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球后注射8-氯腺苷后眼内药代动力学研究 被引量:2
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作者 卢海 张惠蓉 《眼科研究》 CSCD 北大核心 2001年第5期426-428,共3页
观察新型抗代谢药物8-氯腺苷球后注射后眼内的分布情况,以探讨该药物用于视网膜和脉络膜新生血管性病变治疗的可行性。方法 采用高效液相色谱分析法分别测定单次球后注射及反复多次球后注射8-氯腺苷后,眼内的药物分布情况。结果 ... 观察新型抗代谢药物8-氯腺苷球后注射后眼内的分布情况,以探讨该药物用于视网膜和脉络膜新生血管性病变治疗的可行性。方法 采用高效液相色谱分析法分别测定单次球后注射及反复多次球后注射8-氯腺苷后,眼内的药物分布情况。结果 单次球后注射8-氯腺苷后,眼后段的各组织中均检测到不同浓度的8-氯腺苷以及其代谢产物8-氯腺瞟呤。反复多次球后注射8-氯腺苷后未见蓄积效应。结论 球后注射8-Cl-A后,该药在眼后段具有良好的分布。多次应用眼内无明显的蓄积作用。 展开更多
关键词 8-氯腺苷 药代动力学 抗代谢剂 眼科药物
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氟尿嘧啶靶向给药系统 被引量:1
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作者 张志清 王瑞琴 田彩锁 《中国药师》 CAS 2002年第4期236-238,共3页
氟尿嘧啶(Fluorouracil,Fu)为临床应用最广的抗代谢药物,对消化道癌及其他实体瘤有良好疗效.氟尿嘧啶有较强的毒副作用,可引起骨髓抑制、消化道反应等.近年来,国内外对氟尿嘧啶靶向给药系统进行了研究,旨在使氟尿嘧啶聚集靶部位,增强氟... 氟尿嘧啶(Fluorouracil,Fu)为临床应用最广的抗代谢药物,对消化道癌及其他实体瘤有良好疗效.氟尿嘧啶有较强的毒副作用,可引起骨髓抑制、消化道反应等.近年来,国内外对氟尿嘧啶靶向给药系统进行了研究,旨在使氟尿嘧啶聚集靶部位,增强氟尿嘧啶的疗效并降低其全身毒副作用. 展开更多
关键词 氟尿嘧啶 靶向给药系统 微球 脂质体 植入 纳米粒 抗代谢剂
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吉西他滨救治耐药晚期乳腺癌临床进展 被引量:1
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作者 乔华 包兴才 《河南肿瘤学杂志》 2003年第6期461-463,共3页
关键词 吉西他滨 耐药 晚期乳腺癌 临床研究 抗代谢剂 化学疗法
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弓形虫病的治疗 被引量:16
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作者 甘绍伯 《中国抗感染化疗杂志》 2001年第2期118-120,共3页
关键词 弓形虫病 药物治疗 叶酸代谢 生素 免疫治疗 治疗指征 联合用药
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NATIONAL SURVEY OF ANTIMETABOLITE USE IN GLAUCOMA SURGERY IN THE UNITED KINGDOM
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作者 D.Siriwardena B.Edmunds +1 位作者 R.P.L.Wormald P.T.Khaw 《国际眼科杂志》 CAS 2003年第1期37-37,共1页
Purpose: To assess the pattern of antimetabolite use in tra-beculectomy surgery by all consultant ophthalmologists in the U-nited Kingdom (UK). Methods: A postal questionnaire of twelve questions regarding antimetabol... Purpose: To assess the pattern of antimetabolite use in tra-beculectomy surgery by all consultant ophthalmologists in the U-nited Kingdom (UK). Methods: A postal questionnaire of twelve questions regarding antimetabolite use in trabeculectomy surgery was sent to all 749 consultant ophthalmologists in the UK. The consultants were asked to estimate the number of trabeculec- 展开更多
关键词 英国 青光眼 外科手术 眼科医师 抗代谢剂 应用 调查
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CURRENT STATUS OF COMBINED CATARACT AND GLAUCOMA PROCE-DURES
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作者 K.F.Tomey 《国际眼科杂志》 CAS 2003年第1期90-91,共2页
Combining cataract extraction with glaucoma surgery is a widely accepted option nowadays for managing eyes with coexisting cataract and glaucoma. With the modern small-incision techniques, the success of filtration co... Combining cataract extraction with glaucoma surgery is a widely accepted option nowadays for managing eyes with coexisting cataract and glaucoma. With the modern small-incision techniques, the success of filtration continues to improve, and the incidence of complications has decreased signicantly. In 展开更多
关键词 白内障 青光眼 联合手术 小切口 抗代谢剂
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世纪回眸话巨变
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《德国临床用药》 2001年第1期4-8,共5页
关键词 感染药 胰岛素 洋地黄 药物设计 血管紧张素抑制 抗代谢剂 基因技术
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Provenance-specific ecophysiological responses to drought in Cunninghamia lanceolata
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作者 Shuang Gao Ze-Yu Cai +2 位作者 Cong-Cong Yang Jian-Xun Luo Sheng Zhang 《Journal of Plant Ecology》 SCIE CSCD 2021年第6期1060-1072,共13页
Aims Cunninghamia lanceolata is one of the most important coniferous species in southern China,but its high sensitivity to drought restricts its expansion.Understanding the intraspecific variation of physiological res... Aims Cunninghamia lanceolata is one of the most important coniferous species in southern China,but its high sensitivity to drought restricts its expansion.Understanding the intraspecific variation of physiological responses to drought can help us manage this plantation better.Methods We selected 3-year-old seedlings of C.lanceolata,which originated from the low precipitation(LP),middle precipitation(MP)and high precipitation(HP)habitats,respectively.Seedlings were grown under drought stress(20%of soil volumetric water content)for 40 days.The ecophysiological responses and adaptive strategies with different drought tolerance were investigated.Important Findings LP provenance possessed the best tolerance to drought stress,suggesting that considerably increased carbohydrates and nitrogen-containing compounds as osmotic protective materials,which were driven by fast carbon and nitrogen metabolisms.In addition,the highest peroxidase activity could effectively eliminate hydrogen peroxide in drought-stressed LP provenance.The MP provenance reserved a large amount of non-structural carbohydrates,which may act as a certain buffer for encountering drought stress.Importantly,timely closure of stomata to reduce needle transpiration when encountering a water deficiency would help them adapt to long-term drought.MP provenance adopted a conservative water-saving strategy.However,HP provenance regulated root growth(increased root/shoot ratio)and reduced penetration potential to help them absorb water.The different strategies among provenances may be related to the long-term domestication of the geographical environments.Therefore,our results underline the importance of provenance-specific responses to drought stress.It is highly significant to accelerate the selection of drought-resistant germplasms and to cultivate high-yield plantations in the future. 展开更多
关键词 Chinese fir DROUGHT PHYSIOLOGY provenance-specific ANTIOXIDANTS carbon and nitrogen metabolisms
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