Immune checkpoint inhibitors are increasingly drawing much attention in the therapeutic development for cancer treatment. However, many cancer patients do not respond to treatments with immune checkpoint inhibitors, p...Immune checkpoint inhibitors are increasingly drawing much attention in the therapeutic development for cancer treatment. However, many cancer patients do not respond to treatments with immune checkpoint inhibitors, partly because of the lack of tumor-infiltrating effector T cells. Cancer vaccines may prime patients for treatments with immune checkpoint inhibitors by inducing effector T-ceU infiltration into the tumors and immune checkpoint signals. The combination of cancer vaccine and an immune checkpoint inhibitor may function synergistically to induce more effective antitumor immune responses, and clinical trials to test the combination are currently ongoing.展开更多
Aim To study the distribution pattern, antineoplastic activity and immunocompetence of a novel organoselenium compound Eb and investigate its in vivo antineoplastic potential. Methods Eb was administered to Kunming ...Aim To study the distribution pattern, antineoplastic activity and immunocompetence of a novel organoselenium compound Eb and investigate its in vivo antineoplastic potential. Methods Eb was administered to Kunming mice (dosage, 0.1 g·kg^(-1)·d^(-1)) intragastrically for 7 successive days. The contents of selenium in heart, liver, spleen, kidneys, lungs, stomach, brain, muscle, and bone were determined by fluorometric method on the eighth day. MTT assay was used to study tumor growth inhibition of Eb in vitro, and lymphocyte transformation, hemolysin formation and phagocytosis assay were used to study its immunocompetence. Results After 7 days′ administration of Eb, the tissue contents of sele-(nium) in liver, spleen, lungs, kidneys, and bone of mice increased, especially those in liver and spleen increased significan-tly, compared with controls; but no significant changes of such contents were found in muscle, heart, brain, and stomach. Eb demonstrated inhibitory effects on human Bel-7402, BGC-823, and Calu-3 cancer cell lines in vitro. Eb also showed ability to enhance lymphocyte transformation and serum hemolysin formation in vitro and increase the phagocytosis of macrophages. Conclusion The validated antitumor and immunostimulatory activities of Eb suggest a hypothesis that Eb may behave as a biological response modifier when used as an antitumor agent. Eb is worthy of further study in developing a new antineoplastic and immunity enhancing agent in the light of its antitumor activity, immunocompetence and specific distribution in liver, lungs, kidneys, bone, and spleen.展开更多
Kinetic mechanisms describing how THIs （thermodynamic hydrate inhibitors） and KHIs （kinetic hydrate inhibitors） work on gas hydrate formation have drawn interests for decades. These mechanisms could be better reve...Kinetic mechanisms describing how THIs （thermodynamic hydrate inhibitors） and KHIs （kinetic hydrate inhibitors） work on gas hydrate formation have drawn interests for decades. These mechanisms could be better revealed with more fundamental experimental studies. With experiments performed in an isochoric cell with continuous cooling and stirring, this paper presents observed effects of methanol, PVP （polyvinylpyrrolidone, Mw= 15,000） and PVCap （polyvinylcaprolactam, Mw = 6,000） on both nucleation and growth of structure-I methane hydrate at concentrations 100 to 3,000 ppm （i.e., 0.01 to 0.3 wt%）. The results suggest that methanol had no significant effect on nucleation, while it weakly promoted, spontaneous hydrate growth at an early stage. PVP and PVCap gave reduced average nucleation rate at and prior to hydrate onset, while increased the induction time and the degree of sub-cooling. PVP gave no observable effect on total gas intake and average hydrate growth rate. A decreased total gas intake was observed for all concentrations of PVCap.展开更多
An adaptive control scheme is presented,which can simultaneously realize vibration suppression and compliance control for flexible joint robot(FJR).The proposed control scheme provides a unified formulation for both v...An adaptive control scheme is presented,which can simultaneously realize vibration suppression and compliance control for flexible joint robot(FJR).The proposed control scheme provides a unified formulation for both vibration suppression mode,where FJR tracks the desired position with little vibration,and compliance mode,in which FJR presents passive.Instead of designing multiple controllers and switching between them,both modes are integrated into a single controller,and the transition between two modes is smooth and stable.The stability of the closed-loop system is theoretically proven via the Lyapunov method,with the considering the dynamics uncertainties in both link side and motor side.Simulation results are presented to illustrate good performances of the proposed control scheme.展开更多
