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MLS波束扫描控制机理及实现
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作者 雷文军 《导航》 2002年第2期108-112,共5页
移相器是要控阵天线中必不可少的组件,它的控制信号来自于波控机,只有当波控机的输出信号通过控制移相器使射频信号相位值受控时,相控阵天线产生的波束才能实现在规定的空域内扫描,本文所叙述的是微波着陆系统中一维相控阵天线使用... 移相器是要控阵天线中必不可少的组件,它的控制信号来自于波控机,只有当波控机的输出信号通过控制移相器使射频信号相位值受控时,相控阵天线产生的波束才能实现在规定的空域内扫描,本文所叙述的是微波着陆系统中一维相控阵天线使用的波控机的算法及实现。 展开更多
关键词 波束扫描控制机理 MLS 波控机 微波着陆 相控阵天线
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冲击回转钻进条件下硬质合金钻头柱齿磨损机理 被引量:4
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作者 朴金石 殷琨 +1 位作者 赵志强 范黎明 《吉林大学学报(地球科学版)》 EI CAS CSCD 北大核心 2011年第1期195-199,共5页
减缓钻头硬质合金柱齿的磨损速度,对提高钻头工作效率、延长钻头使用寿命、降低钻进成本等具有重要意义。在利用扫描电子显微镜(SEM)对钻头柱齿详细观测的基础上,提出了风动潜孔锤钻头硬质合金柱齿新的劣化机理和磨损机理:劣化机理包括... 减缓钻头硬质合金柱齿的磨损速度,对提高钻头工作效率、延长钻头使用寿命、降低钻进成本等具有重要意义。在利用扫描电子显微镜(SEM)对钻头柱齿详细观测的基础上,提出了风动潜孔锤钻头硬质合金柱齿新的劣化机理和磨损机理:劣化机理包括混合规模裂隙的形成、WC颗粒规模裂隙形成和WC颗粒的氧化和腐蚀;磨损机理包括WC颗粒的破碎和碎片释放、整体或部分WC颗粒的脱离、碳化物的摩擦化学磨损等。分析了边齿因回转线速度大,磨损也增大,WC颗粒的破碎和碎片释放量增大而磨耗严重的机理;因WC颗粒的整体脱离使柱齿产生较大面积的磨损,导致钻进效率的大幅度降低;给出了钻头柱齿必须及时加以修磨的合理使用方法。 展开更多
关键词 扫描电子显微镜I机理I磨损I劣化l硬质合金柱齿 风动潜孔锤
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提高激光大屏幕显示中图像成像质量的途径
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作者 潘正权 诸葛向彬 《浙江师大学报(自然科学版)》 2000年第4期340-342,共3页
从激光大屏幕显示中光学振镜扫描机理及工作特性曲线出发 ,探讨了获得更逼真、更清晰、更复杂图像的途径 .
关键词 光学振镜 激光大屏幕 成像质量 扫描机理
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Anti-cracking mechanism of diatomite asphalt and diatomite asphalt mixture at low temperature 被引量:8
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作者 谭忆秋 单丽岩 +1 位作者 房军 张兴友 《Journal of Southeast University(English Edition)》 EI CAS 2009年第1期74-78,共5页
A kind of neat asphalt and three kinds of diatomite asphalt are tested using differential scanning calorimetry(DSC). The anti-cracking mechanism of diatomite asphalt is analyzed by DSC and the thermal stress restrai... A kind of neat asphalt and three kinds of diatomite asphalt are tested using differential scanning calorimetry(DSC). The anti-cracking mechanism of diatomite asphalt is analyzed by DSC and the thermal stress restrained specimen test(TSRST) of the asphalt mixtures. The results show that the low temperature performance of diatomite asphalt is better than that of neat asphalt. The glass transition temperature can reflect the low temperature performance of the diatomite asphalt better and has a good relationship with breaking temperatures. Besides, the TSRST, the bending test, the compressing test and the contraction coefficient test are used to study the low temperature performance of the diatomite asphalt mixture. The results prove that the low temperature performance of the diatomite asphalt mixture is better than that of the neat asphalt mixture. The critical bending strain energy density and the compressing strain energy density of the diatomite asphalt mixture are greater than those of the neat asphalt mixture. After adding diatomite to the asphalt mixture, the contraction coefficient is reduced. Based on the above results, the anti-cracking mechanism of the diatomite asphalt mixture is analyzed from the angle of contraction performance and breaking energy. 展开更多
关键词 diatomite asphalt low temperature performance glass transition temperature differential scanning calorimetry anticracking mechanism
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Contrast-enhanced ultrasonography assessment of gastric cancer response to neoadjuvant chemotherapy 被引量:18
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作者 Jian Ang Liang Hu +5 位作者 Pin-Tong Huang Jin-Xiu Wu Ling-Na Huang Chun-Hui Cao Yi-Xiong Zheng Li Chen 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第47期7026-7032,共7页
AIM:To quantitatively assess the ability of double contrast-enhanced ultrasound(DCUS) to detect tumor early response to pre-operative chemotherapy.METHODS:Forty-three patients with gastric cancer treated with neoadjuv... AIM:To quantitatively assess the ability of double contrast-enhanced ultrasound(DCUS) to detect tumor early response to pre-operative chemotherapy.METHODS:Forty-three patients with gastric cancer treated with neoadjuvant chemotherapy followed by curative resection between September 2011 and February 2012 were analyzed.Pre-operative chemotherapy regimens of fluorouracil + oxaliplatin or S-1 + oxaliplatin were administered in 2-4 cycles over 6-12 wk periods.All patients underwent contrast-enhanced computed tomography(CT) scan and DCUS before and after two courses of pre-operative chemotherapy.The therapeutic response was assessed by CT using the response evaluation criteria in solid tumors(RECIST 1.1) criteria.Tumor area was assessed by DCUS as enhanced appearance of gastric carcinoma due to tumor vascularity during the contrast phase as