Aiming at the problem of poor observability of measurement information in the loosely-coupled integration of the inertial navigation system (INS) and the wireless sensor network (WSN), this paper presents a tightl...Aiming at the problem of poor observability of measurement information in the loosely-coupled integration of the inertial navigation system (INS) and the wireless sensor network (WSN), this paper presents a tightly-coupled integration based on the Kalman filter (KF). When the WSN is available, the difference between the distances from the blind node(BN) to the reference nodes (RNs) measured by the INS and those measured by the WSN are used as measurement information for the KF due to its better observability and independence, which can effectively improve the accuracy of the KF. Simulations show that the proposed approach reduces the mean error of the position by about 50% compared with loosely-coupled integration, while the mean error of the velocity is a little higher than that of loosely-coupled integration.展开更多
In order to keep stable navigation accuracy when the blind node (BN) moves between two adjacent clusters, a distributed fusion method for the integration of the inertial navigation system (INS) and the wireless se...In order to keep stable navigation accuracy when the blind node (BN) moves between two adjacent clusters, a distributed fusion method for the integration of the inertial navigation system (INS) and the wireless sensor network (WSN) based on H∞ filtering is proposed. Since the process and measurement noise in the integration system are bounded and their statistical characteristics are unknown, the H∞ filter is used to fuse the information measured from local estimators in the proposed method. Meanwhile, the filter can yield the optimal state estimate according to certain information fusion criteria. Simulation results show that compared with the federal Kalman solution, the proposed method can reduce the mean error of position by about 45% and the mean error of velocity by about 85 %.展开更多
The collected spectrum of the fiber Bragg grating(FBG) and the loss of the detected optical power are discussed with respect to the 3-dB bandwidth of a Fabry-Perot(F-P) type tunable optical filter(TOF),respectively.An...The collected spectrum of the fiber Bragg grating(FBG) and the loss of the detected optical power are discussed with respect to the 3-dB bandwidth of a Fabry-Perot(F-P) type tunable optical filter(TOF),respectively.And the optimized parameters of the TOF are obtained consequently.It is demonstrated that the relationship between the transmission wave-length of the TOF and its drive voltage is nonlinear.A new method to compensate the nonlinearity of the TOF is proposed.The linear sweeping of the transmission wavelength of the TOF is achieved through modifying the drive voltage using interpolation algorithm.It is observed that the average error and the maximum error of the transmission wavelength are reduced sharply under linear fit.The dynamic strain sensing is realized by use of a reference FBG and moving averaging algorithm in this system.展开更多
Whipple's disease was initially described in 1907. Over the next century, the clinical and pathological features of this disorder have been better appreciated. Most often, weight loss, diarrhea, abdominal and join...Whipple's disease was initially described in 1907. Over the next century, the clinical and pathological features of this disorder have been better appreciated. Most often, weight loss, diarrhea, abdominal and joint pain occur. Occasionally, other sites of involvement have been documented, including isolated neurological disease, changes in the eyes and culture-negative endocarditis. In the past decade, the responsible organism Tropheryma whipplei has been cultivated, its genome sequenced and its antibiotic susceptibility defined. Although rare, it is a systemic infection that may mimic a wide spectrum of clinical disorders and may have a fatal outcome. If recognized, prolonged antibiotic therapy may be a very successful form of treatment.展开更多
The alpine meadow, as one of the typical vegetation types on the Tibetan Plateau, is one of the most sensitive terrestrial ecosystems to climate warming. However, how climate warming affects the carbon cycling of the ...The alpine meadow, as one of the typical vegetation types on the Tibetan Plateau, is one of the most sensitive terrestrial ecosystems to climate warming. However, how climate warming affects the carbon cycling of the alpine meadow on the Tibetan Plateau is not very dear. A field experiment under controlled experimental warming and clipping conditions was conducted in an alpine meadow on the Northern Tibetan Plateau since July 2008. Open top chambers (0TCs) were used to simulate climate warming. The main objective of this study was to examine the responses of ecosystem respiration (Reco) and its temperature sensitivity to experimental warming and clipping at daily time scale. Therefore, we measured Reco once or twice a month from July to September in 2010, from June to September in 2011 and from August to September in 2012. Air temperature dominated daily variation of Reco whether or not experimental warming and clipping were present. Air temperature was exponentially correlated with Reco and it could significantly explain 58-96% variation of Redo at daily time scale. Experimental warming and clipping decreased daily mean Reco by 5.8-37.7% and -11.9-23.0%, respectively, although not all these changes were significant. Experimental warming tended to decrease the temperature sensitivity of Reco, whereas clipping tended to increase the temperature sensitivity of Reco at daily time scale. Our findings suggest that Reco wasmainly controlled by air temperature and may acclimate to climate warming due to its lower temperature sensitivity under experimental warming at daily time scale.展开更多
