To develop a new method of inducing mdrl multidrug resistance by establishinga nude mice model of orthotopic transplantation of liver carcinoma by sporadic abdominalchemotherapy at intervals. Methods: Hepatocellular c...To develop a new method of inducing mdrl multidrug resistance by establishinga nude mice model of orthotopic transplantation of liver carcinoma by sporadic abdominalchemotherapy at intervals. Methods: Hepatocellular carcinoma HepG2 cell was cultured and injectedsubcutaneously to form the tumor-supplying mice. The tumor bits from the tumor-supplying mice wereimplanted under the envelope of the mice liver and induced by abdominal chemotherapy withPharmorubicin. Physical examination, ultrasonography, spiral CT and operative inspection were usedto examine tumor progression. RT-PCR and immunohistochemistry were adopted to detect the expressionof mdr1-mRNA and its encoded protein P-gp protein (P-gp). Results: There was no operative dead, therate of implanting tumor successfully was 88% (22/25), the rate of implanting secondly successfullywas 100% (3/3), and the rate of inducing successfully was 80% (16/20). The expression of mdrl-mRNAand the P-gp in the inducing group was 23 folds and 13 folds in the control group respectively.Conclusion: We have established an in vivo model of mdr using nude mice transplanted with orthotopicliver neoplasm coupled to chemotherapy.展开更多
Nested Newmark model(NNM) is a conceptual framework to assessing post-earthquake movements including dispersed shear movements. The original NNM omits that the tensile stresses would be encountered in slopes induced b...Nested Newmark model(NNM) is a conceptual framework to assessing post-earthquake movements including dispersed shear movements. The original NNM omits that the tensile stresses would be encountered in slopes induced by earthquakes. The purpose of this study is to introduce the tensile strength cut-off and the relevant failure mechanism into NNM and conduct the limit analysis to determine the seismic displacement. Parametric studies are carried out to further investigate the influence of the tensile strength and input ground motions on permanent displacement. Neglecting the tensile strength can underestimate the permanent displacements of slopes. As the peak acceleration increases, the underestimation becomes more significant. With the reduction of tensile strength, much larger deformation occurs next to the slope crest. Although the present results are limited to an example, the method is of value in practice to predict the post-earthquake profile of slope.展开更多
Effect of soil displacement on friction single pile in the cases of tunneling,surcharge load and uniform soil movement was discussed in details with finite element method.Lateral displacement of the pile caused by soi...Effect of soil displacement on friction single pile in the cases of tunneling,surcharge load and uniform soil movement was discussed in details with finite element method.Lateral displacement of the pile caused by soil displacement reached about 90% of the total displacement,which means that P-Δ effect of axial load can be neglected.The maximum moment of pile decreased from 159 kN·m to 133 kN·m in the case of surcharge load when the axial load increased from 0 to the ultimate load.When deformation of pile caused by soil displacement is large,axial load applied on pile-head plays the role of reducing the maximum bending moment in concrete pile to some extent.When pile is on one side of the tunnel,soil displacements around the pile are all alike,which means that the soil pressures around the pile do not decrease during tunneling.Therefore,Q-s curve of the pile affected by tunneling is very close to that of pile in static loading test.Bearing capacities of piles influenced by surcharge load and uniform soil movement are 2480 kN and 2630 kN,respectively,which are a little greater than that of the pile in static loading test(2400 kN).Soil pressures along pile increase due to surcharge load and uniform soil movement,and so do the shaft resistances along pile,as a result,when rebars in concrete piles are enough,bearing capacity of pile affected by soil displacement increases compared with that of pile in static loading test.展开更多
Scale effect is one of the important aspects in the macro mechanical parame- ters’ research of rock mass, from a new point of view, by means of lab and field rock me- chanics test, establishment of E^Vp relation, cla...Scale effect is one of the important aspects in the macro mechanical parame- ters’ research of rock mass, from a new point of view, by means of lab and field rock me- chanics test, establishment of E^Vp relation, classification of engineering rock mass, nu- merical simulation test and back analysis based on surrounding rock’s displacement monitoring results of Shuibuya Project’s underground power station, rock mass deforma- tion module’s size effect of surrounding rock of Shuibuya Project’s undegroud power sta- tion was studied. It’s shown that rock mass deformation module’s scale effect of sur- rounding rock of Shuibuya Project’s undeground power station is obvious, the rock mass deformation module to tranquilization is 20% of intact rock’s. Finally the relation between rock mass deformation modules and the scale of research was established.展开更多
The seismic behavior of masonry bell-towers located in Corfu, Greece, is considered since constructions of this kind are particularly vulnerable to seismic loadings. Dynamics analyses for different total heights of Co...The seismic behavior of masonry bell-towers located in Corfu, Greece, is considered since constructions of this kind are particularly vulnerable to seismic loadings. Dynamics analyses for different total heights of Corfu bell-towers and according to the seismic data of this region are carried out. A diagram of displacements is determined. The impact of the percentages of damping in the distribution of displacements is examined.展开更多
基金This project was supported by a grant from the Medical Science and Technique Foundation of Ministry of Health of China(No. Wkz-2000-1-15).
