Objective To evaluate metabolic abnormalities in patients with mesial temporal lobe epilepsy （MTLE） with proton magnetic resonance spectroscopy （MRS） using a 3.0T MR scanner. Methods Sixty-three patients （32 wom...Objective To evaluate metabolic abnormalities in patients with mesial temporal lobe epilepsy （MTLE） with proton magnetic resonance spectroscopy （MRS） using a 3.0T MR scanner. Methods Sixty-three patients （32 women and 31 men） with diagnosed MTLE underwent diagnostic MR imaging （MRI） and proton MRS using a 3.0T MR scanner. The clinical history and interictal epileptiform discharges （IEDs） were recorded. Sixteen healthy volunteers served as control. The results of proton MRS were compared with the findings of electroencephalogram and structural MRI findings. Results Twenty-seven of the 63 patients with MTLE showed unilateral hippocampal sclerosis, and 9 showed bilateral hippocampal sclerosis. The concentration ratio of N-acytelaspartate （NAA） / [ creatine （ Cr ） ＋ choline （Cho） ] in the hippocampal region of MTLE patients （0. 64±0. 07） was significantly lower than control （0. 80±0. 05, P = 0.023）. In the patients with unilateral hippocampal sclerosis, NAA/（Cr ＋ Cho） in the hippocampal region ipsilateral to the sclerotic hippocampus （0.56±0.06） was significantly lower than the ratio in the contralateral hippocampal region （0.69±0.07, P 〈 0. 001 ）. There was significant difference in hippocampal NAA/（ Cr ＋ Cho） between the refractory patients and the non-refractory patients （0. 64±0. 05 vs.0.71±0. 07, P =0. 04）. Forty-five patients were lateralized by IEDs, while 49 patients were lateralized by metabolite ratio. And lateralization determined by proton MRS and IEDs was concordant in 33 patients. Conclusions MRS as a noninvasive tool adds helpful metabolite information to routine MRI in evaluation of MTLE. The method is well established and should be a routine clinical application in the investigation of epilepsy.展开更多
AIM: To evaluate the benefit and effectiveness of MRarterioportography (MR-AP) to achieve the highest sensitivity for detection and evaluation of hepatocellular carcinoma (HCC). METHODS: Twenty liver cirrhosis patient...AIM: To evaluate the benefit and effectiveness of MRarterioportography (MR-AP) to achieve the highest sensitivity for detection and evaluation of hepatocellular carcinoma (HCC). METHODS: Twenty liver cirrhosis patients with suspected HCC were included before transarterial chemoembolization. In all patients double-enhanced Magnetic resonance imaging (MRI) was performed. A bolus of 10 mL Magnevist was injected through a selectively placed catheter in the superior mesenteric artery and MRI of the liver was performed in arterioportographic phase. Two independent readers evaluated number, size and localization of detected lesions. Diagnostic quality was determined using a 4-point scale. Differences were analyzed for significance using a t -test. Interobserver variability was calculated. RESULTS: In all 20 patients (100%), MR-AP was feasible. Diagnostic quality was, in all cases, between 1 and2 for both modalities and readers. MR-AP detected significantly more lesions than double-enhanced MRI (102.5 vs 61, respectively, P < 0.0024). The inter-observer variability was 0.881 for MRI and 0.903 for MR-AP. CONCLUSION: Our study confirmed that the MR-AP as an additional modality for detection of HCC is beneficial, as significantly more lesions were detected compared to MRI with liver-specific contrast.展开更多
Molecular imaging(MI)can provide not only structural images using traditional imaging techniques but also functional and molecular information using many newly emerging imaging techniques.Over the past decade,the util...Molecular imaging(MI)can provide not only structural images using traditional imaging techniques but also functional and molecular information using many newly emerging imaging techniques.Over the past decade,the utilization of nanotechnology in MI has exhibited many significant advantages and provided new opportunities for the imaging of living subjects.It is expected that multimodality nanoparticles(NPs)can lead to precise assessment of tumor biology and the tumor microenvironment.This review addresses topics related to engineered NPs and summarizes the recent applications of these nanoconstructs in cancer optical imaging,ultrasound,photoacoustic imaging,magnetic resonance imaging(MRI),and radionuclide imaging.Key challenges involved in the translation of NPs to the clinic are discussed.展开更多
In the last couple of years,as the development ofnew imaging techniques,diffusion-weighted magnetic resonanceimaging (DW-MRI) has been applied increasingly in the evaluationof various diseases in the body,and has been...In the last couple of years,as the development ofnew imaging techniques,diffusion-weighted magnetic resonanceimaging (DW-MRI) has been applied increasingly in the evaluationof various diseases in the body,and has been adopted frequentlyas an imaging tool in clinical tumor assessment.As a completelynon-invasive,highly sensitive,well-tolerated and relatively lowcost technique,diffusion-weighted imaging (DWI) can supplyboth quantitative and qualitative information at the cellular levelby exploring irregular diffusion motion of water molecules withintissues in the body.In this article,we summarized the recentapplication and reliability of DWI in tumor evaluation includingtumor detection,tumor features,and outcome of early treatmentresponse.展开更多
