“抑虑康”治疗郁证(焦虑、抑郁)的疗效观察

临床观察自拟中药“抑虑康”胶囊治疗焦虑、抑郁症疗效。采用汉密顿焦虑量表、抑郁量表积分法选择１８０例患者，设抑郁治疗组、焦虑治疗组（均服抑虑康胶囊）、抑郁对照组（服用阿米替林）、焦虑对照组（服用阿普唑仑）各４５例，观察治疗时间均为３０天。结果显示抑虑康能改善抑郁和焦虑病症，调节患者情绪，疗效优于西药对照组（Ｐ＜００１），副作用亦明显减轻。

抑虑康治疗神经性焦虑、抑郁征群90例

抑虑康治疗神经性焦虑、抑郁征群９０例山西省临汾地区癫痫病医院（０４１５０７）赵志升关键词神经性焦虑征群，神经性抑郁征群，抑虑康胶囊神经性焦虑征群与神经性抑郁征群临床上较为常见，西医多采用阿米替林、阿普唑仑等药进行治疗，由于副作用大，多数患者难以坚持。...

抑虑康治疗郁证180例疗效观察

祖国医学所指郁证是由于情志不舒、气机郁滞而引起的神经精神疾病的总称，狭义的郁证主要指情志不舒、气机不畅而引起的情绪抑郁、情绪不宁、悲伤善哭、胸胁胀痛、咽中如有异物梗阻等多种症状，其描述与现代医学神经性焦虑症、神经性抑郁症、抑郁症、更年期综合征类似［１...

抑虑康治疗郁证180例临床疗效观察

根据中医理论结合现代医学,将郁证临床表现分为焦虑、抑郁二大征群,观察自拟抑虑康胶囊对抑郁、焦虑征群的临床疗效,采用汉密顿焦虑量表(HAMA)及汉密顿抑郁量表(HASD)积分选择病例,将选择病例分为治疗抑郁组45例,治疗焦虑组45例,西药对照抑郁组45例,西药对照焦虑组45例,观察治疗时间均为30天。结果抑虑康能双方调节人体情绪,改善抑郁征群和焦虑征群症状,疗效显著优于西药对照组(P<0.01),副作用显著低于西药对照组。

我院门诊病人抑郁、焦虑状况调查分析

目的:了解我院门诊病人抑郁、焦虑发病率。方法:随即抽取我院门诊病人500例,按汉密尔顿抑郁量表(HAMD),评定总分大于等于8分为有抑郁,汉密尔顿焦虑量表(HAMA),评定总分大于14分为有焦虑。结果:500例患者中,抑郁患病率为20.6%,焦虑患病率30.6%。结论:我院门诊病人抑郁、焦虑患病率较高,临床医生应重视对其识别及处理能力。

功能性消化不良患者焦虑抑郁情绪现状和影响因素调查研究

目的调查研究功能性消化不良患者焦虑抑郁情绪现状和影响因素。方法选取我院自2013年10月至2015年10月这段时期内收治的52例功能性消化不良患者作为临床研究对象,回顾这52例患者的临床诊治资料,并对其发放填写焦虑自评量表和抑郁自评量表来调查患者的焦虑抑郁情绪情况,分析影响患者出现焦虑抑郁情绪的主要因素。结果 52例患者中出现焦虑情绪的共有28例,约占总数的53.8%,平均焦虑评分为(54.24±3.12)分;出现抑郁情绪的共有30例,约占总数的57.7%,平均抑郁评分为(55.18±3.37)分。女性、经济压力大、对疾病知识认知较浅是导致患者出现焦虑情绪的主要因素;年龄大、经济压力大是导致患者出现抑郁情绪的主要因素;另外各种生活中的不遂事件、工作负荷过重以及过度疲劳等是导致患者出现焦虑抑郁情绪的共同因素。结论功能性消化不良患者非常容易出现焦虑抑郁情绪,而焦虑抑郁情绪的产生与多种影响因素有关,因此在临床上护理人员应当给予患者具有针对性的干预措施,尽可能地避免及减少其出现焦虑抑郁情绪,以改善预后、促进疗效。

