食管左房调搏诊断房室结多径路20例分析

食管左房调搏诊断房室结多径路２０例分析赵忠仁，翟魁敏，孔祥泉，杨桂华（聊城地区复退军人医院，聊城地区人民医院，２５２０００）关键词食管左房调搏；房室结多径路；电生理；病例分析我院自１９９０年以来，应用食管心房调搏术对１０２例心律失常者进行电生理检查，...

潘生丁食管心房调搏复合试验诊断冠心病的实用价值

本文设计了潘生丁食管心房调搏复合试验（ＤＴＴ），并对８０例受检者先后作踏车试验（ＥＴ）、潘生丁试验（ＤＰＴ）、食管心房调搏负荷试验（ＴＥＡＰＴ）、潘生丁踏车复合试验（ＤＥＴ），进行对比分析。结果表明：ＤＴＴ的敏感性及准确性分别高达９０．９％和９１．３％，明显优于ＴＥＡＰＴ、ＤＰＴ和ＥＴ（Ｐ〈０．０５）。

红色的保温饭煲

那年,因在井下工作而染上硅肺的父亲离开了人世。为了供我和哥哥读书,妈妈要求从矿灯房调到了井下开绞车。妈妈的工作是'三班倒',从地面走到工作地点得花两个小时左右,工人不干完活是不会出井的,所以妈妈经常在井下一待就是十多个小时。又忙又累的妈妈顾不上家务了,将家里的财政大权交给了哥哥,哥哥成了我们这个三口之家的家长,经营着我们的生活。

Foxp3 rs2294021 polymorphism contributes to the susceptibility to breast carcinoma

Objective:Foxp3,the main regulator of Treg (regulatory T) cells, is down-regulated in breast carcinoma and other cancers. The rs2294021 Foxp3 polymorphism contributes to Foxp3 down-regulation, thereby weakens its tumor suppressing activity. The aim of our study was to evaluate the potential influence of Foxp3 polymorphism on breast cancer, we conducted a case-control study in Han Chinese women. Methods: Foxp3 genotyping was conducted in 677 breast carcinoma patients and 828 age-frequency matched cancer-free controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Experiment data was analyzed using Chi-square test and SPSS software. Results: The T/C genotype was found to be significantly associated with increased risk of breast carcinoma occurrence (OR = 1.462; 95% CI 1.165-1.833, P = 0.001) compared with the T/T or C/C (OR 1.143; 95% CI 0.838-1.559, P = 0.397) genotype. The increased risk for breast carcinoma related to heterozygous genotype was more pronounced in subjects over 50 years (OR 1.631; 95% CI 1.116-2.383, P = 0.011). No significant association was found between the polymorphism and the ER/PR status, metastasis or tumor stage of breast cancer. Conclusion: Our findings suggest that rs2294021 Foxp3 polymorphism may be a potential contributor for development of breast carcinoma in Han Chinese women.

Applicability and Prospect of China's Development Zone Model in Africa

Development zones have been an important spatial approach to opening-up. They have also been major contributors to the processes of promoting economic development since China＇s reform and China＇s industrialization and urbanization. Along with im- provements in the worldwide industrial division of labor and the gradual implementation of China＇s development zones＇ Go Global strategy, it is necessary for Africa, a hot spot of global industrialization in recent years, to learn from China＇s development zone model. By attracting China＇s capital, technology and enterprises to Africa via Sino-African co-built development zones, a pattern of high com- plementarity and mutual development between China and Africa can be formed which does favor further improvement of the global industrial division of labor. In order to study the applicability and prospect of China＇s development zone model in Africa as per the above-mentioned international situation, this paper first sorts out the development course of China＇s development zones and discusses their roles in China＇s industrialization and urbanization. Subsequently, this paper analyzes the status quo of industrial development in Africa as a whole and the differences in industrial development between China and Africa, aiming to justify the timing of industrial transfer from China to Africa by constructing Sino-African co-built development zones. Lastly, this paper analyzes the current situation of six Sino-African co-built development zones by focusing on their operation modes, industry types and investment promotion models. In the authors＇ view, Sino-African co-built development zones can function as a new window of China-African cooperation, a new car- rier of African industrialization, and a new engine of global industrial restructuring. China should adhere to the general principles of ＇Sino-African Integration, Multi-Cooperation, Mutual Benefit, Scientific Location, Systematic Planning, Cluster Growth and Open De- velopment＇ in the planning and construction of development zones in Africa, effectively promoting Africa as the very important part of the global industry system.