This research investigated the outputting circulation current inhibition characteristic which are controlled by the instantaneous feedback voltage in inverter parallel driving of the mine hoist. We established a trans...This research investigated the outputting circulation current inhibition characteristic which are controlled by the instantaneous feedback voltage in inverter parallel driving of the mine hoist. We established a transfer function of the parallel inverters controlled by the close-loop adjustment of instantaneous voltage feedback. The influence of the parameters of the close-loop feedback circuit to the inhibition effects to the outputting circulation current is observed. After analyzing the circulating current inhibition characteristics, the proportion integration （PI） controller is introduced into the close-loop adjustment by instantaneous voltage feedback. The characteristics equation is gained to determine the PI parameters by drawing the Bode plots. The inhibition effects of the proposed controller are examined by the established simulation model of parallel inverter system. The harmonic distortion rate at the outputting voltage frequency value of 4, 10, 20, 41 and 50 Hz, are all lower than 2.32 % by the instantaneous outputting voltage feedback.展开更多
We used a potent and specific monoclonal antibody to somatostatin to test the physiologic inhibitory role of the tetradecapeptide somatostatin on pancreatic secretion.Somatostatin immunoneutralization increased both t...We used a potent and specific monoclonal antibody to somatostatin to test the physiologic inhibitory role of the tetradecapeptide somatostatin on pancreatic secretion.Somatostatin immunoneutralization increased both the total amylase and volume of pancreatic secretion.Cholecystokinin-A receptor antagonism abolished the stimulatory effect of somatostatin immunoneutralization.We conclude that somatostatin tonically inhibits pancreatic secretion in fasted rats via inhibition of the release or action of cholecystokinin.Furthermore,the source of these peptides is likely islet delta cells and intrapancreatic neurons,respectively.展开更多
The vibration of machines due to rotating parts unbalance disturbs the machine functioning and shortens the lifetime of its parts. A dynamic vibration absorber is a favorite solution to suppress the machine vibration ...The vibration of machines due to rotating parts unbalance disturbs the machine functioning and shortens the lifetime of its parts. A dynamic vibration absorber is a favorite solution to suppress the machine vibration since its implementation does not require any modification neither on the machine nor on its installation. The paper considers an unbalanced machine to which a lumped mass dynamic vibration absorber is attached. Firstly, the machine equipped with the absorber is modeled, and the vibration expressions are extracted. Secondly, an original approach to optimize the absorber parameters is presented, and simulation results are advanced, when the absorber is undamped and damped. Thirdly, the absorber optimal parameters allowing the best vibration reduction of the machine are identified, showing bow the absorber should be designed, when the disturbance frequency is stable or unstable. The results are a significant contribution in the vibration control of unbalanced machines.展开更多
基金supported by the Viragh Foundation(L.Z.)National Institutes of Health(NIH)(Grant No.K23 CA148964,L.Z.)the NCI SPORE in Gastrointestinal Cancers(Grant No.P50 CA062924,L.Z.)
文摘Immune checkpoint inhibitors are increasingly drawing much attention in the therapeutic development for cancer treatment. However, many cancer patients do not respond to treatments with immune checkpoint inhibitors, partly because of the lack of tumor-infiltrating effector T cells. Cancer vaccines may prime patients for treatments with immune checkpoint inhibitors by inducing effector T-ceU infiltration into the tumors and immune checkpoint signals. The combination of cancer vaccine and an immune checkpoint inhibitor may function synergistically to induce more effective antitumor immune responses, and clinical trials to test the combination are currently ongoing.
文摘Aim To study the distribution pattern, antineoplastic activity and immunocompetence of a novel organoselenium compound Eb and investigate its in vivo antineoplastic potential. Methods Eb was administered to Kunming mice (dosage, 0.1 g·kg^(-1)·d^(-1)) intragastrically for 7 successive days. The contents of selenium in heart, liver, spleen, kidneys, lungs, stomach, brain, muscle, and bone were determined by fluorometric method on the eighth day. MTT assay was used to study tumor growth inhibition of Eb in vitro, and lymphocyte transformation, hemolysin formation and phagocytosis assay were used to study its immunocompetence. Results After 7 days′ administration of Eb, the tissue contents of sele-(nium) in liver, spleen, lungs, kidneys, and bone of mice increased, especially those in liver and spleen increased significan-tly, compared with controls; but no significant changes of such contents were found in muscle, heart, brain, and stomach. Eb demonstrated inhibitory effects on human Bel-7402, BGC-823, and Calu-3 cancer cell lines in vitro. Eb also showed ability to enhance lymphocyte transformation and serum hemolysin formation in vitro and increase the phagocytosis of macrophages. Conclusion The validated antitumor and immunostimulatory activities of Eb suggest a hypothesis that Eb may behave as a biological response modifier when used as an antitumor agent. Eb is worthy of further study in developing a new antineoplastic and immunity enhancing agent in the light of its antitumor activity, immunocompetence and specific distribution in liver, lungs, kidneys, bone, and spleen.
