Many patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP)-experience excessive fatigue, which may p ersist for years and reduce quality of life. The authors per...Many patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP)-experience excessive fatigue, which may p ersist for years and reduce quality of life. The authors performed a 12-week s tudy of bicycle exercise training in 20 patients with severe fatigue, 16 with re latively good recovery from GBS, and 4 with stable CIDP. Training seemed well to lerated, and self-reported fatigue scores decreased 20% (p = 0.001). Physica l fitness, functional outcome, and quality of life were improved.展开更多
We herein report the case of a 46 year old man with chronic inflammatory demye linating polyneuropathy (CIDP)-with hyperIgEaemia. The patient presented with b ilateral weakness, generalized hyporeflexia, and mild pare...We herein report the case of a 46 year old man with chronic inflammatory demye linating polyneuropathy (CIDP)-with hyperIgEaemia. The patient presented with b ilateral weakness, generalized hyporeflexia, and mild paresthesia of the fingers of both hands. Nerve conduction studies revealed multiple sites of motor conduc tion block inthe absence of sensory abnormalities. Muscle strength increased, as did compound muscle action potential (CMAP)-amplitude immediately after the in travenous infusion of immunoglobulin (IVIg). Serum IgE levels also fluctuated in parallel with his relapsing-remitting clinical course. We propose that pure mo tor CIDP may be immune mediated and suggest that IgE-mediated allergy may be on e potential cause of this condition.展开更多
文摘Many patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP)-experience excessive fatigue, which may p ersist for years and reduce quality of life. The authors performed a 12-week s tudy of bicycle exercise training in 20 patients with severe fatigue, 16 with re latively good recovery from GBS, and 4 with stable CIDP. Training seemed well to lerated, and self-reported fatigue scores decreased 20% (p = 0.001). Physica l fitness, functional outcome, and quality of life were improved.
文摘We herein report the case of a 46 year old man with chronic inflammatory demye linating polyneuropathy (CIDP)-with hyperIgEaemia. The patient presented with b ilateral weakness, generalized hyporeflexia, and mild paresthesia of the fingers of both hands. Nerve conduction studies revealed multiple sites of motor conduc tion block inthe absence of sensory abnormalities. Muscle strength increased, as did compound muscle action potential (CMAP)-amplitude immediately after the in travenous infusion of immunoglobulin (IVIg). Serum IgE levels also fluctuated in parallel with his relapsing-remitting clinical course. We propose that pure mo tor CIDP may be immune mediated and suggest that IgE-mediated allergy may be on e potential cause of this condition.
