord with the theoretical calculations.
基金supported by the Fundamental Research Funds for the Central Universities (2232018D3-03 and 2232018A3-01)the Program for Changjiang Scholars and Innovative Research Team in University (IRT16R13)+2 种基金the National Natural Science Foundation of China (51603033)the Science and Technology Commission of Shanghai Municipality (16JC1400700)the Innovation Program of Shanghai Municipal Education Commission (2017-01-0700-03-E00055)
文摘A series of 1-D polymer ternary composites based on poly(styrene-butadiene-styrene)(SBS)/carbon nanotubes(CNTs)/few-layer graphene(FLG) conductive fibers(SCGFs)were prepared via wet-spinning. Employed as ultra-high stretchable and super-sensitive strain sensors, the ternary composite fiber materials’ interaction, percolation behaviors and mechanism were systematically explored. The resultant SCGFs-based strain sensors simultaneously exhibited high sensitivity, superior stretchability(with a gauge factor of 5,467 under 600% deformation) and excellent durability under different test conditions due to excellent flexibility of SBS, the synergistic effect of hybrid conductive nanofibers and the strong π-π interaction. Besides, the conductive networks in SBS matrix were greatly affected by the mass ratio of CNTs and FLG, and thus the piezoresistive performances of the strain sensors could be controlled by changing the content of hybrid conductive fillers. Especially, the SCGFs with 0.30 wt.%CNTs(equal to their percolation threshold 0.30 wt.%) and 2.7 wt.% FLG demonstrated the highest sensitivity owing to the bridge effect of FLG between adjacent CNTs. Whereas, the SCGFs with 1.0 wt.% CNTs(higher than their percolation threshold) and 2.0 wt.% FLG showed the maximum strain detection range(600%) due to the welding connection caused by FLG between the contiguous CNTs. To evaluate the fabricated sensors, the tensile and the cyclic mechanical recovery properties of SCGFs were tested and analyzed. Additionally, a theoretical piezoresistive mechanism of the ternary composite fiber was investigated by the evolution of conductive networks according to tunneling theory.
文摘To measure the pulsed neutron of a pulsed fission source, an organic scintillation fiber （OSF） detector with separation structure has been designed. The proposed detector employs UV optical fibers as the light guide, and the sensitive region of the detector is composed of a linear array of OSFs, which are individually connected to the optical fibers. The other end of the light guide is coupled to a photomultiplier tube. The key properties of the device including the energy response, time response, neutron sensitivity, and radiation effect of the optical fiber were studied. The detector has a relatively high n/γ sensitivity ratio, which increases as the diameter of the OSF decreases, and ratios greater than 10 could be achieved when the diameter of the OSF is less than 0.3 nun. The sensitivity of the detector to neutrons ranges from 10-14 to 10-20 C cm2/n, and has a response time of 3 ns （FWHM）. The proposed detector is also highly flexible. For instance, the probe can be set close to the source, while the PMT can be placed far away from radiation, allowing easy shielding. Due to these characteristics, pulsed fission neutrons in the vicinity of the source can be accurately measured.
