构式压制下“是+能愿动词双+的”的构式特征及其能产性

文章从构式压制角度考察“是+能愿动词双+的”的构式特征及其能产性。该构式性质为表判断的“是”字句,是谓词隐含的结果。谓词隐含受制于构式压制,“能愿动词双”经构式压制被赋予了谓词性功能。该构式的构件特征包含“的”字结构的物性角色和“能愿动词双”的去范畴化,构体特征侧重表达凸显强调和主观评价。由其衍生出的“能愿动词双+的”构式在“可以”“应该”“必须”三个词上具有话语应答标记的功能,这是高频使用后语用泛化的表现。

试论动感的化学教育

动感的化学教育,是让学生享受化学课堂,是一种智慧的、人性化的教学模式。教师要在课内课外多下工夫,让化学教育有更多"动"的可能和空间。

浅谈政治课堂让学生动起来的策略

基于建构主义认知理论和新课程理念,结合一些课堂教学案例,从转变教师角色、激发学生兴趣、构建政治情境、设计教学活动、改变教学方法和把握教学时机等六个方面入手,简要地阐述如何把学习权利还给学生,让学生成为课堂的主人,从而让课堂教学富有魅力。

实现高效课堂的一种途径是生“动”

通过一节直线和圆的复习课感受到实现高效课堂的一种有效途径是教师精讲、学生多动．通过展示课堂的过程，展现课堂中学生的“动”，体现了通过“动”激发学生的学习兴趣，增加师生间的互动，发展了学生的思维，实现了高效课堂．

Pharmacokinetics of 20(R)-Ginsenoside Rg3 in Human Volunteers

Objective: To study the pharmacokinetics of 20(R)-Ginsenoside Rg3 in the human body. Methods: High-performance liquid chromatography-ultraviolet detection method was used in this study. Results: The pharmacokinetics of Ginsenoside Rg3 in 14 healthy volunteers were investigated. After a single oral dose of 3.2 mg.g-1 Ginsenoside Rg3 in 8 male volunteers, the plasma concentration-time course fitted in well with a two-compartment open model, with the following pharmacokinetic parameters: Tmax 0.660.10 h, Cmax 166 ngmL-1, T1/2a 0.460.12 h, T1/2b 4.91.1 h, T1/2(Ka) 0.280.04 h, AUC0-∞ 7726 ngmL-1h, respectively. No kinetic analysis was made after an oral dose of 0.8 mg.g-1 Rg3 in other 6 volunteers because of the low concentration, but there was a good correlation between Cmax and dosage of the two groups. Conclusion: The absorption of Rg3 was rapid in the human body, and its elimination was rapid too after oral administration of Ginsenoside Rg3. The pharmacokinetic results shows that it exhibited the first-order kinetic characteristics.

PHARMACOKINETICS OF PARACETAMOL ORALLY DISINTEGRATING AND GENERAL TABLETS IN HEALTHY VOLUNTEERS

Objective To compare the pharmacokinetics and relative biological availability of Paracetatool orally disintegrating tablets and general tablets in healthy volunteers. Methods In a random two periods crossover study, 19 healthy male Chinses volunteers received a single dose of Paracetamol 500mg of two formularies respectively. The plasma concentration of paracetamol was determined by HPLC method. The pharmacokinetic parameters of the two preparation and the relative biological availability of Paracetamol orally disintegrating tablets and general tablets were caculated with statistical analysis. Results The main pharmacokinetic parameters of paracetamol orally disintegrating tablets and general tablets were （ 31436. 70 ± 7062. 80 μg · h^ -1· L^-1 and （29871.40 ± 7965.04） μg · h^ -1· L^-1 for AUC0-1 （33295. 7 ±7663. 10） μg · h^ -1· L^-1 and（31845. 20 ± 8830. 83 ） μg · h^ -1· L^-1 forAUC0-1（9. 71 ±2. 78） μg/ml and（10. 36 ±3. 86） μg/mlfor Cmax; （0. 82 ±0. 45）h and （0. 74± 0.67）hforTmax;（2.90±0. 42）h and （3. 13 ±0. 67）h for T1/2ke;（0.24 ±0.04） and （0.23 ±0.04） for Ke; （4. 1481±0. 4492 ） and （4. 0771 ±0. 8131 ） for mean residence time （ MRT） , respectively. Variance analysis showed that there was significant difference in AUC0-12 and Cmax between the two preparations. Conclusion The paracetamol orally disintegrating tablets and general tablets are bioequivalent and the relative biological availability of Paracetamol orally disintegrating tablets is （ 108 ± 19） %.

