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降脂抗氧化合剂对高血压合并高脂血症患者血管内皮功能的影响 被引量:9
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作者 钱卫东 方祝元 +1 位作者 陈艺 鲁海婷 《中成药》 CAS CSCD 北大核心 2014年第5期929-933,共5页
目的探讨高血压合并高脂血症患者应用降脂抗氧化合剂治疗对血管内皮依赖性舒张功能的影响。方法选取84例高血压合并高脂血症患者,随机分为降脂抗氧化合剂组(治疗组)42例及常规降压治疗组(对照组)42例。随访时间12周。治疗前后应用超声... 目的探讨高血压合并高脂血症患者应用降脂抗氧化合剂治疗对血管内皮依赖性舒张功能的影响。方法选取84例高血压合并高脂血症患者,随机分为降脂抗氧化合剂组(治疗组)42例及常规降压治疗组(对照组)42例。随访时间12周。治疗前后应用超声检测肱动脉流量介导性扩张的血管内皮舒张功能及血脂、血压、超敏C反应蛋白(hs-CRP)的变化。结果治疗组治疗后hs-CRP降低(P<0.01),脂质代谢紊乱和血管内皮舒张功能改善(P<0.01),且治疗后与对照组相比,hs-CRP水平明显降低(P<0.05),脂质代谢紊乱和血管内皮舒张功能明显改善(P<0.05);血压控制率差异无统计学意义(P#0.05)。结论高血压合并高脂血症患者应用降脂抗氧化合剂治疗能改善脂质代谢紊乱、改善内皮依赖性血管舒张功能及减轻炎症反应。 展开更多
关键词 高血压 高脂血症 降脂抗氧化合剂 血管内皮功能 超敏C反应蛋白
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降脂抗氧化合剂联合瑞舒伐他汀治疗老年混合型高脂血症的疗效 被引量:4
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作者 钱卫东 方祝元 鲁海婷 《中国老年学杂志》 CAS CSCD 北大核心 2015年第6期1443-1444,1445,共3页
目的观察中药降脂抗氧化合剂联合瑞舒伐他汀治疗老年混合型高脂血症患者的疗效。方法 72例混合型高脂血症患者随机分为治疗组和对照组,对照组单服瑞舒伐他汀(10 mg,1次/晚);治疗组予降脂抗氧化合剂(20 ml,3次/d)联合瑞舒伐他汀(10 mg,1... 目的观察中药降脂抗氧化合剂联合瑞舒伐他汀治疗老年混合型高脂血症患者的疗效。方法 72例混合型高脂血症患者随机分为治疗组和对照组,对照组单服瑞舒伐他汀(10 mg,1次/晚);治疗组予降脂抗氧化合剂(20 ml,3次/d)联合瑞舒伐他汀(10 mg,1次/晚)。服药前和服药12 w后,检测空腹血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、谷丙转氨酶(ALT)、谷草转氨酶(AST)及肌酸激酶(CK)。结果治疗组和对照组均能降低血清TC、LDL-C,但组间无差异(P>0.05);降TG、升高HDL-C疗效治疗组优于对照组(P<0.05),两组均无明显副作用(P>0.05)。结论降脂抗氧化合剂联合瑞舒伐他汀安全,能更有效地纠正老年混合型脂质代谢紊乱。 展开更多
关键词 混合型高脂血症 降脂抗氧化合剂 瑞舒伐他汀
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抗氧化合剂对虚证患者抗脂质过氧化损伤的影响 被引量:6
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作者 徐红 钱宝庆 +2 位作者 张永华 周锦 陈建成 《浙江中医学院学报》 1998年第3期38-39,共2页
观察抗氧化合剂和杞黄口服液治疗的心气虚、肾气虚证患者治疗前后血清超氧化物歧化酶(SOD)和过氧化脂质(LPO)含量变化。结果表明:心气虚、肾气虚患者SOD明显低于健康人(P<0.05),LPO明显高于健康人(P<0.01)。用抗氧化合剂... 观察抗氧化合剂和杞黄口服液治疗的心气虚、肾气虚证患者治疗前后血清超氧化物歧化酶(SOD)和过氧化脂质(LPO)含量变化。结果表明:心气虚、肾气虚患者SOD明显低于健康人(P<0.05),LPO明显高于健康人(P<0.01)。用抗氧化合剂治疗后患者血清SOD明显升高(P<0.05),LPO明显下降(P<0.01);用杞黄口服液治疗者虽有SOD升高和LPO下降,但与前者比较仍有显著差异(P<0.05,P<0.01)。前者总有效率达90%,明显高于后者的总有效率60%(P<0.01)。 展开更多
关键词 抗氧化合剂 虚证 氧化脂质 SOD
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抗氧化合剂防治大鼠膜性肾病的实验研究 被引量:4
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作者 程晓霞 万晨旭 +1 位作者 徐琳 王永钧 《中国中医药科技》 CAS 1999年第5期297-299,共3页
采用C-BSA制作大鼠膜性肾病模型,随机分成正常组、模型组、VitE组、中药Ⅰ组,中药Ⅱ组,观察中药抗氧化合剂及VitE胶囊对实验大鼠的尿蛋白、Cr、Bun、SOD、MDA的影响。结果表明:中药抗氧化合剂能降低实验大鼠的及蛋白、Scr、Bun,提高大... 采用C-BSA制作大鼠膜性肾病模型,随机分成正常组、模型组、VitE组、中药Ⅰ组,中药Ⅱ组,观察中药抗氧化合剂及VitE胶囊对实验大鼠的尿蛋白、Cr、Bun、SOD、MDA的影响。结果表明:中药抗氧化合剂能降低实验大鼠的及蛋白、Scr、Bun,提高大鼠肾皮质匀浆及血清SOD活性,降低MDA含量,减轻肾小球病理改变。其疗效明显优于VitE组。 展开更多
关键词 肾小球肾炎 中医药疗法 抗氧化合剂 病理学
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UPLC法测定降脂抗氧化合剂中葛根素与2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷的含量 被引量:1