The majority of existing papers about spectrum sensing have the assumption that secondary users(SUs) are stationary. However,mobility is an essential feature of mobile communications networks. In this paper,the detect...The majority of existing papers about spectrum sensing have the assumption that secondary users(SUs) are stationary. However,mobility is an essential feature of mobile communications networks. In this paper,the detection performance of spectrum sensing by mobile SUs was analyzed. Three performance metrics,i.e.,detection probability,miss detection probability and false alarm probability,were thoroughly investigated. In our analysis,a critical variable was the real-time received primary user signal power by a mobile SU. Its probability distribution and mathematical expectation were analytically derived. Moreover,the three performance metrics in single-node spectrum sensing and multi-node collaborative spectrum sensing systems were also derived. Extensive simulations were performed. The results are consistent with the theoretical analysis. And it is concluded that SU mobility has a significant impact on the detection probability and the miss detection probability,but not on the false alarm probability.展开更多
AIM:There are conflicting data about p53 function on cellular sensitivity to the cytotoxic action of 5-fluorouracil (5-FU). Therefore the objective of this study was to determine the combined effects of adenovirus-med...AIM:There are conflicting data about p53 function on cellular sensitivity to the cytotoxic action of 5-fluorouracil (5-FU). Therefore the objective of this study was to determine the combined effects of adenovirus-mediated wild-type (wt) p53 gene transfer and 5-FU chemotherapy on pancreatic cancer cells with different p53 gene status. METHODS:Human pancreatic cancer cell lines Capan-1^(p53mut), Capan-2^(p53wt),FAMPAC^(p53mut),PANC1^(p53mut),and rat pancreatic cancer cell lines AS^(p53wt) and DSL6A^(p53null) were used for in vitro studies.Following infection with different ratios of Ad- p53-particles (MOI) in combination with 5-FU,proliferation of tumor cells and apoptosis were quantified by cell proliferation assay (WST-1) and FACS (PI-staining).In addition,DSL6A syngeneic pancreatic tumor cells were inoculated subcutaneously in to Lewis rats for in vivo studies. Tumor size,apoptosis (TUNEL) and survival were determined. RESULTS:Ad-p53 gene transfer combined with 5-FU significantly inhibited tumor cell proliferation and substantially enhanced apoptosis in all four cell lines with an alteration in the p53 gene compared to those two cell lines containing wt-p53.In vivo experiments showed the most effective tumor regression in animals treated with Ad-p53 plus 5-FU.Both in vitro and in vivo analyses revealed that a sublethal dose of Ad-p53 augmented the apoptotic response induced by 5-FU. CONCLUSION:Our results suggest that Ad-p53 may synergistically enhance 5-FU-chemosensitivity most strikingly in pancreatic cancer cells lacking p53 function.These findings illustrate that the anticancer efficacy of this combination treatment is dependent on the p53 gene status of the target tumor cells.展开更多
This study investigated the influence of dropwindsonde observations on typhoon forecasts. The study also evaluated the feasibility of the conditional nonlinear optimal perturbation (CNOP) method as a basis for sensiti...This study investigated the influence of dropwindsonde observations on typhoon forecasts. The study also evaluated the feasibility of the conditional nonlinear optimal perturbation (CNOP) method as a basis for sensitivity analysis of such forecasts. This sensitivity analysis could furnish guidance in the selection of targeted observations. The study was performed by conducting observation system experiments (OSEs). This research used the fifth-generation Mesoscale Model (MM5), the Weather Research and Forecasting (WRF) model, and dropsonde observations of Typhoon Nida at 1200 UTC 17 May 2004. The dropsondes were collected under the operational Dropsonde Observations for Typhoon Surveillance near the Taiwan Region (DOTSTAR) program. In this research, five kinds of experiments were designed and conducted:(1) no observations were assimilated; (2) all observations were assimilated;(3) observations in the sensitive area revealed by the CNOP method were assimilated;(4) the same as in (3), but for the region revealed by the first singular vector (FSV) method;and (5) observations within a randomly selected area were assimilated. The OSEs showed that (1) the DOTSTAR data had a positive impact on the forecast of Nida's track;(2) dropsondes in the sensitive areas identified by the MM5 CNOP and FSV remained effective for improving the track forecast for Nida on the WRF platform;and (3) the greatest improvement in the track forecast resulted from the CNOP-based (third) simulation, which indicated that the CNOP method would be useful in decision making about dropsonde deployments.展开更多
