Objectives: To report three cases of gonorrhea withspectinomycin treatment failure, and to analyze thepossible causes.Methods: Identification of the three Neisseriagonorrhoeae isolates was made by an oxidase test anda...Objectives: To report three cases of gonorrhea withspectinomycin treatment failure, and to analyze thepossible causes.Methods: Identification of the three Neisseriagonorrhoeae isolates was made by an oxidase test anda rapid carbohydrate utilization test. The sensitivitytesting was performed by an agar dilution method.Results: All three isolates were identified as Ngonorrhoeae strains by positive oxidase test andbecause they only utilized glucose in the carbohydrateutilization test. All three strains were resistant tociprofloxacin and susceptible to ceftriaxoneSpectinomycin-resistant strains were found in onlytwo of the three patients, including one penicillinase-producing N. gonorrhoeae (PPNG). The third patienthad a spectinomycin sensitive strain, which was alsoPPNG and tetracycline resistant (TRNG). Based onthe medical history, spectinomycin treatment failurefor the third patient was due to inadequate injection.Conclusion: The causes of spectinomycin treatmentfailure of gonorrhea include spectinomycin resistanceand inadequate injection.展开更多
To improve the sensitivity of protein microarray, a prism surface replaces the surface of the common microscope slide.The protein targets arrayed on the surface are hybridized and labelled by fluorescent probes. Evane...To improve the sensitivity of protein microarray, a prism surface replaces the surface of the common microscope slide.The protein targets arrayed on the surface are hybridized and labelled by fluorescent probes. Evanescent excitation occurs when the convergent laser reaches the surface, and a photomultiplier tube detects the emitted fluorescent signal. A two-dimensional actuator scans the whole surface to achieve planar laser excitation and fluorescence collection. The penetration depth of the evanescent field into the protein targets is only some hundred nanometers and can be controlled by different incident angle of the laser beam, so the undesired background signals are reduced dramatically and the detection sensitivity is improved by a factor of 50 to 100 comparing to confocal excitation. This approach can detect low abundance analytes without signal amplification.展开更多
Ever since the development of quantum mechanics in the first part of the 20th century, a new world view has emerged. Today, the physicalist objective assumption that objects exist independently of acts of observation ...Ever since the development of quantum mechanics in the first part of the 20th century, a new world view has emerged. Today, the physicalist objective assumption that objects exist independently of acts of observation has been challenged. The repercussions of this radical challenge to our common-sense perception of the world are far-reaching, although not yet generally realized. Here we argue that there is a complementary view to the way science which is being practiced, and that consciousness itself is primary and qualia form the foundation of experience. We outline the arguments of why the new science of qualia will tie objects that are being perceived to the subjective experience, through the units of subjective experience called qualia. If there is a reality that exists outside of perceptions in consciousness, it is indeed inconceivable. The reason is that once one subtracts everything that one can sense, imagine, feel, or think about, there's nothing left. Since qualia are subjective, they challenge the dominant world view of science as practiced today, which is reductionist, objective, and mathematical. Our view is a natural continuation of the quantum world view. We outline what the steps will have to be in order to fully develop the science of qualia.展开更多
The mesoscopic nonlinear inductance-capacitance circuit is a typical anharmonie oscillator, due to diodes included in the circuit. In this paper, using the advanced quantum theory of mesoseopie circuits, which based o...The mesoscopic nonlinear inductance-capacitance circuit is a typical anharmonie oscillator, due to diodes included in the circuit. In this paper, using the advanced quantum theory of mesoseopie circuits, which based on the fundamental fact that the electric charge takes discrete value, the diode included mesoscopic circuit is firstly studied. Schrodinger equation of the system is a four-order difference equation in p rep asentation. Using the extended perturbative method, the detail energy spectrum and wave functions axe obtained and verified, as an application of the results, the current quantum fluctuation in the ground state is calculated. Diode is a basis component in a circuit, its quantization would popularize the quantum theory of mesoscopie circuits. The methods to solve the high order difference equation are helpful to the application of mesoscopic quantum theory.展开更多