compared to the normal gastric wall.Histopathologic analysis was carried out according to the Mandard tumor regression grade criteria and used as the reference standard.Receiver operating characteristic(ROC) analysis was used to evaluate the efficacy of DCUS parameters in differentiating histopathological responders from non-responders.RESULTS:The study population consisted of 32 men and 11 women,with mean age of 59.7 ± 11.4 years.Neither age,sex,histologic type,tumor site,T stage,nor N stage was associated with pathological response.The responders had significantly smaller mean tumor size than the non-responders(15.7 ± 7.4 cm vs 33.3 ± 14.1 cm,P < 0.01).According to Mandard's criteria,27 patients were classified as responders,with 11(40.7%) showing decreased tumor size by DCUS.In contrast,only three(18.8%) of the 16 non-responders showed decreased tumor size by DCUS(P < 0.01).The area under the ROC curve was 0.64,with a 95%CI of 0.46-0.81.The effects of several cut-off points on diagnostic parameters were calculated in the ROC curve analysis.By maximizing Youden's index(sensitivity + specificity-1),the best cut-off point for distinguishing responders from non-responders was determined,which had optimal sensitivity of 62.9% and specificity of 56.3%.Using this cut-off point,the positive and negative predictive values of DCUS for distinguishing responders from non-responders were 70.8% and 47.4%,respectively.The overall accuracy of DCUS for therapeutic response assessment was 60.5%,slightly higher than the 53.5% for CT response assessment with RECIST criteria(P = 0.663).Although the advantage was not statistically significant,likely due to the small number of cases assessed.DCUS was able to identify decreased perfusion in responders who showed no morphological change by CT imaging,which can be occluded by such treatment effects as fibrosis and edema.CONCLUSION:DCUS may represent an innovative tool for more accurately predicting histopathological response to neoadjuvant chemotherapy before surgical resection in patients with locally-advanced gastric cancer. 展开更多
关键词 Gastric cancer CHEMOTHERAPY Ultrasonic imaging Predictive value of tests Disease management
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Ignition-proof mechanism of ZM5 magnesium alloy added with rare earth 被引量:3
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作者 饶劲松 李华基 薛寒松 《Journal of Central South University》 SCIE EI CAS 2010年第1期28-33,共6页
The ignition-proof mechanism of ZM5 magnesium alloy added with 0.1% (mass fraction) rare earth (RE) was investigated. The oxide scales and substrates were characterized by scanning electronic microscope (SEM), X... The ignition-proof mechanism of ZM5 magnesium alloy added with 0.1% (mass fraction) rare earth (RE) was investigated. The oxide scales and substrates were characterized by scanning electronic microscope (SEM), X-ray diffraction (XRD), energy dispersive spectrometer (EDS) and tensile test. And an oxidation model of ZM5 alloy with RE was established. The results show that the ignition temperature of ZM5 alloy is particularly elevated from 654 to 823 ℃, the microstructure is refined, and the tensile strength is slightly improved from 168.2 to 174.6 MPa by adding 0.1% RE. A double-layer oxidation film formed on the alloy surface under high temperature mainly consists of MgO, RE203 and A1203, which is 2.5-3.5 μm in thickness. It is found that the forming of protective oxidation film on the thermodynamics is attributed to RE elements congregating on the surface of molten Mg alloy. 展开更多
关键词 rare earth (RE) magnesium alloy oxidation film ignition-proof
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Evaluation of contrast-enhanced computed tomographic colonography in detection of local recurrent colorectal cancer 被引量:7
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作者 Yau-Tong You Chung-Rong Chang Chien +6 位作者 Jeng-Yi Wang Koon-Kwan Ng Jinn-Shiun Chen Reiping Tang Jy-Ming Chiang Chien-Yuh Yeh Pao-Shiu Hsieh 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第1期123-126,共4页