文摘Kinetic mechanisms describing how THIs （thermodynamic hydrate inhibitors） and KHIs （kinetic hydrate inhibitors） work on gas hydrate formation have drawn interests for decades. These mechanisms could be better revealed with more fundamental experimental studies. With experiments performed in an isochoric cell with continuous cooling and stirring, this paper presents observed effects of methanol, PVP （polyvinylpyrrolidone, Mw= 15,000） and PVCap （polyvinylcaprolactam, Mw = 6,000） on both nucleation and growth of structure-I methane hydrate at concentrations 100 to 3,000 ppm （i.e., 0.01 to 0.3 wt%）. The results suggest that methanol had no significant effect on nucleation, while it weakly promoted, spontaneous hydrate growth at an early stage. PVP and PVCap gave reduced average nucleation rate at and prior to hydrate onset, while increased the induction time and the degree of sub-cooling. PVP gave no observable effect on total gas intake and average hydrate growth rate. A decreased total gas intake was observed for all concentrations of PVCap.
基金supported by the National Key R&D Program of China(No.2017YFB1300400)the National Natural Science Foundation of China(No. 51805107)
文摘An adaptive control scheme is presented,which can simultaneously realize vibration suppression and compliance control for flexible joint robot(FJR).The proposed control scheme provides a unified formulation for both vibration suppression mode,where FJR tracks the desired position with little vibration,and compliance mode,in which FJR presents passive.Instead of designing multiple controllers and switching between them,both modes are integrated into a single controller,and the transition between two modes is smooth and stable.The stability of the closed-loop system is theoretically proven via the Lyapunov method,with the considering the dynamics uncertainties in both link side and motor side.Simulation results are presented to illustrate good performances of the proposed control scheme.
文摘This research investigated the outputting circulation current inhibition characteristic which are controlled by the instantaneous feedback voltage in inverter parallel driving of the mine hoist. We established a transfer function of the parallel inverters controlled by the close-loop adjustment of instantaneous voltage feedback. The influence of the parameters of the close-loop feedback circuit to the inhibition effects to the outputting circulation current is observed. After analyzing the circulating current inhibition characteristics, the proportion integration （PI） controller is introduced into the close-loop adjustment by instantaneous voltage feedback. The characteristics equation is gained to determine the PI parameters by drawing the Bode plots. The inhibition effects of the proposed controller are examined by the established simulation model of parallel inverter system. The harmonic distortion rate at the outputting voltage frequency value of 4, 10, 20, 41 and 50 Hz, are all lower than 2.32 % by the instantaneous outputting voltage feedback.
文摘We used a potent and specific monoclonal antibody to somatostatin to test the physiologic inhibitory role of the tetradecapeptide somatostatin on pancreatic secretion.Somatostatin immunoneutralization increased both the total amylase and volume of pancreatic secretion.Cholecystokinin-A receptor antagonism abolished the stimulatory effect of somatostatin immunoneutralization.We conclude that somatostatin tonically inhibits pancreatic secretion in fasted rats via inhibition of the release or action of cholecystokinin.Furthermore,the source of these peptides is likely islet delta cells and intrapancreatic neurons,respectively.
文摘The vibration of machines due to rotating parts unbalance disturbs the machine functioning and shortens the lifetime of its parts. A dynamic vibration absorber is a favorite solution to suppress the machine vibration since its implementation does not require any modification neither on the machine nor on its installation. The paper considers an unbalanced machine to which a lumped mass dynamic vibration absorber is attached. Firstly, the machine equipped with the absorber is modeled, and the vibration expressions are extracted. Secondly, an original approach to optimize the absorber parameters is presented, and simulation results are advanced, when the absorber is undamped and damped. Thirdly, the absorber optimal parameters allowing the best vibration reduction of the machine are identified, showing bow the absorber should be designed, when the disturbance frequency is stable or unstable. The results are a significant contribution in the vibration control of unbalanced machines.
