In order to improve the efficiency of operating rooms,reduce the costs for hospitals and improve the level of service qualities, a scheduling method was developed based on an estimation of distribution algorithm（ EDA...In order to improve the efficiency of operating rooms,reduce the costs for hospitals and improve the level of service qualities, a scheduling method was developed based on an estimation of distribution algorithm（ EDA）. First, a scheduling problem domain is described. Based on assignment constraints and resource capacity constraints, the mathematical programming models are set up with an objective function to minimize the system makespan. On the basis of the descriptions mentioned above, a solution policy of generating feasible scheduling solutions is established. Combined with the specific constraints of operating theatres, the EDA-based algorithm is put forward to solve scheduling problems. Finally, simulation experiments are designed to evaluate the scheduling method. The orthogonal table is chosen to determine the parameters in the proposed method. Then the genetic algorithm and the particle swarm optimization algorithm are chosen for comparison with the EDA-based algorithm, and the results indicate that the proposed method can decrease the makespan of the surgical system regardless of the size of operations. Moreover, the computation time of the EDA-based algorithm is only approximately 5 s when solving the large scale problems, which means that the proposed algorithm is suitable for carrying out an on-line scheduling optimization of the patients.展开更多
Chronic Groin Pain (Inguinodynia) following inguinal hernia repair is a significant,though under-reported problem. Mild pain lasting for a few days is common following mesh inguinal hernia repair. However,moderate to ...Chronic Groin Pain (Inguinodynia) following inguinal hernia repair is a significant,though under-reported problem. Mild pain lasting for a few days is common following mesh inguinal hernia repair. However,moderate to severe pain persisting more than 3 mo after inguinal herniorrhaphy should be considered as pathological. The major reasons for chronic groin pain have been identified as neuropathic cause due to inguinal nerve(s) damage or non-neuropathic cause due to mesh or other related factors. The symptom complex of chronic groin pain varies from a dull ache to sharp shooting pain along the distribution of inguinal nerves. Thorough history and meticulous clinical examination should be performed to identify the exact cause of chronic groin pain,as there is no single test to confirm the aetiology behind the pain or to point out the exact nerve involved. Various studies have been performed to look at the difference in chronic groin pain rates with the use of mesh vs non-mesh repair,use of heavyweight vs lightweight mesh and mesh fixation with sutures vs glue. Though there is no convincing evidence favouring one over the other,lightweight meshes are generally preferred because of their lesser foreign body reaction and better tolerance by the patients. Identification of all three nerves has been shown to be an important factor in reducing chronic groin pain,though there are no well conducted randomised studies to recommend the benefits of nerve excision vs preservation. Both nonsurgical and surgical options have been tried for chronic groin pain,with their consequent risks of analgesic sideeffects,recurrent pain,recurrent hernia and significant sensory loss. By far the best treatment for chronic groin pain is to avoid bestowing this on the patient by careful intra-operative handling of inguinal structures and better patient counselling pre-and post-herniorraphy.展开更多
An efficient chiral Br?nsted acid-catalyzed conjugate addition of indoles to azadienes has been successfully developed,which enables a facile approach to optically active hetero-triarylmethanes with excellent enantios...An efficient chiral Br?nsted acid-catalyzed conjugate addition of indoles to azadienes has been successfully developed,which enables a facile approach to optically active hetero-triarylmethanes with excellent enantioselectivities and broad substrate scope.This chiral Br?nsted acid catalytic system provides a new opportunity for the development of asymmetric reactions of azadienes.展开更多
The separation method using chiral stationary phase （CSP） for the preparation of enantioselective compound was widely used. In this work, supercritical fluid chromatography（SFC） was proposed to resolve the chiral ...The separation method using chiral stationary phase （CSP） for the preparation of enantioselective compound was widely used. In this work, supercritical fluid chromatography（SFC） was proposed to resolve the chiral mixtures. To determine the optimum operating conditions for the chiral separation of the racemic ibuprofen, the retention factors and resolutions with the change in pressure, temperature and the content of IPA （%, by volume） in supercritical CO2 were investigated. Experiments showed that the retention factor decreased with the increase of pressure and decrease in temperature. The retention factor was also influenced by the content of IPA in mobile phase, as the content of IPA in the supercritical fluid increased, the retention factor decreased. The resolution of the enantiomers became worse with the increase of IPA in the supercritical fluid. Through optimizing the experimental conditions, a SFC procedure with 13MPa, 311.15K and 4% IPA in CO2 was obtained. The peak shape of the enantiomers was symmetric with supercritical fluid chromatography when compared to the asymmetric peak shape obtained by the conventional liquid chromatography. This work demonstrated that the developed supercritical fluid chromatography procedure was suitable for the chiral separation of ibuprofen enantiomers.展开更多