AIM: TO evaluate the diagnostic accuracy, sensitivity, specificity of contrast-enhanced computed tomographic colonography in detecting local recurrence of colorectal cancer. METHODS: From January 2000 to December 20... AIM: TO evaluate the diagnostic accuracy, sensitivity, specificity of contrast-enhanced computed tomographic colonography in detecting local recurrence of colorectal cancer. METHODS: From January 2000 to December 2004, 434 patients after potentially curative resection for invasive colorectal cancer were followed up for a period ranging from 20 to 55 mo. Eighty of the four hundred and thirty-four patients showing strong clinical evidence for recurring colorectal cancer during the last followup were enrolled in this study. Each patient underwent contrast-enhanced computed tomographic colonography and colonoscopy on the same day. Any lesions, biopsies, identified during the colonoscopic examination, immediate complications and the duration of the procedure were recorded. The results of contrast-enhanced computed tomographic colonography were evaluated by comparing to those of colonoscopy, surgical finding, and clinical follow-up. RESULTS: Contrast-enhanced computed tomographic colonography had a sensitivity of 100%, a specificity of 83% and an overall accuracy of 94% in detecting local recurrent colorectal cancer. CONCLUSION: Conventional colonoscopy and contrastenhanced tomographic colonography can complement each other in detecting local recurrence of colorectal cancer. 展开更多
关键词 Computed tomographic colonography Recurrent colorectal cancer
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Special diaphragm-like strictures of small bowel unrelated to non-steroidal anti-inflammatory drugs 被引量:1
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作者 Ming-Liang Wang Fei Miao +3 位作者 Yong-Hua Tang Xue-Song Zhao Jie Zhong Fei YuanMing-Liang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第31期3596-3604,共9页
AIM:To summarize clinical,endoscopic,radiologic and pathologic features of special diaphragm-like strictures found in small bowel,with no patient use of nonsteroidal anti-inflammatory drugs(NSAIDs).METHODS:From Januar... AIM:To summarize clinical,endoscopic,radiologic and pathologic features of special diaphragm-like strictures found in small bowel,with no patient use of nonsteroidal anti-inflammatory drugs(NSAIDs).METHODS:From January 2000 to fecember 2009,5 cases(2 men and 3 women,with a mean age of 41.6 years) were diagnosed as having diaphragm-like strictures of small bowel on imaging,,operation and pathology.All the patients denied the use of NSAIDs.The clinical,endoscopic,radiologic and pathologic findings in these 5 patients were retrospectively reviewedfrom the hospital database.Images of capsule endoscopy(CE) and small bowel follow-through(SBFT) obtained in 3 and 3 patients,respectively,and images of double-balloon enteroscopy and computed tomography enterography(CTE) obtained in all 5 patients were available for review.RESULTS:All patients presented with long-term(2-16 years) symptoms of gastrointestinal bleeding and varying degrees of anemia.There was only one stricture in ?our cases and three lesions in one case,and all the lesions were located in the middle or distal segment of ileum.Circumferential stricture was shown in the small bowel in three cases in the CE image,but the capsule was retained in the small bowel of 2 patients.Routine abdomen computed tomography scan showed no other abnormal results except gallstones in one patient.The lesions were shown as circumferential strictures accompanied by dilated small bowel loops in the small bowel on the images of CTE(in all 5 cases),SBFT(in 2 cases) and double-balloon enteroscopy(in all cases).On microscopy,a chronic inflammatory infiltrate and circumferential diaphragm were found in all lesions.CONCLUSION:fiaphragm-like strictures of small bowel might be a special consequence of unclear damaging insults to the intestine,having similar clinical,endoscopic,radiologic and pathologic features. 展开更多
关键词 Small bowel Gastrointestinal bleeding DIAPHRAGM STRICTURE Endoscopy Computed tomography ENTEROGRAPHY
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Value of ^(99m)Tc-MDP SPECT/CT fusion imaging and CT in evaluating the extent of mandibular invasion by malignant tumor of oral cavity 被引量:1
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作者 Qingyun Duan Muyun Jia +6 位作者 Rongtao Yuan Lingxue Bu Wei Shang Xiaoming Jin Ningyi Li Jie Zhao Guoming Wang 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第12期694-698,共5页
Objective: The aim of our study was to compare the value of computed tomography (CT) and 99mTc-methylene- diphosphonate (MDP) SPECT (single photon emission computed tomography)/CT fusion imaging in determining ... Objective: The aim of our study was to compare the value of computed tomography (CT) and 99mTc-methylene- diphosphonate (MDP) SPECT (single photon emission computed tomography)/CT fusion imaging in determining the extent of mandibular invasion by malignant tumor of the oral cavity. Methods: This study had local ethical committee approval, and all patients gave written informed consent. Fifty-three patients were revealed mandibular invasion by malignant tumor of the oral cavity underwent CT and SPECT/CT. The patients were divided into two groups: group A (invasion-periphery-type) and group B (invasion-center- type). Two radiologists assessed the CT images and two nuclear medicine physicians separately assessed the $PECT/CT images in consensus and without knowledge of the results of other imaging tests. The extent of bone involvement suggested with an imaging modality was compared with pathological findings in the surgical specimen. Results: With pathological findings as the standard of reference, Group A: The extent of mandibular invasion by malignant tumor under- went SPECT/CT was 1.02 _+ 0.20 cm larger than that underwent pathological findings. And the extent of mandibular invasion underwent CT was 1.42 + 0.35 cm smaller than that underwent pathological examination. There were significant difference among the three methods (P 〈 0.01). Group B: The extent of mandibular invasion by malignant tumor underwent SPECT/CT was 1.3 + 0.39 cm larger than that underwent pathological examination. The extent of mandibular invasion underwent CT was 2.55 + 1.44 cm smaller than that underwent pathological findings. There were significant difference among the three methods (P 〈 0.01). The extent of mandibular invasion underwent SPECT/CT was the extent which surgeon must excise to get clear margins. Conclusion: SPECT/CT fusion imaging has significant clinical value in determining the extent of mandibular inva- sion by malignant tumor of oral cavity. 展开更多
关键词 SPECT/CT fusion imaging mandibular invasion malignant tumor
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Biliary cysts:Etiology,diagnosis and management 被引量:31
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作者 Beata Jabońska 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第35期4801-4810,共10页
Biliary cysts(BC) are rare dilatations of different parts of a biliary tract.They account for approximately 1% of all benign biliary diseases.BC occur the most frequently in Asian and female populations.They are an im... Biliary cysts(BC) are rare dilatations of different parts of a biliary tract.They account for approximately 1% of all benign biliary diseases.BC occur the most frequently in Asian and female populations.They are an important problem for pediatricians,gastroenterologists,radiologists and surgeons.Clinical presentation and management depend on the BC type.Cholangiocarcinoma is the most serious and dangerous BC complication.The other complications associated with BC involve cholelithiasis and hepatolithiasis,cholangitis,acute and chronic pancreatitis,portal hypertension,liver fibrosis and secondary liver cirrhosis and spontaneous cyst perforation.Different BC classifications have been described in the literature.Todani classification dividing BC into five types is the most useful in clinical practice.The early diagnosis and proper treatment are very important,because BC are associated with a risk of carcinogenesis.A malignancy risk increases with the age.Radiological investigations(ultrasonography,computed tomography,endoscopic retrograde cholangiopancreatography and magnetic resonance cholangiopancreatography) play an important role in BC diagnostics.Currently,prenatal diagnosis using ultrasonography is possible.It allows to differentiate biliary disorders in fetals and to perform the early surgical treatment that improves results.In most patients,total cyst excision with Roux-Y hepaticojejunostomy is the treatment of choice.Surgical treat-ment of BC is associated with high success rate and low morbidity and mortality.The early treatment is associated with a lower number of complications.Patients following BC surgery require permanent and careful postoperative observation using laboratory and imaging investigations because of possibility of biliary anastomosis stricture and biliary cancer in tissue remnant. 展开更多
关键词 Biliary cysts Biliary drainage Hepaticojeju-nostomy
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Non-isothermal decomposition kinetics of hydrogarnet in sodium carbonate solution 被引量:1
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作者 朱小峰 张廷安 +4 位作者 王艳秀 吕国志 张伟光 王聪 赵爱春 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2015年第10期1634-1639,共6页
Carbonation decomposition of hydrogarnet is a significant reaction of the calcification-carbonation new method for alumina production by using low-grade bauxite.In this work,non-isothermal decomposition kinetics of hy... Carbonation decomposition of hydrogarnet is a significant reaction of the calcification-carbonation new method for alumina production by using low-grade bauxite.In this work,non-isothermal decomposition kinetics of hydrogarnet in sodium carbonate solution was studied by high-pressure differential scanning calorimetry(HPDSC) at different heating rates of 2,5,8,10,15 and 20 K·min^(-1),respectively.The activation energy(E_α) was calculated with the help of isoconversional method(model-free),and the reaction mechanism was determined by the differential equation method.The calculated activation energy of this reaction was 115.66 kJ·mol^(-1).Furthermore,the mechanism for decomposition reaction is Avrami-Erofeev(n=1.5),and the decomposition process is diffusion-controlled. 展开更多
