目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对海洛因成瘾者左侧执行控制网络(executive control network,ECN)的影响。材料与方法纳入海洛因成瘾者19例(rTMS组)和年龄、性别、受教育年限相匹配的健康...目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对海洛因成瘾者左侧执行控制网络(executive control network,ECN)的影响。材料与方法纳入海洛因成瘾者19例(rTMS组)和年龄、性别、受教育年限相匹配的健康对照组(healthy control,HC组)22名。收集rTMS组治疗前后的影像学与行为学数据及HC组影像学数据。分析rTMS组治疗前后线索诱导渴求及左侧ECN的功能连接差异。结果rTMS组被试治疗后的海洛因线索诱导渴求评分(1.47±2.61)较治疗前(1.82±2.91)显著下降(P<0.05);rTMS组被试治疗后其异常增高的左侧背外侧前额叶(dorsolateral prefrontal cortex,DLPFC)与右侧DLPFC(坐标:x=27,y=39,z=51;体素:73;GRF校正,P<0.05)的功能连接值明显减少且接近健康人水平。结论rTMS可降低海洛因成瘾者的毒品线索诱导渴求,并利于恢复海洛因成瘾者异常的左侧ECN功能。展开更多
The problem of the stability analysis and controller design which the network-induced delays and data dropout problems network-induced delays are assumed to be time-varying and bounded, for Lurie networked control sys...The problem of the stability analysis and controller design which the network-induced delays and data dropout problems network-induced delays are assumed to be time-varying and bounded, for Lurie networked control systems （NCSs） is investigated, in are simultaneously considered. By considering that the and analyzing the relationship between the delay and its upper bound, employing a Lyapunov-Krasovskii function and an integral inequality approach, an improved stability criterion for NCSs is proposed. Furthermore, the resulting condition is extended to design a less conservative state feedback controller by employing an improved cone complementary linearization （ICCL） algorithm. Numerical examples are provided to show the effectiveness of the method.展开更多
文摘目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对海洛因成瘾者左侧执行控制网络(executive control network,ECN)的影响。材料与方法纳入海洛因成瘾者19例(rTMS组)和年龄、性别、受教育年限相匹配的健康对照组(healthy control,HC组)22名。收集rTMS组治疗前后的影像学与行为学数据及HC组影像学数据。分析rTMS组治疗前后线索诱导渴求及左侧ECN的功能连接差异。结果rTMS组被试治疗后的海洛因线索诱导渴求评分(1.47±2.61)较治疗前(1.82±2.91)显著下降(P<0.05);rTMS组被试治疗后其异常增高的左侧背外侧前额叶(dorsolateral prefrontal cortex,DLPFC)与右侧DLPFC(坐标:x=27,y=39,z=51;体素:73;GRF校正,P<0.05)的功能连接值明显减少且接近健康人水平。结论rTMS可降低海洛因成瘾者的毒品线索诱导渴求,并利于恢复海洛因成瘾者异常的左侧ECN功能。
文摘目的探讨基于静息态功能磁共振成像(Resting-State Functional Magnetic Resonance Imaging,rs-fMRI)的创伤性脑损伤(Traumatic Brain Injury,TBI)患者功能连接。方法以14例TBI患者和12例健康对照(Healthy Controls,HC)为研究对象,对其rs-fMRI图像进行预处理,再通过独立成分分析(Independent Component Analysis,ICA)得到默认模式网络(Default Model Network,DMN)和执行控制网络(Executive Control Network,ECN),从两个脑网络中各选取4个脑区作为种子点进行功能连接分析,最后使用单样本t检验、双样本t检验以及配对t检验探索TBI被试脑损伤后3、6和12个月与HC组的DMN与ECN功能联通性差异及变化情况。结果TBI患者恢复期三个时间点的功能连接均与HC组有显著差异,DMNECN双网络之间的功能联通性与单个网络内部相比变化更为突出。此外,左侧顶叶为一个关键节点,可能为TBI的后续治疗提供新方向。结论TBI后患者大脑静息态脑网络DMN与ECN的功能连接存在显著异常,这种异常可能是导致患者存在长期认知障碍及其他后遗症的原因。
基金Project(61025015)supported by the National Natural Science Foundation of China for Distinguished Young ScholarsProject (IRT1044)supported by the Program for Changjiang Scholars and Innovative Research Team in University of China+2 种基金Projects(61143004,61203136,61074067,61273185)supported by the National Natural Science Foundation of ChinaProjects(12JJ4062,11JJ2033)supported by the Natural Science Foundation of Hunan Province,ChinaProject(12C0078)supported by Hunan Provincial Department of Education,China
文摘The problem of the stability analysis and controller design which the network-induced delays and data dropout problems network-induced delays are assumed to be time-varying and bounded, for Lurie networked control systems （NCSs） is investigated, in are simultaneously considered. By considering that the and analyzing the relationship between the delay and its upper bound, employing a Lyapunov-Krasovskii function and an integral inequality approach, an improved stability criterion for NCSs is proposed. Furthermore, the resulting condition is extended to design a less conservative state feedback controller by employing an improved cone complementary linearization （ICCL） algorithm. Numerical examples are provided to show the effectiveness of the method.
