Air is the ocean we breathe. Air supplies us with oxygen which is essential for our bodies to live. 99.9% air is nitrogen, oxygen, water vapor and inert gases. Human activities can release substances into the air, som...Air is the ocean we breathe. Air supplies us with oxygen which is essential for our bodies to live. 99.9% air is nitrogen, oxygen, water vapor and inert gases. Human activities can release substances into the air, some of which can cause problems for humans, plants and animals. There are several main types of pollution and well-known effects of pollution which are commonly discussed. These include smog, acid rain, the greenhouse effect, and ＂holes＂ in the ozone layer. Each of these problems has serious implications for our health and well-being as well as for the whole environment. The age and health condition are more important also at the response opposite the pollution of air. During the last decade in our country such as result of freely population movement, development and growth of their industrial activities, growth of vehicle number, collapse of roadway infrastructure etc., an increase of air quality pollution is evident. In this study, we exhibited the causers, such as increasing of number of the old cars, which is an important factor of the air pollution and, at the same time, we exhibited the pollution indicators of the air quality, such as PM I 0, total dust, dust levels outdoors and indoors, which are in the high levels. These factors indicated on human health. We have observed the health indicators, especially lung diseases such as bronchial asthma with higher percentage, chronic bronchitis and lung cancer. There was consistency in the finding that relates the acute increases in urban air pollution and the short-term health effects or patients suffering from chronic obstructive pulmonary diseases.展开更多
Glutathione-S-transferase （GST） family enzymes are implicated in the pathopbysiology of bronchial asthma （BA） and chronic obstructive pulmonary disease （COPD）. In some cases both illnesses exhibit similar pathom...Glutathione-S-transferase （GST） family enzymes are implicated in the pathopbysiology of bronchial asthma （BA） and chronic obstructive pulmonary disease （COPD）. In some cases both illnesses exhibit similar pathomorphologic and clinical features, indicating common genetic basis of predisposing to development of disease. To assess genetic susceptibility we conducted association analysis of glutathione-S-transferases Mu （M）, Theta （T） and Pi （P） gene polymorphism with disease development in 85 adult asthma, 60 COPD subjects and 64 control subjects. Present investigation of GST gene polymorphisms indicates that GSTM1 and GSTT null alleles are associated with predisposition for COPD and they do not appear to play a substantial role in susceptibility to BA. However, homozygote ＋/＋ and heterozygote ＋/0 genotypes of GSTT1 revealed to be associated with increasing of IgE level in serum in BA patients. Our findings suggest that the 105 Val variant of GSTP1 contributed to the increasing risk of developing of both diseases, and more likely for COPD.展开更多
Objective To investigate the correlation between human β-defensin-1 (HBD-1) exon 2 variations and chronic obstructive pulmonary disease susceptibility in Han population in south of China. Methods The frequency of pol...Objective To investigate the correlation between human β-defensin-1 (HBD-1) exon 2 variations and chronic obstructive pulmonary disease susceptibility in Han population in south of China. Methods The frequency of polymorphic genotypes of HBD-1 exon 2 (1654G/A) was examined in 120 COPD patients (COPD group) and 108 smokers without COPD (control group) by restriction fragment length polymorphism. Results The frequencies of polymorphic genotypes in HBD-1 exon 2 in COPD group were G/G 82.50%, G/A 10.83%, and A/A 6.67%. The frequencies of polymorphic genotypes in control group were G/G 95.37%, G/A 3.70%, and A/A 0.93%. It showed significant difference between two groups(P<0.01). The differences in allele frequencies were also significant between two groups (G allele frequency: 87.92% vs 97.22%; A allele frequency: 12.08% vs 2.78%; P<0.01). The G→A mutation rised along with the severity of the COPD. Conclusion The genetic polymorphism in HBD-1 exon 2 gene might be associated with the susceptibility to COPD in Han population of South China.展开更多
文摘Air is the ocean we breathe. Air supplies us with oxygen which is essential for our bodies to live. 99.9% air is nitrogen, oxygen, water vapor and inert gases. Human activities can release substances into the air, some of which can cause problems for humans, plants and animals. There are several main types of pollution and well-known effects of pollution which are commonly discussed. These include smog, acid rain, the greenhouse effect, and ＂holes＂ in the ozone layer. Each of these problems has serious implications for our health and well-being as well as for the whole environment. The age and health condition are more important also at the response opposite the pollution of air. During the last decade in our country such as result of freely population movement, development and growth of their industrial activities, growth of vehicle number, collapse of roadway infrastructure etc., an increase of air quality pollution is evident. In this study, we exhibited the causers, such as increasing of number of the old cars, which is an important factor of the air pollution and, at the same time, we exhibited the pollution indicators of the air quality, such as PM I 0, total dust, dust levels outdoors and indoors, which are in the high levels. These factors indicated on human health. We have observed the health indicators, especially lung diseases such as bronchial asthma with higher percentage, chronic bronchitis and lung cancer. There was consistency in the finding that relates the acute increases in urban air pollution and the short-term health effects or patients suffering from chronic obstructive pulmonary diseases.
文摘Glutathione-S-transferase （GST） family enzymes are implicated in the pathopbysiology of bronchial asthma （BA） and chronic obstructive pulmonary disease （COPD）. In some cases both illnesses exhibit similar pathomorphologic and clinical features, indicating common genetic basis of predisposing to development of disease. To assess genetic susceptibility we conducted association analysis of glutathione-S-transferases Mu （M）, Theta （T） and Pi （P） gene polymorphism with disease development in 85 adult asthma, 60 COPD subjects and 64 control subjects. Present investigation of GST gene polymorphisms indicates that GSTM1 and GSTT null alleles are associated with predisposition for COPD and they do not appear to play a substantial role in susceptibility to BA. However, homozygote ＋/＋ and heterozygote ＋/0 genotypes of GSTT1 revealed to be associated with increasing of IgE level in serum in BA patients. Our findings suggest that the 105 Val variant of GSTP1 contributed to the increasing risk of developing of both diseases, and more likely for COPD.
基金Supported by grants from Science and Technology Foundation in the National"10th 5-year Plan", China (2001BA703B03).
文摘Objective To investigate the correlation between human β-defensin-1 (HBD-1) exon 2 variations and chronic obstructive pulmonary disease susceptibility in Han population in south of China. Methods The frequency of polymorphic genotypes of HBD-1 exon 2 (1654G/A) was examined in 120 COPD patients (COPD group) and 108 smokers without COPD (control group) by restriction fragment length polymorphism. Results The frequencies of polymorphic genotypes in HBD-1 exon 2 in COPD group were G/G 82.50%, G/A 10.83%, and A/A 6.67%. The frequencies of polymorphic genotypes in control group were G/G 95.37%, G/A 3.70%, and A/A 0.93%. It showed significant difference between two groups(P<0.01). The differences in allele frequencies were also significant between two groups (G allele frequency: 87.92% vs 97.22%; A allele frequency: 12.08% vs 2.78%; P<0.01). The G→A mutation rised along with the severity of the COPD. Conclusion The genetic polymorphism in HBD-1 exon 2 gene might be associated with the susceptibility to COPD in Han population of South China.