Experimental Study on Roof Structure Characteristics and Its Failure Pattern in Coal Roadway

Based on the investigation and statistics of logs of 211 bole holes and strata data from 79 roadways in 13 coal mines located in Xishan, Jincheng, Lu’an, Fenxi, and Huozhou in China, the roadways’ roof structures were classified as multi-thin-layer, thin-thick combined layer, integrated thick layer, thick-coal layer, and cracked layer according to the geometric features and spatial strength distribution of surrounding rock. Then eight sub-categories were defined as different situations. And seven simulation modeling tests were carried out. The strata structures of these models were different from each other. At last, the relationship between roof structure and its failure pattern was discussed.

N-myc downstream-regulated gene 2 promotes proliferation of HO-8910 ovarian cancer cells

Objective To investigate N-myc downstream-regulated gene 2(NDRG2) expression in ovarian cancer cells and its potential usefulness as a diagnostic marker and/or target for therapeutic intervention.Methods Human NDRG2 L/S gene was obtained by revers-transcription polymerase chain reaction(RT-PCR). Sequence analysis confirmed the identity of NDRG2 L/S gene, which was then inserted into a eukaryotic vector p LNCX2, which was in turn transfected into NDRG2 gene-negative HO-8910 cells. Flow cytometry(FCM) and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide(MTT) assay were conducted to determine the proliferation rate of HO-8910 cells. Cisplatin resistance of HO-8910 cells transfected with p LNCX2-NDRG2 L/S was evaluated by FCM. Tumors were generated in female nude mice by subcutaneous injection of HO-8910 cells.Results NDRG2 gene was isolated and its expression vector was successfully constructed. NDRG2 expression positively correlated with the proliferation of HO-8910 cells. NDRG2 L/S promoted tumorigenicity in HO-8910 cells.Conclusion The present study identified a novel function of NDRG2 L/S gene and demonstrated its involvement in the promotion of ovarian cancer cell proliferation and enhancement of cisplatin resistance in HO-8910 cells. Future studies are warranted to determine the relationship between NDRG2 upregulation and ovarian cancer progression.

A Consideration of Issues in the Government＇s Public Housing Projects in Post-War Iraq

Post-war Iraq is a mix of potential opportunities, promising intentions, and difficult challenges. After 2003, the government adopted a program to manage the housing crisis and satisfy housing needs. Through a fieldwork survey, we aimed to present this program by reviewing the government targets, main housing problems, governmental legislations, and construction process. We found that the government abandoned its centralized role in its National Housing Project as it opened the door of Iraqi housing market to foreign and local investors. We also found that, considering the enormous need for housing the occupancy rate of the governmental housing units are so low and construction is also generally slow. We deduced that the pricing model of the government＇s national housing project is far from our general notion of public housing for low-income post-war people. Moreover, it is necessary for the government to formulate a clearer strategic vision and to adopt more innovative approaches to address effectively and rapidly the trade-offs of the short and long terms objectives of the reconstruction process in post-war Iraq.

Effect of Hue Citadel on the Layout of Traditional Garden Houses Located in Its Area, Vietnam

In Hue, the city located in the middle region of Vietnam, the Citadel is known as the place of the last Dynasty in the history of Vietnam, Nguyen （1802-1945）. Whereas Nguyen Kings lived in the Purple Forbidden City （the third wall of the Citadel）, other members of royal families and high-ranking mandarins lived in Hue Traditional Garden Houses （HTGHs） constructed around and in the Citadel area. This paper is a part of the research that focuses on an approach for sustainable live conservation and application of HTGHs into contemporary use. In this paper, the study aims to consider effects of the Citadel on the layout and arrangement of HTGHs located in its＇ area by studying alteration in layout elements of those house. Based on field surveys of 91 HTGHs in the Citadel area, it is found that although those houses are altered into various configurations under the impacts of urbanization and modernization, several important traditional elements in layout such as Binh Phong （masonry screen）, Be Can （basin）, and facing orientation have been maintained, and their layouts reflect a miniature image of Hue Citadel, i.e., there is an integral relationship between the Citadel and HTGHs located in it. This relationship plays an important role for expressing one of unique characteristics of Hue cultural asset, which is unavailable in other regions of Vietnam.

