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新疆塔河油田奥陶系碳酸盐岩溶洞、裂隙中方解石胶结物元素分析与成因 被引量:16
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作者 钱一雄 陈跃 +1 位作者 马宏强 陈强路 《沉积学报》 CAS CSCD 北大核心 2004年第1期6-12,共7页
通过对新疆塔河油田奥陶系的溶洞 (穴 )和裂隙充填的 31件方解石胶结物元素分析及因子和聚类分析表明 :①方解石中的CaCO3 、MgCO3 、FeCO3 、MnCO3 相对平均摩尔百分含量分别为 98.38%、0 .87%、0 .6 8%和 0 .0 7% ,SiO2 、Al2 O3 平... 通过对新疆塔河油田奥陶系的溶洞 (穴 )和裂隙充填的 31件方解石胶结物元素分析及因子和聚类分析表明 :①方解石中的CaCO3 、MgCO3 、FeCO3 、MnCO3 相对平均摩尔百分含量分别为 98.38%、0 .87%、0 .6 8%和 0 .0 7% ,SiO2 、Al2 O3 平均分别为 1.95 %、0 .73% ,Sr、BaO平均分别为 131.4× 10 6、5 16 .5× 10 6,F和Cl 平均分别为 0 .0 14 %和0 .0 13% ,而Mn +Fe/Mg、Mn/Fe平均分别为 0 .87、0 .10 ;②方解石中Sr/Ca =0 .0 0 6 18Mg/Ca + 0 .0 0 0 5 33( R2 =0 .197) ,主要显示出无机成因特点 ;③方解石常量与微量元素特征均可由六个因子可代表组成 ,具有一定的沉积与成岩作用意义 ;④据聚类分析将样品划分出四组 :其中 ,以S6 9 W 0 37等代表的可能为潜流带中的淡水淋滤的产物 ,并可能经历了相当强烈的水 岩作用或埋藏溶蚀作用 ;以S6 9 W 0 38等为代表的则为大气淋滤的产物 ;以S80 W 0 6 4等代表显示出埋藏作用或海水成岩及混合带的产物特征 ,但不排除埋藏热水作用的影响 ;S85 W 0 0 5等样品推测为海水浓缩背景下埋藏成岩产物 。 展开更多
关键词 方解石 化学分析 因子分析 聚类分析 成因 油气藏 岩溶
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生物质成型燃料热风炉结渣特性及成因试验研究 被引量:6
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作者 刘圣勇 郑丹 +2 位作者 李文雅 苏超杰 王喜云 《河南科学》 2007年第6期1032-1035,共4页
采用生物质成型燃料热风炉,分别进行了炉膛温度、燃料层厚度、燃料粒径和过量空气系数等对结渣率影响的试验,根据试验与观察,得出了生物质成型燃料热风炉的结渣特性,并分析总结了生物质成型燃料热风炉的结渣成因、过程及结渣影响因素.
