针对基频低于1Hz的大挠性太阳帆板,提出了整板主动振动抑制方法。该方法通过在太阳帆板上集成压电元件作为传感器和执行器;针对帆板挠性增大时,同位控制易出现虚假抑制的现象,综合考虑压电传感器的测量数据和板上一点的振动情况,基于正...针对基频低于1Hz的大挠性太阳帆板,提出了整板主动振动抑制方法。该方法通过在太阳帆板上集成压电元件作为传感器和执行器;针对帆板挠性增大时,同位控制易出现虚假抑制的现象,综合考虑压电传感器的测量数据和板上一点的振动情况,基于正向位置反馈控制律(Positive Position Feedback,PPF),设计了整板振动抑制控制系统。通过Adams和Simulink联合仿真,对控制系统的振动抑制能力进行了考核,结果表明所设计的PPF控制系统避免了虚假抑制,具有良好的整板振动抑制效果。展开更多
AIM: To study the secretory inhibitor of platelet microbicidal protein (SIPMP) phenotypes of faecal anaerobic isolates from patients with diarrhea.METHODS: Faecal isolates of anaerobic bacteria (B. fragilis, n = ...AIM: To study the secretory inhibitor of platelet microbicidal protein (SIPMP) phenotypes of faecal anaerobic isolates from patients with diarrhea.METHODS: Faecal isolates of anaerobic bacteria (B. fragilis, n = 42; B. longum, n = 70; A. israelii, n = 21; E. lentum, n = 12) from children with diarrhea were tested. SIPMP production was tested by inhibition of platelet microbicidal protein (PMP) bioactivity against B. subtilis and was expressed as percentage of inhibition of PMP bactericidal activity.RESULTS: Among anaerobic isolates 80% of B. longum strains, 85.7% of A. israeli/strains, 50% of E. lentum strains and 92.86% of B. fragilis strains were SIPMP-positive. The isolated anaerobic organisms demonstrated SIPMP production at a mean level of 13.8% ± 0.7%, 14.7% ± 1.8%, 3.9% ± 0.9% (P 〈 0.05) and 26.8% ± 7.5% (P 〈 0.05) for bifidobacteria, A. israelii, E. lentum and B. fragilis, respectively.CONCLUSION: Data from the present study may have significant implications in understanding the pathogenesis of microecological disorders in the intestine, as well as for future improvement in the prevention and therapy of anaerobe-associated infections.展开更多
OBJECTIVE: To study the antiviral activities of clemastanin B(CB), epigoitrin, phenylpropanoids portion(PEP) and the mixture of phenylpropanoids, alkaloids and organic acid fractions(PEP+ALK+OA)from Banlangen(Radix Is...OBJECTIVE: To study the antiviral activities of clemastanin B(CB), epigoitrin, phenylpropanoids portion(PEP) and the mixture of phenylpropanoids, alkaloids and organic acid fractions(PEP+ALK+OA)from Banlangen(Radix Isatidis).METHODS: The experiment consisted of four parts:therapeutic action, prophylaxsis action, inhibition of virus attachment, and direct virucidal action. Cytopathic effect(CPE) and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium(MTT) were used to assess antiviral activity.RESULTS: CB, epigoitrin, PEP and PEP + ALK + OA fractions from Banlangen(Radix Isatidis) extract significantly increased the viability of MDCK cells pre-infected with the virus compared with the virus control group in all the dilutions(P < 0.01). Pretreated with either pure compounds or chemical frac-tions of Banlangen(Radix Isatidis) extract in all the dilutions significantly improved the viability of MDCK cells(P < 0.01). The inhibition of virus absorption to the host cells by CB, epigoitrin and PEP was in a dose dependent manner.CONCLUSION: CB, epigoitrin, PEP and PEP+ALK+OA exert their anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. The primary mode of action of PEP and PEP + ALK + OA is the inhibition of virus replication. The inhibitory effects on virus attachment and multiplication are the main modes for epigoitrin.展开更多
Platelets are derived from megakaryocytes;they circulate in mammalian blood vessels and play essential roles in hemostasis and thrombosis.When platelets encounter injury,they respond by triggering the formation of a b...Platelets are derived from megakaryocytes;they circulate in mammalian blood vessels and play essential roles in hemostasis and thrombosis.When platelets encounter injury,they respond by triggering the formation of a blood clot to prevent blood loss(hemostasis).While this is vital for survival,展开更多
A new approach,mass injection near the slat cusp,is proposed for the suppression of slat noise.The mechanism and efciency of the slat noise suppression using upstream mass injection are numerically studied with hybrid...A new approach,mass injection near the slat cusp,is proposed for the suppression of slat noise.The mechanism and efciency of the slat noise suppression using upstream mass injection are numerically studied with hybrid Reynolds-averaged Navier-Stokes simulation/Large eddy simulation(RANS/LES)of a three-component high-lift model.Ffowcs-Williams and Hawking(FW-H)integration is employed to obtain far-field acoustic characteristics.Results show that with injection,aerodynamic capability of the high-lift devices is sustained.In addition,a considerable noise reduction is observed in the downward direction.With detailed analysis of the time-averaged and instantaneous flow fields,two mechanisms are identified as the reason accounting for the noise suppression:upstream mass injection significantly reduces the scale and strength of the vortices stemming from the cusp;the shear layer is lifted up,which relieves the shear layer impingement on the slat lower surface.展开更多
