The asymmetric reductive amination of achiral ketones with ammonia is a particularly attractive reaction for the synthesis of chiral amines.Although several engineered amine dehydrogenases have been developed by prote...The asymmetric reductive amination of achiral ketones with ammonia is a particularly attractive reaction for the synthesis of chiral amines.Although several engineered amine dehydrogenases have been developed by protein engineering for the asymmetric reductive amination of ketones,they all display(R)‐stereoselectivity.To date,there is no report of an(S)‐stereoselective biocatalyst for this reaction.Herein,a microorganism named Brevibacterium epidermidis ECU1015 that catalyzes the(S)‐selective reductive amination of ketones with ammonium has been successfully isolated from soil.Using B.epidermidis ECU1015 as the catalyst,the asymmetric reductive amination of a set of phenylacetone derivatives was successfully carried out,yielding the corresponding(S)‐chiral amines with moderate conversion and>99%enantiomeric excess.展开更多
The title compound (+)-(a-hydroxybenzyl)phenylphosphinic acid (C13H13O3P, Mr = 248.20) has been synthesized and characterized by 31P NMR, 1H NMR and elemental analysis. X-ray diffraction analysis at 293(2) K indicates...The title compound (+)-(a-hydroxybenzyl)phenylphosphinic acid (C13H13O3P, Mr = 248.20) has been synthesized and characterized by 31P NMR, 1H NMR and elemental analysis. X-ray diffraction analysis at 293(2) K indicates that the compound belongs to monoclinic system, space group C2 with cell parameters: a = 23.560(8), b = 6.947(2), c = 7.854(3) ? b = 91.273(6)? V = 1285.2(7) 3, Z = 4, Dc = 1.283 g/cm3, F(000) = 520 and m(MoKa) = 0.207 mm-1. The number of independent reflections amounts to 1991, of which 1507 are observed reflections. The crystal structure has been determined by direct methods (SHELXL-97). The structure parameters are refined by full-matrix least-squares on F2 to R = 0.0437 and wR = 0.0893. The flack x parameter is 0.0001. The absolute configuration of the a-carbon in the title compound is S.展开更多
Improving the focusing capability of pre-stack time migration allows the imaged section to reflect structural characteristics, depth, and interface shape and it is a key step for the preparation of the initial depth m...Improving the focusing capability of pre-stack time migration allows the imaged section to reflect structural characteristics, depth, and interface shape and it is a key step for the preparation of the initial depth migration velocity model. The traditional symmetrical travel time equation is derived based on the assumption of a layered model. It is difficult to achieve the desired effect of focusing in media with strong lateral variation. The nonsymmetrical travel time equation based on Lie algebra and a pseudo-differential operator contains a lateral velocity derivative which can improve the focusing capability even in strongly lateral variable media and also the computation precision of the weight coefficients for relative amplitude preservation. Compared with the symmetrical methods, the nonsymmetrical method is more effective. In this paper, we describe several key steps of nonsymmetric pre-stack travel time calculation and present some test results using synthetic and real data.展开更多
financial management is an important part of enterprise management, plays a vital role in production, management, development of enterprises. However, the current financial management in our country the majority of sm...financial management is an important part of enterprise management, plays a vital role in production, management, development of enterprises. However, the current financial management in our country the majority of small and medium-sized enterprises has a lot of problems. This paper analyzes the small and medium-sized enterprise financial management problems, and puts forward the optimize the financial management. and suggestions to展开更多
financial management is an important part of enterprise management, plays a vital role in production, management, development of enterprises. However, the current financial management in our country the majority of sm...financial management is an important part of enterprise management, plays a vital role in production, management, development of enterprises. However, the current financial management in our country the majority of small and medium-sized enterprises has a lot of problems. This paper analyzes the small and medium-sized enterprise financial management problems, and puts forward the countermeasures and suggestions to optimize the financial management.展开更多
We present an analytical analysis of the spatial resolution of quantum ghost imaging implemented by entangled photons from a general, spontaneously parametric, down-conversion process. We find that the resolution is a...We present an analytical analysis of the spatial resolution of quantum ghost imaging implemented by entangled photons from a general, spontaneously parametric, down-conversion process. We find that the resolution is affected by both the pump beam waist and the nonlinear crystal length. Hence, we determined a method to improve the resolution for a certain imaging setup. It should be noted that the resolution is not uniquely related to the degree of entanglement of the photon pair since the resolution can be optimized for a certain degree of entanglement. For certain types of Einstein-Podolsky-Rosen(EPR) states——namely the momentum-correlated or momentum-positively correlated states——the resolution exhibits a simpler relationship with the pump beam waist and crystal length. Further, a vivid numerical simulation of ghost imaging is presented for different types of EPR states,which supports our analysis. This work discusses applicable references to the applications of quantum ghost imaging.展开更多
We focus on second order duality for a class of multiobjective programming problem subject to cone constraints. Four types of second order duality models are formulated. Weak and strong duality theorems are establishe...We focus on second order duality for a class of multiobjective programming problem subject to cone constraints. Four types of second order duality models are formulated. Weak and strong duality theorems are established in terms of the generalized convexity, respectively. Converse duality theorems, essential parts of duality theory, are presented under appropriate assumptions. Moreover, some deficiencies in the work of Ahmad and Agarwal(2010) are discussed.展开更多
