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丝裂霉素C液滴眼治疗重症春季角结膜炎 被引量:1
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作者 黄红深 孙健 +1 位作者 胡桂荣 郑金莲 《眼科新进展》 CAS 2001年第5期357-358,共2页
目的 评价应用低浓度丝裂霉素 C液 (0 .0 1g·L- 1 MMC)局部治疗重症春季角结膜炎 (VKC)患者的疗效与安全性。方法  10例 2 0眼用皮质类固醇难治的重症 VKC局部应用 0 .0 1g· L- 1 MMC液 ,每日 3次滴眼治疗 2周。结果 在治... 目的 评价应用低浓度丝裂霉素 C液 (0 .0 1g·L- 1 MMC)局部治疗重症春季角结膜炎 (VKC)患者的疗效与安全性。方法  10例 2 0眼用皮质类固醇难治的重症 VKC局部应用 0 .0 1g· L- 1 MMC液 ,每日 3次滴眼治疗 2周。结果 在治疗第 1周末患者的自觉症状即有好转 ,至第 2周末 ,粘丝状分泌物、怕光和结膜充血均有明显地减轻 ,未见有任何 MMC治疗的副反应发生。结论 对用传统疗法难于控制的重症 VKC急性恶化期 ,可考虑短期应用低浓度 展开更多
关键词 丝裂霉素C 春季角结膜炎 成纤细胞增生
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Effect of early administration of exogenous basic fibroblast growth factor on acute edematous pancreatitis in rats 被引量:1
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作者 Qiang Yan Xing Yao Li-Cheng Dai Guo-Lei Zhang Jin-Liang Ping Jian-Fang He Chun-Fan Han 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第19期3060-3064,共5页
AIM: To observe the therapeutic effect of early administration of exogenous Basic fibroblast growth factor (bFGF) on acute edematous pancreatitis (AEP) in rats. METHODS: Thirty male Sprague-Dawley rats were rand... AIM: To observe the therapeutic effect of early administration of exogenous Basic fibroblast growth factor (bFGF) on acute edematous pancreatitis (AEP) in rats. METHODS: Thirty male Sprague-Dawley rats were randomly divided into three (n = 10): normal control group (group Ⅰ), AEP group (group Ⅱ) and AEP with bFGF treatment group (group Ⅲ). AEP was induced by subcutaneous injection of cerulein (5.5 μg/kg and 7.5 μg/kg) at 1 h interval into rats of groups Ⅱ and Ⅲ. Three hours after induction of AEP, 100 μg/kg bFGF was administrated intraperitoneally for 1h to group Ⅲ rats. For test of DNA synthesis in acinar cells, 5-bromo-2'-deoxyuridine (BrdU) labeling solution was intraperitoneally injected into the rats of groups Ⅱ and Ⅲ 24 h after bFGF treatment. The changes in serum amylase, lipase, pancreatic tissue wet/dry ratio were detected. RESULTS: In bFGF treatment group, there was a significant decrease in the volume of serum amylase, lipase and the pancreatic wet/dry weight ratio(1383.0 ± 94.6 U/L, 194.0 ± 43.6 U/L, 4.32 ± 0.32) compared to AEP group (3464 ± 223,7 U/L, 456 ±68,7 U/L, 6.89 ± 0,47) (P 〈 0.01), and no significant difference was found between bFGF treatment and control group (1289 ± 94.0 U/L, 171 ± 23.4 U/L, 4.12 ± 0.26, P 〉 0.05). The inflammatory changes such as interstitial edema, polymorphonuclear neutrophUs (PMNs) and vacuolization were significantly ameliorated compared to AEP group (P 〈 0.01). A small number of BrdU-labeled nuclei were observed in acinar cells of AEP rats (1.8 ± 0.3 nuclei/microscopic field, n = 10) while diffuse BrdU-labeled nuclei were found in bFGF-treated rats (18.9 ± 1.4 nuclei/microscopic field, n = 10) (P 〈 0.01). Immunohistochemical study showed increased DNA synthesis in pancreatic acinar cells. CONCLUSION: Early administration of exogenous bFGF has significant therapeutic effect on cerulein-induced acute edematous pancreatitis in rats. Its mechanism is related to the amelioration of inflammation and facilitation of pancreatic regeneration. 展开更多
关键词 Basic fibroblast growth factor Acute edematous pancreatitis CERULEIN
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Matrine inhibits proliferation of mouse skin fibroblasts induced by platelet-derived growth factor-BB
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作者 伍严安 高春芳 +2 位作者 王皓 黄超 孔宪涛 《Journal of Medical Colleges of PLA(China)》 CAS 2001年第2期132-134,共3页
