Objectives To compare the difference in pulmonary function between Caucasians and Chinese and assess the best reference values of pulmonary function for Chinese adults.Methods Values for pulmonary function were pre...Objectives To compare the difference in pulmonary function between Caucasians and Chinese and assess the best reference values of pulmonary function for Chinese adults.Methods Values for pulmonary function were predicted by tests on 4773 Chinese healthy subjects (male: 2560, female: 2213, aged 15-78 years) in six parts (north, northeast, northwest, east, southwest and south) of China. Prediction equations of the European Community for Steel and Coal (ECSC), other equations for overseas Chinese or for Caucasians were also selected. The regression coefficients of forced vital capacity (FVC), forced expiratory volume in one second (FEV 1), FEV 1/FVC, total lung capacity (TLC) and residual volume (RV) were summarized. Results ECSC predictions were closer to the Chinese ones than other selected equations. Comparison with ECSC predictions showed that on average the values for FVC, FEV 1 were 5.3% smaller in Chinese males and 3.3% smaller in Chinese females, with the maximal differences in south China and the minimal differences in North China. RV and TLC in Chinese were lower than in Caucasians (males 4.8%, 5.5%, respectively; females 8.7% and 6.0%, respectively). Conversion factors were given for adjusting ECSC equations to fit Chinese. Conclusions For predicting values of pulmonary function in Chinese, we suggest to use the equations reported here. Alternatively, ECSC regression equations may be used with appropriate conversion factors.展开更多
OBJECTIVE： Appropriate dose guarantees Chinese herb＇s safety and effectiveness. There are adult dose criteria for Chinese herbs in decoction in the Pharmacopoeia of the People＇s Republic of China （2010 Edition） a...OBJECTIVE： Appropriate dose guarantees Chinese herb＇s safety and effectiveness. There are adult dose criteria for Chinese herbs in decoction in the Pharmacopoeia of the People＇s Republic of China （2010 Edition） at present. But Chinese herbs have been frequently used in much higher doses than the dose criteria. This study has been conducted to test the dependability of the dose criteria. METHODS： Twenty Chinese herbs were selected as representatives and their adult doses in decoction in Bei Ji Qian .lin Yao Fang, a famous ancient litera- ture, have been reviewed and compared with those in the Pharmacopoeia of the People＇s Republic of China （2010 Edition）. RESULTS： The adult dose criteria for all these 20 Chinese herbs in the Pharmacopoeia of the People＇s Republic of China （2010 Edition） haven＇t covered those in Bei Ji Qian .fin Yao Fang. Furthermore, maxi- mal adult doses in the dose criteria are much lower than those in Bei Ji Qian Jin Yao Fang. CONCLUSION： The dose criteria in the Pharmaco- poeia of the People＇s Republic of China （2010 Edition） are not comprehensive enough. Studying ancient literatures is an effective method to gain preciousChinese herbs＇ dose data and helps for new dose criteria＇s establishment in the future.展开更多
文摘Objectives To compare the difference in pulmonary function between Caucasians and Chinese and assess the best reference values of pulmonary function for Chinese adults.Methods Values for pulmonary function were predicted by tests on 4773 Chinese healthy subjects (male: 2560, female: 2213, aged 15-78 years) in six parts (north, northeast, northwest, east, southwest and south) of China. Prediction equations of the European Community for Steel and Coal (ECSC), other equations for overseas Chinese or for Caucasians were also selected. The regression coefficients of forced vital capacity (FVC), forced expiratory volume in one second (FEV 1), FEV 1/FVC, total lung capacity (TLC) and residual volume (RV) were summarized. Results ECSC predictions were closer to the Chinese ones than other selected equations. Comparison with ECSC predictions showed that on average the values for FVC, FEV 1 were 5.3% smaller in Chinese males and 3.3% smaller in Chinese females, with the maximal differences in south China and the minimal differences in North China. RV and TLC in Chinese were lower than in Caucasians (males 4.8%, 5.5%, respectively; females 8.7% and 6.0%, respectively). Conversion factors were given for adjusting ECSC equations to fit Chinese. Conclusions For predicting values of pulmonary function in Chinese, we suggest to use the equations reported here. Alternatively, ECSC regression equations may be used with appropriate conversion factors.
基金Supported by Shanghai Municipal Education Commission Budget for Research Projects (No. 2011JW68)
文摘OBJECTIVE： Appropriate dose guarantees Chinese herb＇s safety and effectiveness. There are adult dose criteria for Chinese herbs in decoction in the Pharmacopoeia of the People＇s Republic of China （2010 Edition） at present. But Chinese herbs have been frequently used in much higher doses than the dose criteria. This study has been conducted to test the dependability of the dose criteria. METHODS： Twenty Chinese herbs were selected as representatives and their adult doses in decoction in Bei Ji Qian .lin Yao Fang, a famous ancient litera- ture, have been reviewed and compared with those in the Pharmacopoeia of the People＇s Republic of China （2010 Edition）. RESULTS： The adult dose criteria for all these 20 Chinese herbs in the Pharmacopoeia of the People＇s Republic of China （2010 Edition） haven＇t covered those in Bei Ji Qian .fin Yao Fang. Furthermore, maxi- mal adult doses in the dose criteria are much lower than those in Bei Ji Qian Jin Yao Fang. CONCLUSION： The dose criteria in the Pharmaco- poeia of the People＇s Republic of China （2010 Edition） are not comprehensive enough. Studying ancient literatures is an effective method to gain preciousChinese herbs＇ dose data and helps for new dose criteria＇s establishment in the future.
