Background:Xerotic changes in atopic skin are considered to be related to a decrease in the water permeability barrier.Whether abnormal skin barrier function is the main cause of atopic dermatitis(AD)or a secondary ch...Background:Xerotic changes in atopic skin are considered to be related to a decrease in the water permeability barrier.Whether abnormal skin barrier function is the main cause of atopic dermatitis(AD)or a secondary change of the disease is still controversial.Noninvasive bioengineering methods,including the measurement of the transepidermal water loss(TEWL)and water capacitance,have been commonly used to evaluate skin barrier function.Aim:To evaluate the correlation between the clinical features of each evaluation site(severity of AD)and skin barrier function.Methods:TEWL,capacitance,and pH were checked on five evaluation sites:postauricle,forearm,abdomen,thigh,and popliteal fossa.The subjects included 25 patients,both adolescents and adults,with AD and 25 age-matched normal controls.The clinical severity,from 0(no clinical manifestation)to 3(severe),was also scored for erythema,induration/papulation,lichenification,and xerosis on each evaluation site of the AD patients.Results:Based on the data,we found that the clinical severity score was correlated with TEWL and capacitance in more than one-half of the evaluation sites.Erythema and induration/papulation showed a statistically significant correlation with TEWL in most cases(P < 0.05,four sites).Lichenification and xerosis showed a significant correlation with capacitance in most cases(P < 0.05,four sites).In most cases,severity scoring of the clinical features did not show a significant correlation with skin pH.The patients showed higher TEWL and lower capacitance than normal controls(P < 0.05,all five sites).Conclusions:The results of our study suggest that skin barrier function,measured by TEWL and capacitance,and clinical severity show a statistically significant correlation in patients with AD.展开更多
目的搔抓动作表现为手腕的加速度变化,采用加速度记录仪以手表形式佩戴于利侧手腕客观定量化评价特应性皮炎(atopic dermatitis,AD)瘙痒程度。方法健康志愿者与AD患者连续佩戴加速度记录仪记录手腕的加速度变化,设定ZCM模式第13型Mini-M...目的搔抓动作表现为手腕的加速度变化,采用加速度记录仪以手表形式佩戴于利侧手腕客观定量化评价特应性皮炎(atopic dermatitis,AD)瘙痒程度。方法健康志愿者与AD患者连续佩戴加速度记录仪记录手腕的加速度变化,设定ZCM模式第13型Mini-Motionlogger作为分析参数。为排除非瘙痒引起的干扰,采用夜间睡眠期的变量作为分析对象。评价治疗前后湿疹面积及严重度指数评分(eczema area and severity index,EASI)、视觉模拟评分(visual analogue scale,VAS)值变化,观察平均活动量(night activity,NA)和瘙痒时间占总睡眠时间百分比(the percent of itching time,PIT)的变化。并评价三者与皮损EASI评分间的相关性。结果 AD患者夜间睡眠时活动量较健康受试者更为频密。AD患者治疗前后NA的前后差值(△)与EASI评分的前后差值(△)相关性较低(P>0.05,r=0.42);VAS评分的前后差值与EASI评分的前后差值几乎没有线性关系(P>0.05,r=0.34);而PIT的前后差值与EASI评分的前后差值则呈直线相关(P<0.05,r=0.75)。结论本研究以健康人的夜间活动量作为基础阈值,计算PIT值,将非瘙痒引起的因素尽可能降低,取得了较好的效果。以PIT值作为分析指标,可取得AD患者夜间搔抓行为相对准确的定量。PIT值与EASI有较高的相关性。展开更多
文摘Background:Xerotic changes in atopic skin are considered to be related to a decrease in the water permeability barrier.Whether abnormal skin barrier function is the main cause of atopic dermatitis(AD)or a secondary change of the disease is still controversial.Noninvasive bioengineering methods,including the measurement of the transepidermal water loss(TEWL)and water capacitance,have been commonly used to evaluate skin barrier function.Aim:To evaluate the correlation between the clinical features of each evaluation site(severity of AD)and skin barrier function.Methods:TEWL,capacitance,and pH were checked on five evaluation sites:postauricle,forearm,abdomen,thigh,and popliteal fossa.The subjects included 25 patients,both adolescents and adults,with AD and 25 age-matched normal controls.The clinical severity,from 0(no clinical manifestation)to 3(severe),was also scored for erythema,induration/papulation,lichenification,and xerosis on each evaluation site of the AD patients.Results:Based on the data,we found that the clinical severity score was correlated with TEWL and capacitance in more than one-half of the evaluation sites.Erythema and induration/papulation showed a statistically significant correlation with TEWL in most cases(P < 0.05,four sites).Lichenification and xerosis showed a significant correlation with capacitance in most cases(P < 0.05,four sites).In most cases,severity scoring of the clinical features did not show a significant correlation with skin pH.The patients showed higher TEWL and lower capacitance than normal controls(P < 0.05,all five sites).Conclusions:The results of our study suggest that skin barrier function,measured by TEWL and capacitance,and clinical severity show a statistically significant correlation in patients with AD.
文摘目的搔抓动作表现为手腕的加速度变化,采用加速度记录仪以手表形式佩戴于利侧手腕客观定量化评价特应性皮炎(atopic dermatitis,AD)瘙痒程度。方法健康志愿者与AD患者连续佩戴加速度记录仪记录手腕的加速度变化,设定ZCM模式第13型Mini-Motionlogger作为分析参数。为排除非瘙痒引起的干扰,采用夜间睡眠期的变量作为分析对象。评价治疗前后湿疹面积及严重度指数评分(eczema area and severity index,EASI)、视觉模拟评分(visual analogue scale,VAS)值变化,观察平均活动量(night activity,NA)和瘙痒时间占总睡眠时间百分比(the percent of itching time,PIT)的变化。并评价三者与皮损EASI评分间的相关性。结果 AD患者夜间睡眠时活动量较健康受试者更为频密。AD患者治疗前后NA的前后差值(△)与EASI评分的前后差值(△)相关性较低(P>0.05,r=0.42);VAS评分的前后差值与EASI评分的前后差值几乎没有线性关系(P>0.05,r=0.34);而PIT的前后差值与EASI评分的前后差值则呈直线相关(P<0.05,r=0.75)。结论本研究以健康人的夜间活动量作为基础阈值,计算PIT值,将非瘙痒引起的因素尽可能降低,取得了较好的效果。以PIT值作为分析指标,可取得AD患者夜间搔抓行为相对准确的定量。PIT值与EASI有较高的相关性。