Objective:To studythe effectof matrineon proliferationof mouseskinfibroblastsinducedby platelet-derivedgrowthfactor-BB(PDGF-BB).Methods :MouseskinfibroblastswereobtainedfromnewbornI-CRmiceandpropagatedin vitro.Prolife... Objective:To studythe effectof matrineon proliferationof mouseskinfibroblastsinducedby platelet-derivedgrowthfactor-BB(PDGF-BB).Methods :MouseskinfibroblastswereobtainedfromnewbornI-CRmiceandpropagatedin vitro.Proliferationof cellwasanalyzedby mitochondrialreductionof tetrazoliumsalt MTT andactualcellcount.Re sults:Matrine(50to500μg/ml)causeddose-dependentreductionof serum-stimu-latedcellgrowth.Growthinhibitionwas totallyreversedafterremovalof the drug.Matrinealso inhibited PDGF-BBinducedcellgrowthdose-dependently.Conclusion:Matrineexhibitspotentanti-proliferationeffecton mouseskinfibroblast.Thiseffectappearsto be mediatedby decreaseof PDGF-inducedgrowth.Theseresultssug-gestthatmatrinemighthavepreventiveandtherapeuticimplicationin skinfibrosis. 展开更多
关键词 MATRINE FIBROBLAST platelet-derivedgrowthfactor
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Expression and effect of basic fibroblast growth factor on human cataract lens epithelial cells 被引量:1
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作者 申屠形超 姚克 +2 位作者 孙朝晖 徐雯 吴仁毅 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第2期268-271,156,共4页
OBJECTIVE: To detect the expression of basic fibroblast growth factor (bFGF) in human ocular tissues, and to assess the effect of bFGF on the proliferation of human cataract lens epithelial cells (LECs) and its correl... OBJECTIVE: To detect the expression of basic fibroblast growth factor (bFGF) in human ocular tissues, and to assess the effect of bFGF on the proliferation of human cataract lens epithelial cells (LECs) and its correlation with age. METHODS: Enucleated eyes were subjected to immunostaining for bFGF protein. Human cataract LECs were cultured in vitro, and treated with bFGF for 48 hr. Proliferation was estimated by the positive area ratio of proliferating cell nuclear antigen (PCNA) in immunohistochemistry. RESULTS: bFGF protein was found in various human ocular tissues. bFGF stimulated human cataract LEC proliferation, and there was an age-related decrease in responsiveness of human cataract LECs to bFGF (P 展开更多
关键词 Adolescent Adult Age Factors CATARACT CHILD Child Preschool Epithelial Cells Fibroblast Growth Factor 2 Humans Immunohistochemistry INFANT Infant Newborn Lens Crystalline Middle Aged Proliferating Cell Nuclear Antigen Research Support Non-U.S. Gov't
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Effects of recombinant human basic fibroblast growth factor on cell proliferation during mandibular fracture healing in rabbits 被引量:4
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作者 龚振宇 周树夏 +1 位作者 曹建广 顾晓明 《Chinese Journal of Traumatology》 CAS 2001年第2期110-112,共3页
Objective:: To investigate the effects of recombinant human basic fibroblast growth factor (rhbFGF) on the cell proliferation during mandibular fracture healing in rabbits. Methods: The complex of rhbFGF and bovine ty... Objective:: To investigate the effects of recombinant human basic fibroblast growth factor (rhbFGF) on the cell proliferation during mandibular fracture healing in rabbits. Methods: The complex of rhbFGF and bovine type I collagen was implanted into the mandibular fracture site under periosteum of the animal. The whole mandible was harvested at 7, 14, 28, 56 and 84 days respectively after operation. The expression of proliferating cell nuclear antigen (PCNA) in callus was examined with immunohistochemical staining. Results: PCNA-positive cells in callus in the rhbFGF-treated group on days 7 and 14 were more than that in the control group (P< 0.01 ). Conclusions: It indicates that rhbFGF can stimulate cell proliferation during mandibular fracture healing in rabbits. 展开更多
关键词 Recombinant proteins Fibroblast growth factor basic Mandibular fractures Proliferating cell nuclear antigen RABBITS
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