Chinese Angelica is sweet and pungent in flavour and warm in property. It has the effect of tonifying blood and activating blood circulation and is frequently applied for such gynecological diseases as irregular menst...Chinese Angelica is sweet and pungent in flavour and warm in property. It has the effect of tonifying blood and activating blood circulation and is frequently applied for such gynecological diseases as irregular menstruation and weak constitution after delivery. Therefore, Chinese Angelica has also the name of 'sacred medicament in gynecology'.展开更多
OBJECTIVE:To verify the effects of scraping therapy on the weightlifting ability by measuring the subjective sensation,and changes of biomarkers.METHODS:Five students,who have been trained for 3 years in a sport schoo...OBJECTIVE:To verify the effects of scraping therapy on the weightlifting ability by measuring the subjective sensation,and changes of biomarkers.METHODS:Five students,who have been trained for 3 years in a sport school in China were participated in this study.A course of scraping therapy was applied to intervene during the normal 7-week of weightlifting training programme.The ability of weightlifting,the scale of rating perceived exertion and serum biochemical markers were measured before and after the intervention.RESULTS:Scraping therapy caused a significant increase in weightlifting ability(P<0.05).The level of rating perceived exertion remained stable with the increase in the training volume.Immuno-globulinA was significantly increased(P<0.05),and creatine kinase and blood urea nitrogen were significantly decreased(P<0.05).No significant changes were observed in white blood cell,neutrophil,and testosterone.CONCLUSION:Scraping therapy may facilitate weightlifting ability mainly by decreasing weight sensation and improving serum biochemical parameters.展开更多
We present a study on the retrieval sensitivity of the column-averaged dry-air mole fraction of CO2(XCO2) for the Chinese carbon dioxide observation satellite(TanSat) with a full physical forward model and the optimal...We present a study on the retrieval sensitivity of the column-averaged dry-air mole fraction of CO2(XCO2) for the Chinese carbon dioxide observation satellite(TanSat) with a full physical forward model and the optimal estimation technique. The forward model is based on the vector linearized discrete ordinate radiative transfer model(VLIDORT) and considers surface reflectance, gas absorption, and the scattering of air molecules, aerosol particles, and cloud particles. XCO2 retrieval errors from synthetic TanSat measurements show solar zenith angle(SZA), albedo dependence with values varying from 0.3 to 1 ppm for bright land surface in nadir mode and 2 to 8 ppm for dark surfaces like snow. The use of glint mode over dark oceans significantly improves the CO2 information retrieved. The aerosol type and profile are more important than the aerosol optical depth, and underestimation of aerosol plume height will introduce a bias of 1.5 ppm in XCO2. The systematic errors due to radiometric calibration are also estimated using a forward model simulation approach.展开更多
Ir-based dectrocatalysts have been system- atically studied for a variety of applications, among which the electrocatalysis for oxygen evolution reaction (OER) is one of the most prominent. The investigation on surf...Ir-based dectrocatalysts have been system- atically studied for a variety of applications, among which the electrocatalysis for oxygen evolution reaction (OER) is one of the most prominent. The investigation on surface-micro- structure-sensitive catalytic activity in different pH media is of great significance for developing efficient electrocatalysts and corresponding mechanism research. Herein, shape-tunable Ir- Pd alloy nanocrystals, including nano-hollow-spheres (NHSs), nanowires (NWs), and nanotetrahedrons (NTs), are synthe- sized via a facile one-pot solvothermal method, Electro- chemical studies show that the OER activity of the Ir-Pd alloy nanocatalysts exhibits surface-microstructure-sensitive en- hancement in acidic and alkaline media. Ir-Pd NWs and NTs show more than five times higher mass activity than com- mercial Ir/C catalyst at an overpotential of 0.25 V in acidic and alkaline media. Post-XPS analyses reveal that surface Ir(VI) oxide generated at surface defective sites of Ir-Pd nanocata- lysts is a possible key intermediate for OER. In acidic medium, the specific activity of Ir-Pd nanocatalysts has a positive cor- relation with the surface roughness of NWs 〉 NHSs 〉 NTs. However, the strong dissociation of surface Ir(VI) species (IrO42-) at surface defective sites is a possible obstacle for the formation of Ir(VI) oxide, which reverses the activity sequence for OER in alkaline medium.展开更多