关键词 HYDROGARNET Differential scanning calorimetry(DSC) Activation energy Mechanism function CARBONATION ALUMINA
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Modulatory effects of Azadirachta indica on benzo(a)pyrene-induced forestomach tumorigenesis in mice
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作者 Subhash Chander Gangar Rajat Sandhir +1 位作者 Durg Vijay Rai Ashwani Koul 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第17期2749-2755,共7页
AIM: To evaluate the chemopreventive effects of aqueous Azadimchta indica (A indica) leaf extract (AAILE) against benzo(a)pyrene [B(a)P]-induced forestomach tumorigenesis in Balb/c mice. METHODS: Female Balb... AIM: To evaluate the chemopreventive effects of aqueous Azadimchta indica (A indica) leaf extract (AAILE) against benzo(a)pyrene [B(a)P]-induced forestomach tumorigenesis in Balb/c mice. METHODS: Female Balb/c mice were divided into four groups of 10-12 animals each. For induction of forestomach tumors, starting from d 14 of the experiment, mice of B(a)P and B(a)P+A indica groups were given intra-gastric instillations of B(a)P (40 mg/kg), twice a week for four weeks. Mice ofA indica and B(a)P+A indica groups were orally administered with AAILE (100 mg/kg), two weeks prior to B(a)P instillations till the end of the experiment. After 22 wk of the first B(a)P instillation, mice were sacrificed and the forestomachs were analyzed for development of tumors, scanning electron microscopy (SEM) and histopathology. RESULTS: Tumor incidence was observed to be 100% in mice that received only B(a)P. However, treatment with AAILE reduced the tumor incidence by 58.4% as observed in mice of B(a)P+A indica group when compared to that of B(a)P group. Similarly, the tumor burden and multiplicity were seen to decrease by 87.3% and 69.6% respectively in mice of B(a)P+A indica group when compared to those of B(a)P group. Scanning electron microscopy analysis showed that AAILE treatment itself did not cause any abnormalities on the surface architecture of forestomach epithelium. In tumorous forestomach, surface disruption was observed. Over the forestomach tumors of B(a)P group of mice certain rounded structures were seen in addition to closely placed tongue-shaped squamous cells. Interestingly, these rounded structures were not observed in B(a)P + A indica group of mice. Histopathalogically, the tumors were identical and diagnosed to be papillomas. Mice from control and A indica groups of mice did not develop any forestomach tumors and showed normal histo-architecture. CONCLUSION: The present data suggest that A indica exerts chemopreventive effects against B(a)P-induced forestomach tumors in murine model. Because of lack of toxicity and ubiquitous bioavailability, A indica may play a promising role in future drug discovery and development as far as chemoprevention of cancer is concerned. 展开更多
关键词 Azadirachta indica Benzo(a)pyrene Chemoprevention HISTOPATHOLOGY Scanning electron microscopy
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Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum 被引量:3
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作者 Fabiana Pirani Carneiro Maria de Nazareth Machado Sobreira +6 位作者 Lívia Bravo Maia Alesso Cervantes Sartorelli Luiz Eduardo de Almeida Prado Franceschi Mauro Brito Brando Bárbara Wosnjuk Calaca Fernando Silva Lustosa Joo Vieira Lopes 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第28期3565-3568,共4页
We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum. A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric p... We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum. A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight loss. On computed tomography (CT) a wall thickening of the fourth part of the duodenum was observed. Multiple biopsies obtained from the lesion showed infiltration of plasma cells and lymphocytes, but they were not conclusive. The patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse infiltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular propria. An extensive deposition of amyloid was also observed. Immunohistochemical stains revealed that a few plasmacytoid cells showed λ light chain staining, though most were κ: light chain positive. These cells also were positive for CD138 and CD56 but negative for CD20 and CD79. The findings were consistent with extramedullary plasmocytoma associated with a massive deposit of amyloid in duodenum. A subsequent workup for multiple myeloma was completely negative. The patient showed no signs of local recurrence or dissemination of the disease after 12 mo follow-up. Because of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future. 展开更多