A three-dimensional finite element model of the lumbar motion segment was used to predict the stress distribution in lumbar spine with posterior element resection. It was shown that the stress level in all parts of th...A three-dimensional finite element model of the lumbar motion segment was used to predict the stress distribution in lumbar spine with posterior element resection. It was shown that the stress level in all parts of the lumbar spine was elevated although the stress distribution remained unchanged. The authors concluded that the posterior element resection in lumbar surgery should be avoided as much as possible.展开更多
The bergamot （Citrus bergamia Risso et Poiteau）, a citrus fruit growing almost exclusively in the South Italy, is considered the ＂prince of citrus＂ for its storical role in the perfume industry due to its essentia...The bergamot （Citrus bergamia Risso et Poiteau）, a citrus fruit growing almost exclusively in the South Italy, is considered the ＂prince of citrus＂ for its storical role in the perfume industry due to its essential oil, a product in great demand of a pleasant and refreshing scent. Recently, analgesic, anxiolytic, neuroprotective consistent effects have been ascribed to bergamot essential oil when it is used in aromatherapy, for the relief of pain and symptoms associated with stress-induced anxiety and depression. Moreover, today, bergamot fruit due to a considerable abundance and variety of nutraceutical compounds which are present in its juice, is becoming increasingly important also in the food, pharmaceutical and confectionery industries. In this review, it is discussed that the literature on C. bergamia, focusing on the several studies performed with the experimental data, and recently accumulated, may form the rational basis for further development.展开更多
feet with hallux valgus among 40 patients treated by reconstruction of metatarsal arch and modified McBride operation are reported in this paper. After an average of 4. 5 years of postoperative follow-up, the results ...feet with hallux valgus among 40 patients treated by reconstruction of metatarsal arch and modified McBride operation are reported in this paper. After an average of 4. 5 years of postoperative follow-up, the results showed an overll 9° and 3° correction of the hallux abductus angle and the intermetatarsal angle, respectively. 95% of the cases of bunions disappeared, 66% calli under the heads of the first and second metatarsal disappeared, and 9l% patients were satisfied with the changes of their feet appearance.展开更多
Ibuprofen is widely used as a non-steroidal anti-inflammatory drug and produced as racemic mixture. Its pharmacological activity resides only in S-(+)-enantiomer, and R-()-enantiomer is not only inactive but also has ...Ibuprofen is widely used as a non-steroidal anti-inflammatory drug and produced as racemic mixture. Its pharmacological activity resides only in S-(+)-enantiomer, and R-()-enantiomer is not only inactive but also has many side effects. Thus it is necessary to separate R-enantiomer from racemic ibuprofen. We studied optical separation of racemic Ibuprofen with chiral high performance liquid chromatography (HPLC). Out of three different chiral stationary phases, which were selected on the basis of structure and availability, two were found to be ef-fective. There was optimum eluent composition for each stationary phase for good resolution in optical separation. Resolution decreased with increase of eluent flow rate, but effect of injection volume on resolution was insignificant at high eluent flow rate.展开更多
Green design horizon, explore the hand-painted rendering performance techniques,from conception to take as, composition distribution, global and local processing, local expansion method, the performance of rendering a...Green design horizon, explore the hand-painted rendering performance techniques,from conception to take as, composition distribution, global and local processing, local expansion method, the performance of rendering and other aspects of analysis and propose countermeasures. Accumulation of professional material for designers and nutrients at the same time, raise awareness of the environment, space and natural understanding, To improve the aesthetic horizon, hand-painted rendering green design and students ability to innovate education is of great significance.展开更多
Radio Espana Independiente [REI] [1941-1977], La Pirenaica, was the repository for the public remembrance of the victims of the Franco regime, through letters that its listeners regularly sent to the broadcaster＇s he...Radio Espana Independiente [REI] [1941-1977], La Pirenaica, was the repository for the public remembrance of the victims of the Franco regime, through letters that its listeners regularly sent to the broadcaster＇s headquarters in Bucharest. A study of the 15,500 letters contained in the Spanish Communist Party＇s [PCE] Historical Archive in Madrid confirms this broadcaster＇s major role in the construction of the mythical symbolic image of the anti-Franco movement. Beyond their function as propaganda instruments of the PCE, La Pirenaica＇s letters reveal the radio station＇s role as a vehicle for the expression of public solidarity and ideological and cultural resistance. La Pirenaica was the voice of the defeated after the Spanish Civil War, and was their confidante and advisor. La Pirenaica＇s letters are the chronicle of the horror that anti-Franco society suffered and endured in Spain.展开更多
