LncRNA-疾病关联预测的计算方法是解决传统生物学实验昂贵且费时的有效途径,其中基于机器学习的计算方法是当前研究热点,但其存在着未充分考虑lncRNA-疾病关联矩阵的局部结构和全局结构的问题.因此,本文提出了一种lncRNA与疾病潜在关联...LncRNA-疾病关联预测的计算方法是解决传统生物学实验昂贵且费时的有效途径,其中基于机器学习的计算方法是当前研究热点,但其存在着未充分考虑lncRNA-疾病关联矩阵的局部结构和全局结构的问题.因此,本文提出了一种lncRNA与疾病潜在关联的多层线性投影预测方法(MLPLDA:Multi-layer linear projection for predicting lncRNA-disease association).MLPLDA利用组合加权整合lncRNA和疾病的两种相似性,然后用WKNKN重构原始的lncRNA-疾病关联矩阵,最后使用堆叠层策略的多层线性投影进行lncRNA-疾病关联预测.在留一和五折交叉验证实验中,MLPLDA获得的AUC分别是0.8807和0.8563±0.0045,体现了其可靠的性能.在3种疾病(肺癌,乳腺癌和骨肉瘤)的案例研究中,MLPLDA能够有效预测与3种疾病有关系的lncRNA.展开更多
The optimal selection of schemes of water transportation projects is a process of choosing a relatively optimal scheme from a number of schemes of water transportation programming and management projects, which is of ...The optimal selection of schemes of water transportation projects is a process of choosing a relatively optimal scheme from a number of schemes of water transportation programming and management projects, which is of importance in both theory and practice in water resource systems engineering. In order to achieve consistency and eliminate the dimensions of fuzzy qualitative and fuzzy quantitative evaluation indexes, to determine the weights of the indexes objectively, and to increase the differences among the comprehensive evaluation index values of water transportation project schemes, a projection pursuit method, named FPRM-PP for short, was developed in this work for selecting the optimal water transportation project scheme based on the fuzzy preference relation matrix. The research results show that FPRM-PP is intuitive and practical, the correction range of the fuzzy rained is both stable and accurate; preference relation matrix A it produces is relatively small, and the result obtherefore FPRM-PP can be widely used in the optimal selection of different multi-factor decision-making schemes.展开更多
This paper proposes the concept of projection curves based on the theory of CT image reconstruction to probe the internal structure of the working panel prior to formal mining of the working panel.As well as reducing ...This paper proposes the concept of projection curves based on the theory of CT image reconstruction to probe the internal structure of the working panel prior to formal mining of the working panel.As well as reducing costs,this method provides safe and efficient excavation of the working panel.According to the results of the numerical model and the actual working panel,the new method has been proven to be accurate in detecting the location of the fault that extends into the face.Concealed faults of the internal working panel,as well as the start and end points of the fault,can be detected by this method.Engineering practice has proven that the method is highly reliable,has a highly decisive impact on faults for coal mining,and can be used to guide the safe mining of the working panel.展开更多
The performance of climate models in simulating the linkage of the spring Hadley circulation (HC) to the vertical zonal wind shear and atmospheric divergence in the lower and upper troposphere, which are related to th...The performance of climate models in simulating the linkage of the spring Hadley circulation (HC) to the vertical zonal wind shear and atmospheric divergence in the lower and upper troposphere, which are related to the tropical cyclone frequency over the western North Pacific (WNPTCF) during June-September (JJAS), is evaluated on the basis of the 20th century climate simulations (20C3M). It is found that four models can simulta-neously reproduce the pattern revealed in the observation, with the spring HC in the Northern Hemisphere being positively correlated to the vertical zonal wind shear in the major tropical cyclone (TC) genesis region and negatively (positively) correlated to the atmospheric diver- gence in the upper (lower) troposphere over the western North Pacific (WNP) in the following JJAS. These four models are further used to project their relationship in the late 21st century under the A1B scenario. The results show that the association of spring HC with the vertical zonal wind shear and the upper-and lower-tropospheric divergence over the WNP will weaken in the late 21st century, thereby resulting in a weak relationship between the spring HC and the JJAS WNPTCF.展开更多
文摘LncRNA-疾病关联预测的计算方法是解决传统生物学实验昂贵且费时的有效途径,其中基于机器学习的计算方法是当前研究热点,但其存在着未充分考虑lncRNA-疾病关联矩阵的局部结构和全局结构的问题.因此,本文提出了一种lncRNA与疾病潜在关联的多层线性投影预测方法(MLPLDA:Multi-layer linear projection for predicting lncRNA-disease association).MLPLDA利用组合加权整合lncRNA和疾病的两种相似性,然后用WKNKN重构原始的lncRNA-疾病关联矩阵,最后使用堆叠层策略的多层线性投影进行lncRNA-疾病关联预测.在留一和五折交叉验证实验中,MLPLDA获得的AUC分别是0.8807和0.8563±0.0045,体现了其可靠的性能.在3种疾病(肺癌,乳腺癌和骨肉瘤)的案例研究中,MLPLDA能够有效预测与3种疾病有关系的lncRNA.