关键词 生物质成型燃料 热风炉 渣特性 影响因素 成因
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中太平洋铁锰结壳元素间的关系及其对结壳成因的意义 被引量:1
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作者 X.Wen 周立君 《海洋地质动态》 1997年第5期21-23,共3页
关键词 太平洋 铁锰 元素 成因 铁锰
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冷湖地区上干柴沟组储层碳酸盐胶结物特征及地质意义 被引量:13
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作者 陈波 陈汾君 +3 位作者 马进业 石正灏 孙国强 史基安 《大庆石油地质与开发》 CAS CSCD 北大核心 2016年第5期28-33,共6页
综合运用岩石学、矿物学及碳氧同位素等理论,对冷湖地区上干柴沟组储层的碳酸盐胶结类型、形成机理及其对储层物性的影响进行了研究。结果表明:上干柴沟组发育两期碳酸盐胶结物,成岩早期碳酸盐胶结物大多是孔隙流体中碳酸钙达到过饱和... 综合运用岩石学、矿物学及碳氧同位素等理论,对冷湖地区上干柴沟组储层的碳酸盐胶结类型、形成机理及其对储层物性的影响进行了研究。结果表明:上干柴沟组发育两期碳酸盐胶结物,成岩早期碳酸盐胶结物大多是孔隙流体中碳酸钙达到过饱和形成的,沉淀时温度较低,δ13C、δ18O值大,自形程度较好,多以微晶或泥晶团块似"连晶式"胶结于粒间孔隙中,该胶结物在一定程度上增强了岩石骨架颗粒固结和抗压实能力,且是后期有机酸的主要溶蚀对象,对储层物性起到促进作用;成岩中—晚期碳酸盐胶结物主要来自有机酸脱酸作用相关的碳酸盐,δ13C值、δ18O值小,沉淀时温度较高,多以分散式形态出现在粒间孔隙中,该胶结物形成时间较晚,往往位于粒间孔隙和部分溶蚀孔隙中,对储层物性起到破坏作用。 展开更多
关键词 柴达木盆地 冷湖地区 新近系 碳酸盐胶 碳氧同位素 成因机理
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从《世说新语》中王徽之的形象看魏晋风度
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作者 左攀峰 《商丘职业技术学院学报》 2009年第1期62-63,共2页
从《世说新语》中王徽之的形象,可以看出魏晋风度是崇尚自然、风流自赏、不慕功利、纵情任性、潇洒飘逸等。这种风度产生的根源有战乱、对政界的厌恶、儒家思想崩坏、老庄思想盛行与个人意识的觉醒等四个方面。
关键词 《世说新语》 王徽之 魏晋风度 成因结
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Novel Substrate pn Junction Isolation for RF Integrated Inductors on Silicon 被引量:5
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作者 刘畅 陈学良 严金龙 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2001年第12期1486-1489,共4页
A new method for reducing the substrate rated losses of integrated spiral inductors is presented.The method is to block the eddy currents induced by spiral inductors by directly forming pn junction isolation in the S... A new method for reducing the substrate rated losses of integrated spiral inductors is presented.The method is to block the eddy currents induced by spiral inductors by directly forming pn junction isolation in the Si substrate. The substrate pn junction can be realized by using the standard silicon technologies without any additional processing steps.Integrated inductors on silicon are designed and fabricated. S parameters of the inductor based equivalent circuit are investigated and the inductor parameters are calculated.The impacts of the substrate pn junction isolation on the inductor quality factor are studied.The experimental results show that substrate pn junction isolation in certain depth has achieved a significant improvement.At 3GHz,the substrate pn junction isolation increases the inductor quality factor by 40%. 展开更多
关键词 Si integrated inductor quality factor eddy current pn junction isolation
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Analysis of Genetic Variation and Population Structure of Starch Synthesis-related Genes in Indica Rice Cultivars
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作者 赵春芳 胡庆峰 +7 位作者 强新涛 赵凌 赵庆勇 陈涛 周丽慧 姚姝 梁文化 王才林 《Agricultural Science & Technology》 CAS 2016年第9期1993-1999,共7页
In this study, 34 molecular markers of starch synthesis-related genes were used to evaluate the genetic variation and population structure of 87 indica rice cultivars from different countries and regions. The results ... In this study, 34 molecular markers of starch synthesis-related genes were used to evaluate the genetic variation and population structure of 87 indica rice cultivars from different countries and regions. The results showed that a total of 80 alleles were amplified using 34 primer pairs, with an average of 2.5 alleles per locus. The allele number varied from 2 to 6 among various cultivars. Shannon's diversity index of molecular markers varied from 0.303 to 0.796, with an average of 0.539. Polymorphism information content (PIC) varied from 0.084 to 0.658, with an average of 0.295. The genetic similarity coefficients of 87 indica rice cultivars ranged from 0.265 to 0.990, indicating significant genetic differences of starch synthesis-related genes among different cultivars, but the