Physiography and soil in Mae Rim watershed, Chiang Mai Province, Thailand were investigated by using aerial photographs and satellite image in conjunction with field work, and soil infiltration rate and soil shear res...Physiography and soil in Mae Rim watershed, Chiang Mai Province, Thailand were investigated by using aerial photographs and satellite image in conjunction with field work, and soil infiltration rate and soil shear resistance were measured in field. Many factors affecting runoff were analyzed using the Integrated Land and Water Information System (ILWIS). As a result, a model determining flood hazard was set up. Three maps including runoff curve number map, runoff coefficient map, and flood inundation map were created. In addition, the time of concentration was predicted.展开更多
Round inductosyn is widely used in inertial navigation test equipment, and its accuracy has significant effect on the general accuracy of the equipment. Four main errors of round inductosyn,i.e. the first-order long-p...Round inductosyn is widely used in inertial navigation test equipment, and its accuracy has significant effect on the general accuracy of the equipment. Four main errors of round inductosyn,i.e. the first-order long-period (360°) harmonic error, the second-order long-period harmonic error, the first-order short-period harmonic error and the second-order short-period harmonic error, are described, and the orthogonality of these four kinds of errors is studied. An error separating technology is proposed to separate these four kinds of errors, and in the process of separating the short-period harmonic errors, the arrangement in the order of decimal part of the angle pitch number can be omitted. The effectiveness of the technology proposed is proved through measuring and adjusting the angular errors.展开更多
Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have requ...Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation.展开更多
Using a simplified nonlinearly theoretical grassland ecosystem proposed by Zeng et al.,we study the sensitivity and nonlinear instability of the grassland ecosystem to finiteamplitude initial perturbations with the ap...Using a simplified nonlinearly theoretical grassland ecosystem proposed by Zeng et al.,we study the sensitivity and nonlinear instability of the grassland ecosystem to finiteamplitude initial perturbations with the approach of conditional nonlinear optimal perturbation (CNOP).The results show that the linearly stable grassland (desert or latent desert) states can turn to be nonlinearly unstable with finite amplitude initial perturbations.When the precipitation is between the two bifurcation points,a large enough finite amplitude initial perturbation can induce a transition between the grassland statethe desert state or the latent desert.展开更多
The existing hydraulic system always have problems of temperature rise,runningstability and anti-interference of the implementation components,reliability of hydrauliccomponents,maintenance difficulties,and other issu...The existing hydraulic system always have problems of temperature rise,runningstability and anti-interference of the implementation components,reliability of hydrauliccomponents,maintenance difficulties,and other issues.With high efficiency,energysaving,reliability,easy operating,stable running,anti-interference ability,and other advantages,the load-sensitive hydraulic system is more suitable for coal mine all-hydrauliccore rig.Therefore,for the technical development of the coal mine all-hydraulic core rig,the load-sensitive technology employed by the rig should be of great significance.展开更多
基金The National Basic Research Program of China(973 Program)(No.2009CB724002)the National Natural Science Foundation of China(No.50975049)+3 种基金the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20110092110039)the Aviation Science Foundation(No.20090869008)the Six Peak Talents Foundation in Jiangsu Province(No.2008143)Program of Scientific Innovation Research of College Graduate in Jiangsu Province(No.CXLX_0101)
文摘Aiming at the problem of poor observability of measurement information in the loosely-coupled integration of the inertial navigation system (INS) and the wireless sensor network (WSN), this paper presents a tightly-coupled integration based on the Kalman filter (KF). When the WSN is available, the difference between the distances from the blind node(BN) to the reference nodes (RNs) measured by the INS and those measured by the WSN are used as measurement information for the KF due to its better observability and independence, which can effectively improve the accuracy of the KF. Simulations show that the proposed approach reduces the mean error of the position by about 50% compared with loosely-coupled integration, while the mean error of the velocity is a little higher than that of loosely-coupled integration.