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作者 刘辉 刘永利 王芝燕 《中药材》 CAS CSCD 北大核心 2014年第7期1282-1284,共3页
目的:采用超高效液相色谱法建立降脂抗氧化合剂中葛根素和2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷的含量测定方法。方法:色谱柱:ACQUITY UPLC BEH C18(100 mm×2.1 mm,1.7μm);流动相:乙腈与0.1%甲酸溶液,梯度洗脱;检测... 目的:采用超高效液相色谱法建立降脂抗氧化合剂中葛根素和2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷的含量测定方法。方法:色谱柱:ACQUITY UPLC BEH C18(100 mm×2.1 mm,1.7μm);流动相:乙腈与0.1%甲酸溶液,梯度洗脱;检测波长:305 nm;流速:0.4 mL/min;柱温:30℃;进样量:2μL。结果:葛根素的线性范围为0.02~1.0 mg/mL,r1=0.9998,平均回收率为98.58%,RSD为1.8%;2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷的线性范围为0.005~0.2 mg/mL,r2=0.9990,平均回收率为99.62%,RSD为1.2%。结论:该方法简便、快速、准确,可用于降脂抗氧化合剂的质量控制。 展开更多
关键词 降脂抗氧化合剂 葛根素 2 3 5 4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷 超高效液相色谱法
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“降脂抗氧化合剂”治疗痰瘀互结型高脂血症40例临床研究 被引量:1
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作者 王芝燕 刘辉 《江苏中医药》 CAS 2015年第11期23-24,共2页
目的:观察降脂抗氧化合剂治疗痰瘀互结型高脂血症的临床疗效。方法:70例痰瘀互结型高脂血症患者随机分为治疗组40例和对照组30例。治疗组给予降脂抗氧化合剂治疗,对照组给予瑞舒伐他汀治疗。2组均于治疗12周后观察并比较临床疗效、中医... 目的:观察降脂抗氧化合剂治疗痰瘀互结型高脂血症的临床疗效。方法:70例痰瘀互结型高脂血症患者随机分为治疗组40例和对照组30例。治疗组给予降脂抗氧化合剂治疗,对照组给予瑞舒伐他汀治疗。2组均于治疗12周后观察并比较临床疗效、中医证候疗效、血脂指标改善情况。结果:临床疗效比较,治疗组总有效率92.5%,明显高于对照组的80.0%(P<0.05);中医证候疗效比较,治疗组总有效率95.0%,明显高于对照组的76.7%(P<0.05)。2组治疗后血清总胆固醇、甘油三酯和高、低密度脂蛋白胆固醇均较治疗前明显改善(P<0.05),治疗组改善程度明显优于对照组(P<0.05)。结论:降脂抗氧化合剂能显著改善痰瘀互结型高脂血症患者的临床症状,降低血脂水平。 展开更多
关键词 降脂抗氧化合剂 痰瘀互结 高脂血症 血脂
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降脂抗氧化合剂治疗高血压病合并高脂血症患者的有效性和安全性研究
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作者 郭晨贤 张洪强 陈煜菁 《中国科技期刊数据库 医药》 2022年第9期32-35,共4页
观察降脂抗氧化合剂治疗高血压病合并高脂血症患者的有效性和安全性。方法 选取中医诊断为痰浊中阻型眩晕病,西医诊断为高血压病合并高脂血症的患者,在现代医学规范化治疗基础上随机对照给予降脂抗氧化合剂口服,记录治疗前后的中医证候... 观察降脂抗氧化合剂治疗高血压病合并高脂血症患者的有效性和安全性。方法 选取中医诊断为痰浊中阻型眩晕病,西医诊断为高血压病合并高脂血症的患者,在现代医学规范化治疗基础上随机对照给予降脂抗氧化合剂口服,记录治疗前后的中医证候积分、血压水平、血脂指标、安全性指标。结果 治疗组治疗后较对照组中医证候积分显著降低;其中头晕、恶心、倦怠等三项症状积分降低显著;治疗组治疗后较对照组舒张压显著降低,收缩压改变不明显;血脂指标中治疗组治疗后较对照组的甘油三酯明显降低,但对于血脂指标中胆固醇及低密度脂蛋白的降低不明显;安全性指标无明显差异。结论 降脂抗氧化合剂在改善中医证候尤其是头晕、恶心、倦怠等症状显著有效;在对于舒张压的调节效果较为卓越;可有效降低甘油三酯。 展开更多
关键词 降脂抗氧化合剂 眩晕病 高血压 高脂血症
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降脂抗氧化合剂治疗冠心病合并高脂血症患者的有效性和安全性 被引量:2
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作者 蒋超鹏 郭晨贤 《江苏医药》 CAS 2024年第2期187-190,共4页
目的观察降脂抗氧化合剂治疗冠心病合并高脂血症患者的有效性和安全性。方法选取冠心病合并高脂血症患者50例随机分为A组和C组,每组25例。两组均接受现代医学规范化治疗;A组加用降脂抗氧化合剂口服,每日3次,每次10mL,连续服药2个月。采... 目的观察降脂抗氧化合剂治疗冠心病合并高脂血症患者的有效性和安全性。方法选取冠心病合并高脂血症患者50例随机分为A组和C组,每组25例。两组均接受现代医学规范化治疗;A组加用降脂抗氧化合剂口服,每日3次,每次10mL,连续服药2个月。采用中医证候积分和西雅图心绞痛量表评分评估临床疗效,检测治疗前后的血脂和肝肾功能指标。结果两组治疗后中医证候积分和TG水平均降低(P<0.05),且A组低于C组[(3.26±1.96)分vs.(6.61±1.23)分和(1.39±0.43)mmol/L vs.(1.77±0.59)mmol/L](P<0.05)。两组治疗后西雅图心绞痛量表评分均升高,且A组高于C组[(77.42±3.24)分vs.(69.04±3.85)分](P<0.01)。两组治疗前后血常规和肝肾功能指标差异均无统计学意义(P>0.05)。结论在现代医学规范化治疗的基础上加用降脂抗氧化合剂能改善中医证候尤其是在胸痛、胸闷、倦怠方面,降低TG水平,改善心绞痛症状及生活质量。 展开更多
