A novel subtype of influenza A virus 09H1N1 has rapidly spread across the world. Evolutionary analyses of this virus have revealed that 09H1N1 is a triple reassortant of segments from swine, avian and human influenza ...A novel subtype of influenza A virus 09H1N1 has rapidly spread across the world. Evolutionary analyses of this virus have revealed that 09H1N1 is a triple reassortant of segments from swine, avian and human influenza viruses. In this study, we investigated factors shaping the codon usage bias of 09H1N1 and carried out cluster analysis of 60 strains of influenza A virus from different subtypes based on their codon usage bias. We discovered that more preferentially used codons of 09H1N1 are A-ended or U-ended, and the intra-genomic codon usage bias of 09H1N1 is quite low. Base composition constraint, dinucleotide biases and translational selection are the main factors influencing the codon usage bias of 09H1N1. At the genome level, we find that the codon usage bias of 09H1N1 is similar to H1N1 (A/swine/Kansas/77778/2007H1N1), H9N2 from Asia, H1N2 from Asia and North America and H3N2 from North America. Our results provide insight for understanding the processes governing evolution, regulation of gene expression, and revealing the evolution of 09H1N1.展开更多
Nowadays, there exist various standards for individual management systems （MSs）, at least, one for each stakeholder. New ones will be published. An integrated management system （IMS） aims to integrate some or all ...Nowadays, there exist various standards for individual management systems （MSs）, at least, one for each stakeholder. New ones will be published. An integrated management system （IMS） aims to integrate some or all components of the business into one coherent and efficient MS. Maximizing integration is more and more a strategic priority in that it constitutes an opportunity to eliminate and/or reduce potential factors of destruction of value for the organizations and also to be more competitive and consequently promote its sustainable success. A preliminary investigation was conducted on a Portuguese industrial company which, over the years, has been adopting gradually, in whole or in part, individualized management system standards （MSSs）. A research, through a questionnaire, was performed with the objective to develop, in a real business environment, an adequate and efficient IMS-QES （quality, environment, and safety） model and to potentiate for the future a generic IMS model to integrate other MSSs. The strategy and research methods have taken into consideration the case study. It was obtained a set of relevant conclusions resulting from the statistical analyses of the responses to the survey. Globally, the investigation results, by themselves, justified and prioritized the conception of a model of development of the IMS-QES and consequent definition and validation of a structure of an IMS-QES model, to be implemented at the small- and medium-sized enterprise （SME） where the investigation was conducted.展开更多
This paper discusses theories and methods of climate change risk studies for the research expansion in China. Climate change risks consist of three basic components including sensitivity, exposure, and possibility. Un...This paper discusses theories and methods of climate change risk studies for the research expansion in China. Climate change risks consist of three basic components including sensitivity, exposure, and possibility. Uncertainty, future events, damages, and relativity are the major features of climate change risk. Climate change risk research includes two key steps: risk assessment and risk management, the former is the process, and the latter is the ultimate goal which is the basis for actions to address climate change. We present the main framework and methods for climate change risk research. A case study on China's floods risk is taken as an example of climate change risk study. Finally, we point out main aspects of climate change risk research, including ensemble-based probabilistic projection, quantitative risk assessment, risk zoning and mapping, and risk management.展开更多
Managing the value of the organization is taking place based on factors forming it. It is becoming possible thanks to such managing operations of the organization, when in the end an image in accordance with expectati...Managing the value of the organization is taking place based on factors forming it. It is becoming possible thanks to such managing operations of the organization, when in the end an image in accordance with expectations, giving the state back to the value of organizations is being got. Creating the goodwill is based among others on immaterial factors, which although they are becoming impossible to include in balance, are taken hold in time value of the organization. Creation of the value of an organization may be based on the organizational culture. The article presents the essence of value management and organization characterized the factors affecting the formation of organizational culture, ways of dealing with an organization aimed at consolidating and strengthening the organizational culture. Sometimes organizations feel the need to change the culture in order to achieve increased efficiency and ensure the success of the company to implement the necessary changes. Therefore, the rest of this article presents the elements to ensure a smooth implementation and consolidation of cultural change.展开更多
The development of the logistics work is one of the indispensable important components in the whole construction and development process of colleges and universities. The effective development of the logistics work ca...The development of the logistics work is one of the indispensable important components in the whole construction and development process of colleges and universities. The effective development of the logistics work can lay a solid, powerful foundation for the implementation of the main functions and the education and teaching activities, and also can provide a reliable guarantee for the teaching management work. Therefore, the important significance and value of the logistics management work in colleges and universities are seen. According to the actual situation, in this paper, the logistics work in colleges and universities is deeply considered and discussed, and the main problems in the present logistics management are studied based on fully understanding the logistics management specialties, and then the measures and methods for solving the above problems are proposed. Hopefully, a due effect is played on the quality of the logistics management in colleges and universities at the present time.展开更多
文摘A novel subtype of influenza A virus 09H1N1 has rapidly spread across the world. Evolutionary analyses of this virus have revealed that 09H1N1 is a triple reassortant of segments from swine, avian and human influenza viruses. In this study, we investigated factors shaping the codon usage bias of 09H1N1 and carried out cluster analysis of 60 strains of influenza A virus from different subtypes based on their codon usage bias. We discovered that more preferentially used codons of 09H1N1 are A-ended or U-ended, and the intra-genomic codon usage bias of 09H1N1 is quite low. Base composition constraint, dinucleotide biases and translational selection are the main factors influencing the codon usage bias of 09H1N1. At the genome level, we find that the codon usage bias of 09H1N1 is similar to H1N1 (A/swine/Kansas/77778/2007H1N1), H9N2 from Asia, H1N2 from Asia and North America and H3N2 from North America. Our results provide insight for understanding the processes governing evolution, regulation of gene expression, and revealing the evolution of 09H1N1.
