目的:分析柔肝化纤颗粒联合恩替卡韦治疗肝肾阴虚型慢性乙型肝炎纤维化患者的临床疗效及对血清壳多糖酶3样蛋白1、炎症因子水平的影响。方法:检索2016年1月至2019年1月在广西中医药大学第一附属医院住院的肝肾阴虚型慢性乙型肝炎纤维化...目的:分析柔肝化纤颗粒联合恩替卡韦治疗肝肾阴虚型慢性乙型肝炎纤维化患者的临床疗效及对血清壳多糖酶3样蛋白1、炎症因子水平的影响。方法:检索2016年1月至2019年1月在广西中医药大学第一附属医院住院的肝肾阴虚型慢性乙型肝炎纤维化患者180例,治疗组和对照组各90例,对照组采用恩替卡韦抗病毒治疗,治疗组在对照组基础上加用柔肝化纤颗粒,2组疗程均为48周,观察2组患者治疗前后血清壳多糖酶3样蛋白1、肝功能、肝纤4项、乙肝病毒DNA(hepatitis b virus-DNA,HBV-DNA)转阴率、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素-6(Tnterleukin-6,IL-6)、白介素-8(Interleukin-8,IL-8)及中医临床疗效等指标的变化。结果:治疗48周后,2组患者肝功能、肝纤4项、肝脏硬度值、HBV-DNA转阴率、中医临床疗效、血清壳多糖酶3样蛋白1及炎症因子水平均有不同程度改善,其中治疗组各项指标改善程度均优于对照组(P<0.05),差异有统计学意义。结论:在常规西医抗病毒治疗基础上加用柔肝化纤颗粒治疗肝肾阴虚型慢性乙型肝炎肝纤维化,可能通过降低患者血清壳多糖酶3样蛋白1和炎症因子水平起到减轻患者炎症反应、抗肝纤维化的作用。展开更多
AIM： To construct a noninvasive assessment model consisting of routine laboratory data to predict significant fibrosis and cirrhosis in patients with chronic hepatitis B （CHB）. METHODS： A total of 137 consecutive ...AIM： To construct a noninvasive assessment model consisting of routine laboratory data to predict significant fibrosis and cirrhosis in patients with chronic hepatitis B （CHB）. METHODS： A total of 137 consecutive patients with CriB who underwent percutaneous liver biopsy were retrospectively analyzed. These patients were divided into two groups according to their aminotransferase （ALT） level. The sensitivity, specificity, positive predictive value （PPV）, negative predictive value （NPV）, the likelihood ratio （LR） of aminotransferase/platelet ratio index （APRI） ≥ 1.5 or 〈 1.5 in combination with different hyaluronic acid （HA） cut-off points were calculated for the presence of moderate to severe fibrosis/cirrhosis （fibrosis stages 2 and 4） and no to mild fibrosis/cirrhosis （fibrosis stages 0 and 1）. RESULTS： The APRI correlated with fibrosis stage in CriB patients. The APRI ≥1.5 in combination with a cut-off HA cut-off point 〉 300 ng/mL could detect moderate to severe fibrosis （stages 2-4） in Crib patients. The PPV was 93.7%, the specificity was 98.9%. The APRI 〈 1.5 in combination with different HA cut-off points could not detect no to mild fibrosis in CHB patients. CONCLUSION： The APRI ≥ 1.5 in combination with a HA cut-off point 〉 300 ng/mL can detect moderate to severe fibrosis （stages 2-4） in Crib patients.展开更多
Objective: To investigate the clinical efficacy and safety of the Ganning formula (肝宁方) for the treatment of liver fibrosis in patients with chronic hepatitis B. Methods: In a multicenter, randomized, controlled cl...Objective: To investigate the clinical efficacy and safety of the Ganning formula (肝宁方) for the treatment of liver fibrosis in patients with chronic hepatitis B. Methods: In a multicenter, randomized, controlled clinical trial, 150 patients with liver fibrosis secondary to hepatitis B virus (HBV) infection were randomly assigned in equal numbers to receive either the Ganning formula (a Chinese herbal decoction; active treatment group) or oral entecavir (control group) for two 3-month courses. Patients were monitored for any treatment-induced changes in liver function test parameters (ALT, AST, and GGT), liver fibrosis markers (LN, HA, IV-C, and PCIII), HBV DNA level, hepatosplenic imaging, quality of life scores, or psychological and social functioning scores. Patients were also observed for any adverse effects. Results: After treatment, patients in both groups experienced significant improvements in liver function, HBV DNA load, hepatosplenic B-mode ultrasonography, quality of life, and psychological and social functioning (P<0.05 or P<0.01). Patients receiving the Ganning formula achieved greater improvements in HA, IV-C, quality of life, and psychological and social functioning compared with those on entecavir (P<0.05 or P<0.01). There were no abnormal changes in blood tests, urine, feces, renal function, or electrocardiogram. Additionally, no adverse effects were observed in any patients in either group. Conclusions: The Ganning formula appears to have the potential to inhibit liver fibrosis and therefore improve liver function by inhibiting HBV replication in patients with chronic hepatitis B. Additionally, this formula is helpful in improving quality of life and psychological and social functioning.展开更多