We investigate ultracold fermionic atoms in the trilayer honeycomb lattice. In the low energy approximation, we derive an effective Hamiltonian for pseudospins. The energy spectrum shows a cubic form of the wavevector...We investigate ultracold fermionic atoms in the trilayer honeycomb lattice. In the low energy approximation, we derive an effective Hamiltonian for pseudospins. The energy spectrum shows a cubic form of the wavevector and is gapless. The quasiparticles and quasiholes are ehiral and show Berry＇s phase π when the wavevector adiabatically evolves along a closed circle, Furthermore, the experimental detection of the energy spectrum is proposed with Bragg scattering techniques.展开更多
基金The National Natural Science Foundation of China(No.61273035,71471135)
文摘In order to improve the efficiency of operating rooms,reduce the costs for hospitals and improve the level of service qualities, a scheduling method was developed based on an estimation of distribution algorithm（ EDA）. First, a scheduling problem domain is described. Based on assignment constraints and resource capacity constraints, the mathematical programming models are set up with an objective function to minimize the system makespan. On the basis of the descriptions mentioned above, a solution policy of generating feasible scheduling solutions is established. Combined with the specific constraints of operating theatres, the EDA-based algorithm is put forward to solve scheduling problems. Finally, simulation experiments are designed to evaluate the scheduling method. The orthogonal table is chosen to determine the parameters in the proposed method. Then the genetic algorithm and the particle swarm optimization algorithm are chosen for comparison with the EDA-based algorithm, and the results indicate that the proposed method can decrease the makespan of the surgical system regardless of the size of operations. Moreover, the computation time of the EDA-based algorithm is only approximately 5 s when solving the large scale problems, which means that the proposed algorithm is suitable for carrying out an on-line scheduling optimization of the patients.
文摘Chronic Groin Pain (Inguinodynia) following inguinal hernia repair is a significant,though under-reported problem. Mild pain lasting for a few days is common following mesh inguinal hernia repair. However,moderate to severe pain persisting more than 3 mo after inguinal herniorrhaphy should be considered as pathological. The major reasons for chronic groin pain have been identified as neuropathic cause due to inguinal nerve(s) damage or non-neuropathic cause due to mesh or other related factors. The symptom complex of chronic groin pain varies from a dull ache to sharp shooting pain along the distribution of inguinal nerves. Thorough history and meticulous clinical examination should be performed to identify the exact cause of chronic groin pain,as there is no single test to confirm the aetiology behind the pain or to point out the exact nerve involved. Various studies have been performed to look at the difference in chronic groin pain rates with the use of mesh vs non-mesh repair,use of heavyweight vs lightweight mesh and mesh fixation with sutures vs glue. Though there is no convincing evidence favouring one over the other,lightweight meshes are generally preferred because of their lesser foreign body reaction and better tolerance by the patients. Identification of all three nerves has been shown to be an important factor in reducing chronic groin pain,though there are no well conducted randomised studies to recommend the benefits of nerve excision vs preservation. Both nonsurgical and surgical options have been tried for chronic groin pain,with their consequent risks of analgesic sideeffects,recurrent pain,recurrent hernia and significant sensory loss. By far the best treatment for chronic groin pain is to avoid bestowing this on the patient by careful intra-operative handling of inguinal structures and better patient counselling pre-and post-herniorraphy.
文摘An efficient chiral Br?nsted acid-catalyzed conjugate addition of indoles to azadienes has been successfully developed,which enables a facile approach to optically active hetero-triarylmethanes with excellent enantioselectivities and broad substrate scope.This chiral Br?nsted acid catalytic system provides a new opportunity for the development of asymmetric reactions of azadienes.
文摘The separation method using chiral stationary phase （CSP） for the preparation of enantioselective compound was widely used. In this work, supercritical fluid chromatography（SFC） was proposed to resolve the chiral mixtures. To determine the optimum operating conditions for the chiral separation of the racemic ibuprofen, the retention factors and resolutions with the change in pressure, temperature and the content of IPA （%, by volume） in supercritical CO2 were investigated. Experiments showed that the retention factor decreased with the increase of pressure and decrease in temperature. The retention factor was also influenced by the content of IPA in mobile phase, as the content of IPA in the supercritical fluid increased, the retention factor decreased. The resolution of the enantiomers became worse with the increase of IPA in the supercritical fluid. Through optimizing the experimental conditions, a SFC procedure with 13MPa, 311.15K and 4% IPA in CO2 was obtained. The peak shape of the enantiomers was symmetric with supercritical fluid chromatography when compared to the asymmetric peak shape obtained by the conventional liquid chromatography. This work demonstrated that the developed supercritical fluid chromatography procedure was suitable for the chiral separation of ibuprofen enantiomers.
