It was the first time demonstrated by us that the number of newborn neurons was increajsed after making lesion in forebraill of adult ring dove (Streptopelia risoria)by means of autoradiography and immunohistochemistr...It was the first time demonstrated by us that the number of newborn neurons was increajsed after making lesion in forebraill of adult ring dove (Streptopelia risoria)by means of autoradiography and immunohistochemistry.Neurogenesis in the adult avian is restricted to the telencephalon. In doves with bilateral electrolytic lesion of nucleus ectostriatum (E), the mean number of proliferating cells in the lateral ventricular zone (LVZ) and newborn neurons in the forebrain increased by 1.95 times and 2.38times respectively as compared with that in intact doves. The most relllarkable increase of neurogenesis induced by nucleus ectostriatum lesions was found at the anteriorposterior level 3 (L3), where the lesion site was located.These results showed that the electrolytic brain lesion altered the distribution pattern of proliferating cells in theLVZ and resulted in increase of the number of newborn neurons in the non-VZ areas of forebrain. The changes in number and distribution pattern of proliferating cells in LVZ and newborn neurons in forebrain may be dependent on site of lesion. Studies on the relationship between proliferating cells in LVZ and newly generated neurons in non-VZ areas may help to understand the mechanism of brain plasticity and development.展开更多
文摘It was the first time demonstrated by us that the number of newborn neurons was increajsed after making lesion in forebraill of adult ring dove (Streptopelia risoria)by means of autoradiography and immunohistochemistry.Neurogenesis in the adult avian is restricted to the telencephalon. In doves with bilateral electrolytic lesion of nucleus ectostriatum (E), the mean number of proliferating cells in the lateral ventricular zone (LVZ) and newborn neurons in the forebrain increased by 1.95 times and 2.38times respectively as compared with that in intact doves. The most relllarkable increase of neurogenesis induced by nucleus ectostriatum lesions was found at the anteriorposterior level 3 (L3), where the lesion site was located.These results showed that the electrolytic brain lesion altered the distribution pattern of proliferating cells in theLVZ and resulted in increase of the number of newborn neurons in the non-VZ areas of forebrain. The changes in number and distribution pattern of proliferating cells in LVZ and newborn neurons in forebrain may be dependent on site of lesion. Studies on the relationship between proliferating cells in LVZ and newly generated neurons in non-VZ areas may help to understand the mechanism of brain plasticity and development.
