In 1998, the Chinese Government implemented the NFPP （Natural Forest Protection Program）, which included logging restrictions, protected areas, replanting, and a range of other policies aimed at safeguarding the sta...In 1998, the Chinese Government implemented the NFPP （Natural Forest Protection Program）, which included logging restrictions, protected areas, replanting, and a range of other policies aimed at safeguarding the state of the country＇s forests and reducing the risk of erosion and flooding. A second phase of this program is currently being discussed. In this paper, contingent valuation is used to estimate the WTP （willingness to pay） for maintaining the program among the inhabitants in Heilongjiang Province in northern China. The results show that, even with fairly conservative assumptions, the aggregated WTP for maintaining the program for another five years is some 3.24 billion yuan per year. This can be compared with the current cost of the Program in the province, which is some 1.57 billion yuan per year.展开更多
In the present study, we aimed to investigate the effect of CYP3A4＊ 18 genotype on the pharmacokinetics of zolpidem in healthy Chinese Hui volunteers. Blood samples were collected from volunteers for CYP3A4 genotypin...In the present study, we aimed to investigate the effect of CYP3A4＊ 18 genotype on the pharmacokinetics of zolpidem in healthy Chinese Hui volunteers. Blood samples were collected from volunteers for CYP3A4 genotyping using a polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） assay. A pharmacokinetic study was then carried out in three groups with CYP3A4＊1/＊1 （n = 6）, CYP3A4＊1/＊18 （n = 6） and CYP3A4＊18/＊18 （n = 6） genotypes. Plasma levels of zolpidem were determined by HPLC-FLD method before and after a single oral dose of 10 mg zolpidem tartrate tablet. Significant differences were observed in the pharmacokinetic parameters of zolpidem among the three genotype groups （P〈0.05）. Compared with the CYP3A4＊1/＊1 group, the Cm,x of zolpidem in ＊1/＊18 and ＊18/＊18 groups （mean, 95% CI） was 0.89 （0.65-1.12） and 0.57 （0.47-0.66）, respectively, and the AUC0-1 in the ＊1/＊18 and ＊18/＊18 groups （mean, 95% CI） was 0.74 （0.22-1.26） and 0.61 （0.24-0.98）, respectively. There was a significant trend towards lower Cmax and AUC0-1 values of zolpidem in individuals with more CYP3A＊ 18 alleles, suggesting a gene-dosage effect. The study demonstrated that the CYP3A4＊ 18 allele played an important role in the pharmacokinetics of the zolpidem after oral administration.展开更多
In China,the distribution of water resources is incompatible with the development of productivity.The construction of South-to-North Water Diversion Project has achieved inter-basin water diversion,and the project can...In China,the distribution of water resources is incompatible with the development of productivity.The construction of South-to-North Water Diversion Project has achieved inter-basin water diversion,and the project can alleviate the uneven distribution of water resources phenomenon effectively.However,in recent years,the aggregate effects of water pollution and water resource shortages have been serious.Establishing transverse eco-compensation mechanisms becomes the key method to achieve sustainable use of water resources.Based on statistical and questionnaire data,this paper uses the Opportunity Costs Method and Willingness to Pay approach to establish a transverse eco-compensation standard calculation model for the Middle Route Project of the Southto-North Water Diversion.The results show that the upper and lower limits of the transverse eco-compensation standard for the Middle Route Project is $2.52 billion and $2.20 billion every year,respectively.However,the paying and receiving standards varied widely among different compensation payers and compensation receivers.Meanwhile,the significant factors influencing the paying willingness of the receiver area citizens were age,education level,average revenue per month,knowledge about the South-to-North Water Diversion Project and recognition of the importance of eco-environmental integrity.This study began with a theoretical analysis,then analysed related problems related to calculating transverse eco-compensation standards for the Middle Route Project of the South-to-North Water Diversion by an empirical study.This empirical study helps to establish effective transverse eco-compensation mechanisma and promotea the development of effective policies and legislation.展开更多
文摘In 1998, the Chinese Government implemented the NFPP （Natural Forest Protection Program）, which included logging restrictions, protected areas, replanting, and a range of other policies aimed at safeguarding the state of the country＇s forests and reducing the risk of erosion and flooding. A second phase of this program is currently being discussed. In this paper, contingent valuation is used to estimate the WTP （willingness to pay） for maintaining the program among the inhabitants in Heilongjiang Province in northern China. The results show that, even with fairly conservative assumptions, the aggregated WTP for maintaining the program for another five years is some 3.24 billion yuan per year. This can be compared with the current cost of the Program in the province, which is some 1.57 billion yuan per year.
基金Funds of the Chinese Army Medical Science and Technology Research"Eleventh Five-Year Plan"Project(Grant No.06G023)
文摘In the present study, we aimed to investigate the effect of CYP3A4＊ 18 genotype on the pharmacokinetics of zolpidem in healthy Chinese Hui volunteers. Blood samples were collected from volunteers for CYP3A4 genotyping using a polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） assay. A pharmacokinetic study was then carried out in three groups with CYP3A4＊1/＊1 （n = 6）, CYP3A4＊1/＊18 （n = 6） and CYP3A4＊18/＊18 （n = 6） genotypes. Plasma levels of zolpidem were determined by HPLC-FLD method before and after a single oral dose of 10 mg zolpidem tartrate tablet. Significant differences were observed in the pharmacokinetic parameters of zolpidem among the three genotype groups （P〈0.05）. Compared with the CYP3A4＊1/＊1 group, the Cm,x of zolpidem in ＊1/＊18 and ＊18/＊18 groups （mean, 95% CI） was 0.89 （0.65-1.12） and 0.57 （0.47-0.66）, respectively, and the AUC0-1 in the ＊1/＊18 and ＊18/＊18 groups （mean, 95% CI） was 0.74 （0.22-1.26） and 0.61 （0.24-0.98）, respectively. There was a significant trend towards lower Cmax and AUC0-1 values of zolpidem in individuals with more CYP3A＊ 18 alleles, suggesting a gene-dosage effect. The study demonstrated that the CYP3A4＊ 18 allele played an important role in the pharmacokinetics of the zolpidem after oral administration.
基金National Key R&D Plan of China(2017YFC0506402)National Natural Science Foundation of China(41201586)
文摘In China,the distribution of water resources is incompatible with the development of productivity.The construction of South-to-North Water Diversion Project has achieved inter-basin water diversion,and the project can alleviate the uneven distribution of water resources phenomenon effectively.However,in recent years,the aggregate effects of water pollution and water resource shortages have been serious.Establishing transverse eco-compensation mechanisms becomes the key method to achieve sustainable use of water resources.Based on statistical and questionnaire data,this paper uses the Opportunity Costs Method and Willingness to Pay approach to establish a transverse eco-compensation standard calculation model for the Middle Route Project of the Southto-North Water Diversion.The results show that the upper and lower limits of the transverse eco-compensation standard for the Middle Route Project is $2.52 billion and $2.20 billion every year,respectively.However,the paying and receiving standards varied widely among different compensation payers and compensation receivers.Meanwhile,the significant factors influencing the paying willingness of the receiver area citizens were age,education level,average revenue per month,knowledge about the South-to-North Water Diversion Project and recognition of the importance of eco-environmental integrity.This study began with a theoretical analysis,then analysed related problems related to calculating transverse eco-compensation standards for the Middle Route Project of the South-to-North Water Diversion by an empirical study.This empirical study helps to establish effective transverse eco-compensation mechanisma and promotea the development of effective policies and legislation.