关键词 Extramedullary plasmocytoma AMYLOIDOSIS DUODENUM Plasma cell neoplasms Immunohistochemistry
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Evaluation of sorafenib for hepatocellular carcinoma by contrast-enhanced ultrasonography:A pilot study 被引量:1
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作者 Kazue Shiozawa Manabu Watanabe +3 位作者 Yoshinori Kikuchi Takahide Kudo Kenichi Maruyama Yasukiyo Sumino 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第40期5753-5758,共6页
AIM:To determine the usefulness of arrival time parametric imaging(AtPI) using contrast-enhanced ultrasonography(CEUS) with Sonazoid in evaluating early response to sorafenib for hepatocellular carcinoma(HCC).METHODS:... AIM:To determine the usefulness of arrival time parametric imaging(AtPI) using contrast-enhanced ultrasonography(CEUS) with Sonazoid in evaluating early response to sorafenib for hepatocellular carcinoma(HCC).METHODS:Fourteen advanced HCC patients who received sorafenib 400/800 mg/d for at least 4 wk and were followed up by CEUS were enrolled in this study.CEUS was performed before treatment and 2 and 4 wk after treatment,and images of the target lesion in the arterial phase were recorded for each patient.The images were analyzed by AtPI.Color mapping(CM) images obtained by AtPI were compared before and after the treatment.In these CM images,the mean arrival time of the contrast agent in the region of interest from the starting point [mean time(MT)] was calculated.In each patient,differences between MT before and MT 2 and 4 wk after the treatment were compared with responses evaluated 4-8 wk after the treatment by dynamic computed tomography(CT),and statistical analysis was performed.Modified response evaluation criteria in solid tumors was used for the response evaluation.RESULTS:In CM images both 2 and 4 wk after the treatment,delays in the arrival time of the contrast agent were noted in 8 of the 14 patients.In the other 6 patients,no color changes were observed in the tumor,or red and/or yellow increase,suggesting a decrease in blood flow velocity between images 2 and 4 wk after the treatment and those before the treatment.Dynamic CT could be performed 4-8 wk after the treatment in 13 of the 14 patients.Median differences in the MT were 1.13 s and 1.015 s,2 and 4 wk after the treatment,respectively,in the 8 patients who showed stable disease(SD)/partial response(PR) on dynamic CT.Median differences in the MT were-0.39 s and-0.95 s,2 and 4 wk after the treatment,respectively,in the 5 patients who showed progressive disease(PD).Differences in the median MT between SD/PR and PD groups were significant 2 and 4 wk after the treatment with P = 0.019 and P = 0.028,respectively.CONCLUSION:AtPI by CEUS using Sonazoid is suggested to be useful for evaluating early responses to sorafenib. 展开更多
关键词 SORAFENIB SONAZOID Contrast-enhanced ul-trasonography Hepatocellular carcinoma Therapeutic response
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Carcinoma of the papilla of Vater following treatment of pancreaticobiliary maljunction 被引量:1
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作者 Masato Watanabe Yutaka Midorikawa +5 位作者 Taketoshi Yamano Hiroyuki Mushiake Naoto Fukuda Takashi Kirita Kunio Mizuguchi Yasuyuki Sugiyama 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第48期6126-6128,共3页
Pancreaticobiliary maljunction(PBM)is frequently associated with biliary cancer due to reflux of pancreatic enzymes into the choledochus,and even after surgery to correct the PBM such patients still have a risk of res... Pancreaticobiliary maljunction(PBM)is frequently associated with biliary cancer due to reflux of pancreatic enzymes into the choledochus,and even after surgery to correct the PBM such patients still have a risk of residual bile duct cancer.Here,we report the case of a 59-year-old female with carcinoma of the papilla of Vater which developed 2.5 years after choledochoduodenostomy for PBM.During the postoperative follow-up period,computed tomography obtained 2 years after the first operation demonstrated a tumor in the distal end of the choledochus,although she did not have jaundice and laboratory tests showed no abnormalities caused by the previous operation.As a result,carcinoma of the papilla of Vater was diagnosed at an early stage,followed by surgical cure.For early detection of periampullary cancer in patients undergoing surgery for PBM,careful long-term follow-up is needed. 展开更多
