扑热息痛片剂药品的近红外光谱法非破坏定量分析

The application of artificial neural network(ANN) and near-infrared spectroscopy for pharmaceutical nondestructive quantitative analysis of Paracetamol was investigated. The artificial neural network patterns of Paracetamol tablet medicines, powder medicines, first derivative spectra and second derivative spectra were established, and they were compared each other. The uncertain specimens were predicted. The parameters affecting ANN were discussed. A new network evaluation criterion, i.e., the degree of approximation, was employed, and the predicted results were reliable.

库仑法快速测定扑热息痛片剂中对乙酰氨基酚的含量

以恒电流库仑法测定了扑热息痛片剂中对乙酰氨基酚的含量,以死停终点法指示反应终点。测定结果与药典规定方法相吻合。该方法与药典规定相对比,具有设备简单,测定快速、灵敏等优点。

新铜试剂分光光度法测定片剂中的对乙酰氨基酚含量及其反应机理的研究

使用分光光度法测定扑热息痛中主要化学成分对乙酰氨基酚的含量。结果表明：在0.04~8.00 mg·L-1范围内对乙酰氨基酚含量与吸光度（A）呈良好的线性关系,其线性方程：A=0.1210c＋0.0261,相关系数r=0.9968。表观摩尔吸光系数为1.8×10^4 L·mol-1·cm-1,平均回收率为100.2%,相对标准偏差RSD为1.51%。该实验所用仪器简单,且操作方便、快速。用该方法测定扑热息痛片剂对乙酰氨基酚的含量,取得了较好的效果。