PHARMACOKINETICS OF MAGNESIUM ISOGLYCYRRHI-ZINATE AFTER SINGLE INTRAVENOUS DOSE IN HEALTHY VOLUNTEERS

Objective To study the pharmacokinetics of intravenous magnesium isoglycyrrhizinate injection in health volunteers with HPLC-UV. Methods Single doses of 2OOmg magnesium isoglycyrrhizinate were administrated to 10 health volunteers by i. v. infusion. The concentrations of magnesium isoglycyrrhizinate in plasma were assayed by HPLC-UV method. The pharmacokinetic parameters of magnesium isoglycyrrhizinate injection were calculated by program 3P87. Results The main pharmacokinetic parameters of intravenous magnesium isoglycyrrhizinate were as follows： cmax （ 67. 58 ± 8. 84 ） mg/L, T1/2α （ 1.46 ± 0. 35 ） h, T1/2β （ 23. 95 ± 4. 72 ） h, Vd （ 2. 921 ± 0. 382） L, CL （0. 186 ±0. 048） L/h,k10（0. 064 ±0. 016） h^-1, AUC0-T（1015.29 ±225. 14） mg·h^-1·L^-1 ,respectively. Conclusion We have successfully used the analytical method for magnesium isoglycyrrhizinate to study its pharmacokinetical properties of health volunteers after i. v. infusion. The method is found to be simple, accurate, stable and sensitive for application in clinical pharmacokinetics study. The concentration-time plot was fitted to a two-compartment open model with first-order elimination.

Public Diplomacy and Beijing City Image Research From Major International Sporting Events Perspective

This paper focuses on Beijing as the host city for the major international sporting events and its influence on the city image building of Beijing. Major international sporting events are the key channels for the exchange and dissemination of information among athletes from various countries, media coverages, national and international audiences which involves interpersonal communication, organizational communication, and mass communication at all levels. At the same time, the volunteers, especially young volunteers （mostly college student volunteers） considered as the Beijing city spokesperson and also as a group of ＂public diplomacy ambassadors＂, transfer positive energy in international communication during major international sporting events. Therefore, major international sporting events held in Beijing play an irreplaceable role in the image building of the capital city of China, Beijing.

Effect of CYP3A4*18 genotype on the pharmacokinetics of zolpidem in healthy Chinese Hui subjects

In the present study, we aimed to investigate the effect of CYP3A4＊ 18 genotype on the pharmacokinetics of zolpidem in healthy Chinese Hui volunteers. Blood samples were collected from volunteers for CYP3A4 genotyping using a polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） assay. A pharmacokinetic study was then carried out in three groups with CYP3A4＊1/＊1 （n = 6）, CYP3A4＊1/＊18 （n = 6） and CYP3A4＊18/＊18 （n = 6） genotypes. Plasma levels of zolpidem were determined by HPLC-FLD method before and after a single oral dose of 10 mg zolpidem tartrate tablet. Significant differences were observed in the pharmacokinetic parameters of zolpidem among the three genotype groups （P〈0.05）. Compared with the CYP3A4＊1/＊1 group, the Cm,x of zolpidem in ＊1/＊18 and ＊18/＊18 groups （mean, 95% CI） was 0.89 （0.65-1.12） and 0.57 （0.47-0.66）, respectively, and the AUC0-1 in the ＊1/＊18 and ＊18/＊18 groups （mean, 95% CI） was 0.74 （0.22-1.26） and 0.61 （0.24-0.98）, respectively. There was a significant trend towards lower Cmax and AUC0-1 values of zolpidem in individuals with more CYP3A＊ 18 alleles, suggesting a gene-dosage effect. The study demonstrated that the CYP3A4＊ 18 allele played an important role in the pharmacokinetics of the zolpidem after oral administration.