社会资本的感性基础初探

社会资本的“关系论”视角,超越了其他类型的资本理论。其他社会资本理论研究的局限在于对社会资本工具理性取向的特殊强调,“投资—收益”模式过分强调了社会资本的经济功能;以往的研究大多集中在对社会资本功效的经验研究层面,而不对社会资本的产生、维持做动态的过程研究。作为社会资本本质属性的“关系”,是一种相对稳定的社会联系,它必然涉及作为关系主体的意识活动、关系本身的发展变化过程以及不同场域对嵌入在关系中的社会资源价值的不同评价。只有进行溯源性的考察,才能对社会资本有一个清晰、完整的认识;而从社会资本的形成和维系过程入手,结合日常生活中常见的个案来探讨社会资本得以存续的感性基础,能够扩展以理性选择行为模式为基础的社会资本理论的研究范式。

工商管理类课程实践教学环节探索

在管理类课程的本科教学中,由于学生实践经验与专业感性认识的匮乏,学生在学习时往往难以较好理解和掌握所学课程理论知识,给教学带来一定困难并影响到教学效果。鉴于管理类课程知识体系自身的特殊性,因而只有通过各种形式的课程实践教学活动,教学双方共同互动努力,强化学生专业和课程感性认识,才能为学生很好理解并掌握相关管理理论知识奠定必要基础,取得良好的课程教学效果。

Assessing Vulnerability to Drought Based on Exposure,Sensitivity and Adaptive Capacity:A Case Study in Middle Inner Mongolia of China

In this paper,we proposed a framework for evaluating the performance of ecosystem strategies prepared for enhancing vulnerability reduction in the face of hazards due to climate change.The framework highlights the positive effects of human activities in the coupled human and natural system(CHANS) by introducing adaptive capacity as an evaluation criterion.A built-in regional vulnerability to a certain hazard was generated based upon interaction of three dimensions of vulnerability:exposure,sensitivity and adaptive capacity.We illustrated the application of this framework in the temperate farming-grazing transitional zone in the middle Inner Mongolia of the northern China,where drought hazard is the key threat to the CHANS.Specific indices were produced to translate such climate variance and social-economic differences into specific indicators.The results showed that the most exposed regions are the inner land areas,while counties located in the eastern part are potentially the most adaptive ones.Ordos City and Bayannur City are most frequently influenced by multiple climate variances,showing highest sensitivity.Analysis also indicated that differences in the ability to adapt to changes are the main causes of spatial differences.After depiction of the spatial differentiations and analysis of the reasons,climate zones were divided to depict the differences in facing to the drought threats.The climate zones were shown to be similar to vulnerability zones based on the quantitative structure of indexes drafted by a triangular map.Further analysis of the composition of the vulnerability index showed that the evaluation criteria were effective in validating the spatial differentiation but potentially ineffective because of their limited time scope.This research will be a demonstration of how to combine the three dimensions by quantitative methods and will thus provide a guide for government to vulnerability reduction management.

Reconstruction based approach to sensor fault diagnosis using auto-associative neural networks

Fault diagnostics is an important research area including different techniques.Principal component analysis(PCA)is a linear technique which has been widely used.For nonlinear processes,however,the nonlinear principal component analysis(NLPCA)should be applied.In this work,NLPCA based on auto-associative neural network(AANN)was applied to model a chemical process using historical data.First,the residuals generated by the AANN were used for fault detection and then a reconstruction based approach called enhanced AANN(E-AANN)was presented to isolate and reconstruct the faulty sensor simultaneously.The proposed method was implemented on a continuous stirred tank heater(CSTH)and used to detect and isolate two types of faults(drift and offset)for a sensor.The results show that the proposed method can detect,isolate and reconstruct the occurred fault properly.

