The 2,5-bis（ethyldisulfanyl）-l,3,4-thiadiazole （T561）, benzotriazole （BTA）,1-N, N-bis （2-ethylhexyl） aminomethyl-4-methyl-lh-benzotriazole （IRGAMET39） and I-IN, N-bis （2-ethylhexyl） aminomethyl] methyl ben...The 2,5-bis（ethyldisulfanyl）-l,3,4-thiadiazole （T561）, benzotriazole （BTA）,1-N, N-bis （2-ethylhexyl） aminomethyl-4-methyl-lh-benzotriazole （IRGAMET39） and I-IN, N-bis （2-ethylhexyl） aminomethyl] methyl benzotriazole （TT- LX） have been evaluated as corrosion inhibitors used in rolling oil for cold rolling of copper foil. The MRS-10A four-ball friction and wear tests have been carried out to compare their tribological properties, and the lubricating performance of rolling oils has been studied through rolling experiments. The oil sample containing IRGAMET 39 has the same PB value as that one containing T561, with the coefficient of friction increased by 35.6% and wear scar diameter decreased by 4%. The minimum rolling gauge has been studied after rolling lubrication, but the results show that inhibitors have no effect on it. Scanning electron microscopy （SEM） and energy dispersive spectrometry （EDS） analyses have indicated that the inhibitor is adsorbed on the copper surface to prevent copper from being corroded easily. In addition, the LEXT OLS4000 laser confocal microscopy has been used to observe the foil surface which shows that the streaks of foil surface are clear, the scratches are shallow and the surface failure is improved effectively.展开更多
Objective Letrozole, a next-generation aromatase inhibitor, has become a favored drug for the treatment of breast cancer in postmenopausal women. Although letrozolc is generally well tolerated, its adverse effects on ...Objective Letrozole, a next-generation aromatase inhibitor, has become a favored drug for the treatment of breast cancer in postmenopausal women. Although letrozolc is generally well tolerated, its adverse effects on the central nervous system have been reported. The present study aimed to assess the behavioural outcomes of letrozole administra- tion in mice to determine its side effects. Methods C57BL/6J female ovariectomized mice received administration of letrozole （2.5 mg/kg per day） or vehicle by gavage for 3 weeks. Behavioural tasks were used to assess anxiety, depression, as well as learning and memory in mice. Results Letrozole-treated mice showed an increased latency to enter the inner area of the chamber on the third day of the open field test, and traveled a shorter distance in the open arms of the elevated plus maze. No significant difference was found in the light-dark box or forced swimming task between letrozole-treated and vehicle-treated mice. Besides, letrozole did not change the spontaneous alternation behaviour of mice in the Y-maze. In the Morris water maze, mice administered with letrozole exhibited an improvement in spatial learning and memory compared with the vehicle-treated mice. Conclusion Our results indicate that the inhibition of oestrogen biosynthesis results in mild anxious behaviour, which may be a consideration in the treatment of breast cancer in postmenopausal women using aromatase inhibitors.展开更多
基金financially supported by the National Natural Science Foundation of China (No.51274037)the Key Science and Technology Project of China (No.2011BAE23B00)the Cooperation Program between USTB and SINOPEC (No.112116)
文摘The 2,5-bis（ethyldisulfanyl）-l,3,4-thiadiazole （T561）, benzotriazole （BTA）,1-N, N-bis （2-ethylhexyl） aminomethyl-4-methyl-lh-benzotriazole （IRGAMET39） and I-IN, N-bis （2-ethylhexyl） aminomethyl] methyl benzotriazole （TT- LX） have been evaluated as corrosion inhibitors used in rolling oil for cold rolling of copper foil. The MRS-10A four-ball friction and wear tests have been carried out to compare their tribological properties, and the lubricating performance of rolling oils has been studied through rolling experiments. The oil sample containing IRGAMET 39 has the same PB value as that one containing T561, with the coefficient of friction increased by 35.6% and wear scar diameter decreased by 4%. The minimum rolling gauge has been studied after rolling lubrication, but the results show that inhibitors have no effect on it. Scanning electron microscopy （SEM） and energy dispersive spectrometry （EDS） analyses have indicated that the inhibitor is adsorbed on the copper surface to prevent copper from being corroded easily. In addition, the LEXT OLS4000 laser confocal microscopy has been used to observe the foil surface which shows that the streaks of foil surface are clear, the scratches are shallow and the surface failure is improved effectively.
基金supported bythe National Natural Science Foundation of China(No.30870822)
文摘Objective Letrozole, a next-generation aromatase inhibitor, has become a favored drug for the treatment of breast cancer in postmenopausal women. Although letrozolc is generally well tolerated, its adverse effects on the central nervous system have been reported. The present study aimed to assess the behavioural outcomes of letrozole administra- tion in mice to determine its side effects. Methods C57BL/6J female ovariectomized mice received administration of letrozole （2.5 mg/kg per day） or vehicle by gavage for 3 weeks. Behavioural tasks were used to assess anxiety, depression, as well as learning and memory in mice. Results Letrozole-treated mice showed an increased latency to enter the inner area of the chamber on the third day of the open field test, and traveled a shorter distance in the open arms of the elevated plus maze. No significant difference was found in the light-dark box or forced swimming task between letrozole-treated and vehicle-treated mice. Besides, letrozole did not change the spontaneous alternation behaviour of mice in the Y-maze. In the Morris water maze, mice administered with letrozole exhibited an improvement in spatial learning and memory compared with the vehicle-treated mice. Conclusion Our results indicate that the inhibition of oestrogen biosynthesis results in mild anxious behaviour, which may be a consideration in the treatment of breast cancer in postmenopausal women using aromatase inhibitors.