文摘目的:分析柔肝化纤颗粒联合恩替卡韦治疗肝肾阴虚型慢性乙型肝炎纤维化患者的临床疗效及对血清壳多糖酶3样蛋白1、炎症因子水平的影响。方法:检索2016年1月至2019年1月在广西中医药大学第一附属医院住院的肝肾阴虚型慢性乙型肝炎纤维化患者180例,治疗组和对照组各90例,对照组采用恩替卡韦抗病毒治疗,治疗组在对照组基础上加用柔肝化纤颗粒,2组疗程均为48周,观察2组患者治疗前后血清壳多糖酶3样蛋白1、肝功能、肝纤4项、乙肝病毒DNA(hepatitis b virus-DNA,HBV-DNA)转阴率、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素-6(Tnterleukin-6,IL-6)、白介素-8(Interleukin-8,IL-8)及中医临床疗效等指标的变化。结果:治疗48周后,2组患者肝功能、肝纤4项、肝脏硬度值、HBV-DNA转阴率、中医临床疗效、血清壳多糖酶3样蛋白1及炎症因子水平均有不同程度改善,其中治疗组各项指标改善程度均优于对照组(P<0.05),差异有统计学意义。结论:在常规西医抗病毒治疗基础上加用柔肝化纤颗粒治疗肝肾阴虚型慢性乙型肝炎肝纤维化,可能通过降低患者血清壳多糖酶3样蛋白1和炎症因子水平起到减轻患者炎症反应、抗肝纤维化的作用。
文摘AIM： To construct a noninvasive assessment model consisting of routine laboratory data to predict significant fibrosis and cirrhosis in patients with chronic hepatitis B （CHB）. METHODS： A total of 137 consecutive patients with CriB who underwent percutaneous liver biopsy were retrospectively analyzed. These patients were divided into two groups according to their aminotransferase （ALT） level. The sensitivity, specificity, positive predictive value （PPV）, negative predictive value （NPV）, the likelihood ratio （LR） of aminotransferase/platelet ratio index （APRI） ≥ 1.5 or 〈 1.5 in combination with different hyaluronic acid （HA） cut-off points were calculated for the presence of moderate to severe fibrosis/cirrhosis （fibrosis stages 2 and 4） and no to mild fibrosis/cirrhosis （fibrosis stages 0 and 1）. RESULTS： The APRI correlated with fibrosis stage in CriB patients. The APRI ≥1.5 in combination with a cut-off HA cut-off point 〉 300 ng/mL could detect moderate to severe fibrosis （stages 2-4） in Crib patients. The PPV was 93.7%, the specificity was 98.9%. The APRI 〈 1.5 in combination with different HA cut-off points could not detect no to mild fibrosis in CHB patients. CONCLUSION： The APRI ≥ 1.5 in combination with a HA cut-off point 〉 300 ng/mL can detect moderate to severe fibrosis （stages 2-4） in Crib patients.
基金supported by the Guangxi Medicine Research Grant Program (No.2010095)the Guangxi Science and Technology Research Grant Program (No.2010GXNSFA013217)the Guangxi Natural Science Foundation (No. 0832174)
文摘Objective: To investigate the clinical efficacy and safety of the Ganning formula (肝宁方) for the treatment of liver fibrosis in patients with chronic hepatitis B. Methods: In a multicenter, randomized, controlled clinical trial, 150 patients with liver fibrosis secondary to hepatitis B virus (HBV) infection were randomly assigned in equal numbers to receive either the Ganning formula (a Chinese herbal decoction; active treatment group) or oral entecavir (control group) for two 3-month courses. Patients were monitored for any treatment-induced changes in liver function test parameters (ALT, AST, and GGT), liver fibrosis markers (LN, HA, IV-C, and PCIII), HBV DNA level, hepatosplenic imaging, quality of life scores, or psychological and social functioning scores. Patients were also observed for any adverse effects. Results: After treatment, patients in both groups experienced significant improvements in liver function, HBV DNA load, hepatosplenic B-mode ultrasonography, quality of life, and psychological and social functioning (P<0.05 or P<0.01). Patients receiving the Ganning formula achieved greater improvements in HA, IV-C, quality of life, and psychological and social functioning compared with those on entecavir (P<0.05 or P<0.01). There were no abnormal changes in blood tests, urine, feces, renal function, or electrocardiogram. Additionally, no adverse effects were observed in any patients in either group. Conclusions: The Ganning formula appears to have the potential to inhibit liver fibrosis and therefore improve liver function by inhibiting HBV replication in patients with chronic hepatitis B. Additionally, this formula is helpful in improving quality of life and psychological and social functioning.