Zhang Heng's Seismoscope( 1):Its Emergence

The emergence of Zhang Heng's seismoscope has a profound historical background. This paper intends to explore the formation and material basis of Zhang Heng's scientific thought. It appears that the simple intention of "observing visions and distinguishing good fortune or misfortune"was his motivation to develop the seismoscope. Tracing its historical background,the authors proposed in this paper that the development of this seismoscope started around 128 A. D., and based on perceptual knowledge, two ideas about earthquakes came into being,i. e.,earthquake location could be judged according to the instrument shaking direction, and the earthquake and earth split were essentially different. In the instrument manufacture,Zhang Heng advocated a principle of "making utensils to imitate cosmos". By this principle,the following three problems were readily solved: the seismoscope imitated the response of the suspension system to earthquakes( i. e. natural seismoscope). Technically,the trigger mechanism of the latch was used for reference,and it recorded the physical evidence of earthquake occurrence by an ingenious way of a ball dropping from a dragon's mouth. The solution of these three key problems lead to the emergence of the seismoscope in 132 A. D. and the successful detection of an earthquake in 134 A. D. His invention deepened humanity's knowledge of natural laws, and promoted the development of science and technology in that time and later.

Association between Two Polymorphisms of Follicle Stimulating Hormone Receptor Gene and Susceptibility to Polycystic Ovary Syndrome: a Meta-analysis

Objective To investigate the association between two polymorphisms of follicle stimulating hormone receptor （FSHR） gene and polycystic ovary syndrome （PCOS） susceptibility. Methods Case-control studies on relationship of Thr307Ala and Asn680Ser polymorphisms in FSHR gene and PCOS susceptibility were searched from PubMed, ISI web of knowledge, EBSCO, and China National Knowledge Infrastructure （CNKI） databases up to March 21, 2013. The pooled odds ratio （OR） and 95% confidence interval （CO were calculated using fixed- or random-effect model based on heterogeneity test in 5 genotype models analyses. Results A total of 11 studies were included in the Meta-analysis. The random-effect analysis showed Asn680Ser was significantly associated with the reduced susceptibility to PCOS with dominant model （Asn/Asn＋Asn/Ser vs. Ser/Ser, OR=0.83, 95% CI： 0.69-1.00）, recessive model （Asn/Asn vs. Asn/Ser＋ Ser/Ser, OR=0.84, 95% CI： 0.72-0.98）, homozygote comparison （Ash/Ash vs. Ser/Ser, 0R=0.79, 95% CI： 0.63-0.98）, and the allele contrast （Asn vs. Ser, OR=0.87, 95% CI： 0.79-0.97） respectively（P=0.02, I2=56.0%）, being protective factors for PCOS. However, no significant associations were found between Thr307Ala and PCOS. Conclusion There might be a significant association between Asn680Ser polymorphism and PCOS.

X-ray repair cross-complementing group 1 polymorphisms and hepatocellular carcinoma:A meta-analysis

AIM： To perform a systematic meta-analysis to in- vestigate the association between X-ray repair crosscomplementing group 1 （XRCC1） polymorphisms and hepatocellular carcinoma （HCC） risk. METHODS： Relevant studies extracted from PubMed, Embase, Wanfang, VIP and the Chinese National Knowledge Infrastructure databases up to March 2012 were included in the study. Stata software, version 11.0, was used for the statistical analysis. The odds ratios （ORs） and 95% confidence interval （CI） of the XRCC1 polymorphisms in HCC patients were analyzed and compared with healthy controls. The meta-analysis was performed using fixed-effect or random-effect methods, depending on the absence or presence of significant heterogeneity. RESULTS： Eleven studies with 2075 HCC cases and 2604 controls met our eligibility criteria （four studies, 888 cases and 938 controls for Arg194Trp, four studies, 858 cases and 880 controls for Arg280His, and nine studies, 1845 cases and 2401 controls for Arg399Gln）. The meta-analysis revealed no associations between the Arg194Trp and Arg399GIn polymorphisms of the XRCC1 gene and HCC risk under all contrast models （codominant, dominant and recessive models） in the overall analysis and sensitivity analysis （the studies with controls not in the Hardy-Weinberg equilibrium were excluded）. For XRCC1 Arg280His polymorphism, the overall analysis revealed the significant associa- tion between the His/His genotype and the increased risk of HCC （His/His vs Arg/Arg model, OR： 1.96, 95% CI： 1.03-3.75, P = 0.04）. However, sensitivity analysis showed an altered pattern of result and non-significant association （OR： 2.06, 95% CI： 0.67-6.25, P = 0.20）. The heterogeneity hypothesis test did not reveal any heterogeneity, and Begg＇s and Egger＇s tests did not find any obvious publication bias. CONCLUSION： The XRCC1 Arg194Trp and Arg399GIn polymorphisms are not associated with HCC risk. More rigorous association studies are needed to verify the involvement ofXRCC1 Arg280His polymorphism in HCC susceptibility.