文摘针对基频低于1Hz的大挠性太阳帆板,提出了整板主动振动抑制方法。该方法通过在太阳帆板上集成压电元件作为传感器和执行器;针对帆板挠性增大时,同位控制易出现虚假抑制的现象,综合考虑压电传感器的测量数据和板上一点的振动情况,基于正向位置反馈控制律(Positive Position Feedback,PPF),设计了整板振动抑制控制系统。通过Adams和Simulink联合仿真,对控制系统的振动抑制能力进行了考核,结果表明所设计的PPF控制系统避免了虚假抑制,具有良好的整板振动抑制效果。
基金The Russian Foundation of Basic Research and Government of Orenburg region, No. 07-04-97624 and No. 08-04-99105
文摘AIM: To study the secretory inhibitor of platelet microbicidal protein (SIPMP) phenotypes of faecal anaerobic isolates from patients with diarrhea.METHODS: Faecal isolates of anaerobic bacteria (B. fragilis, n = 42; B. longum, n = 70; A. israelii, n = 21; E. lentum, n = 12) from children with diarrhea were tested. SIPMP production was tested by inhibition of platelet microbicidal protein (PMP) bioactivity against B. subtilis and was expressed as percentage of inhibition of PMP bactericidal activity.RESULTS: Among anaerobic isolates 80% of B. longum strains, 85.7% of A. israeli/strains, 50% of E. lentum strains and 92.86% of B. fragilis strains were SIPMP-positive. The isolated anaerobic organisms demonstrated SIPMP production at a mean level of 13.8% ± 0.7%, 14.7% ± 1.8%, 3.9% ± 0.9% (P 〈 0.05) and 26.8% ± 7.5% (P 〈 0.05) for bifidobacteria, A. israelii, E. lentum and B. fragilis, respectively.CONCLUSION: Data from the present study may have significant implications in understanding the pathogenesis of microecological disorders in the intestine, as well as for future improvement in the prevention and therapy of anaerobe-associated infections.
基金the National Natural Science Foundation of China Grant(No.81073023)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(No.ysxk-2010)2013 Program sponsored for scientific innovation research of college graduate in Jiangsu province(No.CXZZ13_0631)
文摘OBJECTIVE: To study the antiviral activities of clemastanin B(CB), epigoitrin, phenylpropanoids portion(PEP) and the mixture of phenylpropanoids, alkaloids and organic acid fractions(PEP+ALK+OA)from Banlangen(Radix Isatidis).METHODS: The experiment consisted of four parts:therapeutic action, prophylaxsis action, inhibition of virus attachment, and direct virucidal action. Cytopathic effect(CPE) and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium(MTT) were used to assess antiviral activity.RESULTS: CB, epigoitrin, PEP and PEP + ALK + OA fractions from Banlangen(Radix Isatidis) extract significantly increased the viability of MDCK cells pre-infected with the virus compared with the virus control group in all the dilutions(P < 0.01). Pretreated with either pure compounds or chemical frac-tions of Banlangen(Radix Isatidis) extract in all the dilutions significantly improved the viability of MDCK cells(P < 0.01). The inhibition of virus absorption to the host cells by CB, epigoitrin and PEP was in a dose dependent manner.CONCLUSION: CB, epigoitrin, PEP and PEP+ALK+OA exert their anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. The primary mode of action of PEP and PEP + ALK + OA is the inhibition of virus replication. The inhibitory effects on virus attachment and multiplication are the main modes for epigoitrin.
基金supported by the National Natural Science Foundation of China(91439115)the National Basic Research Program of China(NO2012CB518000)
文摘Platelets are derived from megakaryocytes;they circulate in mammalian blood vessels and play essential roles in hemostasis and thrombosis.When platelets encounter injury,they respond by triggering the formation of a blood clot to prevent blood loss(hemostasis).While this is vital for survival,
文摘A new approach,mass injection near the slat cusp,is proposed for the suppression of slat noise.The mechanism and efciency of the slat noise suppression using upstream mass injection are numerically studied with hybrid Reynolds-averaged Navier-Stokes simulation/Large eddy simulation(RANS/LES)of a three-component high-lift model.Ffowcs-Williams and Hawking(FW-H)integration is employed to obtain far-field acoustic characteristics.Results show that with injection,aerodynamic capability of the high-lift devices is sustained.In addition,a considerable noise reduction is observed in the downward direction.With detailed analysis of the time-averaged and instantaneous flow fields,two mechanisms are identified as the reason accounting for the noise suppression:upstream mass injection significantly reduces the scale and strength of the vortices stemming from the cusp;the shear layer is lifted up,which relieves the shear layer impingement on the slat lower surface.