关键词 降脂抗氧化合剂 冠心病 高脂血症
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降脂抗氧化合剂对高血压患者高敏C反应蛋白和血管内皮功能的影响 被引量:4
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作者 钱卫东 方祝元 +1 位作者 蒋卫民 鲁海婷 《中国中药杂志》 CAS CSCD 北大核心 2013年第20期3583-3586,共4页
该研究观察了降脂抗氧化合剂对原发性高血压(EH)患者高敏C反应蛋白(hs-CRP)和血管内皮功能的影响。入选江苏省常州市武进中医医院心内科门诊原发性高血压患者72例,随机分为2组。对照组36例:氨氯地平(5 mg·d-1)+缬沙坦(80 mg·d... 该研究观察了降脂抗氧化合剂对原发性高血压(EH)患者高敏C反应蛋白(hs-CRP)和血管内皮功能的影响。入选江苏省常州市武进中医医院心内科门诊原发性高血压患者72例,随机分为2组。对照组36例:氨氯地平(5 mg·d-1)+缬沙坦(80 mg·d-1);试验组36例:对照组治疗基础上+中药降脂抗氧化合剂(20 mL·3d-1)。2组均治疗2月,分别测量治疗前后hs-CRP,ET-1,NO水平。结果发现2组治疗后hs-CRP,ET-1水平均降低(P<0.05),试验组hs-CRP,ET-1水平降低幅度较对照组更显著(P<0.05)。2组治疗后,NO水平均升高,试验组较对照组升高更明显(P<0.05)。研究表明,中药降脂抗氧化合剂可降低原发性高血压患者hs-CRP和ET-1水平,提高NO水平。 展开更多
关键词 降脂抗氧化合剂 原发性高血压 高敏C反应蛋白 血管内皮
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降脂抗氧化合剂对ApoE-/-小鼠5-脂氧化酶通路表达的影响 被引量:2
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作者 钱卫东 方祝元 +3 位作者 胡春萍 庞中化 曹鹏 王振盛 《中国实验方剂学杂志》 CAS 北大核心 2014年第17期137-141,共5页
目的:探讨降脂抗氧化合剂对ApoE基因敲除小鼠(ApoE-/-小鼠)5-脂氧化酶(5-LO)通路表达的影响。方法:采用高脂饲料连续喂养12周ApoE-/-小鼠,建立动脉粥样硬化动物模型,将已经形成动脉粥样硬化的ApoE-/-小鼠分为模型对照组、降脂抗氧化合... 目的:探讨降脂抗氧化合剂对ApoE基因敲除小鼠(ApoE-/-小鼠)5-脂氧化酶(5-LO)通路表达的影响。方法:采用高脂饲料连续喂养12周ApoE-/-小鼠,建立动脉粥样硬化动物模型,将已经形成动脉粥样硬化的ApoE-/-小鼠分为模型对照组、降脂抗氧化合剂低剂量组、降脂抗氧化合剂高剂量组、阳性药(辛伐他汀)对照组,每组10只。同时选用同遗传背景正常C57BL/6J小鼠10只,作为正常对照组,予饲喂普通饲料。阳性药(辛伐他汀)对照组以0.05 g·kg-1·d-1ig,降脂抗氧化合剂低、高剂量组分别含生药17.41,69.66 g·kg-1·d-1ig,正常对照组及模型对照组分别给予同体积的蒸馏水,连续ig 28 d后,心脏取血用于酶联免疫测定,取腹主动脉,采用HE染色对腹主动脉的形态学改变进行观察;提取腹主动脉RNA,进行RT-PCR检测5-LO基因的表达量;同时采用ELISA方法检测血清中白三烯B4(LTB4)及白三烯D4(LTD4)的蛋白含量。结果:与正常组比较,模型组的动脉硬化病变、组织5-LO、血清LTB4及LTD4水平都有明显加重或升高(P<0.01)。与模型组比较,高剂量的降脂抗氧化合剂较低剂量的降脂抗氧化合剂可以更显著下调5-LO的基因表达量(P<0.01),病理切片HE染色显示给药降脂抗氧化合剂后,高剂量给药组血管的组织形态较模型组有明显改变,和阳性药组结果类似,显示出药物对动脉粥样硬化具有较好的治疗效果;血清ELISA法结果显示高剂量的降脂抗氧化合剂可以显著降低血液LTB4及LTD4水平,与模型组间比较差异显著(P<0.01)。结论:降脂抗氧化合剂可降低组织5-LO的水平,改善动脉粥样硬化血管组织形态,减少脂质沉积,还可以降低血清LTB4及LTD4水平,改善炎症,达到治疗动脉粥样硬化的目的。 展开更多
关键词 降脂抗氧化合剂 5-脂氧化 半胱氨酰白三烯 炎症反应 粥样斑块
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夏天高温季节添加生物抗氧化复合剂对奶牛产量和乳品质的影响 被引量:2
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作者 朱勇 徐建雄 《中国奶牛》 2006年第9期21-23,共3页
本文研究了日粮中添加不同水平的生物抗氧化复合剂(40g/头·d、60g/头·d、80g/头·d)对夏天高温季节奶牛的产奶量和乳品质的影响。结果表明,当添加量为40g/头·d时,该添加剂能有效缓解乳脂率和乳糖率下降。
关键词 生物氧化合剂 奶牛 高温 产奶量 乳品质
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《中国科学美容》 2009年第4期24-25,共2页
法国思蒂细胞新活夜间抗皱修护系列细胞新活夜间抗皱修护系列产品内含思蒂独创的细胞健康存储综合体成分——H2CR^TM,即肽+天然的抗氧化合剂,
关键词 试用 抗氧化合剂 体成分 细胞 修护 美容
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Use of Natural Antioxidants in Meat and Meat Products 被引量:8