variation frequency of alleles varied among different cultivars. Population structure analysis showed that these 87 indica rice cultivars were divided into three categories. Genetic differences were small within the same category but great among different categories. Moreover, indica rice cultivars with simple genetic components accounted for 39.1% and those with complex genetic background accounted for 60.9%. This study may not only provide theoretical basis for genetic improvement of rice starch quality, but also lay a solid foundation for subsequent association analysis of rice quality-related traits. 展开更多
关键词 Indica rice Starch synthesis-related gene Genetic variation Population structure
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鄂尔多斯盆地西南部上古生界致密砂岩中碳酸盐胶结物特征及成因 被引量:1
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作者 宋昆鹏 罗静兰 +4 位作者 刘新社 侯云东 盛伟琰 曹江骏 毛倩茹 《天然气地球科学》 EI CAS CSCD 北大核心 2020年第11期1562-1573,共12页
在盆地内部钻井岩心与盆地西南缘野外露头观察基础上,综合运用薄片鉴定、扫描电镜、电子探针、微区碳氧同位素、流体包裹体均一温度与激光拉曼成分分析,开展了鄂尔多斯盆地西南部上古生界盒8段致密砂岩储层中碳酸盐胶结的成因机制研究... 在盆地内部钻井岩心与盆地西南缘野外露头观察基础上,综合运用薄片鉴定、扫描电镜、电子探针、微区碳氧同位素、流体包裹体均一温度与激光拉曼成分分析,开展了鄂尔多斯盆地西南部上古生界盒8段致密砂岩储层中碳酸盐胶结的成因机制研究。结果显示,盒8段致密砂岩储层中存在4期碳酸盐胶结:①同生成岩阶段碳酸盐胶结物形成于烃类充注之前,直接从碳酸盐过饱和的沉积水中析出;②早成岩阶段B期和中成岩阶段A期的碳酸盐胶结物与烃源岩中生烃、排烃提供的有机碳源有关;③盆地抬升阶段形成的碳酸盐胶结物受到大气降水等无机碳源的影响。盆地西南缘盒8段储层中的烃类充注始于烃源岩演化早期(80℃左右),在早成岩阶段B期就形成了规模较大的有机碳源成因的碳酸盐胶结物;盆地内部规模较大的烃类充注发生在烃源岩成熟之后(120℃左右),有机碳源成因的碳酸盐胶结物主要形成于中成岩阶段A期。 展开更多
关键词 碳酸盐胶成因 稳定碳氧同位素 流体包裹体 上古生界 鄂尔多斯盆地
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蒸汽洗井在花土沟油田的应用 被引量:1
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作者 赵东 《中国新技术新产品》 2012年第7期158-158,共1页
在油田开发过程中,油井结蜡现象普遍存在,严重影响了油井的正常生产。本文简要介绍了油井结蜡的成因及其危害,分析了花土沟油田结蜡的原因,而蒸汽洗井作为清蜡的一个重要方式,本文重点介绍了蒸汽洗井清蜡的原理和特点,以及蒸汽洗井清蜡... 在油田开发过程中,油井结蜡现象普遍存在,严重影响了油井的正常生产。本文简要介绍了油井结蜡的成因及其危害,分析了花土沟油田结蜡的原因,而蒸汽洗井作为清蜡的一个重要方式,本文重点介绍了蒸汽洗井清蜡的原理和特点,以及蒸汽洗井清蜡在花土沟采油作业区的应用,并对蒸汽洗井的效果进行了分析,最后通过数据分析,对蒸汽洗井在花土沟采油作业区的应用进行了总结并提出了建议。 展开更多
关键词 成因 蒸汽洗井 清蜡原理 效果分析 建议
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Quantitative Effect of Soil Texture Composition on Retardation Factor of K^+ Transport 被引量:15
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作者 WANGYU ZHANGYIPING 《Pedosphere》 SCIE CAS CSCD 2001年第4期377-382,共6页
With six packed columns composed of < 1 μm and 5 μm~0.25 mm fractions from an Eum-Orthic An- throsol (Columns 1~6) and one column of the Eum-Orthic Anthrosol (Column 7), K~(+) transport experiments under the c... With six packed columns composed of < 1 μm and 5 μm~0.25 mm fractions from an Eum-Orthic An- throsol (Columns 1~6) and one column of the Eum-Orthic Anthrosol (Column 7), K~(+) transport experiments under the condition of saturated steady water flow were conducted to qualify the effects of soil texture com- position on the retardation factor (R) of K~(+) transport. The results showed that the retardation factor of K~ (+) transport in the tested soil columns greatly increased with increasing clay contents. In an attempt to use pedo-transfer function (PTF) approach in the solute transport study, a preliminary PTF was established through the six packed columns (Columns 1~6) with soil basic data including soil bulk density, volumet- ric water content and clay content to predict the retardation factor, and proved valid by the satisfactory prediction of R in Column 7. 展开更多
关键词 pedo-transfer function retardation factor soil basic properties soil solute transport
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Effects of endostatin on expression of vascular endothelial growth factor and its receptors and neovascularization in colonic carcinoma implanted in nude mice 被引量:17
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作者 Yun-HeJia Xin-ShuDong Xi-ShanWang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第22期3361-3364,共4页