老年患者心肌梗死健康知识与健康功能损失及情绪的相关性分析

目的了解老年患者心肌梗死健康知识与健康功能损失及情绪的关系。方法应用健康知识达标问卷、疾病影响程度测定表及焦虑自评量表和抑郁自评量表对70例住院治疗的老年心肌梗死患者进行调查。结果老年患者心肌梗死健康知识评分较低,健康功能各个维度均呈现不同程度的损失;其健康知识与健康功能损失总分及各维度评分呈显著负相关(均P<0.01),与焦虑和抑郁评分呈显著负相关(均P<0.01)。结论老年心肌梗死患者健康知识不容乐观,应采取针对性护理干预,提高其知识水平,减少其健康功能损失程度,减轻其焦虑和抑郁水平。

急诊患者心理评估及护理探讨

目的探讨急诊患者的心理特点及护理方法而达到优质护理目的。方法应用汉密顿抑郁量表和汉密顿焦虑量表调查和自行设计的调查问卷对120名急诊患者心理状态进行调查分析。结果急诊患者存在明显的焦虑、抑郁心理,恐惧、担心、焦虑、紧张、急躁等是急诊患者常见的心理反应。结论通过对急诊患者心理状态分析,针对急诊患者心理特点采取心理护理措施,达到消除急诊患者不良的心理反应,使其主动配合治疗,促进身心健康。

黛力新在双心疾病治疗中的疗效观察

目的研究双心疾病患者应用氟哌噻吨美利曲辛片(商品名:黛力新)治疗对改善患者临床症状的疗效观察。方法68例双心疾病患者,采用随机抽样方式分为对照组和观察组,每组34例。对照组患者予以心血管疾病常规治疗、心理行为治疗以及心脏康复锻炼,观察组患者在对照组基础上加用黛力新治疗。对比两组患者临床效果、治疗前后综合医院焦虑抑郁情绪测定表(HAD)评分、不良反应发生情况。结果观察组临床治疗总有效率97.06%高于对照组的79.41%,差异具有统计学意义(P<0.05)。治疗后,两组焦虑情绪评分、抑郁情绪评分均较治疗前降低,且观察组焦虑情绪评分、抑郁情绪评分均较对照组下降更明显,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论双心疾病患者在常规治疗基础上联合应用黛力新治疗能够取得较为理想的治疗效果,值得在临床中广泛应用。

攻治癫痫病的名医——记山西临汾地区癫痫病医院院长赵志升

久闻山西临汾有位医治癫痫病的高手赵志升先生,笔者拨通了电话(0357)3631018进行了电话采访。 癫痫、精神病均是常见的神经系统疾病,亦属使医生头痛的顽疾。癫痫发病时,患者口吐白沫、四肢抽搐、不省人事;精神病发作时,患者蓬头垢面、胡言乱语、丧失常人理智。这两种疾病都为世界医学疑难病,较难根治。患者往往都以“复发——住院——再复发——再住院”的不良循环往复遭受着“病魔”的折磨和摧残。这两个危害人类健康的“大敌”,使多少人的青春被它断送;多少人的梦幻被它破碎;又有多少个家庭被它蒙上难以消失的阴影,无数病人付出巨资和精力常年奔波为求得病情好转。患者、家人做梦都在企盼着有“灵丹妙药”和“克星”的降临。

Prevalence and correlates of lifestyle behavior,anxiety and depression in Chinese college freshman:A cross-sectional survey

Objectives:First-year college students had exposure to unhealthy lifestyle behaviors that correlate with a high prevalence of anxiety and depression.Regarding to the modifiable lifestyle behaviors factors,this study investigated the prevalence and correlation of multiple lifestyle behaviors,anxiety and depression in a sample of Chinese first-year college students.Methods:Cross-sectional data were extracted from Residents eHealth app of health lifestyle behaviors survey from September to October 2019.Anxiety,depression,eating regular meals,consumption of snacks in-between meals,consumption of fruit,dessert and sugar-sweetened beverages,smoking and secondhand smoke exposure,consuming alcohol,physical activity,sedentary time were assessed by self-report.Socio-demographic including age,gender,education,family income,religion,and health condition were captured.Logistic regression was used to explore the association of multiple lifestyle behaviors,anxiety and depression.Results:Totally 1,017 participants were included in the study.The prevalence of anxiety and depression(from mild to severe) were 40.3% and 45.3%,respectively.In multivariable analyses,religion (believe in Buddhism,OR =2.438,95%CI:1.097-5.421;believe in Christian,OR =5.886,95%CI:1.604-21.597),gender (Female,OR =1.405,95%CI:1.001-1.971),secondhand smoke exposure (OR =1.089,95%CI:1.001-1.184),and eating regular meals (OR =0.513,95%C1:0.346-0.759) were associated with anxiety.Family income (OR =0.732,95%CI:0.596-0.898),eating regular meals (OR =0.641,95%CI:0.415-0.990),frequency of breakfast (OR =0.813,95%CI:0.690-0.959),with a chronic disease (OR =1.902,95%CI:1.335-2.712),and consumption of nocturnal snack (OR =1.337,95%CI:1.108-1.612) were associated with depression.Conclusions:These results highlighted the need for early lifestyle behavior intervention,especially modifying diet patterns considering the background of religion,health condition,and social-economic status in first-year college students to improve their mental health.