The Rician noise introduced into the diffusion tensor images （DTIs） can bring serious impacts on tensor calculation and fiber tracking. To decrease the effects of the Rician noise, we propose to consider the wavelet...The Rician noise introduced into the diffusion tensor images （DTIs） can bring serious impacts on tensor calculation and fiber tracking. To decrease the effects of the Rician noise, we propose to consider the wavelet-based diffusion method to denoise multiehannel typed diffusion weighted （DW） images. The presented smoothing strategy, which utilizes anisotropic nonlinear diffusion in wavelet domain, successfully removes noise while preserving both texture and edges. To evaluate quantitatively the efficiency of the presented method in accounting for the Rician noise introduced into the DW images, the peak-to-peak signal-to-noise ratio （PSNR） and signal-to-mean squared error ratio （SMSE） metrics are adopted. Based on the synthetic and real data, we calculated the ap- parent diffusion coefficient （ADC） and tracked the fibers. We made comparisons between the presented model, the wave shrinkage and regularized nonlinear diffusion smoothing method. All the experiment results prove quantitatively and visually the better performance of the presented filter.展开更多
MRSI plays a more and more important role in clinical application. In this paper,we compare several fast MRSI technologies and data reconstruction methods. For the conventional phase encoding MRSI,the data reconstruct...MRSI plays a more and more important role in clinical application. In this paper,we compare several fast MRSI technologies and data reconstruction methods. For the conventional phase encoding MRSI,the data reconstruction using FFT is simple. But the data acquisition is very time consuming and thus prohibitive in clinical settings. Up to now,the MRSI technologies based on echo-planar, spiral trajectories and sensitivity encoding are the fastest in data acquisition,but their data reconstruction is complex. EPSI reconstruction uses shift of odd and even echoes. Spiral SI uses gridding FFT. SENSE-SI,a new approach to reducing the acquisition time,uses the distinct spatial sensitivities of the individual coil elements to recover the missing encoding information. These improvements in data acquisition and image reconstruction provide a potential value of metabolic imaging as a clinical tool.展开更多
This paper presents the ageing mechanism of fuse in nuclear power plant in detail. Metal Electromigration is identified as the dominant ageing mechanism. On this basis, the dominant status indicators, temperature and ...This paper presents the ageing mechanism of fuse in nuclear power plant in detail. Metal Electromigration is identified as the dominant ageing mechanism. On this basis, the dominant status indicators, temperature and resistance of fuse were ensured, and current-temperature curve was proposed. The infrared thermal imaging technology was used to inspect the ageing condition and prove the current-temperature curve. Finally, the accelerated ageing testing was conducted abiding by the dominant ageing mechanism, and the lifetime was evaluated.展开更多
文摘Objective To evaluate metabolic abnormalities in patients with mesial temporal lobe epilepsy （MTLE） with proton magnetic resonance spectroscopy （MRS） using a 3.0T MR scanner. Methods Sixty-three patients （32 women and 31 men） with diagnosed MTLE underwent diagnostic MR imaging （MRI） and proton MRS using a 3.0T MR scanner. The clinical history and interictal epileptiform discharges （IEDs） were recorded. Sixteen healthy volunteers served as control. The results of proton MRS were compared with the findings of electroencephalogram and structural MRI findings. Results Twenty-seven of the 63 patients with MTLE showed unilateral hippocampal sclerosis, and 9 showed bilateral hippocampal sclerosis. The concentration ratio of N-acytelaspartate （NAA） / [ creatine （ Cr ） ＋ choline （Cho） ] in the hippocampal region of MTLE patients （0. 64±0. 07） was significantly lower than control （0. 80±0. 05, P = 0.023）. In the patients with unilateral hippocampal sclerosis, NAA/（Cr ＋ Cho） in the hippocampal region ipsilateral to the sclerotic hippocampus （0.56±0.06） was significantly lower than the ratio in the contralateral hippocampal region （0.69±0.07, P 〈 0. 001 ）. There was significant difference in hippocampal NAA/（ Cr ＋ Cho） between the refractory patients and the non-refractory patients （0. 64±0. 05 vs.0.71±0. 07, P =0. 04）. Forty-five patients were lateralized by IEDs, while 49 patients were lateralized by metabolite ratio. And lateralization determined by proton MRS and IEDs was concordant in 33 patients. Conclusions MRS as a noninvasive tool adds helpful metabolite information to routine MRI in evaluation of MTLE. The method is well established and should be a routine clinical application in the investigation of epilepsy.