文摘A three-dimensional finite element model of the lumbar motion segment was used to predict the stress distribution in lumbar spine with posterior element resection. It was shown that the stress level in all parts of the lumbar spine was elevated although the stress distribution remained unchanged. The authors concluded that the posterior element resection in lumbar surgery should be avoided as much as possible.
文摘The bergamot （Citrus bergamia Risso et Poiteau）, a citrus fruit growing almost exclusively in the South Italy, is considered the ＂prince of citrus＂ for its storical role in the perfume industry due to its essential oil, a product in great demand of a pleasant and refreshing scent. Recently, analgesic, anxiolytic, neuroprotective consistent effects have been ascribed to bergamot essential oil when it is used in aromatherapy, for the relief of pain and symptoms associated with stress-induced anxiety and depression. Moreover, today, bergamot fruit due to a considerable abundance and variety of nutraceutical compounds which are present in its juice, is becoming increasingly important also in the food, pharmaceutical and confectionery industries. In this review, it is discussed that the literature on C. bergamia, focusing on the several studies performed with the experimental data, and recently accumulated, may form the rational basis for further development.
文摘feet with hallux valgus among 40 patients treated by reconstruction of metatarsal arch and modified McBride operation are reported in this paper. After an average of 4. 5 years of postoperative follow-up, the results showed an overll 9° and 3° correction of the hallux abductus angle and the intermetatarsal angle, respectively. 95% of the cases of bunions disappeared, 66% calli under the heads of the first and second metatarsal disappeared, and 9l% patients were satisfied with the changes of their feet appearance.
文摘Ibuprofen is widely used as a non-steroidal anti-inflammatory drug and produced as racemic mixture. Its pharmacological activity resides only in S-(+)-enantiomer, and R-()-enantiomer is not only inactive but also has many side effects. Thus it is necessary to separate R-enantiomer from racemic ibuprofen. We studied optical separation of racemic Ibuprofen with chiral high performance liquid chromatography (HPLC). Out of three different chiral stationary phases, which were selected on the basis of structure and availability, two were found to be ef-fective. There was optimum eluent composition for each stationary phase for good resolution in optical separation. Resolution decreased with increase of eluent flow rate, but effect of injection volume on resolution was insignificant at high eluent flow rate.
文摘Green design horizon, explore the hand-painted rendering performance techniques,from conception to take as, composition distribution, global and local processing, local expansion method, the performance of rendering and other aspects of analysis and propose countermeasures. Accumulation of professional material for designers and nutrients at the same time, raise awareness of the environment, space and natural understanding, To improve the aesthetic horizon, hand-painted rendering green design and students ability to innovate education is of great significance.
文摘Radio Espana Independiente [REI] [1941-1977], La Pirenaica, was the repository for the public remembrance of the victims of the Franco regime, through letters that its listeners regularly sent to the broadcaster＇s headquarters in Bucharest. A study of the 15,500 letters contained in the Spanish Communist Party＇s [PCE] Historical Archive in Madrid confirms this broadcaster＇s major role in the construction of the mythical symbolic image of the anti-Franco movement. Beyond their function as propaganda instruments of the PCE, La Pirenaica＇s letters reveal the radio station＇s role as a vehicle for the expression of public solidarity and ideological and cultural resistance. La Pirenaica was the voice of the defeated after the Spanish Civil War, and was their confidante and advisor. La Pirenaica＇s letters are the chronicle of the horror that anti-Franco society suffered and endured in Spain.
基金Supported by the Teaching and Research Foundation for the Outstanding Young Faculty of Southeast University
文摘We investigate ultracold fermionic atoms in the trilayer honeycomb lattice. In the low energy approximation, we derive an effective Hamiltonian for pseudospins. The energy spectrum shows a cubic form of the wavevector and is gapless. The quasiparticles and quasiholes are ehiral and show Berry＇s phase π when the wavevector adiabatically evolves along a closed circle, Furthermore, the experimental detection of the energy spectrum is proposed with Bragg scattering techniques.