基金Acknowledgements： This work had the financial support of the Portuguese National Science Foundation （FCT） through the Research Unit, UI 4005, Project Reference PEst-OE/EME/UI4005/2011.
文摘Nowadays, there exist various standards for individual management systems （MSs）, at least, one for each stakeholder. New ones will be published. An integrated management system （IMS） aims to integrate some or all components of the business into one coherent and efficient MS. Maximizing integration is more and more a strategic priority in that it constitutes an opportunity to eliminate and/or reduce potential factors of destruction of value for the organizations and also to be more competitive and consequently promote its sustainable success. A preliminary investigation was conducted on a Portuguese industrial company which, over the years, has been adopting gradually, in whole or in part, individualized management system standards （MSSs）. A research, through a questionnaire, was performed with the objective to develop, in a real business environment, an adequate and efficient IMS-QES （quality, environment, and safety） model and to potentiate for the future a generic IMS model to integrate other MSSs. The strategy and research methods have taken into consideration the case study. It was obtained a set of relevant conclusions resulting from the statistical analyses of the responses to the survey. Globally, the investigation results, by themselves, justified and prioritized the conception of a model of development of the IMS-QES and consequent definition and validation of a structure of an IMS-QES model, to be implemented at the small- and medium-sized enterprise （SME） where the investigation was conducted.
基金supported by National Science and Technology Support Program (No. 2012BAC19B10)Knowledge Innovation Project of the Chinese Academy of Sciences (No. KZCXZ-YW-QO3-01)
文摘This paper discusses theories and methods of climate change risk studies for the research expansion in China. Climate change risks consist of three basic components including sensitivity, exposure, and possibility. Uncertainty, future events, damages, and relativity are the major features of climate change risk. Climate change risk research includes two key steps: risk assessment and risk management, the former is the process, and the latter is the ultimate goal which is the basis for actions to address climate change. We present the main framework and methods for climate change risk research. A case study on China's floods risk is taken as an example of climate change risk study. Finally, we point out main aspects of climate change risk research, including ensemble-based probabilistic projection, quantitative risk assessment, risk zoning and mapping, and risk management.
文摘Managing the value of the organization is taking place based on factors forming it. It is becoming possible thanks to such managing operations of the organization, when in the end an image in accordance with expectations, giving the state back to the value of organizations is being got. Creating the goodwill is based among others on immaterial factors, which although they are becoming impossible to include in balance, are taken hold in time value of the organization. Creation of the value of an organization may be based on the organizational culture. The article presents the essence of value management and organization characterized the factors affecting the formation of organizational culture, ways of dealing with an organization aimed at consolidating and strengthening the organizational culture. Sometimes organizations feel the need to change the culture in order to achieve increased efficiency and ensure the success of the company to implement the necessary changes. Therefore, the rest of this article presents the elements to ensure a smooth implementation and consolidation of cultural change.
文摘The development of the logistics work is one of the indispensable important components in the whole construction and development process of colleges and universities. The effective development of the logistics work can lay a solid, powerful foundation for the implementation of the main functions and the education and teaching activities, and also can provide a reliable guarantee for the teaching management work. Therefore, the important significance and value of the logistics management work in colleges and universities are seen. According to the actual situation, in this paper, the logistics work in colleges and universities is deeply considered and discussed, and the main problems in the present logistics management are studied based on fully understanding the logistics management specialties, and then the measures and methods for solving the above problems are proposed. Hopefully, a due effect is played on the quality of the logistics management in colleges and universities at the present time.