文摘AIM: To evaluate the benefit and effectiveness of MRarterioportography (MR-AP) to achieve the highest sensitivity for detection and evaluation of hepatocellular carcinoma (HCC). METHODS: Twenty liver cirrhosis patients with suspected HCC were included before transarterial chemoembolization. In all patients double-enhanced Magnetic resonance imaging (MRI) was performed. A bolus of 10 mL Magnevist was injected through a selectively placed catheter in the superior mesenteric artery and MRI of the liver was performed in arterioportographic phase. Two independent readers evaluated number, size and localization of detected lesions. Diagnostic quality was determined using a 4-point scale. Differences were analyzed for significance using a t -test. Interobserver variability was calculated. RESULTS: In all 20 patients (100%), MR-AP was feasible. Diagnostic quality was, in all cases, between 1 and2 for both modalities and readers. MR-AP detected significantly more lesions than double-enhanced MRI (102.5 vs 61, respectively, P < 0.0024). The inter-observer variability was 0.881 for MRI and 0.903 for MR-AP. CONCLUSION: Our study confirmed that the MR-AP as an additional modality for detection of HCC is beneficial, as significantly more lesions were detected compared to MRI with liver-specific contrast.
文摘Molecular imaging(MI)can provide not only structural images using traditional imaging techniques but also functional and molecular information using many newly emerging imaging techniques.Over the past decade,the utilization of nanotechnology in MI has exhibited many significant advantages and provided new opportunities for the imaging of living subjects.It is expected that multimodality nanoparticles(NPs)can lead to precise assessment of tumor biology and the tumor microenvironment.This review addresses topics related to engineered NPs and summarizes the recent applications of these nanoconstructs in cancer optical imaging,ultrasound,photoacoustic imaging,magnetic resonance imaging(MRI),and radionuclide imaging.Key challenges involved in the translation of NPs to the clinic are discussed.
文摘In the last couple of years,as the development ofnew imaging techniques,diffusion-weighted magnetic resonanceimaging (DW-MRI) has been applied increasingly in the evaluationof various diseases in the body,and has been adopted frequentlyas an imaging tool in clinical tumor assessment.As a completelynon-invasive,highly sensitive,well-tolerated and relatively lowcost technique,diffusion-weighted imaging (DWI) can supplyboth quantitative and qualitative information at the cellular levelby exploring irregular diffusion motion of water molecules withintissues in the body.In this article,we summarized the recentapplication and reliability of DWI in tumor evaluation includingtumor detection,tumor features,and outcome of early treatmentresponse.
基金National‘973’ProjectGrant number:2003 CB716103+1 种基金Shanghai Normal University ProjectGrant number:SK200734
文摘The Rician noise introduced into the diffusion tensor images （DTIs） can bring serious impacts on tensor calculation and fiber tracking. To decrease the effects of the Rician noise, we propose to consider the wavelet-based diffusion method to denoise multiehannel typed diffusion weighted （DW） images. The presented smoothing strategy, which utilizes anisotropic nonlinear diffusion in wavelet domain, successfully removes noise while preserving both texture and edges. To evaluate quantitatively the efficiency of the presented method in accounting for the Rician noise introduced into the DW images, the peak-to-peak signal-to-noise ratio （PSNR） and signal-to-mean squared error ratio （SMSE） metrics are adopted. Based on the synthetic and real data, we calculated the ap- parent diffusion coefficient （ADC） and tracked the fibers. We made comparisons between the presented model, the wave shrinkage and regularized nonlinear diffusion smoothing method. All the experiment results prove quantitatively and visually the better performance of the presented filter.
基金National NaturalScinece Foundation of China.Grant number:30 0 70 336.U niversity FoundationofHUST.Grant number:0 10 1170 0 5 4
文摘MRSI plays a more and more important role in clinical application. In this paper,we compare several fast MRSI technologies and data reconstruction methods. For the conventional phase encoding MRSI,the data reconstruction using FFT is simple. But the data acquisition is very time consuming and thus prohibitive in clinical settings. Up to now,the MRSI technologies based on echo-planar, spiral trajectories and sensitivity encoding are the fastest in data acquisition,but their data reconstruction is complex. EPSI reconstruction uses shift of odd and even echoes. Spiral SI uses gridding FFT. SENSE-SI,a new approach to reducing the acquisition time,uses the distinct spatial sensitivities of the individual coil elements to recover the missing encoding information. These improvements in data acquisition and image reconstruction provide a potential value of metabolic imaging as a clinical tool.
文摘This paper presents the ageing mechanism of fuse in nuclear power plant in detail. Metal Electromigration is identified as the dominant ageing mechanism. On this basis, the dominant status indicators, temperature and resistance of fuse were ensured, and current-temperature curve was proposed. The infrared thermal imaging technology was used to inspect the ageing condition and prove the current-temperature curve. Finally, the accelerated ageing testing was conducted abiding by the dominant ageing mechanism, and the lifetime was evaluated.
