AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with tre...AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer.展开更多
Objective:Cancer-associated inflammation and coagulation cascades play vital roles in cancer progression and survival.In this study,we investigated the significance of the combination of preoperative fibrinogen and th...Objective:Cancer-associated inflammation and coagulation cascades play vital roles in cancer progression and survival.In this study,we investigated the significance of the combination of preoperative fibrinogen and the neutrophil-to-lymphocyte ratio(NLR)in predicting the survival of patients with non-small cell lung cancer(NSCLC).Methods:We retrospectively enrolled 589 patients with NSCLC who underwent surgery.The univariate and multivariate Cox survival analyses were used to evaluate the prognostic indicators,including the combination of fibrinogen and NLR(F-NLR).The cut-off values for fibrinogen,NLR,and clinical laboratory variables were defined by the receiver operating characteristic(ROC)curve analysis.According to the ROC curve,the recommended cut-off values for fibrinogen and the NLR were 3.48 g/L and 2.30,respectively.Patients with both a high NLR(≥2.30)and hyperfibrinogenemia(≥3.48 g/L)were given a score of 2,whereas those with one or neither were scored as 1 or 0,respectively.Results:Our results showed that F-NLR was an independent prognostic indicator for disease-free survival(DFS)[hazard ratio(HR),1.466;95%confidence interval(CI),1.243–1.730;P<0.001]and overall survival(OS)(HR,1.512;95%CI,1.283–1.783;P<0.001).The five-year OS rates were 66.1%,53.5%,and 33.3%for the F-NLR=0,F-NLR=1,and F-NLR=2,respectively(P<0.001).Correspondingly,their five-year DFS rates were 62.2%,50.3%,and 30.4%,respectively(P<0.001).In the subgroup analyses of the pathological stages,the F-NLR level was significantly correlated with DFS and OS in stage I and IIIA cancers.Conclusions:Preoperative F-NLR score can be used as a valuable prognostic marker for patients with resectable early-stage NSCLC.展开更多
Objective To compare the therapeutic effects and safety of monopolar and bipolar radiofrequency(RF) ablation used during cardiac surgery to treat atrial fibrillation.Methods We retrospectively studied a total of 81 pa...Objective To compare the therapeutic effects and safety of monopolar and bipolar radiofrequency(RF) ablation used during cardiac surgery to treat atrial fibrillation.Methods We retrospectively studied a total of 81 patients with chronic atrial fibrillation who underwent open cardiac surgery with concomitant RF ablation between January 2007 and March 2011.Fifty-eight patients received bipolar RF ablation and 23 received monopolar RF ablation,respectively.The sinus rhythm restoration rate,the procedural duration,the frequency of severe perioperative complications,and mortality were compared between the two groups.Results The sinus rhythm restoration rate did not differ significantly between the two groups after follow-up of 15.1 ± 12.6 months(P=0.199).The frequencies of severe perioperative complications and mortality were also similar in the two groups.The total procedural time using bipolar RF ablation was significantly shorter than that using monopolar ablation(19.7±4.6 minutes vs.28.1±8.5 minutes,P< 0.001).Conclusions Both monopolar and bipolar RF ablation are safe and effective in treating chronic atrial fibrillation patients during open cardiac surgery,but bipolar RF ablation is more convenient in practice.展开更多
As the demand for high-performance housing grows, so does the need for improvements in building science education. Trial and error has long been the method for learning how to avoid problems in the construction of ene...As the demand for high-performance housing grows, so does the need for improvements in building science education. Trial and error has long been the method for learning how to avoid problems in the construction of energy-efficient housing, including water intrusion and mold growth. Building codes have addressed these issues in prescriptive ways that were not evidence-based. Stricter building codes or builder licensing requirements are not necessarily the solutions to problems associated with misunderstandings about building science. Motivating professionals currently involved in the housing industry to learn through continuing education is a start, but the core problem must be addressed by including building science education in curricula related to architecture, engineering, construction management and other fields. The long-term solution is to include building science education in academic construction management programs. The purpose of this paper is to review the history of what has come to be known as building science and its importance to the residential construction industry. Problems that result from a lack of knowledge about the field are covered and a potential solution is proposed.展开更多
The House of the Scorpion （2002） is a National Book Award winner by American YA （young adult） novelist Nancy Farmer. It is a coming-of-age story about Matt, a young clone struggling for acceptance and survival in ...The House of the Scorpion （2002） is a National Book Award winner by American YA （young adult） novelist Nancy Farmer. It is a coming-of-age story about Matt, a young clone struggling for acceptance and survival in a dystopian world. Under the veil of science fiction, The House of the Scorpion not only allegorically exposes the evil of dehumanization, totalitarianism, and the abuse of technology, but also successfully builds up the brave image of Matt. Through depicting protagonist Matt＇s initiation journey in a dystopian world, Nancy Farmer expresses her belief that goodness triumphs and hope is indestructible.展开更多
