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鲎试剂法检测抗凝剂溶液细菌内毒素干扰因素分析 被引量:4
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作者 柏玉碧 韩炼 +1 位作者 王成树 刘蓉莉 《中国输血杂志》 CAS CSCD 2005年第3期215-217,共3页
目的排除鲎试法检测抗凝剂溶液中细菌内毒素时的抑制性干扰。方法取家兔法热原试验合格的4%枸椽酸钠注射(简称AC)初筛,在此基础上,1∶40稀释的AC溶液(简称40倍稀释AC)和细菌内毒素检查用水分别制成含2.0、1.0、0.5、0.25λ的细菌内毒素... 目的排除鲎试法检测抗凝剂溶液中细菌内毒素时的抑制性干扰。方法取家兔法热原试验合格的4%枸椽酸钠注射(简称AC)初筛,在此基础上,1∶40稀释的AC溶液(简称40倍稀释AC)和细菌内毒素检查用水分别制成含2.0、1.0、0.5、0.25λ的细菌内毒素溶液,做干扰试验。结果通过不含内毒素的供试品稀释系列溶液(NPC)和含2λ内毒素的供试品稀释系列溶液(PPC)试验,发现NPC试验结果全为阴性;PPC试验结果AC稀释倍数<30时,皆为阴性,≥35时,为阳性。干扰试验表明40倍稀释AC对细菌内毒素检测(鲎试法)无干扰。结论鲎试法检测AC中的细菌内毒素时,须事先将AC适当稀释,以排除其抑制性干扰因素。 展开更多
关键词 鲎试法 细菌内毒素检查 构橼酸钠注射液 抑制性干扰
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BET法检测3种血液保存液细菌内毒素的效果观察 被引量:1
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作者 王洪 王欣 +1 位作者 张晓寒 牛海江 《中国输血杂志》 CAS CSCD 2007年第1期49-50,共2页
目的排除细菌内毒素检测(BET)法检测血液保存液细菌内毒素时的抑制性干扰。方法用无热原水(BET水)分别将输血用1号抗凝液、血液保存液Ⅱ(ACD-B)、红细胞保存液(MAP)稀释11、22、44、88、176倍,按《药典》制备A、B、C、D溶液,进行干扰初... 目的排除细菌内毒素检测(BET)法检测血液保存液细菌内毒素时的抑制性干扰。方法用无热原水(BET水)分别将输血用1号抗凝液、血液保存液Ⅱ(ACD-B)、红细胞保存液(MAP)稀释11、22、44、88、176倍,按《药典》制备A、B、C、D溶液,进行干扰初筛试验,以初步确定无干扰的稀释倍数,将供试品稀释到无干扰的倍数做干扰试验。结果通过干扰试验证明1号抗凝液、ACD-B稀释44倍时无干扰;MAP稀释22倍时无干扰。结论BET法检测3种血液保养液时做一定倍数以上的稀释,可以排除抑制性干扰因素。 展开更多
关键词 细菌内毒素 细菌内毒素检测法 试剂 构橼酸根 血液保养液 抑制性干扰
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输血用1号抗凝液细菌内毒素的一种检测方法
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作者 王洪 张红岩 +2 位作者 王欣 王学刚 张晓寒 《中国输血杂志》 CAS CSCD 2007年第2期138-139,共2页
关键词 细菌内毒素 检测法 构橼酸根 抑制性干扰 CA(OH)2
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A New Tuning Method for Two-Degree-of-Freedom Internal Model Control under Parametric Uncertainty 被引量:10
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作者 Juwari Purwo sutikno Badhrulhisham Abdul aziz +1 位作者 Chin Sim yee Rosbi Mamat 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2013年第9期1030-1037,共8页
Internal model control (IMC) yields very good performance for set point tracking, but gives sluggish response for disturbance rejection problem. A two-degree-of-freedom IMC (2DOF-IMC) has been developed to overcom... Internal model control (IMC) yields very good performance for set point tracking, but gives sluggish response for disturbance rejection problem. A two-degree-of-freedom IMC (2DOF-IMC) has been developed to overcome the weakness. However, the setting of parameter becomes a complicated matter if there is an uncertainty model. The present study proposes a new tuning method for the controller. The proposed tuning method consists of three steps. Firstly, the worst case of the model uncertainty is determined. Secondly, the parameter of set point con- troller using maximum peak (Mp) criteria is specified, and finally, the parameter of the disturbance rejection con- troller using gain margin (GM) criteria is obtained. The proposed method is denoted as Mp-GM tuning method. The effectiveness of Mp-GM tuning method has evaluated and compared with IMC-controller tuning program (IMCTUNE) as bench mark. The evaluation and comparison have been done through the simulation on a number of first order plus dead time (FOPDT) and higher order processes. The FOPDT process tested includes processes with controllability ratio in the range 0.7 to 2.5. The higher processes include second order with underdarnped and third order with nonminimum phase processes. Although the two of higher order processes are considered as difficult processes, the proposed Mp-GM tuning method are able to obtain the good controller parameter even under process uncertainties. 展开更多
关键词 tuning 2DOF-IMC model uncertainty dead time process Mp-GM tuning IMCTUNE
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ADRC BASED INPUT DISTURBANCE REJECTION FOR MINIMUM-PHASE PLANTS WITH UNKNOWN ORDERS AND/OR UNCERTAIN RELATIVE DEGREES 被引量:15
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作者 Chunzhe ZHAO Yi HUANG 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2012年第4期625-640,共16页
The capability of ADRC is studied for linear time-invariant SISO minimum-phase systems with unknown orders, uncertain relative degrees, and unknown input disturbances. It is proved that ADRC can reject the unknown inp... The capability of ADRC is studied for linear time-invariant SISO minimum-phase systems with unknown orders, uncertain relative degrees, and unknown input disturbances. It is proved that ADRC can reject the unknown input disturbance and guarantee the close-loop stability for the plants with unknown but bounded relative degrees. Meanwhile, some close-loop performances can be achieved. The influence of the sensor noise is also discussed. And it is demonstrated by numerical examples that one ADRC with fixed parameters can be applied to a group of plants of different orders, relative degrees, and parameters. 展开更多
关键词 ADRC frequency performance sensor noise uncertain relative degree unknown input disturbance unknown order.
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