Using the conditional nonlinear optimal perturbation(CNOP) approach, sensitive areas of adaptive observation for predicting the seasonal reduction of the upstream Kuroshio transport(UKT) were investigated in the Regio...Using the conditional nonlinear optimal perturbation(CNOP) approach, sensitive areas of adaptive observation for predicting the seasonal reduction of the upstream Kuroshio transport(UKT) were investigated in the Regional Ocean Modeling System(ROMS). The vertically integrated energy scheme was utilized to identify sensitive areas based on two factors: the specific energy scheme and sensitive area size. Totally 27 sensitive areas, characterized by three energy schemes and nine sensitive area sizes, were evaluated. The results show that the total energy(TE) scheme was the most effective because it includes both the kinetic and potential components of CNOP. Generally, larger sensitive areas led to better predictions. The size of 0.5% of the model domain was chosen after balancing the effectiveness and efficiency of adaptive observation. The optimal sensitive area OSen was determined accordingly. Sensitivity experiments on OSen were then conducted, and the following results were obtained:(1) In OSen, initial errors with CNOP or CNOP-like patterns were more likely to yield worse predictions, and the CNOP pattern was the most unstable.(2) Initial errors in OSen rather than in other regions tended to cause larger prediction errors. Therefore, adaptive observation in OSen can be more beneficial for predicting the seasonal reduction of UKT.展开更多
Monckton of Brenchley et al.(Sci Bull60:122–135, 2015)(hereafter called M15) use a simple energy balance model to estimate climate response. They select parameters for this model based on semantic arguments, leading ...Monckton of Brenchley et al.(Sci Bull60:122–135, 2015)(hereafter called M15) use a simple energy balance model to estimate climate response. They select parameters for this model based on semantic arguments, leading to different results from those obtained in physics-based studies. M15 did not validate their model against observations, but instead created synthetic test data based on subjective assumptions. We show that M15 systematically underestimate warming: since 1990, most years were warmer than their modelled upper limit. During 2000–2010, RMS error and bias are approximately 150 % and 350 % larger than for the CMIP5 median, using either the Berkeley Earth or Cowtan and Way surface temperature data. We show that this poor performance can be explained by a logical flaw in theparameter selection and that selected parameters contradict observational estimates. M15 also conclude that climate has a near-instantaneous response to forcing, implying no net energy imbalance for the Earth. This contributes to their low estimates of future warming and is falsified by Argo float measurements that show continued ocean heating and therefore a sustained energy imbalance. M15's estimates of climate response and future global warming are not consistent with measurements and so cannot be considered credible.展开更多
Reflectance measurements of both the visible and infrared bands of passive remote sensing sensors are widely used to retrieve aerosol optical depth(AOD) information. This is performed commonly for data obtained over b...Reflectance measurements of both the visible and infrared bands of passive remote sensing sensors are widely used to retrieve aerosol optical depth(AOD) information. This is performed commonly for data obtained over both ocean and land, and these measurements allow for the off line development of a lookup table using radiative transfer models. Owing to molecular and aerosol effects, the reflected light received by the sensor is usually highly polarized. The linear polarization effect may be up to 100%, and the polarization factor of a sensor optical system will change the total intensity as well as the polarization status of the signal reaching the detector. The detector response will be different when the incident light polarization status changes, even if the total intensity remains constant. However, if the polarization calibration is neglected, it will cause obvious errors in the aerosol data retrieval. This is especially true for aerosol optical depth retrieval over an ocean. This measurement relies directly on the reflectance output of the sensor. Cases involving land surfaces are not discussed herein because the inhomogeneous properties conceal the error due to polarization. Taking the 550 and 860 nm bands as examples, the difference between the real top-of-atmosphere(TOA) reflectance and the reflectance reaching the detector is calculated using three different sensor polarization standards according to the Sea-viewing Wide Field-of-view Sensor(Sea Wi FS) and Moderate Resolution Imaging Spectroradiometer(MODIS) standards. The differences in AOD retrieval are also demonstrated using the lookup table developed previously from a vector radiative transfer code. The results reveal that under a normal situation in which the AOD is 0.15, the maximum AOD retrieval error could reach 0.04 in 550 nm but only 0.02 in 860 nm for the dust aerosol model. For the soot aerosol model, the maximum AOD retrieval error is 0.1 in 550 nm and 0.12 in 860 nm, indicating that the lack of polarization calibration will lead to large errors in aerosol retrieval over an ocean.展开更多
