Objective: To investigate the long-term differential drug effects on cognitiv e functioning in school-aged children exposed to antiepileptic drugs (AEDs) in utero. Methods: Mothers with epilepsy were recruited from sp...Objective: To investigate the long-term differential drug effects on cognitiv e functioning in school-aged children exposed to antiepileptic drugs (AEDs) in utero. Methods: Mothers with epilepsy were recruited from specialist epilepsy cl inics and obstetric clinics from the Liverpool and Manchester region. The mother s and their children were recruited without prior knowledge of their AED treatme nt during pregnancy or the health of the offspring. A battery of neuropsychologi cal tests was applied to each mother-child pair in order to obtain a neuropsych ological profile for each child. Results: Neuropsychological investigation was p erformed on 249 children between the ages of 6 and 16. Children exposed to sodiu m valproate had a significantly lower verbal IQ when compared to children expose d to other antiepileptic drugs or not exposed at all. The same children were mor e likely to have an IQ below 69 and more likely to have memory impairment when c ompared to the othergroups. The mothers’IQ, exposure to sodium valproate, and t he number of tonic-clonic seizures during pregnancy were significant predictors of verbal IQ in this population. Conclusions:This retrospective study highlights the potential harmful effects of sodium valproate exposure in utero on neuropsychological development.展开更多
狼毒大戟碱性提取液(EBLE)两种剂量分别腹腔注射给药,可明显对抗小鼠最大电休克惊厥,抗惊率分别为53％和63％。EBLE 亦能提高戊四唑、印防己毒素所致惊厥发作和电刺激大鼠皮层运动区诱发惊厥发作的惊厥阈值。同时降低戊四唑惊厥小鼠的...狼毒大戟碱性提取液(EBLE)两种剂量分别腹腔注射给药,可明显对抗小鼠最大电休克惊厥,抗惊率分别为53％和63％。EBLE 亦能提高戊四唑、印防己毒素所致惊厥发作和电刺激大鼠皮层运动区诱发惊厥发作的惊厥阈值。同时降低戊四唑惊厥小鼠的死亡率,延长印防己毒素惊厥小鼠的存活时间。在上述动物惊厥模型中,丙戊酸钠的抗惊厥作用较 EBLE 强。测得灌胃小鼠 EBLE 的最大耐受量为145.38g/kg。由此可见,EBLE 具有明显的抗惊厥作用而几无毒性。展开更多
文摘Objective: To investigate the long-term differential drug effects on cognitiv e functioning in school-aged children exposed to antiepileptic drugs (AEDs) in utero. Methods: Mothers with epilepsy were recruited from specialist epilepsy cl inics and obstetric clinics from the Liverpool and Manchester region. The mother s and their children were recruited without prior knowledge of their AED treatme nt during pregnancy or the health of the offspring. A battery of neuropsychologi cal tests was applied to each mother-child pair in order to obtain a neuropsych ological profile for each child. Results: Neuropsychological investigation was p erformed on 249 children between the ages of 6 and 16. Children exposed to sodiu m valproate had a significantly lower verbal IQ when compared to children expose d to other antiepileptic drugs or not exposed at all. The same children were mor e likely to have an IQ below 69 and more likely to have memory impairment when c ompared to the othergroups. The mothers’IQ, exposure to sodium valproate, and t he number of tonic-clonic seizures during pregnancy were significant predictors of verbal IQ in this population. Conclusions:This retrospective study highlights the potential harmful effects of sodium valproate exposure in utero on neuropsychological development.
文摘狼毒大戟碱性提取液(EBLE)两种剂量分别腹腔注射给药,可明显对抗小鼠最大电休克惊厥,抗惊率分别为53％和63％。EBLE 亦能提高戊四唑、印防己毒素所致惊厥发作和电刺激大鼠皮层运动区诱发惊厥发作的惊厥阈值。同时降低戊四唑惊厥小鼠的死亡率,延长印防己毒素惊厥小鼠的存活时间。在上述动物惊厥模型中,丙戊酸钠的抗惊厥作用较 EBLE 强。测得灌胃小鼠 EBLE 的最大耐受量为145.38g/kg。由此可见,EBLE 具有明显的抗惊厥作用而几无毒性。