AIM:To investigate the antiangiogenic effects of endostatin on colonic carcinoma cell line implanted in nude mice and its mechanism. METHODS:Nude mice underwent subcutaneous injection with LS-174t colonic carcinoma ce... AIM:To investigate the antiangiogenic effects of endostatin on colonic carcinoma cell line implanted in nude mice and its mechanism. METHODS:Nude mice underwent subcutaneous injection with LS-174t colonic carcinoma cell line to generate carcinoma and were randomly separated into two groups.Mice received injection of vehicle or endostatin every day for two weeks. After the tumor was harvested,the tumor volumes were determined,and the expressions of CD34,VEGF and FIk-1 were examined by immunohistochemical method. RESULTS:Tumor volume was significantly inhibited in the endostatin group(84.17%)and tumor weight was significantly inhibited in the endostatin group(0.197±0.049) compared to the control group(1.198±0.105)(F=22.56, P=0.001),microvessel density(MVD)was significantly decreased in the treated group(31.857±3.515)compared to the control group(100.143±4.290)(F=151.62,P<0.001). Furthermore,the expression of FIk-1 was significantly inhibited in the treated group(34.29%) ompared to the control group(8.57%)(X^2=13.745,P=0.001).However no significant decrease was observed in the expression of vascular endothelial growth factor(VEGF)between these two groups(X^2=0.119,P=0.730). CONCLUSION:Endostatin can inhibit tumor growth and angiogenesis by blocking Vegf/FIk-1 pathway.This experiment provides the theory basis for developing a new anti-carcinoma drug through studying the properties of anti-angiogenesis inhibitors. 展开更多
关键词 Angiogenesis Inhibitors Animals Antigens CD34 Cell Line Tumor Colonic Neoplasms ENDOSTATINS MICE Mice Nude Neovascularization Pathologic Research Support Non-U.S. Gov't Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-2 Xenograft Model Antitumor Assays
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Leafy head formation of the progenies of transgenic plants of Chinese cabbage with exogenous auxin genes 被引量:10
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作者 HE YU KE WAN XIN XUE +3 位作者 YU DONG SUN XU HONG YU PING LIN LIU(Fax:021-64042090 E-mail: heyk@iris. sipp.ac.cn)(National Laboratory of Plant Molecular Genetics, ShanghaiInstitute of Plant Physiology, Chinese Academy of Sciences,Shanghai 200032, China) 《Cell Research》 SCIE CAS CSCD 2000年第2期151-160,共10页
The experiment was performed to evaluate the progenies of plant lines transgenic for auxin synthesis genes derived from Ri T-DNA. Four lines of the transgenic plants were selfcrossed and the foreign auxin genes in pla... The experiment was performed to evaluate the progenies of plant lines transgenic for auxin synthesis genes derived from Ri T-DNA. Four lines of the transgenic plants were selfcrossed and the foreign auxin genes in plants of T5 generation were confirmed by Southern hybridization. Two lines, D1232 and D1653, showed earlier folding of expanding leaves than untransformed line and therefore had early initiation of leaf y head. Leaf cuttings derived from plant of transgenic line D1653 produced more adventitious roots than the control whereas the cuttings from folding leaves had much more roots than rosette leaves at folding stage, and the cuttings from head leaves had more roots than rosette leaves at heading stage. It is demonstrated that early folding of transgenic leaf may be caused by the relatively higher concentration of auxin. These plant lines with auxin transgenes can be used for the study of hormonal regulation in differentiation and development of plant organs nd for the breeding of new varietywith rapid growth trait. 展开更多
关键词 Auxin genes Chinese cabbage leafy head transgenic plants
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Cost Management Research Based on E-commerce Logistics Mode
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作者 Zhi Wang 《International Journal of Technology Management》 2014年第12期129-130,共2页
