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细胞因子对体外牛眼小梁细胞生成SPARC的调节 被引量:1
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作者 申笛 张德秀 《国际眼科杂志》 CAS 2006年第6期1329-1332,共4页
目的:了解房水中细胞因子对体外培养牛眼小梁细胞合成富含半胱氨酸的酸性分泌蛋白(secretedprotein,acidicandrichincysteine,SPARC)的影响。方法:体外培养牛眼小梁细胞并传3代,应用免疫组化染色法验证SPARC存在于小梁细胞内,并将传3代... 目的:了解房水中细胞因子对体外培养牛眼小梁细胞合成富含半胱氨酸的酸性分泌蛋白(secretedprotein,acidicandrichincysteine,SPARC)的影响。方法:体外培养牛眼小梁细胞并传3代,应用免疫组化染色法验证SPARC存在于小梁细胞内,并将传3代的小梁细胞无血清培养24h后分别加入房水中的细胞因子bFGF,TGF-β,EGF及IGF-1,72h后提取细胞上清液,并用酶联免疫吸附法(ELISA)测定SPARC的浓度。结果:细胞因子bFGF,TGF-β不影响小梁细胞对SPARC的合成,EGF和IGF-1分别减少和增加小梁细胞对SPARC的合成。结论:细胞因子可通过影响SPARC的生成而调节眼内压。 展开更多
关键词 SPARC 小梁细胞 房水中细胞因子 原发性开角型青光眼
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Measuring Bubble Levels in China's Urban Housing Market
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作者 吕江林 《China Economist》 2011年第1期84-91,共8页
In this paper we demonstrate that price-to-income ratio (PIR) is the most precise indicator of measuring bubble levels in China's urban hoasing market under current conditions. We have built a model to measure the ... In this paper we demonstrate that price-to-income ratio (PIR) is the most precise indicator of measuring bubble levels in China's urban hoasing market under current conditions. We have built a model to measure the reasonable PIR ceiling. Based on current mortgage rates, loan terms and down payment ratios, we conclude that the reasonable PIR for China 's urban residents should lie between 4.38-6.78 and should not exceed 7. 7hen, using statistical data, we calculate current PIR in China 's major cities. With reference to proper PIR, we conclude the existence of bubbles in China 's urban housing market; in particular, bubbles hace grown enormously large in some first-tier cities, which pose a huge financial risk. Based on the above analysis, we propose some policy suggestions to carefully deflate the bubbles in these housing markets. 展开更多
关键词 housing market BUBBLE price-to-income ratio (PIR)
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Research on the coordination of the urbanization level and the economic development in China
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作者 Xue Tingting Wu Na 《International English Education Research》 2014年第11期53-56,共4页
At present, part of the local government officials who like to do grandiose things to impress people blindly promote the development of the real estate, resulting in the gap with the population migration, so many ghos... At present, part of the local government officials who like to do grandiose things to impress people blindly promote the development of the real estate, resulting in the gap with the population migration, so many ghost towns are born. In addition, while building the local infrastructure of some of the districts, they also ignore the problem of the rational allocation of their own financial funds. Visibly, the implementation of the coordination between the two will help make China's urbanization level advancing in the health and right directions. 展开更多
关键词 Urbanization level economic development COORDINATION RESEARCH
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抗VEGF药物联合引流器植入术治疗新生血管性青光眼的效果 被引量:1
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作者 韩智 李维欣 +2 位作者 岳晓红 王沛 董敬民 《中华眼外伤职业眼病杂志》 2022年第10期781-786,共6页
目的评价玻璃体内注射抗VEGF药物联合EX-PRESS引流器植入术治疗新生血管性青光眼(NVG)的临床效果。方法前瞻性随机对照研究。纳入2020年1月至2021年10月就诊于郑州大学第一附属医院眼科的NVG 92例(92眼), 采用随机数字表法分为对照组和... 目的评价玻璃体内注射抗VEGF药物联合EX-PRESS引流器植入术治疗新生血管性青光眼(NVG)的临床效果。方法前瞻性随机对照研究。纳入2020年1月至2021年10月就诊于郑州大学第一附属医院眼科的NVG 92例(92眼), 采用随机数字表法分为对照组和试验组, 每组各46例(46眼), 两组均行玻璃体内注射抗VEGF药物(康柏西普)进行常规治疗, 在此基础上对照组行小梁切除术, 试验组行EX-PRESS引流器植入术。随访3个月, 比较两组术后成功率、视力、眼压及房水相关因子水平。结果术后3个月试验组手术相对成功率36.00%(9/25)高于对照组的12.00%(3/25)(χ2=3.95, P=0.047);试验组的视力提高率44.00%(11/25)高于对照组的16.00%(4/25)(χ2=4.67, P=0.031)。术后5 d两组房水中血管内皮生长因子(VEGF)、IL-6及IL-8水平降低, 且试验组低于对照组(均P<0.05)。结论 NVG采用玻璃体内注射抗VEGF药物及EX-PRESS引流器植入术治疗可更好地提升手术相对成功率、改善视力, 并可减轻机体炎症反应。 展开更多
关键词 青光眼 新生血管性 康柏西普 引流器植入术 血管内皮生长因子 房水中 白细胞介素-6 白细胞介素-8
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Modeling study of residence time and water age in Dahuofang Reservoir in China 被引量:18
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作者 SHEN YongMing WANG JinHua +4 位作者 ZHENG BingHui ZHEN Hong FENG Yu WANG ZaiXing YANG Xu 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2011年第1期127-142,共16页
