Delivering pharmacologic agents directly into the brain has been proposed as a means of bypassing the blood brain barrier.However,despite 16 years of research on a number of central nervous system disorders,an effecti...Delivering pharmacologic agents directly into the brain has been proposed as a means of bypassing the blood brain barrier.However,despite 16 years of research on a number of central nervous system disorders,an effective treatment using this strategy has only been observed in the brain tumor glioblastoma multiforme.Within this study we propose a novel system for delivering drugs into the brain named the simple diffusion (SDD) system.To validate this technique,rats were subjected to a single intracranial (at the caudate nucleus),or intraperitoneal injection,of the compound citicoline,followed two hours later by a permanent middle cerebral artery occlusion (pMCAO).Results showed that 12 h after pMCAO,with 0.0025 g kg-1 citicoline,an infarct volume 1/6 the size of the intraperitoneal group was achieved with a dose 1/800 of that required for the intraperitoneal group.These results suggest that given the appropriate injection point,through SDD a pharmacologically effective concentration of citicoline can be administered.展开更多
This paper deals with backward stochastic differential equations with jumps,whose data(the terminal condition and coefficient) are given functions of jump-diffusion process paths. The author introduces a type of nonli...This paper deals with backward stochastic differential equations with jumps,whose data(the terminal condition and coefficient) are given functions of jump-diffusion process paths. The author introduces a type of nonlinear path-dependent parabolic integrodifferential equations, and then obtains a new type of nonlinear Feynman-Kac formula related to such BSDEs with jumps under some regularity conditions.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos. 30972811 and 81071148)Natural Science Foundation of Beijing(Grant No. 7093137)
文摘Delivering pharmacologic agents directly into the brain has been proposed as a means of bypassing the blood brain barrier.However,despite 16 years of research on a number of central nervous system disorders,an effective treatment using this strategy has only been observed in the brain tumor glioblastoma multiforme.Within this study we propose a novel system for delivering drugs into the brain named the simple diffusion (SDD) system.To validate this technique,rats were subjected to a single intracranial (at the caudate nucleus),or intraperitoneal injection,of the compound citicoline,followed two hours later by a permanent middle cerebral artery occlusion (pMCAO).Results showed that 12 h after pMCAO,with 0.0025 g kg-1 citicoline,an infarct volume 1/6 the size of the intraperitoneal group was achieved with a dose 1/800 of that required for the intraperitoneal group.These results suggest that given the appropriate injection point,through SDD a pharmacologically effective concentration of citicoline can be administered.
基金supported by the National Natural Science Foundation of China(Nos.10921101,11471190)the Shandong Provincial Natural Science Foundation of China(No.ZR2014AM002)the Programme of Introducing Talents of Discipline to Universities of China(No.B12023)
文摘This paper deals with backward stochastic differential equations with jumps,whose data(the terminal condition and coefficient) are given functions of jump-diffusion process paths. The author introduces a type of nonlinear path-dependent parabolic integrodifferential equations, and then obtains a new type of nonlinear Feynman-Kac formula related to such BSDEs with jumps under some regularity conditions.