This paper describes the real-time and the importance of the study about e-commerce logistics cost management ,analyzes the development status of today' s e-commerce logistics and compares it with the traditional log... This paper describes the real-time and the importance of the study about e-commerce logistics cost management ,analyzes the development status of today' s e-commerce logistics and compares it with the traditional logistics, defines the e-commerce logistics cost management .Based on this, it summarizes the cost structure of e-commerce logistics, proposes factors affecting the cost of logistics, builds the basic ideas of logistics cost management, and thus introducts the accounting methods about logistics cost .Finally, puts forward to the content and methods of logistics costs budget, controling the cost effectively. 展开更多
关键词 e-commerce logistics model Logistics costs Cost Management CONTROL
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Agency, Narrativity, and the Sense of an Ending
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作者 Femando Broncano 《Journal of Philosophy Study》 2013年第7期596-608,共13页
The relation between narratives and agency can be sometimes considered as mutually constitutive. There are cases in which telling a story expresses higher degrees of agency, and respectively, agency is shaped as a nar... The relation between narratives and agency can be sometimes considered as mutually constitutive. There are cases in which telling a story expresses higher degrees of agency, and respectively, agency is shaped as a narrative that expresses the agent's reasons. From henceforth, I will contend that a narrative theory, beyond the personal identity problem, can also enlighten how the agent attains giving reasons for the action by making sense of sequences of events. In order to explain how agency is constituted from understanding and control, we must assume a primitive competence for narratives. Agency supposes an ordering that cannot be reduced to temporality, but expresses a certain sense of accomplishment that can be narratively constituted. In this context, I will examine Welleman's theory of emotions as an ordering framework of the events in structures of means-ends. A possible objection to his explanation of the agential narratives is that emotions themselves need to be understood as narrative processes. I suggest then that an enactivist approach would be a way of explaining the narrative constitution of agency. One virtue of this approach is that it harmonizes the biological and cultural components of the agency from the most basic layers to the ordinary folk-psychological narratives. 展开更多
关键词 Narrativity Narrative Identity SELF Action Enactivism Emotions
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海南岛鹿回头水尾岭海滩岩中的微生物碳酸盐沉积研究 被引量:3
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作者 滕建彬 沈建伟 《中国科学(D辑)》 CSCD 北大核心 2007年第10期1338-1348,共11页
般呈叠层状、薄的结壳状、穹状、微生物石等多种形态生长,黏结细小的生物碎屑,大多具有微生物的管形丝状体和纹层状的生长纹.珊瑚骨骼孔穴中的微生物碳酸盐沉积呈叠层的尖锥体,生长方向不定,随珊瑚骨骼孔穴的延伸方向生长,具有清晰的生... 般呈叠层状、薄的结壳状、穹状、微生物石等多种形态生长,黏结细小的生物碎屑,大多具有微生物的管形丝状体和纹层状的生长纹.珊瑚骨骼孔穴中的微生物碳酸盐沉积呈叠层的尖锥体,生长方向不定,随珊瑚骨骼孔穴的延伸方向生长,具有清晰的生长纹层,显示明显的阶段性,是隐生微生物碳酸盐沉积的一种独特发育形式.微生物成因的胶结物多以针纤状方解石、钙化的菌类丝状体和莓状钙球的形式出现,并以针纤状方解石最为常见.这表明微生物活动和微生物碳酸盐沉积在热带海洋受季风影响下的以碳酸盐为主要成分的海滩岩形成中起着重要的作用.研究工作第一次发现和描述了我国南海北部海岸海滩岩中的微生物碳酸盐沉积和与微生物活动有关的胶结物,研究结果支持海滩岩中的胶结物部分是源于微生物成因的,肯定了微生物在碳酸盐沉积方面的重要作用,从一个新的研究角度拓宽了海滩岩的认知领域. 展开更多
关键词 微生物碳酸盐沉积 微生物成因的胶 海滩岩 全新世海南岛
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Causes of Environmental Pollution after Industrial Restructuring in Gansu Province 被引量:1
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作者 万永坤 董锁成 +1 位作者 毛琦梁 王隽妮 《Journal of Resources and Ecology》 CSCD 2013年第1期88-92,共5页
The paper analyzes coupling mechanisms and the evolution between industrial restructuring and environmental pollution. We empirically examined a case study from Gansu Province and found that industrial restructuring h... The paper analyzes coupling mechanisms and the evolution between industrial restructuring and environmental pollution. We empirically examined a case study from Gansu Province and found that industrial restructuring had promoted economic development but increased pressure on the environment. Given that heterogeneous industries generate different kinds of pollution, optimizing industrial structure is a feasible solution to fully realizing sustainable development. 展开更多
