TREATMENT OF SODIUM DISORDERS AFTER SURGERY OF CRANIOPHARYNGIOMA

Objective.To study the treatment of the patients with blood sodium disorder after craniopharyngioma surgery. Method.The blood sodium in 44 patients with craniopharyngiomas was daily examined from operative to post-operative days. Hypernatremia is defined as [Na]>145 mmol/l, and hyponatremia as [Na]<135 mmol/L. Results.Of the 44 patients, 36 developed sodium disorder. Among them, simple hyponatremia was 16 patients, simple hypernatremia was 9 patients, and alternative sodium disorder was 11 patients. Conclusion.The blood sodium disorder in patients with craniopharyngiomas after surgery appears to present complicated changes. Three types of blood sodium disorder could be determined as simple hyponatremia, simple hypernatremia, and alternative sodium disorder. Treatment of the sodium disorder in patients with craniopharyngiomas after surgery could be carried in accordance with the above three types.

脊髓G蛋白偶联受体激酶2在持续性术后痛中的表达变化

目的观察脊髓G蛋白耦联受体激酶2(GRK2)在大鼠持续性术后痛中的表达变化。方法雄性SD大鼠40只,按随机数字表法将大鼠分为2组(n=20):假手术组和皮肤/肌肉切口和牵拉模型组(SMIR组);采用Flatters法制备大鼠SMIR模型;分别于术前1 d(T_0),术后3 (T_1)、7 d(T2)、14 d(T3)、21 d(T4)用von Frey细丝法测定机械缩足反应阈值(MWT);在相应时间点行为学测定后随机抽取4只大鼠处死,取L_4～L_6节段脊髓组织,Western blot法检测脊髓GRK2表达。结果 T_(1～4)时,SMIR组MWT较T_0时明显下降,脊髓GRK2蛋白表达较T_0时明显下调(P均<0. 05);与假手术组比较,SMIR组在T_(1～4)时MWT和脊髓GRK2蛋白表达较低,差异均有统计学意义(P <0. 05)。结论脊髓GRK2表达水平下调与大鼠SMIR持续性术后痛的发生、发展有关。