Objective To identify new genes required for neurosecretory control of aging in C. elegans. Methods In view of the importance of nervous system in aging regulation, we performed the screen for genes involved in the ag...Objective To identify new genes required for neurosecretory control of aging in C. elegans. Methods In view of the importance of nervous system in aging regulation, we performed the screen for genes involved in the aging regulation from genetic loci encoding synaptic proteins by lifespan assay and accumulation of lipofuscin autofluorescence. We further investigated the dauer formation phenotypes of their corresponding mutants and whether they were possibly up-regulated by the insulin-like signaling pathway. Results The genetic loci of unc-10, syd-2, hlb-1, dlk-1, mkk-4, scd- 2, snb-1, ric-4, nrx-1, unc-13, sbt-1 and unc-64 might be involved in the aging control. In addition, functions of unc-10, syd-2, hlb-1, dlk-1, mkk-4, scd-2, snb-1, ric-4 and nrx-1 in regulating aging may be opposite to those of unc-13, sbt-1 and unc-64. The intestinal autofluorescence assay further indicated that the identified long-lived and short-lived mutants were actually due to the suppressed or accelerated aging. Among the identified genes, syd-2, hlb-1, mkk-4, scd-2, snb-1, ric-4 and unc-64 were also involved in the control of dauer formation. Moreover, daf-2 mutation positively regulated the expression of syd-2 and hlb-1, and negatively regulated the expression of mkk-4, nrx-1, ric-4, sbt-1, rpm-1, unc-10, dlk- 1 and unc-13. The daf-16 mutation positively regulated the expression of syd-2 and hlb-1, and negatively regulated the expression of mkk-4, nrx-1, sbt-1, rpm-1, unc-10, dlk-1 and unc-13. Conclusion These data suggest the possibly important status of the synaptic transmission to the animal＇ s life-span control machinery, as well as the dauer formation control.展开更多
A method of space-time block coding （STBC） system based on adaptive beamforming of cyclostationarity signal algorithm is proposed.The method uses cyclostationarity of signals to achieve adaptive beamforming,then con...A method of space-time block coding （STBC） system based on adaptive beamforming of cyclostationarity signal algorithm is proposed.The method uses cyclostationarity of signals to achieve adaptive beamforming,then constructs a pair of low correlated transmit beams based on beamform estimation of multiple component signals of uplink.Using these two selected transmit beams,signals encoded by STBC are transmitted to achieve diversity gain and beamforming gain at the same time,and increase the signal to noise ratio （SNR） of downlink.With simple computation and fast convergence performance,the proposed scheme is applicable for time division multiple access （TDMA） wireless communication operated in a complex interference environment.Simulation results show that the proposed scheme has better performance than conventional STBC,and can obtain a gain of about 5 dB when the bit error ratio （BER） is 10-4.展开更多
This paper derives an approximate formula for probability density function(PDF) of received signal-to-interference-and-noise ratio(SINR) at user terminal when matched filter(MF) is adopted at a base station(BS).This d...This paper derives an approximate formula for probability density function(PDF) of received signal-to-interference-and-noise ratio(SINR) at user terminal when matched filter(MF) is adopted at a base station(BS).This distribution of SINR can be used to make an analysis of average sum-rate,outage probability,and symbol error rate of massive MIMO downlink with MF at BS.From simulation,it is found that the derived approximate analytical expression for PDF of SINR is consistent with the simulated exact PDF from the definition of SINR in medium-scale and large-scale MIMO systems.展开更多
The molecular mechanisms that regulate synapse formation have been well documented. However, little is known about the factors that modulate synaptic stability. Synapse loss is an early and invariant feature of neurod...The molecular mechanisms that regulate synapse formation have been well documented. However, little is known about the factors that modulate synaptic stability. Synapse loss is an early and invariant feature of neurodegenerative diseases including Alzheimer＇s lAD） and Parkinson＇s disease. Notably, in AD the extent of synapse loss correlates with the severity of the disease. Hence, understanding the molecular mechanisms that underlie synaptic maintenance is crucial to reveal potential targets that will allow the development of ther- apies to protect synapses. Writs play a central role in the formation and function of neuronal circuits. Moreover, Wnt signaling compo- nents are expressed in the adult brain suggesting their role in synaptic maintenance in the adult. Indeed, blockade of Wnts with the Wnt antagonist Dickkopf-1 （Dkkl） causes synapse disassembly in mature hippocampal cells. Dkkl is elevated in brain biopsies from AD patients and animal models. Consistent with these findings, Amyloid-β （Aβ） oUgomers induce the rapid expression of Dkkl. Importantly, Dkkl neutralizing antibodies protect synapses against Aβ toxicity, indicating that Dkkl is required for Aβ-mediated synapse loss. In this review, we discuss the role of Wnt signaling in synapse maintenance in the adult brain, particularly in relation to synaptic loss in neurodegenerative diseases.展开更多
To effectively suppress white noise and preserve more useful components of electrocardiogram(ECG) signal, a novel de-noising method based on morphological component analysis(MCA) is proposed. MCA is a method which all...To effectively suppress white noise and preserve more useful components of electrocardiogram(ECG) signal, a novel de-noising method based on morphological component analysis(MCA) is proposed. MCA is a method which allows us to separate features contained in an original signal when these features present different morphological aspects. According to the features of ECG, we used the UWT dictionary to sparsely represent mutated component, and used the DCT dictionary to sparsely represent smooth component. The experimental results of the samples choosing from MIT-BIH databases show that the MCA-based method is effective for white noise removal.展开更多