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作者 M. Karakaya E. Bayrak K. Ulusoy 《Journal of Food Science and Engineering》 2011年第1期1-10,共10页
Antioxidants are used to minimize lipid oxidation. Antioxidants can act as metal chelators and free radical or oxygen scavengers, which can slow the progression of lipid oxidation. Lipid oxidation may have negative ef... Antioxidants are used to minimize lipid oxidation. Antioxidants can act as metal chelators and free radical or oxygen scavengers, which can slow the progression of lipid oxidation. Lipid oxidation may have negative effects on the quality of meat and meat products, causing changes in sensory attributes such as color, texture, odor and flavor, and nutritional quality. Several synthetic antioxidants have been used to successfully prevent lipid oxidation in the meat industry, but consumers are concerned about the health risks related to consumption of some synthetic antioxidants. Therefore, there has been a growing interest in natural antioxidants. Nowadays, compounds obtained from natural sources such as grains, oilseeds, spices, fruit and vegetables have been investigated to decrease the lipid oxidation. In this review, the potential effects of natural antioxidants were evaluated that are widely used in meat and meat products. 展开更多
关键词 Natural antioxidants HERBS SPICES TEAS FRUITS VEGETABLES meat products
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Physical Properties of Ⅲ-Antiminodes—a First Principles Study 被引量:4
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作者 Rashid Ahmed Fazal-e-Aleem +2 位作者 S.Javad Hashemifar Haris Rashid H.Akbarzadeh 《Communications in Theoretical Physics》 SCIE CAS CSCD 2009年第9期527-533,共7页
A comprehensive first principles study of III-Antimonide binary compounds is hardly found in literature. We report a broad study of structural and electronic properties of boron antimonide (BSb), aluminium antimoni... A comprehensive first principles study of III-Antimonide binary compounds is hardly found in literature. We report a broad study of structural and electronic properties of boron antimonide (BSb), aluminium antimonide (AlSb), gallium antimonide (GaSb) and indium antimonide (InSb) in zineblende phase based on density functional theory (DFT). Our calculations are based on Full-PotentiM Lineaxized Augmented Plane wave plus local orbitals (FP- L(APWq-lo)) method. Different forms of exchange-correlation energy functional and corresponding potential are employed for structural and electronic properties. Our computed results for lattice parameters, bulk moduli, their pressure derivatives, and cohesive energy are consistent with the available experimental data. Boron antimonide is found to be the hardest compound of this group. For band structure calculations, in addition to LDA and GGA, we used GGA-EV, an approximation employed by Engel and Vosko. The band gap results with GGA-EV are of significant improvement over the earlier work. 展开更多