文摘To develop a new method of inducing mdrl multidrug resistance by establishinga nude mice model of orthotopic transplantation of liver carcinoma by sporadic abdominalchemotherapy at intervals. Methods: Hepatocellular carcinoma HepG2 cell was cultured and injectedsubcutaneously to form the tumor-supplying mice. The tumor bits from the tumor-supplying mice wereimplanted under the envelope of the mice liver and induced by abdominal chemotherapy withPharmorubicin. Physical examination, ultrasonography, spiral CT and operative inspection were usedto examine tumor progression. RT-PCR and immunohistochemistry were adopted to detect the expressionof mdr1-mRNA and its encoded protein P-gp protein (P-gp). Results: There was no operative dead, therate of implanting tumor successfully was 88% (22/25), the rate of implanting secondly successfullywas 100% (3/3), and the rate of inducing successfully was 80% (16/20). The expression of mdrl-mRNAand the P-gp in the inducing group was 23 folds and 13 folds in the control group respectively.Conclusion: We have established an in vivo model of mdr using nude mice transplanted with orthotopicliver neoplasm coupled to chemotherapy.
基金Projects(41630638,51878248)supported by the National Natural Science Foundation of China
文摘Nested Newmark model(NNM) is a conceptual framework to assessing post-earthquake movements including dispersed shear movements. The original NNM omits that the tensile stresses would be encountered in slopes induced by earthquakes. The purpose of this study is to introduce the tensile strength cut-off and the relevant failure mechanism into NNM and conduct the limit analysis to determine the seismic displacement. Parametric studies are carried out to further investigate the influence of the tensile strength and input ground motions on permanent displacement. Neglecting the tensile strength can underestimate the permanent displacements of slopes. As the peak acceleration increases, the underestimation becomes more significant. With the reduction of tensile strength, much larger deformation occurs next to the slope crest. Although the present results are limited to an example, the method is of value in practice to predict the post-earthquake profile of slope.
基金Project(51208071)supported by the National Natural Science Foundation of ChinaProject(2010CB732106)supported by the National Basic Research Program of China
文摘Effect of soil displacement on friction single pile in the cases of tunneling,surcharge load and uniform soil movement was discussed in details with finite element method.Lateral displacement of the pile caused by soil displacement reached about 90% of the total displacement,which means that P-Δ effect of axial load can be neglected.The maximum moment of pile decreased from 159 kN·m to 133 kN·m in the case of surcharge load when the axial load increased from 0 to the ultimate load.When deformation of pile caused by soil displacement is large,axial load applied on pile-head plays the role of reducing the maximum bending moment in concrete pile to some extent.When pile is on one side of the tunnel,soil displacements around the pile are all alike,which means that the soil pressures around the pile do not decrease during tunneling.Therefore,Q-s curve of the pile affected by tunneling is very close to that of pile in static loading test.Bearing capacities of piles influenced by surcharge load and uniform soil movement are 2480 kN and 2630 kN,respectively,which are a little greater than that of the pile in static loading test(2400 kN).Soil pressures along pile increase due to surcharge load and uniform soil movement,and so do the shaft resistances along pile,as a result,when rebars in concrete piles are enough,bearing capacity of pile affected by soil displacement increases compared with that of pile in static loading test.
文摘Scale effect is one of the important aspects in the macro mechanical parame- ters’ research of rock mass, from a new point of view, by means of lab and field rock me- chanics test, establishment of E^Vp relation, classification of engineering rock mass, nu- merical simulation test and back analysis based on surrounding rock’s displacement monitoring results of Shuibuya Project’s underground power station, rock mass deforma- tion module’s size effect of surrounding rock of Shuibuya Project’s undegroud power sta- tion was studied. It’s shown that rock mass deformation module’s scale effect of sur- rounding rock of Shuibuya Project’s undeground power station is obvious, the rock mass deformation module to tranquilization is 20% of intact rock’s. Finally the relation between rock mass deformation modules and the scale of research was established.
文摘The seismic behavior of masonry bell-towers located in Corfu, Greece, is considered since constructions of this kind are particularly vulnerable to seismic loadings. Dynamics analyses for different total heights of Corfu bell-towers and according to the seismic data of this region are carried out. A diagram of displacements is determined. The impact of the percentages of damping in the distribution of displacements is examined.