A mesoscopic model has been established to investigate the thermodynamic mechanisms and densification behavior of nickel-based superalloy during additive manufacturing/three-dimensional （3D） printing （AM/3DP） by n...A mesoscopic model has been established to investigate the thermodynamic mechanisms and densification behavior of nickel-based superalloy during additive manufacturing/three-dimensional （3D） printing （AM/3DP） by numerical simulation, using a finite volume method （FVM）. The influence of the applied linear energy density （LED） on dimensions of the molten pool, thermodynamic mechanisms within the pool, bubbles migration and resultant densification behavior of AM/3DP-processed superalloy has been discussed. It reveals that the center of the molten pool slightly shifts with a lagging of 4 ktm towards the center of the moving laser beam. The Mar- angoni convection, which has various flow patterns, plays a crucial role in intensifying the convective heat and mass transfer, which is responsible for the bubbles migration and densification behavior of AM/3DP-processed parts. At an optimized LED of 221.5 J/m, the outward convection favors the numerous bubbles to escape from the molten pool easily and the resultant considerably high relative density of 98.9 % is achieved. However, as the applied LED further increases over 249.5 J/m, the convection pattern is apparently intensified with the formation of vortexes and the bubbles tend to be entrapped by the rotating flow within the molten pool, resulting in a large amount of residual porosity and a sharp reduction in densification of the superalloy. The change rules of the relative density and the corresponding distribution of porosity obtained by experiments are in accordance with the simulation results.展开更多
A new model,called object model,for the simulation of cold roll-forming of tubes is presented.The model inherits the advantages of old models and is the embodiment of forming process that the strip is rolled step by s...A new model,called object model,for the simulation of cold roll-forming of tubes is presented.The model inherits the advantages of old models and is the embodiment of forming process that the strip is rolled step by step from feed rollers to last rolling pass.The elastic-plastic large deformation spline finite strip method based on updated Lagrangian method has been developed by improving the stiffness and transition matrix.Combined theory formulas and new analytical model,the forming process of a tube has been simulated successfully as an example.The analytical results are submitted and indicate that the proposed simulation method and new model are applicable.展开更多
基金supported by the National Natural Science Foundation of China(21472045,21536004)the National Defense Scientific and Technological Innovation Special Zone(17-163-12-ZT-003-055-01)~~
文摘The asymmetric reductive amination of achiral ketones with ammonia is a particularly attractive reaction for the synthesis of chiral amines.Although several engineered amine dehydrogenases have been developed by protein engineering for the asymmetric reductive amination of ketones,they all display(R)‐stereoselectivity.To date,there is no report of an(S)‐stereoselective biocatalyst for this reaction.Herein,a microorganism named Brevibacterium epidermidis ECU1015 that catalyzes the(S)‐selective reductive amination of ketones with ammonium has been successfully isolated from soil.Using B.epidermidis ECU1015 as the catalyst,the asymmetric reductive amination of a set of phenylacetone derivatives was successfully carried out,yielding the corresponding(S)‐chiral amines with moderate conversion and>99%enantiomeric excess.
基金Financial support by the National Natural Science Foundation of China (No.29872016)
文摘The title compound (+)-(a-hydroxybenzyl)phenylphosphinic acid (C13H13O3P, Mr = 248.20) has been synthesized and characterized by 31P NMR, 1H NMR and elemental analysis. X-ray diffraction analysis at 293(2) K indicates that the compound belongs to monoclinic system, space group C2 with cell parameters: a = 23.560(8), b = 6.947(2), c = 7.854(3) ? b = 91.273(6)? V = 1285.2(7) 3, Z = 4, Dc = 1.283 g/cm3, F(000) = 520 and m(MoKa) = 0.207 mm-1. The number of independent reflections amounts to 1991, of which 1507 are observed reflections. The crystal structure has been determined by direct methods (SHELXL-97). The structure parameters are refined by full-matrix least-squares on F2 to R = 0.0437 and wR = 0.0893. The flack x parameter is 0.0001. The absolute configuration of the a-carbon in the title compound is S.
基金This research was supported by the National Basic Research Program of China （Grant No. 2007CB209603）, Key Project of the National Natural Science Foundation （Grant No. 40830424）, State Key Laboratory of Geological Processes and Mineral Resources Geo-detection Laboratory of the Ministry of Education for their sponsorship （GPMR 200633, GDL0801）.
文摘Improving the focusing capability of pre-stack time migration allows the imaged section to reflect structural characteristics, depth, and interface shape and it is a key step for the preparation of the initial depth migration velocity model. The traditional symmetrical travel time equation is derived based on the assumption of a layered model. It is difficult to achieve the desired effect of focusing in media with strong lateral variation. The nonsymmetrical travel time equation based on Lie algebra and a pseudo-differential operator contains a lateral velocity derivative which can improve the focusing capability even in strongly lateral variable media and also the computation precision of the weight coefficients for relative amplitude preservation. Compared with the symmetrical methods, the nonsymmetrical method is more effective. In this paper, we describe several key steps of nonsymmetric pre-stack travel time calculation and present some test results using synthetic and real data.