Prevalence of depressive and anxiety disorders in Chinese gastroenterological outpatients

AIM:To investigate the prevalence and physicians' detection rate of depressive and anxiety disorders in gastrointestinal(GI)outpatients across China. METHODS:A hospital-based cross-sectional survey was conducted in the GI outpatient departments of 13 general hospitals.A total of 1995 GI outpatients were recruited and screened with the Hospital Anxiety and Depression Scale(HADS).The physicians of the GI departments performed routine clinical diagnosis and management without knowing the HADS score results.Subjects with HADS scores≥8 were subsequently interviewed by psychiatrists using the Mini International Neuropsy-chiatric Interview(MINI)to make further diagnoses. RESULTS:There were 1059 patients with HADS score ≥8 and 674(63.64%)of them undertook the MINI interview by psychiatrists.Based on the criteria of Diagnostic and Statistical Manual of Mental Disorders (4th edition),the adjusted current prevalence for depressive disorders,anxiety disorders,and comorbidity of both disorders in the GI outpatients was 14.39%, 9.42%and 4.66%,respectively.Prevalence of depressive disorders with suicidal problems[suicide attempt or suicide-related ideation prior or current;module C (suicide)of MINI score≥1]was 5.84%in women and 1.64%in men.The GI physicians'detection rate of depressive and anxiety disorders accounted for 4.14%. CONCLUSION:While the prevalence of depressive and anxiety disorders is high in Chinese GI outpatients, the detection rate of depressive and anxiety disorders by physicians is low.

Retrospective analysis of exercise capacity in patients with coronary artery disease after percutaneous coronary intervention or coronary artery bypass graft

Objectives:To describe the current state of exercise capacity as well as to identify its predictors in patients with coronary artery disease (CAD) following percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) in the mainland of China.Methods:A retrospective study design was employed.We evaluated 230 CAD patients following PCI or CABG in a cardiac rehabilitation center from January 2019 to October 2019.The patients were referred to undergo incremental cardiopulmonary exercise testing with a cycle ergometer.The Zung Self-Rating Anxiety Scale and the Zung Self-Rating Depression Scale were used to evaluate patients' mental health.Statistical analysis was performed using the chi-square test,Fisher's exact test,t-test,Mann-Whitney U test,and binary logistic regression.Results:Among the 230 patients,223 patients demonstrated reduced exercise capacity.Resutlts of the logistic regression analysis showed that anxiety (OR =1.13,95% CI 1.01-1.32,P =0.029) was an independent risk factor for reduced exercise capacity in patients following the PCI or CABG.Conclusions:Exercise capacity of Chinese CAD patients after PCI or CABG was relatively poor.Alleviating symptoms of anxiety and making exercise prescriptions according to the results of the cardiopulmonary exercise test should be considered during the intervention to improve CAD patients' exercise capacity.

Analysis of the application of Chinese medicine nursing technology in obstetrics

Objective:To analyze the application value of traditional Chinese medicine(TCM)nursing technology in obstetrics.Methods:204 patients with obstetrics were enrolled in the study and entered into the Chinese medicine group and thereference group according to the random number(n=102).The reference group received routine care,and the Chinesemedicine group received Chinese medicine nursing.The anxiety and depression scores of the two groups of patientsand the patient's nursing satisfaction status were compared.Results:There was no difference in the scores betweenthe pre-treatment groups.The value of the reduction in anxiety and depression scores in the TCM group wassignificantly higher than that in the reference group.The numerical comparison was statistically significant(P<0.05).The comprehensive nursing satisfaction rate of patients in the Chinese medicine group was 99.02%,and the comprehensivenursing satisfaction rate of the reference group was 80.39%.The numerical comparison was statistically significant(P<0.05).Conclusion:The application of TCM nursing technology in obstetrics helps to improve the negativeemotions of patients and improve the overall satisfaction rate of patients.The value of nursing intervention is higher