The treatment and general care for womendiagnosed with breast cancer has made a tremendous change andadvance in the last decades. Better methods for early detectionand screening of the disease, higher compliance of wo...The treatment and general care for womendiagnosed with breast cancer has made a tremendous change andadvance in the last decades. Better methods for early detectionand screening of the disease, higher compliance of women to gofor screening, an open social and political discourse of women andthe health care team and others, are just a few that both enabledand are a result of this change. Nurses have been highly involvedin these changes, which resulted in the specialization of nursingin the field of breast cancer. This article will focus on the mainfour points that influence the nursing specialist care, that is, thetailoring of treatment and the ability to offer women treatmentwhich is more specific to their own cancer; the importance of themultidisciplinary team as providing a State of the Art care; theinvolvement of women in the decision-making regarding theirtreatment and the specific developing role of the specialist breastcare nurse.展开更多
Health care is an area in which all who are involved should try to ensure that the quality of the provision is at a high level, especially in maternity wards. The quality of these services is not only the competence o...Health care is an area in which all who are involved should try to ensure that the quality of the provision is at a high level, especially in maternity wards. The quality of these services is not only the competence of the medical staff, but the whole set of factors prevailing in the ward and in the hospital, from cleanliness of the delivery room to the staff courtesy of the institution. The article presents the results of research on clients＇ satisfaction with the quality of the services offered by the selected maternity ward in Provincial Hospital in Bielsko-Biala. Customer Satisfaction Index （CSI） method was used for analysis.展开更多
The room temperature phosphorescences（RTP）are of growing interest owing to their promising applications in material science and bioimaging.To date,the lumiogens showing persistent RTP effect mainly contain the noble...The room temperature phosphorescences（RTP）are of growing interest owing to their promising applications in material science and bioimaging.To date,the lumiogens showing persistent RTP effect mainly contain the noble metals which have the shortcomings such as high cost,potential toxicity.The exploration of metal free luminogens,i.e.,purely organic RTP luminogens,is thus of great importance for the community.展开更多
There exists great room for ＂rational imaginary＂ in the discourse of news narration, the myth formed and enhanced therein becoming widely accepted as commonsense. The discourse in economic news through systematic an...There exists great room for ＂rational imaginary＂ in the discourse of news narration, the myth formed and enhanced therein becoming widely accepted as commonsense. The discourse in economic news through systematic and disciplinebound ＂objective＂ description disguises the power of the capital as the natural result of scientific laws. FoUowing the same logic, the news on real estate implicates the myth of development and investment. A critical reflection on such myth is of great necessity for us to better understand the discourse system in news production.展开更多
基金Supported by a Japan Society for the Promotion of Science(JSPS)KAKENHI Grant-in-Aid for Challenging Exploratory Research(in part)No.23659308JSPS KAKENHI Grantin-Aid for Scientific Research,No.26460688
文摘AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer.
基金supported by grants from National Key R&D Program of China (Grant No. 2016YFC0905501)the Tianjin Science and Technology Major Project, China (Grant No. 12ZCDZSY15400)
文摘Objective:Cancer-associated inflammation and coagulation cascades play vital roles in cancer progression and survival.In this study,we investigated the significance of the combination of preoperative fibrinogen and the neutrophil-to-lymphocyte ratio(NLR)in predicting the survival of patients with non-small cell lung cancer(NSCLC).Methods:We retrospectively enrolled 589 patients with NSCLC who underwent surgery.The univariate and multivariate Cox survival analyses were used to evaluate the prognostic indicators,including the combination of fibrinogen and NLR(F-NLR).The cut-off values for fibrinogen,NLR,and clinical laboratory variables were defined by the receiver operating characteristic(ROC)curve analysis.According to the ROC curve,the recommended cut-off values for fibrinogen and the NLR were 3.48 g/L and 2.30,respectively.Patients with both a high NLR(≥2.30)and hyperfibrinogenemia(≥3.48 g/L)were given a score of 2,whereas those with one or neither were scored as 1 or 0,respectively.Results:Our results showed that F-NLR was an independent prognostic indicator for disease-free survival(DFS)[hazard ratio(HR),1.466;95%confidence interval(CI),1.243–1.730;P<0.001]and overall survival(OS)(HR,1.512;95%CI,1.283–1.783;P<0.001).The five-year OS rates were 66.1%,53.5%,and 33.3%for the F-NLR=0,F-NLR=1,and F-NLR=2,respectively(P<0.001).Correspondingly,their five-year DFS rates were 62.2%,50.3%,and 30.4%,respectively(P<0.001).In the subgroup analyses of the pathological stages,the F-NLR level was significantly correlated with DFS and OS in stage I and IIIA cancers.Conclusions:Preoperative F-NLR score can be used as a valuable prognostic marker for patients with resectable early-stage NSCLC.