Trial of the correlation between cytochrome oxidase CYP3A4 with the susceptibility of paclitaxel-based regimen for advanced gastric cancer

Objective: The aim of the study was to investigate the relationship between susceptibility of paclitaxel-based regimen and gene polymorphisms of cytochrome oxidase CYP3A4 for advanced gastric cancer. Methods: Peripheral venous blood sample of 53 advanced gastric cancer patients were enrolled to test the mutation of CYP3A4 gene by denaturing high performance liquid chromatography(DHPLC) and DNA sequencing. The relation between the efficacy of paclitaxel-based regimen and CYP3A4 gene polymorphisms was further analyzed. Results: DHPLC indicated that among the 53 patients, 21 cases showed biomodal type(mutation) and 32 cases were of unimodal type(wild-type). Sequencing results showed that the deletion mutation was found at the 27 th basic group of C in exon 10 of CYP3A4 gene. The response rate(RR) and disease control rate(DCR) of wild-type group were 40.6% and 84.4%, while in mutation group they were 33.3% and 85.7%, respectively, with no significances between the two groups(P > 0.05). Of all 53 cases, the median progression-free survival(PFS) was 6.5 months(95% CI: 3.576–9.424 months), and the median overall survival(OS) was 11.0 months(95% CI: 6.955–15.045 months). The median PFS and OS in wild-type group had no differences compared with those in mutation group(7.0 months vs. 7.0 months, P > 0.05; 10.0 months vs. 14.0 months, P > 0.05). Between wild-type and mutation groups, the median PFS of patients applied with oxaliplatin containing regimen and the median OS in patients applied with/without oxaliplatin had no significant differences(P > 0.05), while the median PFS in patients received non-oxaliplatin regime had statistical differences(P = 0.024). The median PFS and OS in patients receiving 3-drug or 2-drug regimes had no correlation with CYP3A4 gene polymorphisms. The adverse effects in the two groups were mild, mainly in grades 1–2. The common adverse effects were anorexia, nausea/vomiting and leucopenia. Conclusion: Deletion mutation was located in the 27 th basic group of C in exon 10 of CYP3A4 gene. Paclitaxel-based regime has a trend to prolong the OS of advanced gastric cancer with mutation type.

Key-insulated encryption based group key management for wireless sensor network

The key exposure problem is a practical threat for many security applications. In wireless sensor networks (WSNs), keys could be compromised easily due to its limited hardware protections. A secure group key management scheme is responsible for secure distributing group keys among valid nodes of the group. Based on the key-insulated encryption (KIE), we propose a group key management scheme (KIE-GKMS), which integrates the pair-wise key pre-distribution for WSN. The KIE-GKMS scheme updates group keys dynamically when adding or removing nodes. Moreover, the security analysis proves that the KIE-GKMS scheme not only obtains the semantic security, but also provides the forward and backward security. Finally, the theoretical analysis shows that the KIE-GKMS scheme has constant performance on both communication and storage costs in sensor nodes.

Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis

AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC.