Clinical evaluation of Xiaoyao Jieyu prescription in the treatment of persistent postural-perceptual dizziness

Objective： The objective of this study is to evaluate the clinical efficacy of Xiaoyao Jieyu prescription （XJP） in the treatment of persistent postural-perceptual dizziness （PPPD）. Methods： A total of 33 PPPD patients were randomly divided into test group and control group. Two groups of patients were given psychological treatment. The test group was given XJP and the control group was given escitalopram. The course of treatment was 12 weeks. Before and after 4 weeks and 8 weeks and 12 weeks, the dizziness handicap inventory （DHI）, Hamilton anxiety scale （HAMA） and Hamilton Depression scale （HAMD） were used to evaluate the treatment effect. Results： The total scores of HAMA, HAMD, DHI and the respective factor scores of DHI significantly decreased in both groups after 4 weeks of treatment compared with those before the treatment （P 〈 0.01）. The DHI scores and the score of function, physiology at 8-week, 12-week, as well as the HAMA and HAMD scores at 4-week, 8-week, 12-week in the test group were significantly lower than those in the control group （P 〈 0.05）. The incidence of adverse reactions in the test group was significantly lower than the control group （P 〈 0.05）. Conclusion： XJP can improve the clinical symptoms of patients with PPPD. It can both improve the physical and functional symptoms of PPPD and reduce anxiety and depression. In the course of treatment, the adverse reaction of the prescription is less and mild. It has the advantages of high efficiency, safety, low price and easy access to materials.

Depression, anxiety, and cardiac morbidity outcomes after coronary artery bypass surgery： a contemporary and practical review

Research to date indicates that the number of coronary artery bypass graft （CABG） surgery patients affected by depression （i.e., major, minor, dysthymia） approximates between 30% and 40% of all cases. A longstanding empirical interest on psychosocial factors in CABG surgery patients highlights an association with increased risk of morbidity in the short and longer term. Recent evidence suggests that both depression and anxiety increase the risk for mortality and morbidity after CABG surgery independent of medical factors, although the behavioral and biological mechanisms are poorly understood. Though neither depression nor anxiety seem to markedly affect neuropsy- chological dysfunction, depression confers a risk for incident delirium. Following a comprehensive overview of recent literature, practical advice is described for clinicians taking into consideration possible screening aids to improve recognition of anxiety and depression among CABG surgery patients. An overview of contemporary interventions and randomized, controlled trials are described, along with suggestions for future CABG surgery research.

Clinical observation of acupuncture combined with medication for mild-to-moderate depression

Objective:To discuss the clinical efficacy and plausible mechanism of Tiao Yang Qu Xie(regulating Yang to eliminate pathogenic factors)needling method plus paroxetine in treating mild-to-moderate depression.Methods:Sixty-six patients with mild-to-moderate depression were divided into an observation group and a control group using the random number table method,each consisting of 33 cases.Another 25 healthy subjects were recruited as a healthy group.The control group took oral paroxetine tablets for treatment,and the observation group received additional acupuncture treatment 3 times weekly.Both groups underwent 4-week treatment.Before treatment,after 2-week and 4-week treatment,and 2 weeks after treatment(follow-up),the patients were assessed using the Hamilton depression scale-17-item(HAMD-17),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and traditional Chinese medicine(TCM)pattern element identification scale for depression.The two groups each randomly contributed 25 cases to detect the protein content of brain-derived neurotrophic factor(BDNF)before treatment and after 4-week treatment,and compared with the healthy group.Results:After 2-week treatment,the markedly effective and total effective rates were significantly higher in the observation group than in the control group(P<0.05);after 4-week treatment,the observation group significantly surpassed the control group in comparing the markedly effective rate(P<0.05).After 2 and 4 weeks of treatment and at the follow-up,the HAMD-17 total score and sleep disorder factor score were lower in the observation group than in the control group(P<0.05);the anxiety-somatic score was lower in the observation group than in the control group after 2-week treatment(P<0.05).After 2 and 4 weeks of treatment and at the follow-up,the observation group was lower than the control group in comparing the scores of SDS,SAS,and TCM pattern element identification scale for depression(P<0.05).After 4-week treatment,the observation group had an increased serum BDNF protein content,higher than that in the control group(P<0.05)and had no significant difference compared to the healthy group(P>0.05).Conclusion:Compared to the use of oral paroxetine alone,acupuncture plus paroxetine can produce more significant efficacy in treating mild-to-moderate depression and act faster in improving sleep disorder and anxiety-somatic symptoms;increasing the serum BDNF protein content may be a part of the mechanism underlying its antidepressant actions.