关键词 industrial structure environmental pollution cause analysis GANSU
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CAUSAL ATTRIBUTION REGARDING SUCCESS AND FAILURE IN ENGLISH LEARNING
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作者 黎丽 韩跃勤 韩翠霞 《Chinese Journal of Applied Linguistics》 2007年第6期57-65,127,共10页
According to the attribution theory,achievement attributions have significant consequences for subsequent achievement motivation and future behavior.This study sought to determine some of the causes to which junior st... According to the attribution theory,achievement attributions have significant consequences for subsequent achievement motivation and future behavior.This study sought to determine some of the causes to which junior students at vocational college attributed success or failure in their English learning.The results of the present study revealed that the majority of the students participated in the study identified themselves as unsuccessful English learners and collectively the students placed more importance on the causal attributions of interest in English learning,effort and teachers' help.When divided by their perceived learning performances (successful learners vs.unsuccessful),the successful learners placed more importance on English learning ability,interests in English,and teacher's help than did the unsuccessful ones.The paper analyzes the attribution tendency,gender difference and group difference as well. 展开更多
关键词 ATTRIBUTION causal attribution SUCCESS FAILURE unsuccessful learner
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In vivo investigation of the role of SfmO2 in saframycin A biosynthesis by structural characterization of the analogue saframycin O 被引量:1
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作者 PENG Chao TANG Yu-Min +5 位作者 LI Lei DING Wei DENG Wei PU Jin-Yue LIU Wen TANG Gong-Li 《Science China Chemistry》 SCIE EI CAS 2012年第1期90-97,共8页
Saframycin A(SFM-A),a tetrahydroisoquinoline antibiotic isolated from Streptomyces lavendulae,shows potent anti-proliferation activities against a variety of tumor cell lines,and shares the core structure with ecteina... Saframycin A(SFM-A),a tetrahydroisoquinoline antibiotic isolated from Streptomyces lavendulae,shows potent anti-proliferation activities against a variety of tumor cell lines,and shares the core structure with ecteinascidin 743(ET-743),the anticancer drug for soft-tissue sarcoma.Characterization of the SFM-A biosynthetic gene cluster revealed three nonribosomal peptide synthetase genes and a series of genes encoding oxygenases.To investigate the function of sfmO2 gene,encoding a FAD-dependent monooxygenase/hydroxylase,we constructed the gene replacement mutant(△sfmO2) strain S.lavendulae TL2007 and the corresponding gene complementation mutant strain S.lavendulae TL2008.A novel compound,SFM-O,was isolated from the △sfmO2 replacement mutant strain and its structure was characterized by comparison to the HRMS and NMR spectra of SFM-A.These findings indicated that SfmO2 is responsible for the oxidation of ring A in the biosynthetic pathway of SFM-A,and the new compound SFM-O could be considered as an advanced intermediate in the semisynthesis of ET-743. 展开更多
关键词 saframycin A BIOSYNTHESIS SfmO2 OXYGENASE saframycin O
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Non-surgical porto-mesenteric vein thrombosis is associated with worse long-term outcomes in inflammatory bowel diseases
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作者 Zubin Arora Xianrui Wu +1 位作者 Udayakumar Navaneethan Bo Shen 《Gastroenterology Report》 SCIE EI 2016年第3期210-215,I0002,共7页