文摘financial management is an important part of enterprise management, plays a vital role in production, management, development of enterprises. However, the current financial management in our country the majority of small and medium-sized enterprises has a lot of problems. This paper analyzes the small and medium-sized enterprise financial management problems, and puts forward the optimize the financial management. and suggestions to
文摘financial management is an important part of enterprise management, plays a vital role in production, management, development of enterprises. However, the current financial management in our country the majority of small and medium-sized enterprises has a lot of problems. This paper analyzes the small and medium-sized enterprise financial management problems, and puts forward the countermeasures and suggestions to optimize the financial management.
基金supported by the National Natural Science Foundation of China(Grant Nos.11174121,11321063,91121001,and 91321312)the National Program on Key Basic Research Project(Grant No.2012CB921802)
文摘We present an analytical analysis of the spatial resolution of quantum ghost imaging implemented by entangled photons from a general, spontaneously parametric, down-conversion process. We find that the resolution is affected by both the pump beam waist and the nonlinear crystal length. Hence, we determined a method to improve the resolution for a certain imaging setup. It should be noted that the resolution is not uniquely related to the degree of entanglement of the photon pair since the resolution can be optimized for a certain degree of entanglement. For certain types of Einstein-Podolsky-Rosen(EPR) states——namely the momentum-correlated or momentum-positively correlated states——the resolution exhibits a simpler relationship with the pump beam waist and crystal length. Further, a vivid numerical simulation of ghost imaging is presented for different types of EPR states,which supports our analysis. This work discusses applicable references to the applications of quantum ghost imaging.
基金supported by National Natural Science Foundation of China (Grant Nos. 11431004, 11271391 and 11201511)the Project of Chongqing Science and Technology Committee (Grant No. cstc2014pt-sy00001)Theoretical Foundation and Application Procedure of Environmental Data Envelopment Analysis Model (Grant No. B-Q22L)
文摘We focus on second order duality for a class of multiobjective programming problem subject to cone constraints. Four types of second order duality models are formulated. Weak and strong duality theorems are established in terms of the generalized convexity, respectively. Converse duality theorems, essential parts of duality theory, are presented under appropriate assumptions. Moreover, some deficiencies in the work of Ahmad and Agarwal(2010) are discussed.
基金supported by the National Natural Science Foundation of China (51575267, 51322509)the Top-Notch Young Talents Program of China+9 种基金the Outstanding Youth Foundation of Jiangsu Province of China (BK20130035)the Program for New Century Excellent Talents in University (NCET-13-0854)the Science and Technology Support Program (the Industrial Part)Jiangsu Provincial Department of Science and Technology of China (BE2014009-2)the 333 high-level talents training project (BRA2015368)the Science and Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Human Resources and Social Security of Chinathe Aeronautical Science Foundation of China (2015ZE52051)the Shanghai Aerospace Science and Technology Innovation Fund (SAST2015053)the Fundamental Research Funds for the Central Universities (NE2013103, NP2015206 and NZ2016108)the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘A mesoscopic model has been established to investigate the thermodynamic mechanisms and densification behavior of nickel-based superalloy during additive manufacturing/three-dimensional （3D） printing （AM/3DP） by numerical simulation, using a finite volume method （FVM）. The influence of the applied linear energy density （LED） on dimensions of the molten pool, thermodynamic mechanisms within the pool, bubbles migration and resultant densification behavior of AM/3DP-processed superalloy has been discussed. It reveals that the center of the molten pool slightly shifts with a lagging of 4 ktm towards the center of the moving laser beam. The Mar- angoni convection, which has various flow patterns, plays a crucial role in intensifying the convective heat and mass transfer, which is responsible for the bubbles migration and densification behavior of AM/3DP-processed parts. At an optimized LED of 221.5 J/m, the outward convection favors the numerous bubbles to escape from the molten pool easily and the resultant considerably high relative density of 98.9 % is achieved. However, as the applied LED further increases over 249.5 J/m, the convection pattern is apparently intensified with the formation of vortexes and the bubbles tend to be entrapped by the rotating flow within the molten pool, resulting in a large amount of residual porosity and a sharp reduction in densification of the superalloy. The change rules of the relative density and the corresponding distribution of porosity obtained by experiments are in accordance with the simulation results.
基金the National Natural Science Foundation of China (No. 50375135)the Talent Foundation of Beijing Jiaotong University (No. 2003RC059)
文摘A new model,called object model,for the simulation of cold roll-forming of tubes is presented.The model inherits the advantages of old models and is the embodiment of forming process that the strip is rolled step by step from feed rollers to last rolling pass.The elastic-plastic large deformation spline finite strip method based on updated Lagrangian method has been developed by improving the stiffness and transition matrix.Combined theory formulas and new analytical model,the forming process of a tube has been simulated successfully as an example.The analytical results are submitted and indicate that the proposed simulation method and new model are applicable.
