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基于连续-离散扩展卡尔曼建模的p53-Mdm2调控关系研究 被引量:3
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作者 姜莉 李玉榕 《中国生物医学工程学报》 CAS CSCD 北大核心 2017年第2期180-186,共7页
生物医学研究揭示,肿瘤抑制基因p53的表达水平与肿瘤的形成相关。p53相关的信号转导网络研究为揭示癌症、肿瘤的发病机制和寻找其治疗方法提供新思路,而p53和癌基因Mdm2的负反馈关系是该信号转导网络的核心部分。因此,研究p53-Mdm2的调... 生物医学研究揭示,肿瘤抑制基因p53的表达水平与肿瘤的形成相关。p53相关的信号转导网络研究为揭示癌症、肿瘤的发病机制和寻找其治疗方法提供新思路,而p53和癌基因Mdm2的负反馈关系是该信号转导网络的核心部分。因此,研究p53-Mdm2的调控关系意义重大。基于电离辐射后人类白血病细胞中测得的时间序列基因表达数据,利用连续-离散的扩展卡尔曼(EKF)算法,建立带有延迟特性的非线性动态连续随机生物网络模型,模拟电离辐射后的p53-Mdm2动态调控过程。同时,对所建立网络的准确性进行验证,可得模型的误差率为0.85%。结果表明:所提出的算法是收敛的,可以预测基因的表达水平,准确地模拟p53-Mdm2调控网络受到电离辐射后的衰减震荡响应过程,该过程和生物实验结果一致。所提出的算法为生物学实验建模提供一种有效的方法,并可以为网络系统动力学特性的研究提供条件。 展开更多
关键词 p53-Mdm2网络 连续-离散扩展卡尔曼(EKF)算法 时间序列数据 延迟
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INVESTIGATION OF FLIGHT DYNAMICS OF THRUST VECTORING AIRCRAFT USING EXTENDED CONTINUATION METHODS
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作者 沈宏良 刘昶 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2002年第2期151-156,共6页
This paper presents the flight dynamical behavior of the thrust vectoring aircraft with extended bifurcation and continuation methods. In contrast to the standard bifurcation and continuation methods, the extended met... This paper presents the flight dynamical behavior of the thrust vectoring aircraft with extended bifurcation and continuation methods. In contrast to the standard bifurcation and continuation methods, the extended methods are capable of calculating the continuation curves of the equilibrium points for the particular type of trimming flight. Therefore, these methods can not only give the performance measures of aircraft, but also determine the stability of trimming points. In this paper, the methods are used to verify the effectiveness of the thrust vectoring control law, to define the flight envelope boundary, to analyze the stability and controllability of trimming flight, and to predict the departures of the instable flight. The result shows that the extended methods provide more flight dynamic information and are useful in preliminary design of the thrust vectoring aircraft. 展开更多
关键词 thrust vectoring control continuation methods flight envelope flight stability
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Candidate Expansion Algorithm Based on WeightedSyllable Confusion Matrix for Mandarin LVCSR 被引量:2
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作者 常凤香 李宝祥 +1 位作者 刘刚 郭军 《China Communications》 SCIE CSCD 2013年第7期104-112,共9页
The inclusion of more potentially correct words in the candidate sets is important to improve the accuracy of Large Vocabulary Continuous Speech Recognition (LVCSR). A candidate expansion algorithm based on the Weig... The inclusion of more potentially correct words in the candidate sets is important to improve the accuracy of Large Vocabulary Continuous Speech Recognition (LVCSR). A candidate expansion algorithm based on the Weighted Syllable Confusion Matrix (WSCM) is proposed. First, WSCM is derived from a confusion network. Then, the reeognised candidates in the confusion network is used to conjeeture the most likely correct words based on WSCM, after which, the conjectured words are combined with the recognised candidates to produce an expanded candidate set. Finally, a combined model having mutual information and a trigram language model is used to rerank the candidates. The experiments on Mandarin film data show that an improvement of 9.57% in the character correction rate is obtained over the initial recognition performance on those light erroneous utterances. 展开更多
关键词 speech recognition candidate expansion confusion matrix
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