关键词 III-antimonides DFT FPLAPW exchange correlation functional structural properties of solids band structure of crystalline solids
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The Potential Application of Plant Essential Oils/Extracts as Natural Preservatives in Oils during Processing: A Review 被引量:1
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作者 Tugba lnanc Medeni Maskan 《Journal of Food Science and Engineering》 2012年第1期1-9,共9页
The present work summarizes recent investigations carried out about the usage of natural antioxidants in lipid-rich food during processing. Synthetic antioxidants have been used as food additives to retard lipid oxida... The present work summarizes recent investigations carried out about the usage of natural antioxidants in lipid-rich food during processing. Synthetic antioxidants have been used as food additives to retard lipid oxidation and development of off-flavor for over 50 years. However, the literature has expressed safety concerns and health risks (toxic and carcinogenic effects) associated with the use of synthetic antioxidants recently. Natural antioxidative substances from the polyphenols of edible plants are believed to be safer and may provide with additional health benefits and more effective compared to synthetic antioxidants. Due to the fact that natural antioxidants are additives that people mixed with food and consumed for centuries, they are known to be safe by the consumer. Therefore, it is an area worth to investigate due to consumer concerns about health. In the literature, there are many studies showing that the natural antioxidants have important antioxidant effect. Plants (oil seeds, cereals, vegetables, fruits, herb and spices), compounds from animal source (peptides and amino acids), enzymes and some microorganisms are important natural antioxidants. Plant extracts have been widely used to retard lipid oxidation in foods during frying and accelerated storage processes. They were found as strong antioxidant sources due to their high contents of phenolic compounds. There are countless studies about natural antioxidants. However, they have not been investigated completely by means of toxicology. 展开更多
关键词 FRYING OIL STORAGE stability natural antioxidants synthetic antioxidants.