基金The National Basic Research Program of China (973 Program) (No. 2009CB724002)the National Natural Science Foundation of China (No. 50975049)+2 种基金the Specialized Research Fund for the Doctoral Program of Higher Education (No. 20110092110039)the Program for Special Talents in Six Fields of Jiangsu Province (No.2008143)the Program Sponsored for Scientific Innovation Research of College Graduates in Jiangsu Province,China (No. CXLX_0101)
文摘In order to keep stable navigation accuracy when the blind node (BN) moves between two adjacent clusters, a distributed fusion method for the integration of the inertial navigation system (INS) and the wireless sensor network (WSN) based on H∞ filtering is proposed. Since the process and measurement noise in the integration system are bounded and their statistical characteristics are unknown, the H∞ filter is used to fuse the information measured from local estimators in the proposed method. Meanwhile, the filter can yield the optimal state estimate according to certain information fusion criteria. Simulation results show that compared with the federal Kalman solution, the proposed method can reduce the mean error of position by about 45% and the mean error of velocity by about 85 %.
基金the National Natural Science Foundation of China (Contact No. 60577013)the New Cen-tury Support Program for Talented Young Teachers in Universities of Ministry of Education, China
文摘The collected spectrum of the fiber Bragg grating(FBG) and the loss of the detected optical power are discussed with respect to the 3-dB bandwidth of a Fabry-Perot(F-P) type tunable optical filter(TOF),respectively.And the optimized parameters of the TOF are obtained consequently.It is demonstrated that the relationship between the transmission wave-length of the TOF and its drive voltage is nonlinear.A new method to compensate the nonlinearity of the TOF is proposed.The linear sweeping of the transmission wavelength of the TOF is achieved through modifying the drive voltage using interpolation algorithm.It is observed that the average error and the maximum error of the transmission wavelength are reduced sharply under linear fit.The dynamic strain sensing is realized by use of a reference FBG and moving averaging algorithm in this system.
文摘Whipple's disease was initially described in 1907. Over the next century, the clinical and pathological features of this disorder have been better appreciated. Most often, weight loss, diarrhea, abdominal and joint pain occur. Occasionally, other sites of involvement have been documented, including isolated neurological disease, changes in the eyes and culture-negative endocarditis. In the past decade, the responsible organism Tropheryma whipplei has been cultivated, its genome sequenced and its antibiotic susceptibility defined. Although rare, it is a systemic infection that may mimic a wide spectrum of clinical disorders and may have a fatal outcome. If recognized, prolonged antibiotic therapy may be a very successful form of treatment.
