Objective:Pediatric cancer patients endure multiple symptoms during treatment and also in survivorship.Digital health technologies provide an innovative way to support their symptom management.This review aimed to exa...Objective:Pediatric cancer patients endure multiple symptoms during treatment and also in survivorship.Digital health technologies provide an innovative way to support their symptom management.This review aimed to examine the effect of digital health technologies on managing symptoms among across pediatric cancer continuum.Methods:A systematic literature search of six English and three Chinese electronic databases was combined with hand searching,to identify eligible research studies from database establishment to November 30,2019.Two reviewers carried out data selection,data extraction,and quality appraisal independently.A narrative approach was taken to summarize data.Results:Four randomized control trials,two quasi-experiments,and five one group pre-posttest designed studies,were included in the review with a total of 425 participants.The methodological quality of the studies was generally fair.Seven symptoms(anxiety,depression,pain,anger,fatigue,fear,distress)and seven digital health technologies(visual reality,website,humanoid robot,app,wearable devices,short messages and videoconference)were reported in the included studies.Conclusions:Current evidence supports the effect of digital health technologies is generally mixed and inconclusive.There is a trend of positive effects found in the interventions that feature digital health technologies’interactive function.This review highlights the need for further investigation with rigorous research designs and the consideration of influencing factors from the symptoms,participants,and context levels to inform a better digital health implementation.展开更多
In the current study, we determined concentrations and transfer rates of Ag, Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, P, Rb, Sr and Zn to Brown Birch Scaber Stalks （Leccinum scabrum） mushrooms emerged ...In the current study, we determined concentrations and transfer rates of Ag, Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, P, Rb, Sr and Zn to Brown Birch Scaber Stalks （Leccinum scabrum） mushrooms emerged in the area of Sudety Mountains （Sudetes） in Poland. Fruiting bodies and topsoil samples beneath L. scabrum were collected form the Ktodzka Dale. The trace elements were determined using validated method and inductively coupled plasma - atomic emission spectroscopy （ICP-AES） for final measurement. Mushrooms contained Ag, Cr, Hg, Co, Ni and Sr at 〈 1.0μg/g dry weight; Ba and Pb at -1.0μg/g dw; Cd at 〈 5μPg/g dw; Cu and Mn at 〉 10 μg/g dw; Al and Ca at -100μg/g dw; Fe, Na, Rb and Zn at lOO to 500μg/g dw, Mg at -1.000μg/g dw; P at -5,000 μg/g dw and K at -30,000 μg/g dw. Ca, Mn and Ni were nearly equally distributed between stipes and caps; stipes compared to caps were enriched in Ba, Na and Sr, while caps were enriched in Ag, Al, Cd, Co, Cr, Cu, Fe, K, P, Pb, Rb and Zn. The values of bioconcentration factor （BCF） varied highly depending on chemical element and were 〉1 for Ag, Cd, Cu, K, Mg, Na, P, Rb and Zn, while 〈1 for A1, Ba, Ca, Co, Cr, Fe, Mn, Ni, Pb and Sr. Topsoil showed elevated content of lead and mean concentration was 99 ± 32 μg/g dw, while cadmium was at 0.41 ± 0.15 and those two highly toxic to human elements occurred in edible caps of L. scabrum at 4.5 ± 2.2 and 2.9 ± 2.0 μg/g dw, respectively.展开更多
基金supported by the China National Natural Science Foundation of China Youth Science Foundation(71904030)Shanghai Pujiang Talent Program(2019PJC006).
文摘Objective:Pediatric cancer patients endure multiple symptoms during treatment and also in survivorship.Digital health technologies provide an innovative way to support their symptom management.This review aimed to examine the effect of digital health technologies on managing symptoms among across pediatric cancer continuum.Methods:A systematic literature search of six English and three Chinese electronic databases was combined with hand searching,to identify eligible research studies from database establishment to November 30,2019.Two reviewers carried out data selection,data extraction,and quality appraisal independently.A narrative approach was taken to summarize data.Results:Four randomized control trials,two quasi-experiments,and five one group pre-posttest designed studies,were included in the review with a total of 425 participants.The methodological quality of the studies was generally fair.Seven symptoms(anxiety,depression,pain,anger,fatigue,fear,distress)and seven digital health technologies(visual reality,website,humanoid robot,app,wearable devices,short messages and videoconference)were reported in the included studies.Conclusions:Current evidence supports the effect of digital health technologies is generally mixed and inconclusive.There is a trend of positive effects found in the interventions that feature digital health technologies’interactive function.This review highlights the need for further investigation with rigorous research designs and the consideration of influencing factors from the symptoms,participants,and context levels to inform a better digital health implementation.
基金supported in part by the National Science Centre(NCN) of Poland under Grant PRELUDIUM project NoUMO-2011/03/N/NZ9/04136the Chinese Academy of Science(Project No 2010T1Z26)
文摘In the current study, we determined concentrations and transfer rates of Ag, Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, P, Rb, Sr and Zn to Brown Birch Scaber Stalks （Leccinum scabrum） mushrooms emerged in the area of Sudety Mountains （Sudetes） in Poland. Fruiting bodies and topsoil samples beneath L. scabrum were collected form the Ktodzka Dale. The trace elements were determined using validated method and inductively coupled plasma - atomic emission spectroscopy （ICP-AES） for final measurement. Mushrooms contained Ag, Cr, Hg, Co, Ni and Sr at 〈 1.0μg/g dry weight; Ba and Pb at -1.0μg/g dw; Cd at 〈 5μPg/g dw; Cu and Mn at 〉 10 μg/g dw; Al and Ca at -100μg/g dw; Fe, Na, Rb and Zn at lOO to 500μg/g dw, Mg at -1.000μg/g dw; P at -5,000 μg/g dw and K at -30,000 μg/g dw. Ca, Mn and Ni were nearly equally distributed between stipes and caps; stipes compared to caps were enriched in Ba, Na and Sr, while caps were enriched in Ag, Al, Cd, Co, Cr, Cu, Fe, K, P, Pb, Rb and Zn. The values of bioconcentration factor （BCF） varied highly depending on chemical element and were 〉1 for Ag, Cd, Cu, K, Mg, Na, P, Rb and Zn, while 〈1 for A1, Ba, Ca, Co, Cr, Fe, Mn, Ni, Pb and Sr. Topsoil showed elevated content of lead and mean concentration was 99 ± 32 μg/g dw, while cadmium was at 0.41 ± 0.15 and those two highly toxic to human elements occurred in edible caps of L. scabrum at 4.5 ± 2.2 and 2.9 ± 2.0 μg/g dw, respectively.