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Synthesis of Environmentally Friendly Multifunctional Metal (Calcium,Magnesium) Oleate Detergent with Antioxidation Property 被引量:4
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作者 Wang Yonglei Mamat Xamxikamar Eli Wumanjiang 《China Petroleum Processing & Petrochemical Technology》 SCIE CAS 2011年第3期64-68,共5页
This article covers a method for synthesizing environmentally friendly multifunctional metal (calcium,magnesium) oleate detergents with antioxidation property.These multifunctional metal (calcium,magnesium) oleate det... This article covers a method for synthesizing environmentally friendly multifunctional metal (calcium,magnesium) oleate detergents with antioxidation property.These multifunctional metal (calcium,magnesium) oleate detergents with antioxidation property were synthesized using oil-soluble liquid antioxidants (PPIBP,PPIBTSTBP,and PPIBPDA) as reactive functional materials.These oil-soluble liquid antioxidants have the potential to be used as functional materials for application in synthesizing other kinds of substrate detergents. 展开更多
关键词 OIL-SOLUBLE liquid antioxidant calcium oleate magnesium oleate multifimctional detergent
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Preparation and Evaluation of High Antioxidant Talbina as a Protective and Therapeutic Meal
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作者 Ahmed M. Abdel-Salam 《Journal of Agricultural Science and Technology(B)》 2014年第5期418-425,共8页
Functional properties of Talbina were used in ancient Arab for nutritional purpose. It was a meal made from barley flour and milk. The high antioxidant Talbina was formulated from whole flour of harley and oat, milk, ... Functional properties of Talbina were used in ancient Arab for nutritional purpose. It was a meal made from barley flour and milk. The high antioxidant Talbina was formulated from whole flour of harley and oat, milk, date palm syrup (debis) and date palm seeds. The chemical composition, organoleptic properties and antioxidant activity of high antioxidant Talbina were determined. Sensory evaluation of traditional and high antioxidant Talbina showed that the developed product Talbina was considered as good for overall acceptability of all panelists. Also, the formulated Talbina contains high values of antioxidants components and natural nutrients. The antioxidant activity of formulated Talbina containing barley or oat may be due to presence of phenolic compounds and proanthocyanidins in the barley and oat. Increasing the antioxidant activity of high antioxidant Talbina containing barley and oat may be due to the adding of dates palm seeds which contain very high values of phenolic compounds and other antioxidants components. Date palm seeds as well as barley and/or oat give high antioxidants components which protect cells from oxidative stress and help to reduce the risk of cancer and heart disease as well as natural anti-depressant. Moreover, increasing the antioxidant activity in the formulated Talbina may play a role for reducing power, radical scavenging activity and the lipid peroxidation inhibition. In conclusion, supplementation of traditional Talbina containing barley and/or oat with date palm syrup (debis) and date palm seeds can produce simple and healthy meal to provide a good source of daily dietary antioxidants and micronutrients. 展开更多
关键词 Talbina ANTIOXIDANT BARLEY oat milk debis date palm seeds protective effect therapeutic meal.