基金funded by the National Natural Science Foundation of China (Grant Nos. 41171084and 40771121)Innovation Project of the Institute of Geographic Sciences and Natural Resources Research,Chinese Academy of Sciences (Grant No.2012ZD005)+2 种基金the Natural Science Foundation of the Tibet Autonomous Region (Name. the Response Experiment of the Alpine Meadow Vegetation to Climate Warming)the National Basic Research Program of China (Grant No.2010CB951704)the National Science and Technology Plan Project of China (Grant No.2011BAC09B03)
文摘The alpine meadow, as one of the typical vegetation types on the Tibetan Plateau, is one of the most sensitive terrestrial ecosystems to climate warming. However, how climate warming affects the carbon cycling of the alpine meadow on the Tibetan Plateau is not very dear. A field experiment under controlled experimental warming and clipping conditions was conducted in an alpine meadow on the Northern Tibetan Plateau since July 2008. Open top chambers (0TCs) were used to simulate climate warming. The main objective of this study was to examine the responses of ecosystem respiration (Reco) and its temperature sensitivity to experimental warming and clipping at daily time scale. Therefore, we measured Reco once or twice a month from July to September in 2010, from June to September in 2011 and from August to September in 2012. Air temperature dominated daily variation of Reco whether or not experimental warming and clipping were present. Air temperature was exponentially correlated with Reco and it could significantly explain 58-96% variation of Redo at daily time scale. Experimental warming and clipping decreased daily mean Reco by 5.8-37.7% and -11.9-23.0%, respectively, although not all these changes were significant. Experimental warming tended to decrease the temperature sensitivity of Reco, whereas clipping tended to increase the temperature sensitivity of Reco at daily time scale. Our findings suggest that Reco wasmainly controlled by air temperature and may acclimate to climate warming due to its lower temperature sensitivity under experimental warming at daily time scale.
基金supported by National Natural Science Foundation of China under Grand No.61671183
文摘The majority of existing papers about spectrum sensing have the assumption that secondary users(SUs) are stationary. However,mobility is an essential feature of mobile communications networks. In this paper,the detection performance of spectrum sensing by mobile SUs was analyzed. Three performance metrics,i.e.,detection probability,miss detection probability and false alarm probability,were thoroughly investigated. In our analysis,a critical variable was the real-time received primary user signal power by a mobile SU. Its probability distribution and mathematical expectation were analytically derived. Moreover,the three performance metrics in single-node spectrum sensing and multi-node collaborative spectrum sensing systems were also derived. Extensive simulations were performed. The results are consistent with the theoretical analysis. And it is concluded that SU mobility has a significant impact on the detection probability and the miss detection probability,but not on the false alarm probability.
文摘AIM:There are conflicting data about p53 function on cellular sensitivity to the cytotoxic action of 5-fluorouracil (5-FU). Therefore the objective of this study was to determine the combined effects of adenovirus-mediated wild-type (wt) p53 gene transfer and 5-FU chemotherapy on pancreatic cancer cells with different p53 gene status. METHODS:Human pancreatic cancer cell lines Capan-1^(p53mut), Capan-2^(p53wt),FAMPAC^(p53mut),PANC1^(p53mut),and rat pancreatic cancer cell lines AS^(p53wt) and DSL6A^(p53null) were used for in vitro studies.Following infection with different ratios of Ad- p53-particles (MOI) in combination with 5-FU,proliferation of tumor cells and apoptosis were quantified by cell proliferation assay (WST-1) and FACS (PI-staining).In addition,DSL6A syngeneic pancreatic tumor cells were inoculated subcutaneously in to Lewis rats for in vivo studies. Tumor size,apoptosis (TUNEL) and survival were determined. RESULTS:Ad-p53 gene transfer combined with 5-FU significantly inhibited tumor cell proliferation and substantially enhanced apoptosis in all four cell lines with an alteration in the p53 gene compared to those two cell lines containing wt-p53.In vivo experiments showed the most effective tumor regression in animals treated with Ad-p53 plus 5-FU.Both in vitro and in vivo analyses revealed that a sublethal dose of Ad-p53 augmented the apoptotic response induced by 5-FU. CONCLUSION:Our results suggest that Ad-p53 may synergistically enhance 5-FU-chemosensitivity most strikingly in pancreatic cancer cells lacking p53 function.These findings illustrate that the anticancer efficacy of this combination treatment is dependent on the p53 gene status of the target tumor cells.