Geospatial susceptibility mapping of earthquake-induced landslides in Nuweiba area, Gulf of Aqaba, Egypt

Earthquake induced landslides are one of the most severe geo-environmental hazards that cause enormous damage to infrastructure, property, and loss of life in Nuweiba area. This study developed a model for mapping the earthquake-induced landslide susceptibility in Nuweiba area in Egypt with considerations of geological, geomorphological, topographical, and seismological factors. An integrated approach of remote sensing and GIS technologies were applied for that target. Several data sources including Terra SAR-X and SPOT 5 satellite imagery, topographic maps, field data, and other geospatial resources were used to model landslide susceptibility. These data were used specifically to produce important thematic layers contributing to landslide occurrences in the region. A rating scheme was developed to assign ranks for the thematic layers and weights for their classes based on their contribution in landslide susceptibility. The ranks and weights were defined based on the knowledge from field survey and authors experiences related to the study area. The landslide susceptibility map delineates the hazard zones to three relative classes of susceptibility: high, moderate, and low. Therefore, the current approach provides a way to assess landslide hazards and serves for geo-hazard planning and prediction in Nuweiba area.

PIR-based data integrity verification method in sensor network

Since a sensor node handles wireless communication in data transmission and reception and is installed in poor environment, it is easily exposed to certain attacks such as data transformation and sniffing. Therefore, it is necessary to verify data integrity to properly respond to an adversary's ill-intentioned data modification. In sensor network environment, the data integrity verification method verifies the final data only, requesting multiple communications. An energy-efficient private information retrieval(PIR)-based data integrity verification method is proposed. Because the proposed method verifies the integrity of data between parent and child nodes, it is more efficient than the existing method which verifies data integrity after receiving data from the entire network or in a cluster. Since the number of messages for verification is reduced, in addition, energy could be used more efficiently. Lastly, the excellence of the proposed method is verified through performance evaluation.

Research progress in the use of combinations of platinum-based chemotherapy and epidermal growth factor receptor-tyrosine kinase inhibitors

In the past decade,the advent of the epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs)has dramatically influenced the therapeutic strategies for treating lung cancer,but with tumor progression and drug resistance,patients will ultimately develop reduced sensitivity to EGFR-TKIs.How can we delay the emergence of drug resistance? What is the next strategy after drug resistance? How to reasonably combine platinum-based chemotherapy and EGFR-TKIs? These questions are currently the focus of lung cancer research.Clinical studies have reported that platinum-based chemotherapy can increase the sensitivity to EGFR-TKIs.However,results of pre-clinical and clinical studies have been inconsistent.The mechanisms of platinum chemotherapy and EGFR-TKIs are still unknown due to the lack of systematic research.Therefore,systematic studies are required to show the mechanisms of EGFR-TKIs and chemotherapy agents and define the markers sensitive to their combinations when given concurrently or sequentially.

Study on Sensitivity Improving of Fiber Bragg Grating Based pH Sensor

The key factor of the sensitivity in the FBG-based pH sensor is analyzed in detail. A multi-thin-layer structure of the gel coated cover was proposed and implemented with a special process. The sensors with the coated thickness of 420 ~m, 500 ~m, and 580 ~m were built up, respectively. The corresponding spectral shifts of 0.08nm, 0.13nm, and 0.22nm were detected when the pH sensors were soaked in the pH value of 3-9. Meanwhile, the sensor with the gel layer thickness of 580 ~tm was measured in the optimum measurement time period with the pH value changing from 3-12, in which the detected sensitivity of 52pm/pH was achieved in the pH range of 6-12.