关键词 Pancreaticobiliary maljunction Biliary cancer Carcinoma of the papilla of Vater
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Morphology and growth of porous anodic oxide films on Ti-10V-2Fe-3Al in neutral tartrate solution 被引量:5
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作者 易俊兰 刘建华 +3 位作者 李松梅 于美 吴国龙 吴量 《Journal of Central South University》 SCIE EI CAS 2011年第1期6-15,共10页
Porous anodic oxide films were fabricated galvanostatically on titanium alloy Ti-10V-2Fe-3Al in ammonium tartrate solution with different anodizing time.Scanning electron microscopy(SEM) and field emission scanning el... Porous anodic oxide films were fabricated galvanostatically on titanium alloy Ti-10V-2Fe-3Al in ammonium tartrate solution with different anodizing time.Scanning electron microscopy(SEM) and field emission scanning electron microscopy(FE-SEM) were used to investigate the morphology evolution of the anodic oxide film.It is shown that above the breakdown voltage,oxygen is generated with the occurrence of drums morphology.These drums grow and extrude,which yields the compression stress.Subsequently,microcracks are generated.With continuous anodizing,porous oxides form at the microcracks.Those oxides grow and connect to each other,finally replace the microcrack morphology.The depth profile of the anodic oxide film formed at 1 800 s was examined by Auger electron spectroscopy(AES).It is found that the film is divided into three layers according to the molar fractions of elements.The outer layer is incorporated by carbon,which may come from electrolyte solution.The thickness of the outer layer is approximately 0.2-0.3 μm.The molar fractions of elements in the intermediate layer are extraordinarily stable,while those in the inner layer vary significantly with sputtering depth.The thicknesses of the intermediate layer and the inner layer are 2 μm and 1.0-1.5 μm,respectively.Moreover,the growth mechanism of porous anodic oxide films in neutral tartrate solution was proposed. 展开更多
关键词 titanium alloy porous anodic oxide films morphology evolution growth mechanism
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Metachronous penile metastasis from rectal cancer after total pelvic exenteration 被引量:2
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作者 Yuta Kimura Keiichi Nasu +2 位作者 Hiroki Matsunaga Masahiro Warabi Satoru Inoue 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第38期5476-5478,共3页
Despite its abundant vascularization and extensive circulatory communication with neighboring organs, metastases to the penis are a rare event. A 57-yearold male, who had undergone total pelvic exenteration for rectal... Despite its abundant vascularization and extensive circulatory communication with neighboring organs, metastases to the penis are a rare event. A 57-yearold male, who had undergone total pelvic exenteration for rectal cancer sixteen months earlier, demonstrated an abnormal uptake within his penis by positron emission tomography/computed tomography. A single elastic nodule of the middle penis shaft was noted deep within Bucks fascia. No other obvious recurrent site was noted except the penile lesion. Total penectomy was performed as a curative resection based on a diagnosis of isolated penile metastasis from rectal cancer. A histopathological examination revealed an increase of well differentiated adenocarcinoma in the corpus spongiosum consistent with his primary rectal tumor. The immunohistochemistry of the tumor cells demonstrated positive staining for cytokeratin 20 and negative staining for cytokeratin 7, which strongly supported a diagnosis of penile metastasis from the rectum. The patient is alive more than two years without any recurrence. 展开更多
关键词 Penile metastasis Rectal cancer Corpus spongiosum
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Synchronous primary cancer of the rectum and lung:a case report
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作者 Wentao Zhao Fengliang Hu +5 位作者 Jiyong Wang Xin Jin Xiong Zhang Hongjie Li Yuying Li Mingneng Ren 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第1期55-58,共4页