文摘Objectives: To report three cases of gonorrhea withspectinomycin treatment failure, and to analyze thepossible causes.Methods: Identification of the three Neisseriagonorrhoeae isolates was made by an oxidase test anda rapid carbohydrate utilization test. The sensitivitytesting was performed by an agar dilution method.Results: All three isolates were identified as Ngonorrhoeae strains by positive oxidase test andbecause they only utilized glucose in the carbohydrateutilization test. All three strains were resistant tociprofloxacin and susceptible to ceftriaxoneSpectinomycin-resistant strains were found in onlytwo of the three patients, including one penicillinase-producing N. gonorrhoeae (PPNG). The third patienthad a spectinomycin sensitive strain, which was alsoPPNG and tetracycline resistant (TRNG). Based onthe medical history, spectinomycin treatment failurefor the third patient was due to inadequate injection.Conclusion: The causes of spectinomycin treatmentfailure of gonorrhea include spectinomycin resistanceand inadequate injection.
文摘To improve the sensitivity of protein microarray, a prism surface replaces the surface of the common microscope slide.The protein targets arrayed on the surface are hybridized and labelled by fluorescent probes. Evanescent excitation occurs when the convergent laser reaches the surface, and a photomultiplier tube detects the emitted fluorescent signal. A two-dimensional actuator scans the whole surface to achieve planar laser excitation and fluorescence collection. The penetration depth of the evanescent field into the protein targets is only some hundred nanometers and can be controlled by different incident angle of the laser beam, so the undesired background signals are reduced dramatically and the detection sensitivity is improved by a factor of 50 to 100 comparing to confocal excitation. This approach can detect low abundance analytes without signal amplification.
文摘Ever since the development of quantum mechanics in the first part of the 20th century, a new world view has emerged. Today, the physicalist objective assumption that objects exist independently of acts of observation has been challenged. The repercussions of this radical challenge to our common-sense perception of the world are far-reaching, although not yet generally realized. Here we argue that there is a complementary view to the way science which is being practiced, and that consciousness itself is primary and qualia form the foundation of experience. We outline the arguments of why the new science of qualia will tie objects that are being perceived to the subjective experience, through the units of subjective experience called qualia. If there is a reality that exists outside of perceptions in consciousness, it is indeed inconceivable. The reason is that once one subtracts everything that one can sense, imagine, feel, or think about, there's nothing left. Since qualia are subjective, they challenge the dominant world view of science as practiced today, which is reductionist, objective, and mathematical. Our view is a natural continuation of the quantum world view. We outline what the steps will have to be in order to fully develop the science of qualia.
基金Supported by National Natural Science Foundation of China under Grant No.10575028
文摘The mesoscopic nonlinear inductance-capacitance circuit is a typical anharmonie oscillator, due to diodes included in the circuit. In this paper, using the advanced quantum theory of mesoseopie circuits, which based on the fundamental fact that the electric charge takes discrete value, the diode included mesoscopic circuit is firstly studied. Schrodinger equation of the system is a four-order difference equation in p rep asentation. Using the extended perturbative method, the detail energy spectrum and wave functions axe obtained and verified, as an application of the results, the current quantum fluctuation in the ground state is calculated. Diode is a basis component in a circuit, its quantization would popularize the quantum theory of mesoscopie circuits. The methods to solve the high order difference equation are helpful to the application of mesoscopic quantum theory.