基金The authors would like to acknowledge the funding support of the National Natural Science Foundation of China （Nos. 50579009, 70425001 ） the National 10th Five Year Scientific Project of China for Tackling the Key Problems （2004BA608B-02-02）the Excellence Youth Teacher Sustentation Fund Program of the Ministry of Education of China （Department of Education and Personnel [ 2002 ] 350）.
文摘The optimal selection of schemes of water transportation projects is a process of choosing a relatively optimal scheme from a number of schemes of water transportation programming and management projects, which is of importance in both theory and practice in water resource systems engineering. In order to achieve consistency and eliminate the dimensions of fuzzy qualitative and fuzzy quantitative evaluation indexes, to determine the weights of the indexes objectively, and to increase the differences among the comprehensive evaluation index values of water transportation project schemes, a projection pursuit method, named FPRM-PP for short, was developed in this work for selecting the optimal water transportation project scheme based on the fuzzy preference relation matrix. The research results show that FPRM-PP is intuitive and practical, the correction range of the fuzzy rained is both stable and accurate; preference relation matrix A it produces is relatively small, and the result obtherefore FPRM-PP can be widely used in the optimal selection of different multi-factor decision-making schemes.
基金supported by the National Natural Science Foundation of China general Projects(No.51174193)the Youth Fund Project of the National Natural Science Foundation of China(No.51004102)the National High Technology Research and Development Program of China(No.2012AA062101)
文摘This paper proposes the concept of projection curves based on the theory of CT image reconstruction to probe the internal structure of the working panel prior to formal mining of the working panel.As well as reducing costs,this method provides safe and efficient excavation of the working panel.According to the results of the numerical model and the actual working panel,the new method has been proven to be accurate in detecting the location of the fault that extends into the face.Concealed faults of the internal working panel,as well as the start and end points of the fault,can be detected by this method.Engineering practice has proven that the method is highly reliable,has a highly decisive impact on faults for coal mining,and can be used to guide the safe mining of the working panel.
基金supported by the National Basic Research Program of China(2009CB421407)the National Natural Science Foundation of China(41275078)the Special Fund for Public Welfare Industry (Meteorology) (GYHY200906018)
文摘The performance of climate models in simulating the linkage of the spring Hadley circulation (HC) to the vertical zonal wind shear and atmospheric divergence in the lower and upper troposphere, which are related to the tropical cyclone frequency over the western North Pacific (WNPTCF) during June-September (JJAS), is evaluated on the basis of the 20th century climate simulations (20C3M). It is found that four models can simulta-neously reproduce the pattern revealed in the observation, with the spring HC in the Northern Hemisphere being positively correlated to the vertical zonal wind shear in the major tropical cyclone (TC) genesis region and negatively (positively) correlated to the atmospheric diver- gence in the upper (lower) troposphere over the western North Pacific (WNP) in the following JJAS. These four models are further used to project their relationship in the late 21st century under the A1B scenario. The results show that the association of spring HC with the vertical zonal wind shear and the upper-and lower-tropospheric divergence over the WNP will weaken in the late 21st century, thereby resulting in a weak relationship between the spring HC and the JJAS WNPTCF.