文摘Objective To compare the therapeutic effects and safety of monopolar and bipolar radiofrequency(RF) ablation used during cardiac surgery to treat atrial fibrillation.Methods We retrospectively studied a total of 81 patients with chronic atrial fibrillation who underwent open cardiac surgery with concomitant RF ablation between January 2007 and March 2011.Fifty-eight patients received bipolar RF ablation and 23 received monopolar RF ablation,respectively.The sinus rhythm restoration rate,the procedural duration,the frequency of severe perioperative complications,and mortality were compared between the two groups.Results The sinus rhythm restoration rate did not differ significantly between the two groups after follow-up of 15.1 ± 12.6 months(P=0.199).The frequencies of severe perioperative complications and mortality were also similar in the two groups.The total procedural time using bipolar RF ablation was significantly shorter than that using monopolar ablation(19.7±4.6 minutes vs.28.1±8.5 minutes,P< 0.001).Conclusions Both monopolar and bipolar RF ablation are safe and effective in treating chronic atrial fibrillation patients during open cardiac surgery,but bipolar RF ablation is more convenient in practice.
文摘As the demand for high-performance housing grows, so does the need for improvements in building science education. Trial and error has long been the method for learning how to avoid problems in the construction of energy-efficient housing, including water intrusion and mold growth. Building codes have addressed these issues in prescriptive ways that were not evidence-based. Stricter building codes or builder licensing requirements are not necessarily the solutions to problems associated with misunderstandings about building science. Motivating professionals currently involved in the housing industry to learn through continuing education is a start, but the core problem must be addressed by including building science education in curricula related to architecture, engineering, construction management and other fields. The long-term solution is to include building science education in academic construction management programs. The purpose of this paper is to review the history of what has come to be known as building science and its importance to the residential construction industry. Problems that result from a lack of knowledge about the field are covered and a potential solution is proposed.
文摘The House of the Scorpion （2002） is a National Book Award winner by American YA （young adult） novelist Nancy Farmer. It is a coming-of-age story about Matt, a young clone struggling for acceptance and survival in a dystopian world. Under the veil of science fiction, The House of the Scorpion not only allegorically exposes the evil of dehumanization, totalitarianism, and the abuse of technology, but also successfully builds up the brave image of Matt. Through depicting protagonist Matt＇s initiation journey in a dystopian world, Nancy Farmer expresses her belief that goodness triumphs and hope is indestructible.
文摘The treatment and general care for womendiagnosed with breast cancer has made a tremendous change andadvance in the last decades. Better methods for early detectionand screening of the disease, higher compliance of women to gofor screening, an open social and political discourse of women andthe health care team and others, are just a few that both enabledand are a result of this change. Nurses have been highly involvedin these changes, which resulted in the specialization of nursingin the field of breast cancer. This article will focus on the mainfour points that influence the nursing specialist care, that is, thetailoring of treatment and the ability to offer women treatmentwhich is more specific to their own cancer; the importance of themultidisciplinary team as providing a State of the Art care; theinvolvement of women in the decision-making regarding theirtreatment and the specific developing role of the specialist breastcare nurse.
文摘Health care is an area in which all who are involved should try to ensure that the quality of the provision is at a high level, especially in maternity wards. The quality of these services is not only the competence of the medical staff, but the whole set of factors prevailing in the ward and in the hospital, from cleanliness of the delivery room to the staff courtesy of the institution. The article presents the results of research on clients＇ satisfaction with the quality of the services offered by the selected maternity ward in Provincial Hospital in Bielsko-Biala. Customer Satisfaction Index （CSI） method was used for analysis.
文摘The room temperature phosphorescences（RTP）are of growing interest owing to their promising applications in material science and bioimaging.To date,the lumiogens showing persistent RTP effect mainly contain the noble metals which have the shortcomings such as high cost,potential toxicity.The exploration of metal free luminogens,i.e.,purely organic RTP luminogens,is thus of great importance for the community.
文摘There exists great room for ＂rational imaginary＂ in the discourse of news narration, the myth formed and enhanced therein becoming widely accepted as commonsense. The discourse in economic news through systematic and disciplinebound ＂objective＂ description disguises the power of the capital as the natural result of scientific laws. FoUowing the same logic, the news on real estate implicates the myth of development and investment. A critical reflection on such myth is of great necessity for us to better understand the discourse system in news production.