文摘Chinese Angelica is sweet and pungent in flavour and warm in property. It has the effect of tonifying blood and activating blood circulation and is frequently applied for such gynecological diseases as irregular menstruation and weak constitution after delivery. Therefore, Chinese Angelica has also the name of 'sacred medicament in gynecology'.
文摘OBJECTIVE:To verify the effects of scraping therapy on the weightlifting ability by measuring the subjective sensation,and changes of biomarkers.METHODS:Five students,who have been trained for 3 years in a sport school in China were participated in this study.A course of scraping therapy was applied to intervene during the normal 7-week of weightlifting training programme.The ability of weightlifting,the scale of rating perceived exertion and serum biochemical markers were measured before and after the intervention.RESULTS:Scraping therapy caused a significant increase in weightlifting ability(P<0.05).The level of rating perceived exertion remained stable with the increase in the training volume.Immuno-globulinA was significantly increased(P<0.05),and creatine kinase and blood urea nitrogen were significantly decreased(P<0.05).No significant changes were observed in white blood cell,neutrophil,and testosterone.CONCLUSION:Scraping therapy may facilitate weightlifting ability mainly by decreasing weight sensation and improving serum biochemical parameters.
基金supported by the Strategic Priority Research Program- Climate Change: Carbon Budget and Relevant Issues (Grant No. XDA05040200)the National High-tech Research and Development Program of China (Grant No. 2011AA12A104)
文摘We present a study on the retrieval sensitivity of the column-averaged dry-air mole fraction of CO2(XCO2) for the Chinese carbon dioxide observation satellite(TanSat) with a full physical forward model and the optimal estimation technique. The forward model is based on the vector linearized discrete ordinate radiative transfer model(VLIDORT) and considers surface reflectance, gas absorption, and the scattering of air molecules, aerosol particles, and cloud particles. XCO2 retrieval errors from synthetic TanSat measurements show solar zenith angle(SZA), albedo dependence with values varying from 0.3 to 1 ppm for bright land surface in nadir mode and 2 to 8 ppm for dark surfaces like snow. The use of glint mode over dark oceans significantly improves the CO2 information retrieved. The aerosol type and profile are more important than the aerosol optical depth, and underestimation of aerosol plume height will introduce a bias of 1.5 ppm in XCO2. The systematic errors due to radiometric calibration are also estimated using a forward model simulation approach.
基金supported by the National Natural Science Foundation of China (21573005, 21771009 and 21621061)the National Key Research and Development Program (2016YFB0701100)Beijing Natural Science Foundation (2162019)
文摘Ir-based dectrocatalysts have been system- atically studied for a variety of applications, among which the electrocatalysis for oxygen evolution reaction (OER) is one of the most prominent. The investigation on surface-micro- structure-sensitive catalytic activity in different pH media is of great significance for developing efficient electrocatalysts and corresponding mechanism research. Herein, shape-tunable Ir- Pd alloy nanocrystals, including nano-hollow-spheres (NHSs), nanowires (NWs), and nanotetrahedrons (NTs), are synthe- sized via a facile one-pot solvothermal method, Electro- chemical studies show that the OER activity of the Ir-Pd alloy nanocatalysts exhibits surface-microstructure-sensitive en- hancement in acidic and alkaline media. Ir-Pd NWs and NTs show more than five times higher mass activity than com- mercial Ir/C catalyst at an overpotential of 0.25 V in acidic and alkaline media. Post-XPS analyses reveal that surface Ir(VI) oxide generated at surface defective sites of Ir-Pd nanocata- lysts is a possible key intermediate for OER. In acidic medium, the specific activity of Ir-Pd nanocatalysts has a positive cor- relation with the surface roughness of NWs 〉 NHSs 〉 NTs. However, the strong dissociation of surface Ir(VI) species (IrO42-) at surface defective sites is a possible obstacle for the formation of Ir(VI) oxide, which reverses the activity sequence for OER in alkaline medium.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA11010303)the National Natural Science Foundation of China (Grant Nos. 41230420, 41306023 & 41421005)+1 种基金the National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers (Grant No. U1406401)the support of K. C. Wong Foundation
文摘Using the conditional nonlinear optimal perturbation(CNOP) approach, sensitive areas of adaptive observation for predicting the seasonal reduction of the upstream Kuroshio transport(UKT) were investigated in the Regional Ocean Modeling System(ROMS). The vertically integrated energy scheme was utilized to identify sensitive areas based on two factors: the specific energy scheme and sensitive area size. Totally 27 sensitive areas, characterized by three energy schemes and nine sensitive area sizes, were evaluated. The results show that the total energy(TE) scheme was the most effective because it includes both the kinetic and potential components of CNOP. Generally, larger sensitive areas led to better predictions. The size of 0.5% of the model domain was chosen after balancing the effectiveness and efficiency of adaptive observation. The optimal sensitive area OSen was determined accordingly. Sensitivity experiments on OSen were then conducted, and the following results were obtained:(1) In OSen, initial errors with CNOP or CNOP-like patterns were more likely to yield worse predictions, and the CNOP pattern was the most unstable.(2) Initial errors in OSen rather than in other regions tended to cause larger prediction errors. Therefore, adaptive observation in OSen can be more beneficial for predicting the seasonal reduction of UKT.
