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可转化为国际标准的科技成果选择决策研究——基于VIKOR法 被引量:4
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作者 张瑞 丁日佳 郝素利 《科技进步与对策》 CSSCI 北大核心 2015年第10期5-8,共4页
对具有潜力的科技成果予以重点支持,促使其转化为国际标准,对于提高我国产业国际竞争力具有重要意义。从成果性质、技术水平、经济效益、社会效益4个方面,构建了可转化为国际标准的科技成果选择指标体系,建立了基于VIKOR法的可转化为国... 对具有潜力的科技成果予以重点支持,促使其转化为国际标准,对于提高我国产业国际竞争力具有重要意义。从成果性质、技术水平、经济效益、社会效益4个方面,构建了可转化为国际标准的科技成果选择指标体系,建立了基于VIKOR法的可转化为国际标准的科技成果选择决策模型,并对材料领域6项国家科技计划成果进行了实证检验。结果表明:该方法能够有效反映科技成果转化为国际标准的潜力,可为国家主导制定国际标准的科技成果选择提供依据。 展开更多
关键词 科技成果 国际标准 VIKOR 成果选择
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Semi-synthesis of mangiferin-7-O-β-D-glucuronide 被引量:1
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作者 杨博威 梁丹琳 +2 位作者 魏雄 孟祥豹 李中军 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2017年第8期556-565,共10页
Mangiferin is a natural plant polyphenol with a structure of xanthone C-glycoside and it displays a wide spectrum of pharmacological activities. Investigation of the metabolites of mangiferin is valuable in studying t... Mangiferin is a natural plant polyphenol with a structure of xanthone C-glycoside and it displays a wide spectrum of pharmacological activities. Investigation of the metabolites of mangiferin is valuable in studying the mechanisms of its various pharmacological properties and developing novel drugs from the mangiferin derivatives. Among the metabolites of mangiferin, mangiferin-7-O-β-D-glucuronide has been reported as the phase Ⅱ metabolite of mangiferin. Herein we described the first semi-synthesis of mangiferin-7-O-β-D-glucuronide with the natural product mangiferin as the starting material. In this work, we adopted several regioselective protection procedures to distinguish the different hydroxyl groups in the structure of mangiferin, and we accomplished the glycosylation under the phase-transfer catalysis conditions. In this method, we efficiently synthesized the glucuronide derivative of mangiferin in 10 steps with highly regioselective protection. 展开更多
关键词 Mangiferin-7-O-β-D-glucuronide Semi-synthesis Regioselective protection Glycosylation
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