文摘Objective To identify new genes required for neurosecretory control of aging in C. elegans. Methods In view of the importance of nervous system in aging regulation, we performed the screen for genes involved in the aging regulation from genetic loci encoding synaptic proteins by lifespan assay and accumulation of lipofuscin autofluorescence. We further investigated the dauer formation phenotypes of their corresponding mutants and whether they were possibly up-regulated by the insulin-like signaling pathway. Results The genetic loci of unc-10, syd-2, hlb-1, dlk-1, mkk-4, scd- 2, snb-1, ric-4, nrx-1, unc-13, sbt-1 and unc-64 might be involved in the aging control. In addition, functions of unc-10, syd-2, hlb-1, dlk-1, mkk-4, scd-2, snb-1, ric-4 and nrx-1 in regulating aging may be opposite to those of unc-13, sbt-1 and unc-64. The intestinal autofluorescence assay further indicated that the identified long-lived and short-lived mutants were actually due to the suppressed or accelerated aging. Among the identified genes, syd-2, hlb-1, mkk-4, scd-2, snb-1, ric-4 and unc-64 were also involved in the control of dauer formation. Moreover, daf-2 mutation positively regulated the expression of syd-2 and hlb-1, and negatively regulated the expression of mkk-4, nrx-1, ric-4, sbt-1, rpm-1, unc-10, dlk- 1 and unc-13. The daf-16 mutation positively regulated the expression of syd-2 and hlb-1, and negatively regulated the expression of mkk-4, nrx-1, sbt-1, rpm-1, unc-10, dlk-1 and unc-13. Conclusion These data suggest the possibly important status of the synaptic transmission to the animal＇ s life-span control machinery, as well as the dauer formation control.
文摘A method of space-time block coding （STBC） system based on adaptive beamforming of cyclostationarity signal algorithm is proposed.The method uses cyclostationarity of signals to achieve adaptive beamforming,then constructs a pair of low correlated transmit beams based on beamform estimation of multiple component signals of uplink.Using these two selected transmit beams,signals encoded by STBC are transmitted to achieve diversity gain and beamforming gain at the same time,and increase the signal to noise ratio （SNR） of downlink.With simple computation and fast convergence performance,the proposed scheme is applicable for time division multiple access （TDMA） wireless communication operated in a complex interference environment.Simulation results show that the proposed scheme has better performance than conventional STBC,and can obtain a gain of about 5 dB when the bit error ratio （BER） is 10-4.
基金Supported by the National Natural Science Foundation of China(No.61271230,61301107)the Fundamental Research Funds for the Central Universities(No.30920130122004)Open Research Fund of National Mobile Communications Research Laboratory,Southeast University(No.2013D02)
文摘This paper derives an approximate formula for probability density function(PDF) of received signal-to-interference-and-noise ratio(SINR) at user terminal when matched filter(MF) is adopted at a base station(BS).This distribution of SINR can be used to make an analysis of average sum-rate,outage probability,and symbol error rate of massive MIMO downlink with MF at BS.From simulation,it is found that the derived approximate analytical expression for PDF of SINR is consistent with the simulated exact PDF from the definition of SINR in medium-scale and large-scale MIMO systems.
文摘The molecular mechanisms that regulate synapse formation have been well documented. However, little is known about the factors that modulate synaptic stability. Synapse loss is an early and invariant feature of neurodegenerative diseases including Alzheimer＇s lAD） and Parkinson＇s disease. Notably, in AD the extent of synapse loss correlates with the severity of the disease. Hence, understanding the molecular mechanisms that underlie synaptic maintenance is crucial to reveal potential targets that will allow the development of ther- apies to protect synapses. Writs play a central role in the formation and function of neuronal circuits. Moreover, Wnt signaling compo- nents are expressed in the adult brain suggesting their role in synaptic maintenance in the adult. Indeed, blockade of Wnts with the Wnt antagonist Dickkopf-1 （Dkkl） causes synapse disassembly in mature hippocampal cells. Dkkl is elevated in brain biopsies from AD patients and animal models. Consistent with these findings, Amyloid-β （Aβ） oUgomers induce the rapid expression of Dkkl. Importantly, Dkkl neutralizing antibodies protect synapses against Aβ toxicity, indicating that Dkkl is required for Aβ-mediated synapse loss. In this review, we discuss the role of Wnt signaling in synapse maintenance in the adult brain, particularly in relation to synaptic loss in neurodegenerative diseases.
基金Natural Science Foundatoin of Fujian Province of Chinagrant number:2012J01280
文摘To effectively suppress white noise and preserve more useful components of electrocardiogram(ECG) signal, a novel de-noising method based on morphological component analysis(MCA) is proposed. MCA is a method which allows us to separate features contained in an original signal when these features present different morphological aspects. According to the features of ECG, we used the UWT dictionary to sparsely represent mutated component, and used the DCT dictionary to sparsely represent smooth component. The experimental results of the samples choosing from MIT-BIH databases show that the MCA-based method is effective for white noise removal.