Multiple primary cancers refer to the condition where more than two cancers occur independently in an individual. The incidence of lung cancer in cases of colorectal cancer is rare and synchronous rectal cancer and lu... Multiple primary cancers refer to the condition where more than two cancers occur independently in an individual. The incidence of lung cancer in cases of colorectal cancer is rare and synchronous rectal cancer and lung cancer is even rare. A 61-year-old man was referred to our hospital with a 2-month history of blood in his stool, tenesmus, and mucous discharge in July 2010. Colonoscopy showed an irregular ulcerated rectal mass and histological examination of biopsy material showed a poorly differentiated adenocarcinoma. Computed tomography (CT) scan of the chest and abdomen showed a mass in the posterior segment of the right upper lobe of the lung and a mass in the right rectal wall of upper rectum. The rectal tumor was diagnosed as primary cancer based on the findings of immunohistochemical stain. An anterior resection (AR) and video assisted thoracoscopic (VAT) wedge resection were performed and histological findings of resected rectal and lung tumor specimen showed synchronous primary rectal cancer and lung cancer. A combination chemotherapy regimen with docetaxel and Iobaplatin was used and the patient was successfully discharged from hospital in August 2010. Although the incidence of synchronous multiple primary cancers is very low, we need to remain suspicious, when faced with two or even multiple organ lesions, and employ the necessary examination methods to confirm the diagnosis. For synchronous multiple primary cancers, if conditions allow, surgical resection for all the cancers can be performed in a single operation. 展开更多
关键词 multiple primary cancers SYNCHRONOUS rectal neoplasm lung neoplasm
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Mechanism study on the effect of different surfactants on dissolution rate of recrystallized prednisolone in various concentrations
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作者 Soheyla Honary Pouneh Ebrahimi Mohammad Alimohamadi 《Journal of Chemistry and Chemical Engineering》 2009年第6期54-62,共9页
The effects of re-crystallization of prednisolone as a poorly water-soluble drug in aqueous surfactant solutions on its dissolution rate were investigated. A significant enhancement was observed for crystal dissolutio... The effects of re-crystallization of prednisolone as a poorly water-soluble drug in aqueous surfactant solutions on its dissolution rate were investigated. A significant enhancement was observed for crystal dissolution rate in hydrophilic surfactants such as tween 80 and sodium lauryl sulfate (SLS). Differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR) indicated the existence of both form Ⅰ and Ⅱ ofprednisolone in SLS treated crystals. The FT-IR results also showed that, only form Ⅱ could be detected in prednisolone crystals without surfactant and prednisolone form Ⅲ was produced in tween 80 treated crystals. These results were also confirmed by X-ray (XRD) diffraction and scanning electron microscopy (SEM). In general, the results indicated that the presence of hydrophilic surfactants could generate forms Ⅱ and Ⅲ of the crystals. These forms would give rlse to the increase of prednisolone's dissolution rate owing to their physicochemical instability and more hydrophilic property in comparison with stable polymorph of form Ⅰ. 展开更多
关键词 PREDNISOLONE POLYMORPHISM dissolution rate SURFACTANT
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Pulmonary lymphoma: computed tomography features with pathologic correlation
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作者 Miaoyu Zeng Zhenjun Zhao +2 位作者 Jine Zhang Jinlei Li Yanhui Liu 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第11期632-635,共4页
Objective: The aim of this study was to analyze the CT and pathology features of pulmonary lymphoma and to improve the understanding of this disease. Methods: The CT findings of 23 cases with pulmonary lymphoma were r... Objective: The aim of this study was to analyze the CT and pathology features of pulmonary lymphoma and to improve the understanding of this disease. Methods: The CT findings of 23 cases with pulmonary lymphoma were retrospectively analyzed and correlated with histopathology. Results: Of the 23 cases with pulmonary lymphoma, there were Hodgkin lymphoma (5 cases) and non-Hodgkin lymphoma (18 cases). Multiple lesions were assessed in 16 cases and single lesion in 7 cases. The imaging findings were classified into 3 types: lobar and segmental involvement type (9/23 cases, 39.13%), nodular or mass-like involvement type (8/23 cases, 34.78%) and mixed type (6/23 cases, 26.09%). Air bronchogram sign (14/23 cases, 60.8%), CT angiogram sign (12/23 cases, 52.17%), ground glass opacity nodules (3/23 cases, 13.04%) and lesion across pulmonary lobes (4/23,17.39%) were the characteristic features of pulmonary lymphoma. Conclusion: Relative characteristic CT features of pulmonary lymphoma could be revealed, which shows clinical significance in the diagnosis of the disease. 展开更多
关键词 lung neoplasms LYMPHOMA TOMOGRAPHY X-ray computed PATHOLOGY
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