Objective:Our aim was to assess the risk factors for non-surgery-related portal and mesenteric vein thrombosis(PMVT)and its impact on the outcomes of inflammatory bowel diseases(IBD).Methods:All patients with a concur... Objective:Our aim was to assess the risk factors for non-surgery-related portal and mesenteric vein thrombosis(PMVT)and its impact on the outcomes of inflammatory bowel diseases(IBD).Methods:All patients with a concurrent diagnosis of IBD and PMVT between January 2004 and October 2013 were identified from the electronic medical record(study group;n=20).Patients were matched for age,sex,and IBD phenotype with control IBD patients who had no PMVT,with a ratio of 1:3(control group;n=60).Risk factors for PMVT and IBD-related outcomes at one year after diagnosis of PMVT were compared between the two groups.Results:Of the 20 patients in the Study group,6(30%)had UC,14(70%)had CD and 11(55%)were male.On multivariable analysis,inpatient status(odds ratio[OR]6.88;95%confidence interval[CI]1.88-25.12)and baseline corticosteroid use(OR 4.39;95%CI 1.27-15.19)were found to be independent risk factors for the development of PMVT.At one-year follow-up,PMVT patients were more likely to have an adverse outcome of IBD,including subsequent emergency room visit(26.3%vs.1.7%;P=0.003),hospitalization for medical management(60.0%vs.20.0%;P=0.001)or IBD-related surgery(65.0%vs.26.7%;P=0.003)than the non-PMVT controls.In multivariable analysis,PMVT(OR 5.19;95%CI 1.07-25.28)and inpatient status(OR 8.92;95%CI 1.33-59.84)were found to be independent risk factors for poor outcome,whereas baseline immunomodulator use(OR 0.07;95%CI 0.01-0.51)was found to be a protective factor.Conclusions:IBD patients who were inpatients or receiving corticosteroid therapy had an increased risk of the development of PMVT.The presence of PMVT was associated with poor clinical outcomes in IBD. 展开更多
关键词 inflammatory bowel diseases portal vein thrombosis OUTCOMES risk factors
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Eplerenone inhibits atrial fibrosis in mutant TGF-β1 transgenic mices.. 被引量:4
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作者 Xiaoqing Chen Wuchang Zhang +5 位作者 Qian Wang Lili Du Yi Yi Yan Liu Xu Liu Shengzhong Duan 《Science China(Life Sciences)》 SCIE CAS CSCD 2016年第10期1042-1047,共6页
The purpose of the present study was to study the impacts of eplerenone (EPL), an antagonist of mineralocorticoid receptors (MR), on atrial fibrosis in a mouse model with selective fibrosis in the atrium, and to e... The purpose of the present study was to study the impacts of eplerenone (EPL), an antagonist of mineralocorticoid receptors (MR), on atrial fibrosis in a mouse model with selective fibrosis in the atrium, and to explore the possible mechanisms. Using mutant TGF-β1 transgenic (Tx) mice, we first demonstrated that EPL inhibited atrial fibrosis specifically and decreased mac- rophage accumulation in the atria of these mice. Results from immunohistochemistry and western blotting showed that EPL attenuated protein expression of fibrosis-related molecules such as connective tissue growth factor (CTGF) and fibronectin in the atria of Tx mice. In culture, EPL inhibited gene expression of fibrosis-related molecules such as fibronectin, ct-SMA, and CTGF in TGF-β1-stimulated atrial fibroblasts, Finally, using a co-culture system, we showed that TGF-β1 stimulated atrial fi- broblasts induced migration of macrophages and this was blocked by EPL. EPL also blocked TGF-β1 induced gene expression of intedeukin-6 (IL-6) in atrial fibroblasts. Therefore, we conclude that EPL attenuated atrial fibrosis and macrophage infiltra- tion in Tx mice. TGF-I31 and IL-6 were involved in the impacts of EPL on activation of atrial fibroblasts and interactions be- tween fibroblasts and macrophages. 展开更多
关键词 EPLERENONE atrial fibrosis atrial fibroblasts MACROPHAGES TGF-Β1
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