Understanding the dynamics of water renewal in a reservoir is essential when the transport and fate of dissolved substances are evaluated.A three-dimensional hydrodynamic model was implemented to compute average resid... Understanding the dynamics of water renewal in a reservoir is essential when the transport and fate of dissolved substances are evaluated.A three-dimensional hydrodynamic model was implemented to compute average residence time and water age in Dahuofang Reservoir in China.The model was verified for a one-year time period in 2006.A simulation reproduced intra-annual variation of mixing represented by the fall/winter mixing and the spring/summer stratification.The simulated variation of vertical thermal structures also matched observation.The spatially varying average residence times and age distribution were investigated through a series of numerical experiments using a passively dissolved and conservative tracer as a surrogate.Residence time estimations yield a broad range of values depending on the position.The average residence time for a tracer placed at the head of the reservoir under high-,mean-,and low flow conditions was found to be about 125,236 and 521 days,respectively.The age simulation reveals that the age distribution is a function of the freshwater discharge.In the vertical direction,the age of the surface layers is larger than that of the bottom layers and the age difference between the surface and bottom layers decreases further downstream.The density-induced circulation plays an important role in the circulation in the reservoir,and can generate vertical age distribution in the reservoir.These findings provide useful information for understanding the transport process in Dahuofang Reservoir that can be used to assist the water quality management of the reservoir. 展开更多
关键词 Dahuofang reservoir RESERVOIR three-dimensional model residence time age
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Three-dimensional numerical modelling of water quality in Dahuofang Reservoir in China 被引量:7
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作者 WANG JinHua SHEN YongMing +3 位作者 ZHEN Hong FENG Yu WANG ZaiXing YANG Xu 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2011年第7期1328-1341,共14页
A three-dimensional eutrophication model was applied to assist the management of Dahuofang Reservoir in China.Transport processes were obtained from the three-dimensional,finite volume hydrodynamic model.The hydrodyna... A three-dimensional eutrophication model was applied to assist the management of Dahuofang Reservoir in China.Transport processes were obtained from the three-dimensional,finite volume hydrodynamic model.The hydrodynamic model was verified for a one-year time period in 2006.Our simulation reproduced intra-annual variation of stratification.The simulated variation of vertical thermal structures also matched observations.The water quality model included 8 state variables,including dissolved oxygen,phytoplankton as carbon,carbonaceous biochemical oxygen demand,ammonium nitrogen,nitrate and nitrite nitrogen,ortho-phosphorus,organic nitrogen,and organic phosphorus.Sensitivity of the parameters has been analyzed to decide which process would affect the water quality in the simulation.The water quality verification suggested the model successfully computed the temporal cycles and spatial distributions of key water quality components.The comparison between water quality components before and after the first phase of the water conveyance project suggests that the project has a slight effect on the reservoir ecosystem.The model could be used as a tool to guide physico-biological engineering design or management strategies for Dahuofang Reservoir. 展开更多
关键词 Dahuofang Reservoir RESERVOIR water quality HYDRODYNAMIC three-dimensional model
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Invasive house geckos (hemidactylus spp.): their current, potential and future distribution 被引量:2
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作者 Robbie WETERINGS Kai C. VETTER 《Current Zoology》 SCIE CAS CSCD 2018年第5期559-573,共15页
In this study, we identified the current distribution of five globally distributed invasive Hemidactylus species and predicted their potential and future distribution using species distribution models based on climate... In this study, we identified the current distribution of five globally distributed invasive Hemidactylus species and predicted their potential and future distribution using species distribution models based on climate and elevation data. These species included H. brookii, H. frenatus, H. garnotii, FI. mabouia, and H. turcicus. We show that many regions with tropical and Mediterranean climates are suitable for most of these species. However, their current and potential distributions sug- gest that climate is not the only limiting factor. We hypothesize that climatic conditions may affect competition and other interactions resulting in a segregated distribution of the studied Hemidactylus species. As an effect of global climate change it is likely that H. brookiiwill expand its range to areas that are currently colonized by H. mabouia and/or H. frenatus, while H. turcicus is likely to expand its range to areas that are not yet invaded by any Hemidactylus species. The role of species interactions in the range expansion of these five Hemidactylus species still remains poorly understood, but could be of major importance in understanding and managing these invasive species. 展开更多
关键词 HEMIDACTYLUS invasive species species distribution modeling climate change
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