Integrity assurance of GNSS-based train integrated positioning system

This paper presents a novel Autonomous Integrity Monitoring and Assurance （AIMA） scheme for integrity assurance of the GNSS-based train integrated positioning system. In this scheme, integrity assurance strategies are combined with a three-stage hierarchical architecture, considering the coupling effects among sensor collection, sensor fusion and matching decision level in train integrated positioning. In sensor collecting stage, the AIMA scheme deals with sensor faults and failures with a PCA-based fault detection, diagnosis and isolation approach. In multi-sensor fusion stage, a novel cubature point H0o filter is presented to enhance the fault tolerance capability, and a hybrid approach is applied to indicating and monitoring the protection level of position estimation, concerning both the estimating covariance and measurement slopes. In map matching stage, hypothesis testing with specific test statistic is carried out to determine effectiveness of positioning results. Position calculation will be invalid with an alarm triggered if the specific integrity criterion is not satisfied in any stage. Since independent solutions are applied in AIMA, integrity assurance is closely coupled with information processing in train integrated positioning. Numerical results of the three cases correspond to the hierarchical architecture with field data and simulations are presented to illustrate features and applicability of the proposed AIMA scheme and specific solutions.

A trait-based approach to assess climate change sensitivity of freshwater invertebrates across Swedish ecoregions

Freshwater habitats and organisms are among the most threatened on Earth, and freshwater ecosystems have been subject to large biodiversity losses. We developed a Climate Change Sensitivity （CCS） indicator based on trait information for a selection of stream- and lake-dwelling Ephemeroptera, Plecoptera and Trichoptera taxa. We calculated the CCS scores based on ten species traits identified as sensitive to global climate change. We then assessed climate change sensitivity between the six main ecoregions of Sweden as well as the three Swedish regions based on lilies. This was done using biological data from 1,382 stream and lake sites where we compared large-scale （ecoregional） patterns in climate change sensitivity with potential future exposure of these ecosystems to increased temperatures using ensemble-modelled future changes in air temperature. Current （1961-1990） measured temperature and ensemble-modelled future （2100） temperature showed an increase from the northernmost towards the southern ecoregions, whereas the predicted temperature change increased from south to north. The CCS indicator scores were highest in the two northernmost boreal ecoregions where we also can expect the largest global climate change-induced increase in temperature, indicating an unfortunate congruence of exposure and sensitivity to climate change. These results are of vital importance when planning and implementing management and conservation strategies in freshwater ecosystems, e.g., to mitigate increased temperatures using riparian buffer strips. We conclude that traits information on taxa specialization, e.g., in terms of feeding specialism or taxa having a preference for high altitudes as well as sensitivity to changes in temperature are important when assessing the risk from future global climate change to freshwater ecosystems [Current Zoology 60 （2）： 221-232, 2014].

Reputation-based linear cooperation for spectrum sensing in cognitive radio networks

We propose a reputation-based cooperative spectrum sensing scheme in cognitive radio (CR) networks to solve the uncertainty resulting from the multipath fading and shadowing effect. In the proposed scheme, each cooperative CR user has a reputation degree that is initialized and adjusted by the central controller, and used to weight the sensing result from the corresponding CR user in the linear fusion process at the central controller. A simple method for adjusting the reputation degree of CR users is also presented. We analyzed and evaluated the detection performance of the reputation-based cooperative spectrum sensing scheme. Simulation results showed that our proposed scheme alleviates the problem of corrupted detection resulting from destructive channel conditions between the primary transmitter and the CR user. The performance of our proposed scheme was improved compared to the average-based linear cooperation scheme, and was similar to that of the optimal linear cooperation scheme with feasible computational complexity. Moreover, our proposed scheme does not require knowledge of channel statistics.

Aptamer-based competitive electrochemical assay of small biomolecules

A convenient aptamer-based competitive electrochemical biosensor for a small biomolecule,adenosine,was described. The sensing surface was fabricated by self-assembly of an aptamer/mercaptohexanol monolayer on a gold disk electrode. The principle of this aptasensor is based on the competition between an adenosine target molecule and a ferrocene-conjugated signaling DNA strand for the aptamer binding site on the sensing surface. Due to the competitive nature of this assay,the electrochemical responses of the surface captured ferrocene are inversely proportional to log[adenosine] in the range from 0.05 to 3.2 μM,with a detection limit of 25 nM. Moreover,the aptasensor also shows high selectivity for adenosine. The proposed aptasensor thus holds great potential for the detection of other small biomolecules.