The effects of miR-375 expression in NSCLC via the 14-3-3ζ/ERK/MYC pathway

Objective There are several reports that suggest a significant role played by microRNAs(miRNAs) in cell invasion, metastasis, differentiation, and apoptosis in lung cancers. miR-375 is one such miRNA that has been detected in a variety of tumors, but its specific activity in non-small cell lung cancer(NSCLC) remains unclear. Methods In this study, we regulated the expression of miR-375, to evaluate its influence on the 14-3-3ζ/ERK/MYC pathway in NSCLC. Results The results of our experiments suggest that miR-375 and 14-3-3ζ are highly expressed in NSCLC, and the over-expression of miR-375 increases the invasive, metastatic, and proliferative ability and decreases the apoptotic ability of NSCLC cells. In addition, protein expression levels of 14-3-3ζ, p-ERK, and MYC increased following the overexpression of miR-375. Conclusion Overall, our findings indicate that miR-375 increases the malignant potential of NSCLC via the 14-3-3ζ/ERK/MYC pathway.

Maison du Bresil： A Student Residence for the Brazilian Elite in Paris

This paper presents some thoughts about the Maison du Bresil. The objective is to research this temporary residency for researchers through the meanings that characterize it as a Brazilian territory in Paris and through the very belonging to the category elite as a peculiarity of its residents. The author wish to analyze the international circulation of students and researchers that live there and have an educational experience of multiple dimensions as experiences of deterritorialization of identities and its consequences in a housing space which is at the same time in public and private. Based on documental analysis and ethnographic fieldwork, the paper presents some aspects of the history and the everyday life of the Maison du Bresil and Paris＇ Cite Internationale Universitaire. Also, it intends to show how the meanings of Brazilianness are used as support for the identity crisis lived by the members of a supposed Brazilian elite in Paris, as it analyzes the particularities of the mediations established by the residents of the Maison du Bresil, in the formation and international insertion of some researchers.

After the Rot： Improving the Durability of Building Envelopes in Domestic Housing New Zealand

The issue of weathertightness of the external building envelope in domestic scaled timber frames continues to be an issue in New Zealand, some ten years after the results of a major cladding survey into the durability and weathertightness of the exterior cladding envelope carried out by the writer in the year 2000. The fallout from leaking buildings has estimated to have cost the country billions of dollars in lost production and expensive repair. The social impact on those caught up in the leaking home issue has been considerable; with often heart rending tales of stress and financial hardship. This paper will explore the initiatives taken by the building industry and the government since the issue became a major public concern. It will examine the influences, both positive and negative, that resulting legislation and changed building practices, brought in as a result of this crisis, have had on the sustainability and affordability of the domestic dwelling in New Zealand.

Rainwater Harvesting in Multifamily Social Interest Housing

This study evaluated the reduction of water consumption in a SIH （social interest housing） complex from the simulation of implanting a rainwater harvesting system. The methodology consisted of characterization of the case study, survey data of water consumption and data of precipitation in the area, on-site visits to define the average consumption and monthly water distribution, and sizing of a rainwater harvesting tank following the Netuno Program. It was obtained 22.500 L as the ideal volume for the tank, supplying the demand for drinkingwater in 32%, although the reduction in the drinking water bills would be minor, since the object of the case study is considered SIH, and residents pay a fixed fee for consuming up to 10 m3 per month. Therefore, it becomes necessary to analyze this situation from a sustainable and environmental perspective, and the benefits are no longer only economic, but rather they take on a more comprehensive social dimension.

Fuzzy Online Auto-Tuning for an Industrial PID Controller

This paper presents a fuzzy tuning system for real-time industrial PID （proportional-integral-derivative） controllers. The algorithm set the proportional gain, integral time and derivative time of a classical PID structure according to the set point, error and error derivative of the process, respectively. The tuning of the PID controller is based on a fuzzy inference machine. The set of rules of the fuzzy inference machine was obtained by experts engineering. The system is tested in an austempering process but can be applied in any industrial plant. Besides, an analysis between the response of the process with a PID controller and the system of fuzzy auto-tuning for P1D proposed was made.