基金jointly sponsored by the National Natural Science Foundation of China(Grant No.40830955)the China Meteorological Administration(Grant No.GYHY200906009)
文摘This study investigated the influence of dropwindsonde observations on typhoon forecasts. The study also evaluated the feasibility of the conditional nonlinear optimal perturbation (CNOP) method as a basis for sensitivity analysis of such forecasts. This sensitivity analysis could furnish guidance in the selection of targeted observations. The study was performed by conducting observation system experiments (OSEs). This research used the fifth-generation Mesoscale Model (MM5), the Weather Research and Forecasting (WRF) model, and dropsonde observations of Typhoon Nida at 1200 UTC 17 May 2004. The dropsondes were collected under the operational Dropsonde Observations for Typhoon Surveillance near the Taiwan Region (DOTSTAR) program. In this research, five kinds of experiments were designed and conducted:(1) no observations were assimilated; (2) all observations were assimilated;(3) observations in the sensitive area revealed by the CNOP method were assimilated;(4) the same as in (3), but for the region revealed by the first singular vector (FSV) method;and (5) observations within a randomly selected area were assimilated. The OSEs showed that (1) the DOTSTAR data had a positive impact on the forecast of Nida's track;(2) dropsondes in the sensitive areas identified by the MM5 CNOP and FSV remained effective for improving the track forecast for Nida on the WRF platform;and (3) the greatest improvement in the track forecast resulted from the CNOP-based (third) simulation, which indicated that the CNOP method would be useful in decision making about dropsonde deployments.
文摘Physiography and soil in Mae Rim watershed, Chiang Mai Province, Thailand were investigated by using aerial photographs and satellite image in conjunction with field work, and soil infiltration rate and soil shear resistance were measured in field. Many factors affecting runoff were analyzed using the Integrated Land and Water Information System (ILWIS). As a result, a model determining flood hazard was set up. Three maps including runoff curve number map, runoff coefficient map, and flood inundation map were created. In addition, the time of concentration was predicted.
文摘Round inductosyn is widely used in inertial navigation test equipment, and its accuracy has significant effect on the general accuracy of the equipment. Four main errors of round inductosyn,i.e. the first-order long-period (360°) harmonic error, the second-order long-period harmonic error, the first-order short-period harmonic error and the second-order short-period harmonic error, are described, and the orthogonality of these four kinds of errors is studied. An error separating technology is proposed to separate these four kinds of errors, and in the process of separating the short-period harmonic errors, the arrangement in the order of decimal part of the angle pitch number can be omitted. The effectiveness of the technology proposed is proved through measuring and adjusting the angular errors.
文摘Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation.
基金Supported by the NSF of Chian(4080502010702050+1 种基金60704015) Supported by the Natural Science Foundation of Henan Education Department(2010A100003)
文摘Using a simplified nonlinearly theoretical grassland ecosystem proposed by Zeng et al.,we study the sensitivity and nonlinear instability of the grassland ecosystem to finiteamplitude initial perturbations with the approach of conditional nonlinear optimal perturbation (CNOP).The results show that the linearly stable grassland (desert or latent desert) states can turn to be nonlinearly unstable with finite amplitude initial perturbations.When the precipitation is between the two bifurcation points,a large enough finite amplitude initial perturbation can induce a transition between the grassland statethe desert state or the latent desert.
基金Supported by the Youth Innovation Fund of China Coal Research Institute(2007QN50)
文摘The existing hydraulic system always have problems of temperature rise,runningstability and anti-interference of the implementation components,reliability of hydrauliccomponents,maintenance difficulties,and other issues.With high efficiency,energysaving,reliability,easy operating,stable running,anti-interference ability,and other advantages,the load-sensitive hydraulic system is more suitable for coal mine all-hydrauliccore rig.Therefore,for the technical development of the coal mine all-hydraulic core rig,the load-sensitive technology employed by the rig should be of great significance.