文摘Monckton of Brenchley et al.(Sci Bull60:122–135, 2015)(hereafter called M15) use a simple energy balance model to estimate climate response. They select parameters for this model based on semantic arguments, leading to different results from those obtained in physics-based studies. M15 did not validate their model against observations, but instead created synthetic test data based on subjective assumptions. We show that M15 systematically underestimate warming: since 1990, most years were warmer than their modelled upper limit. During 2000–2010, RMS error and bias are approximately 150 % and 350 % larger than for the CMIP5 median, using either the Berkeley Earth or Cowtan and Way surface temperature data. We show that this poor performance can be explained by a logical flaw in theparameter selection and that selected parameters contradict observational estimates. M15 also conclude that climate has a near-instantaneous response to forcing, implying no net energy imbalance for the Earth. This contributes to their low estimates of future warming and is falsified by Argo float measurements that show continued ocean heating and therefore a sustained energy imbalance. M15's estimates of climate response and future global warming are not consistent with measurements and so cannot be considered credible.
基金supported by the Risk Reduction Programs of the Ministry of Civil Affairs of the People’s Republic of China(Grant No.TC088641)
文摘Reflectance measurements of both the visible and infrared bands of passive remote sensing sensors are widely used to retrieve aerosol optical depth(AOD) information. This is performed commonly for data obtained over both ocean and land, and these measurements allow for the off line development of a lookup table using radiative transfer models. Owing to molecular and aerosol effects, the reflected light received by the sensor is usually highly polarized. The linear polarization effect may be up to 100%, and the polarization factor of a sensor optical system will change the total intensity as well as the polarization status of the signal reaching the detector. The detector response will be different when the incident light polarization status changes, even if the total intensity remains constant. However, if the polarization calibration is neglected, it will cause obvious errors in the aerosol data retrieval. This is especially true for aerosol optical depth retrieval over an ocean. This measurement relies directly on the reflectance output of the sensor. Cases involving land surfaces are not discussed herein because the inhomogeneous properties conceal the error due to polarization. Taking the 550 and 860 nm bands as examples, the difference between the real top-of-atmosphere(TOA) reflectance and the reflectance reaching the detector is calculated using three different sensor polarization standards according to the Sea-viewing Wide Field-of-view Sensor(Sea Wi FS) and Moderate Resolution Imaging Spectroradiometer(MODIS) standards. The differences in AOD retrieval are also demonstrated using the lookup table developed previously from a vector radiative transfer code. The results reveal that under a normal situation in which the AOD is 0.15, the maximum AOD retrieval error could reach 0.04 in 550 nm but only 0.02 in 860 nm for the dust aerosol model. For the soot aerosol model, the maximum AOD retrieval error is 0.1 in 550 nm and 0.12 in 860 nm, indicating that the lack of polarization calibration will lead to large errors in aerosol retrieval over an ocean.