Objective We investigated the correlation between the expression of the sodium-iodide symporter(NIS) and the detection of circulating tumor cells(CTCs) in differentiated thyroid carcinoma(DTC).Methods NIS expression i...Objective We investigated the correlation between the expression of the sodium-iodide symporter(NIS) and the detection of circulating tumor cells(CTCs) in differentiated thyroid carcinoma(DTC).Methods NIS expression in differentiated thyroid and the positive rate of CTCs in the peripheral blood were determined by immunohistochemistry S-P and flow cytometry from the records of 172 cases of differentiated thyroid carcinoma.Results Seventy-six cases(44.2%) expressed NIS in the differentiated thyroid and 63 cases(36.6%) were positive for CTCs in the peripheral blood. There was a significant difference between N0 and N1 in the expression of NIS(χ~2 = 6.015, P = 0.014) and the positive rate of CTCs(χ~2 = 14.035, P = 0.001). N0 and N1 also differed significantly in the expression of NIS(r =-0.383,-0.610, P = 0.002, < 0.001). The differences in the NIS expression, but not in the positive rate of CTCs, were significant among the different pathological subtypes(χ~2 = 7.897, P = 0.005; χ~2 = 1.455, P = 0.228, respectively). There was a significant negative correlation between the highly differentiated type and intermediate differentiation type both in the expression of NIS and positive rate of CTCs(r =-0.591,-0.443, P < 0.001, P = 0.002). Conclusion There was a significant negative correlation between the expression of tissue NIS and positive rate of CTCs in the peripheral blood in DTC. The malignancy level and lymph node metastasis in differentiated thyroid carcinoma were negatively correlated with NIS expression and positively correlated with the positive rate of CTC.展开更多
In order to research the characteristic and mechanism of fracture of rock-like materials,the morphology of rock fracture surface under the breakages of uniaxial compression and triaxial compression was observed and me...In order to research the characteristic and mechanism of fracture of rock-like materials,the morphology of rock fracture surface under the breakages of uniaxial compression and triaxial compression was observed and measured by means of a new-type 3D laser scanning system.Based on geographic information system(GIS)technique,the fracture surfaces were 3D visualized and reestablished.According to GIS 3D statistics,the geometrical characteristics of fracture surfaces under different breakage conditions were analyzed,and then based on fractal theory,the change laws of fractal dimension of fracture surfaces were discussed under the conditions of different cell pressures and initial water contents of rock.Furthermore,the relationships between characteristics of fracture surface and mechanical properties of rock were discussed.The results indicate that cell pressure,initial water content,and mechanical parameters of rock are the important factors to influence on the geometrical characteristics of fracture surface.The research provides a new experimental method for quantitative study on the fracture characteristics of various materials under different breakage conditions.展开更多
This research analyzed amino acid sequence similarity between non-self T cell epitopes recognized by mouse antibodies and mouse proteins. Using sequence alignment,we found that only 8 of 1 108 epitopes are highly simi...This research analyzed amino acid sequence similarity between non-self T cell epitopes recognized by mouse antibodies and mouse proteins. Using sequence alignment,we found that only 8 of 1 108 epitopes are highly similar to mouse protein sequences. The result shows that non-self T cell epitopes are not similar or have little similarity to mouse protein sequences. Furthermore,reviewing the related literature,we also found that the eight epitopes would trigger immune responses in some particular environment,which are ignored by T cells in normal condition. The result suggests that no or low-similarity peptide vaccines can reduce the chance of collateral cross-reactions and enhance the antigen-specific immune response to vaccine.展开更多
基金Supported by a grant from the Gansu Province Key Traditional Chinese Medicine Project(No.GZK-2010-Z9)
文摘Objective We investigated the correlation between the expression of the sodium-iodide symporter(NIS) and the detection of circulating tumor cells(CTCs) in differentiated thyroid carcinoma(DTC).Methods NIS expression in differentiated thyroid and the positive rate of CTCs in the peripheral blood were determined by immunohistochemistry S-P and flow cytometry from the records of 172 cases of differentiated thyroid carcinoma.Results Seventy-six cases(44.2%) expressed NIS in the differentiated thyroid and 63 cases(36.6%) were positive for CTCs in the peripheral blood. There was a significant difference between N0 and N1 in the expression of NIS(χ~2 = 6.015, P = 0.014) and the positive rate of CTCs(χ~2 = 14.035, P = 0.001). N0 and N1 also differed significantly in the expression of NIS(r =-0.383,-0.610, P = 0.002, < 0.001). The differences in the NIS expression, but not in the positive rate of CTCs, were significant among the different pathological subtypes(χ~2 = 7.897, P = 0.005; χ~2 = 1.455, P = 0.228, respectively). There was a significant negative correlation between the highly differentiated type and intermediate differentiation type both in the expression of NIS and positive rate of CTCs(r =-0.591,-0.443, P < 0.001, P = 0.002). Conclusion There was a significant negative correlation between the expression of tissue NIS and positive rate of CTCs in the peripheral blood in DTC. The malignancy level and lymph node metastasis in differentiated thyroid carcinoma were negatively correlated with NIS expression and positively correlated with the positive rate of CTC.
文摘In order to research the characteristic and mechanism of fracture of rock-like materials,the morphology of rock fracture surface under the breakages of uniaxial compression and triaxial compression was observed and measured by means of a new-type 3D laser scanning system.Based on geographic information system(GIS)technique,the fracture surfaces were 3D visualized and reestablished.According to GIS 3D statistics,the geometrical characteristics of fracture surfaces under different breakage conditions were analyzed,and then based on fractal theory,the change laws of fractal dimension of fracture surfaces were discussed under the conditions of different cell pressures and initial water contents of rock.Furthermore,the relationships between characteristics of fracture surface and mechanical properties of rock were discussed.The results indicate that cell pressure,initial water content,and mechanical parameters of rock are the important factors to influence on the geometrical characteristics of fracture surface.The research provides a new experimental method for quantitative study on the fracture characteristics of various materials under different breakage conditions.
基金Supported by the National Natural Science Foundation of China (90608020, 30971642)the Program for New Century Excellent Talents in University (NCET-060651)+2 种基金the National Platform Project of China (2005DKA64001)Ministry of Education of China (20050487037)the Natural Science Foundation of Hubei Province (2009CDA161)
文摘This research analyzed amino acid sequence similarity between non-self T cell epitopes recognized by mouse antibodies and mouse proteins. Using sequence alignment,we found that only 8 of 1 108 epitopes are highly similar to mouse protein sequences. The result shows that non-self T cell epitopes are not similar or have little similarity to mouse protein sequences. Furthermore,reviewing the related literature,we also found that the eight epitopes would trigger immune responses in some particular environment,which are ignored by T cells in normal condition. The result suggests that no or low-similarity peptide vaccines can reduce the chance of collateral cross-reactions and enhance the antigen-specific immune response to vaccine.
