技术发生学的发轫及其背景

有理由认为,以人类大大丰富了的已有知识为劳动对象的技术创造,是现代知识生产的一个重要门类。由于技术对于当代社会的巨大影响,技术创造过程获得了广泛关注和研究。对于这种社会化的知识生产的组织、工艺。

Current advances in solid free-form techniques for osteochondral tissue engineering

Osteochondral （OC） lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds＇ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form （SFF） techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

ALK5 transfection of bone marrow mesenchymal stem cells to repair osteoarthritis of knee joint

Previous studies have suggested that the transforming growth factor-β receptor ALK5 is crucial for articular chondrogenesis by bone marrow mesenchymal stem cells. Here, the wild-type ALK5 plasmids were mutated by overlapping extended PCR and transfected into bone marrow mesenchymal stem cells. The knee joint osteoarthritis mouse model was constructed by cutting oft＂ the anterior cruciate ligament and divided into three groups： saline group, bone marrow mesenchymal stem cells and ALK5-transfected bone marrow mesenchymal stem cells group. HE staining showed that the articular cartilage lesions were more serious of saline group compared with that of mesenchymal stem cell group, and this trend was more pronounced as time goes on. Immunohistochemical staining showed that although the expression level of type II collagen in all three groups down-regulated gradually upon time, its expression in ALK5-transfected bone marrow mesenchymal stem cells group was significantly enhanced compared with the other two groups. Micro-CT also suggested that ALK5 transfection of mouse bone marrow mesenchymal stem cells would promote repairing the knee cartilage lesions with arthritis of the mice. Although the osteoarthritis mechanism underlying a variety of factors work together, and the appropriate proportion of ALKS/ALK1 was also emphasized for the treatment of osteoarthritis. This work therefore demonstrated that ALK5 transfection of bone marrow mesenchymal stem cells could be a promising stem cell therapy for repair of cartilage lesions.

Technology Use Takes a Boost among University Students

The speed with which the information technology has evolved is unparallel to any other technological evolution man has ever witnessed. From hospitals to classrooms, technology seems to have taken over people＇s lives. Where there have been studies to see the impact of technology in varying aspects of life, there seem to be little or no studies on the actual rate of increase in usage of e-technologies among university students and why they have become so popular. This paper uses a survey tool that captures responses from 900 students to study the rate of increase in student use of various e-technologies in and out of classrooms along with some viable reasons why students are acquiring and using such technologies and suggests ways to use this study to better understand student behavior in terms of e-cheating, and how to enhance teaching and learning environments for students.

Sanitary Regulation of Pharmaceutical Products in Mexico （Sanitary Registration-Board Arrangement-Patent）-Monoclonal Antibody Case Study

The Federal Commission for Protection against Health Risks in Mexico （COFEPRIS） is responsible for the regulation and health promotion of the production, commercialization, import, export, publicity or involuntary exposure of medicines and technologies for health. For its part, the Mexican Institute of Industrial Property （IMPI） is a decentralized public body with legal personality, own property and legal authority to administer the industrial property system in our country. In the year 2000, on September 19, the official journal published the linking of patents related to allopathic medicines and the sanitary registry. Objectives： To publicize the process of linking the Sanitary-Patent Registry as a case study to delimit the scope of the new pharmaceutical products. Methodology： Request the information to COFEPRIS for the registration of a new pharmaceutical product; Establish flow diagrams for the registration of： innovative products, generic products, biotech products and bio similar products; Integrate the documents in the dossier of the pharmaceutical product for sanitary registration; Elaborate sworn letter of non-invasion of patents and study of patents; Submit the Health Registry; Intergovernmental consultation. Sanitary Registry Results： Search of patents in databases to elaborate state of the art, to write letter under protest to say truth that is not invading any patent, when developing a composition of cetuximab, as generic product since the patent molecule expired in 2016 and 11 patents related to compositions, preparations and finished product preparation processes. Conclusions： COFEPRIS will determine through intergovernmental consultation with the IMPI whether or not a patent is invaded, according to the case it will grant the registration or send the corresponding prevention for cetuximab, in case that invading can also be a refusal of grant.

Educational Software Development Life Cycle Stages

Technological innovations have revolutionized the educational technology into various dimensions. Educational processes without educational technology have no value in this modern world. In education domain, the educational software has simplified the processes in greater extend. A implemented while developing such educational software. In particu proper lar, the development methodology has to be software developed to enrich these education processes should follow a development strategy to motivate the end users to utilize the hypermedia potentials. The software development life cycle （SDLC） has different phases in designing such educationa technology and assists the end users to benefit from the modern technology. This study identifies the various factors to be considered at each phase of the SDLC while developing educational software. Also, this study proposes some suggestions to be followed in ESDLC with respect to educational processes perspectives. The core idea of this study is to identify the various issues in implementing such educational software in day to day teaching and learning processes.

Application of ICT in Schools

The rhythm and lifestyle of the twenty-first century are closely connected to information and communication technology （ICT） which is essential for further development of the economy and society. In the world of globalization and rapid changes, the application of ICT in schools has become a significant factor of social development. Classic methods of teaching as well as managing a school interweave with the modern ones. Lifelong learning has become a necessity. The extent of ICT application is demonstrated in this paper.

Letter from Editors-in-Chief

Engineering comes to you at last. As the Editors-in-Chief of En- gineering, first of all, we wish to thank all the scholars at home and abroad for their eager responses and full support, and all those who have provided encouragement and contributions toward the emergence of this journal. Looking back over the history of human civilization, hu- man survival is closely related to the development of social productive forces, which come from engineering science and technology （EST）. Along with today＇s rapid economic and social development, we face common threats from global problems such as food safety, resource shortages, energy cri- ses, environmental pollution, climate change, network attacks, population expansion, poverty, the prevalence of disease, and economic crises. Therefore, EST research that addresses these major issues of economic development appears to be par- ticularly important. At present, a new scientific and technical revolution, including wide spread industrial transformation, is flowing together with new developments in human society. Historically, we know that progress and innovation in EST is a crucial engine for promotin~ progress in human society.