Chemical modulation of cell fates： in situ regeneration

Chemical modulation of cell fates has been widely used to promote tissue and organ regeneration. Small molecules can target the self-renewal, expansion, differentiation, and survival of endogenous stem cells for enhancing their regenerative power or induce dedifferentiation or transdifferentiation of mature cells into proliferative progenitors or specialized cell types needed for regeneration. Here, we discuss current progress and potential using small molecules to promote in vivo regenerative processes by regulating the cell fate. Current studies of small molecules in regeneration will provide insights into developing safe and efficient chemical approaches for in situ tissue repair and regeneration.

RelB intrinsically regulates the development and function of medullary thymic epithelial cells

Medullary thymic epithelial cells(mTECs) act as one of the major stromal components in the thymus for selection and maturation of both conventional T cells and non-conventional T cells. Extensive efforts have been spent to understand how mTEC development and function are regulated. Although RelB has been well accepted to be a critical transcriptional factor for mTEC development, the underlying mechanisms still remain largely unclear. In this study, by generating thymic epithelial cell specific RelB deficient mice, we found that epithelial intrinsic RelB is required for mTEC homeostatic proliferation. Mechanistically, RelB regulates the expression of genes involved in cell cycle. Functionally, lack of intrinsic RelB in thymic epithelial cells results in dramatically reduced population of mTECs and impaired development of thymic invariant natural killer T(iNKT) cells and intraepithelial lymphocyte precursors(IELPs). This study thus reveals an epithelial intrinsic role of RelB on mTEC development and function.

Cdc42 regulates the cellular localization of Cdc42ep1 in controlling neural crest cell migration

The member of Rho family of small GTPases Cdc42 plays important and conserved roles in cell polarity and motility. The Cdc42ep family proteins have been identified to bind to Cdc42, yet how they interact with Cdc42 to regulate cell migration remains to be elucidated. In this study, we focus on Cdc42epl, which is expressed predominantly in the highly migratory neural crest ceils in frog embryos. Through morpholino-mediated knockdown, we show that Cdc42epl is required for the migration of cranial neural crest cells. Loss of Cdc42epl leads to rounder cell shapes and the formation of membrane blebs, consistent with the observed disruption in actin organization and focal adhesion alignment. As a result, Cdc42ep1 is critical for neural crest cells to apply traction forces at the correct place to migrate efficiently. We further show that Cdc42ep1 is localized to two areas in neural crest celts： in membrane protrusions together with Cdc42 and in perinuciear patches where Cdc42 is absent. Cdc42 directly interacts with Cdc42epl （through the CRIB domain） and changes in Cdc42 level shift the distribution of Cdc42epl between these two subcellular locations, controlling the formation of membrane protrusions and directionality of migration as a consequence. These results suggest that Cdc42ep1 elaborates Cdc42 activity in neural crest cells to promote their efficient migration.

Intensive photocatalytic activity enhancement of Bi5O7I via coupling with band structure and content adjustable BiOBrxI1-x

Band structure and component content are the key factors for determining the activity of semiconductor heterojunction. In this study, a novel Bi5O7I/BiOBrxI1-x heterostructure was synthesized by a simple hydrobromic （HBr） acid etching method through transforming partial of Bi5O7I to I ion doped BiOBr （BiOBrxI1-x） at room temperature without adding extra dopant. Both the band structure and component content of Bi5O7I/BiOBrxI1-x alter with the additive HBr acid. The Bi5O7I/BiOBrxI1-x （S3.0） sample exhibits the best photocatalytic activity, 6 times higher than that of pure Bis071, for the degradation of methyl orange under visible-light （2 〉 420 nm）. The activity enhancement of Bi5O7I/BiOBrxI1-x is primarily ascribed to the improved separation efficiency of photocharges, originated from the adjustable band structure and component content, The significant findings of this paper provide a facile way to construct highly efficient semiconductor heterojunction via playing the synergetic effect of adjustable band struc- ture and component content for purifying organic pollutants in wastewater.