Effectiveness of a theory-based tailored mHealth physical activity intervention for women undergoing chemotherapy for breast cancer:A quasi-experimental study

Objectives:This study aimed to explore the effectiveness of the theory-based tailored mHealth physical activity(PA)intervention among patients with breast cancer undergoing chemotherapy.Methods:A quasi-experimental study design was adopted.A total of 60 breast cancer patients were selected from two tertiary hospitals in Shanghai and Hangzhou City from September 2019 to August 2021.According to the admission order,30 patients werefirst included in the control group,followed by 30 patients in the intervention group.A smartphone application(app)named“Breast Care”was developed based on social cognitive theory,self-efficacy theory,and the theory of planned behavior.The app integrated various functions,including information browsing,PA monitoring and feedback,symptom reporting,and social interaction.Patients in the intervention group received three months of personalized online PA guidance in addition to routine care.The control group received routine care.Baseline and post-intervention investigations after three months were conducted in two groups using the Short Form of International Physical Activity Questionnaire,the Hospital Anxiety and Depression Scale,and the Functional Assessment of Cancer TherapydBreast cancer.Results:After three months of intervention,compared to the control group,breast cancer patients in the intervention group showed significant improvements in walking,moderate PA,and overall PA(P<0.05).Compared to the baseline data,breast cancer patients in the intervention group had significant improvements in walking and overall PA after three months(P<0.05),whereas the control group experienced significant declines in walking,moderate PA,and overall PA after three months(P<0.05).There were statistically differences between the two groups in scores for anxiety,overall quality of life,and its dimensions,such as physical well-being,emotional well-being,and additional breast cancer well-being(P<0.05).Conclusions:The theory-based tailored mHealth PA intervention has demonstrated a positive impact on promoting PA behavior change and emotional management among breast cancer patients.The‘Breast Care’app integrated various practical behavior change strategies,offering valuable guidance for personalized remote rehabilitation support for cancer patients.

急诊患者心理护理方法的研究进展研究

目的研究针对急诊患者使用心理护理的临床应用价值。方法通过问卷调查法收集316名急诊患者的心理状态,以汉密顿抑郁量表和汉密顿焦虑量表作为心理护理应用效果的评判标准,对比分析患者在抑郁和焦虑方面的具体表现,从而得出心理护理的临床应用价值。结果急诊患者通常存在焦虑,抑郁,恐惧,担心等各类负面情绪,依据急诊患者的心理特征分析结果实施心理护理能够显著改善患者的心理状态。结论通过分析急诊患者心理状态的方式得出其心理特征,并采取针对性的心理护理措施,用于消除急诊患者的不良心理反应。提高患者的治疗依从性。因此心理护理方式值得在临床上进行推广应用。

Inhibition of oestrogen biosynthesis induces mild anxiety in C57BL/6J ovariectomized female mice

Objective Letrozole, a next-generation aromatase inhibitor, has become a favored drug for the treatment of breast cancer in postmenopausal women. Although letrozolc is generally well tolerated, its adverse effects on the central nervous system have been reported. The present study aimed to assess the behavioural outcomes of letrozole administra- tion in mice to determine its side effects. Methods C57BL/6J female ovariectomized mice received administration of letrozole （2.5 mg/kg per day） or vehicle by gavage for 3 weeks. Behavioural tasks were used to assess anxiety, depression, as well as learning and memory in mice. Results Letrozole-treated mice showed an increased latency to enter the inner area of the chamber on the third day of the open field test, and traveled a shorter distance in the open arms of the elevated plus maze. No significant difference was found in the light-dark box or forced swimming task between letrozole-treated and vehicle-treated mice. Besides, letrozole did not change the spontaneous alternation behaviour of mice in the Y-maze. In the Morris water maze, mice administered with letrozole exhibited an improvement in spatial learning and memory compared with the vehicle-treated mice. Conclusion Our results indicate that the inhibition of oestrogen biosynthesis results in mild anxious behaviour, which may be a consideration in the treatment of breast cancer in postmenopausal women using aromatase inhibitors.