Putaminal hemorrhage presenting pure sensory stroke is rare.We describe a case of left putaminal hemorrhage presenting contral ateral hemisensory disturbance without hemiparesis. A 52-year-old man developed analgesia ...Putaminal hemorrhage presenting pure sensory stroke is rare.We describe a case of left putaminal hemorrhage presenting contral ateral hemisensory disturbance without hemiparesis. A 52-year-old man developed analgesia and thermoanesthesi a in the right half of his body, but deep sensation was relatively well preserve d. Neuroradiological and somatosensory evoked potential findings suggested that thalamocortical sensory pathways to the secondary somatosensory cortex (S2)were involved, whereas those to the primary somatosensory cortex(S1) were spared. In experimental animals, spinothalamic projections from the thalamic nucleus input directly to S2. In humans, thalamocortical pathways are still a subject of debat e,but results of recent functional imaging studies suggest that the pathway of p ain inputs directly to S2 and that of tactile sensation to S2 via S1. Our findin gs support these reports.展开更多
目的探讨慢性下腰腿痛(LBLP)患者静息态初级躯体感觉皮层的功能连接情况。方法采用3.0 T MRI对26例椎间盘突出所致LBLP患者(LBLP组)和34例健康志愿者(对照组)进行静息态fMRI扫描,使用脑成像数据处理及分析助手V3.0对静息态fMRI数据进行...目的探讨慢性下腰腿痛(LBLP)患者静息态初级躯体感觉皮层的功能连接情况。方法采用3.0 T MRI对26例椎间盘突出所致LBLP患者(LBLP组)和34例健康志愿者(对照组)进行静息态fMRI扫描,使用脑成像数据处理及分析助手V3.0对静息态fMRI数据进行预处理。以双侧初级躯体感觉皮层(S1leg:初级躯体感觉皮层足代表区)作为种子点,进行功能连接分析并采用两样本t检验与健康对照组进行组间比较。将功能连接系数有显著性差异的脑区分别选为感兴趣区,以峰值坐标为中心提取球形区域内功能连接系数的平均值,与临床评估(视觉模拟量表评分、日本骨科协会评分、两点触觉辨别测试等)参数进行偏相关分析。结果与对照组相比,左侧S1leg和左侧前扣带回功能连接减弱(体素水平P<0.01,簇水平<0.05,GRF校正),而右侧S1leg和双侧小脑后叶功能连接增强(体素水平P<0.01,簇水平<0.05,GRF校正)。在LBLP患者组,右侧S1leg和双侧小脑后叶的功能连接系数与Barthel指数呈正相关(r=0.422,P=0.040)、与左手两点触觉辨别测试评分呈负相关(r=-0.447,P=0.028)、与右足两点触觉辨别测试评分呈负相关(r=-0.510,P=0.011)。结论静息状态下慢性LBLP患者存在和临床症状相关的初级躯体感觉皮层功能连接异常。展开更多
文摘Putaminal hemorrhage presenting pure sensory stroke is rare.We describe a case of left putaminal hemorrhage presenting contral ateral hemisensory disturbance without hemiparesis. A 52-year-old man developed analgesia and thermoanesthesi a in the right half of his body, but deep sensation was relatively well preserve d. Neuroradiological and somatosensory evoked potential findings suggested that thalamocortical sensory pathways to the secondary somatosensory cortex (S2)were involved, whereas those to the primary somatosensory cortex(S1) were spared. In experimental animals, spinothalamic projections from the thalamic nucleus input directly to S2. In humans, thalamocortical pathways are still a subject of debat e,but results of recent functional imaging studies suggest that the pathway of p ain inputs directly to S2 and that of tactile sensation to S2 via S1. Our findin gs support these reports.
文摘目的探讨慢性下腰腿痛(LBLP)患者静息态初级躯体感觉皮层的功能连接情况。方法采用3.0 T MRI对26例椎间盘突出所致LBLP患者(LBLP组)和34例健康志愿者(对照组)进行静息态fMRI扫描,使用脑成像数据处理及分析助手V3.0对静息态fMRI数据进行预处理。以双侧初级躯体感觉皮层(S1leg:初级躯体感觉皮层足代表区)作为种子点,进行功能连接分析并采用两样本t检验与健康对照组进行组间比较。将功能连接系数有显著性差异的脑区分别选为感兴趣区,以峰值坐标为中心提取球形区域内功能连接系数的平均值,与临床评估(视觉模拟量表评分、日本骨科协会评分、两点触觉辨别测试等)参数进行偏相关分析。结果与对照组相比,左侧S1leg和左侧前扣带回功能连接减弱(体素水平P<0.01,簇水平<0.05,GRF校正),而右侧S1leg和双侧小脑后叶功能连接增强(体素水平P<0.01,簇水平<0.05,GRF校正)。在LBLP患者组,右侧S1leg和双侧小脑后叶的功能连接系数与Barthel指数呈正相关(r=0.422,P=0.040)、与左手两点触觉辨别测试评分呈负相关(r=-0.447,P=0.028)、与右足两点触觉辨别测试评分呈负相关(r=-0.510,P=0.011)。结论静息状态下慢性LBLP患者存在和临床症状相关的初级躯体感觉皮层功能连接异常。