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Kinetically Controlled Carboxypeptidase-Catalyzed Synthesis of Novel Antioxidant Dipeptide Precursor BOC-Tyr-Ala
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作者 Yuyao Shan Wei Qi +2 位作者 Mengfan Wang Rongxin Su Zhimin He 《Transactions of Tianjin University》 EI CAS 2018年第6期513-521,共9页
Recently, enzymatic peptide synthesis has drawn increasing attention due to its eco-friendly reagents and mild conditions, as compared to traditional chemical peptide synthesis. In this study, we successfully produced... Recently, enzymatic peptide synthesis has drawn increasing attention due to its eco-friendly reagents and mild conditions, as compared to traditional chemical peptide synthesis. In this study, we successfully produced an important antioxidant dipeptide precursor, BOC-Tyr-Ala, via a kinetically controlled enzymatic peptide synthesis reaction, catalyzed by the recombinant car- boxypeptidase Y (CPY) expressed in P. pastoris GS 115. In this reaction, the enzyme activity was 95.043 U/mL, and we used t-butyloxycarbonyl-L-tyrosine-methyl ester (BOC-Tyr-OMe) as the acyl donor and L-alanine (L-Ala) was the amino donor. We optimized the reaction conditions to be: 30 ℃, pH 9.5, organic phase (methanol)/aqueous phase = 1:20, BOC-Tyr-OMe 0.05 mol/L, Ala 0.5 mol/L, and a reaction time of 12 h. Under these conditions, the dipeptide yield reached 49.84%. Then, we established the kinetic model of the synthesis reaction in the form of Michaelis-Menten equation according to the con-centration-time curve during the process and the transpeptidation mechanism. We calculated the apparent Michaelis constant K^(app)mand the apparent maximum reaction rate r^(app)max to be 2.9946 x 10^-2 mol/L and 2.0406 x 10.2 mmol/(mL h), respectively. 展开更多
关键词 Antioxidant dipeptide precursor Kinetic control Reaction kinetic model Enzymatic peptide synthesis
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Oleuropein from Olive Leaf Extract as Natural Antioxidant of Frozen Hamburger
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作者 Claude Elama Mohammed Tarawa Fuad Al-Rimawi 《Journal of Food Science and Engineering》 2017年第8期406-412,共7页
Oxidation is one of the major causes of hamburger deterioration. Antioxidants are used to minimize oxidation process. There is a growing interest in the substitution of synthetic food antioxidants by natural ones from... Oxidation is one of the major causes of hamburger deterioration. Antioxidants are used to minimize oxidation process. There is a growing interest in the substitution of synthetic food antioxidants by natural ones from vegetable sources. In meat industry, sodium erythorbate is antioxidant that is usually used and is an example of chemical antioxidant. Effect of olive leaf extract rich in olenropein on the quality of frozen hamburger was investigated. The objective of this study was to evaluate the usage of oleuropein from olive leaf extract as natural antioxidant in frozen hamburger stored at -12 ℃ compared with sodium erythorbate. Results suggested that olive leaf extracts might be useful to the meat industry as an efficient alternative to synthetic antioxidants by retarding oxidation of hamburger compared with sodium erythorbate 0.5% of olenropein and 0.5% of sodium erythorbate are the best concentrations to be used in frozen hamburger. 展开更多
关键词 OLEUROPEIN olive leaf extract lipid oxidation frozen storage beef burger quality natural antioxidants.
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Bibliometric analysis of synthetic phenol antioxidants in marine environment based on CNKI database
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作者 DONG Yubo GAO Yan +2 位作者 ZHANG Jingwei HOU Chunqiang DAI Yuanyuan 《Marine Science Bulletin》 CAS 2020年第2期88-96,共9页
To investigate the application of synthetic phenolic antioxidants in marine research by bibliometrics analysis.Papers on the theme of synthetic phenolic antioxidants(N=135)was retrieved from the database of China Nati... To investigate the application of synthetic phenolic antioxidants in marine research by bibliometrics analysis.Papers on the theme of synthetic phenolic antioxidants(N=135)was retrieved from the database of China National Knowledge Infrastructure(CNKI),and the bibliometrics analysis was carried out in terms of article trend and keywords.Results show that the output of literature in this field has grown steadily and rapidly in the past 8 years.64.4%of the papers were published in the past 5 years.The relevance of research topics has increased in recent years.Current researches mainly focus on spatial and temporal distribution characteristics,metabolites and optimized detection methods.The analysis of its metabolites is helpful to understand the development of integrated microorganisms in Marine research. 展开更多
关键词 CNKI database synthetic phenolic antioxidants BIBLIOMETRICS
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