增色方联合毫火针治疗对白癜风患者抗氧化应激反应及生活质量的影响

目的:探讨增色方联合毫火针治疗对白癜风患者抗氧化应激反应及生活质量的影响。方法:选取本院2023年6月~2024年5月收治的100例白癜风患者,随机分为2组,西医组50例采用0.1%他克莫司软膏治疗,中西医组50例采用0.1%他克莫司软膏 + 增色方联合毫火针治疗。对比2组患者的中医证候积分、皮损面积、抗氧化应激反应[超氧化物歧化酶(SOD)、丙二醛(MDA)]、生活质量[皮肤病生活质量指数(DLQI)]、总体疗效。结果:2组治疗后中医证候积分的各项评分均较本组治疗前降低,中西医组低于西医组,P Objective: To explore the effects of Zengse Fang combined with Haohuo Needle therapy on antioxidant stress response and quality of life in vitiligo patients. Method: 100 vitiligo patients admitted to our hospital from June 2023 to May 2024 were randomly divided into two groups. The Western medicine group (50 cases) was treated with 0.1% tacrolimus ointment, while the Chinese and Western medicine group (50 cases) was treated with 0.1% tacrolimus ointment + color enhancing formula combined with filiform needle. Compare the traditional Chinese medicine syndrome score, skin lesion area, antioxidant stress response (superoxide dismutase (SOD), malondialdehyde (MDA)), quality of life (Dermatological Quality of Life Index (DLQI)), and overall efficacy between two groups of patients. Result: After treatment, the scores of traditional Chinese medicine syndrome scores in both groups decreased compared to before treatment, with the Chinese and Western medicine group being lower than the Western medicine group, P < 0.05. The area of skin lesions in both groups decreased compared to before treatment, and the Chinese and Western medicine group was smaller than the Western medicine group, P < 0.05. The SOD in both groups increased compared to before treatment, and MDA decreased compared to before treatment. The SOD in the Chinese and Western medicine group was higher than that in the Western medicine group, and MDA was lower than that in the Western medicine group, P < 0.05. The DLQI scores in both groups decreased compared to before treatment, with the Chinese and Western medicine group being lower than that in the Western medicine group, P < 0.05. The total effective rate in the Chinese and Western medicine group was higher than that in the Western medicine group, P < 0.05. Conclusion: The combination of Zengse Fang and Haohuo Needle has a good effect on treating vitiligo, which can alleviate patient symptoms, reduce skin lesion area, improve antioxidant stress response indicators, and improve quality of life. It is worth using.

抗氧化应激反应临床观察

随着科技水平和保健意识的不断提高，抗氧化制剂在医疗保健领域已被广泛应用。笔者应用足反射法治疗一例25年顽固性便秘所致的周围血象中反应性氧化物（Reaccive OxygenSpecies简称ROS）增多而导致可溶性纤维蛋白（SFC）大量堆积的患者，取得了较为满意的抗氧化应激的疗效。

左旋多巴联合恩他卡朋治疗帕金森病对患者认知功能及生活质量的影响

目的探讨左旋多巴联合恩他卡朋治疗帕金森病对患者认知功能及生活质量的影响。方法将99例帕金森病患者按随机数字表法分观察组(50例)和对照组(49例)。对照组予以左旋多巴治疗,观察组予以左旋多巴联合恩他卡朋治疗,观察16周。比较两组的疗效,治疗前及治疗16周患者运动功能、认知功能、生活质量、睡眠质量、抗氧化应激反应情况,不良反应发生状况。结果(1)观察组总有效率为96.0%,对照组为81.63%,观察组显著高于对照组(P<0.05)。(2)治疗后两组运动功能、认知功能评分均显著改善(P<0.01),观察组帕金森氏病综合评分量表-Ⅲ评分显著低于对照组(P<0.01),简易智力状态检查量表评分显著高于对照组(P<0.01)。(3)治疗后两组抗氧化应激反应情况均显著改善(P<0.01),观察组血清胱抑素C、白细胞介素-1β水平显著低于对照组(P<0.01),血清超氧化物歧化酶水平显著高于对照组(P<0.01)。(4)治疗后两组生活质量及睡眠质量均显著改善(P<0.01),观察组帕金森患者生活质量问卷评分显著低于对照组(P<0.01),帕金森病睡眠量表评分显著高于对照组(P<0.01)。(5)观察组不良反应总发生率为18.0%,对照组为38.8%,观察组显著低于对照组(P<0.05)。结论左旋多巴联合恩他卡朋治疗帕金森病临床疗效显著,能有效改善患者的运动功能及认知功能,缓解氧化应激反应,提高生活质量及睡眠质量,减轻左旋多巴引起的不良反应。

Effects of 60-day NO_2 fumigation on growth,oxidative stress and antioxidative response in Cinnamomum camphora seedlings

Objective： To study the oxidative stress and antioxidative response of Cinnamomum camphora seedlings exposed to nitrogen dioxide （NO2） fumigation. Methods： Measurements were made up of the growth, chlorophyll content, chlorophyll fluorescence, antioxidant system and lipid peroxidation of one-year-old C. camphora seedlings exposed to NO2 （0.1, 0.5, and 4 μl/L） fumigation in open top chambers over a period of 60 d. Results： After the first 30 d, 0.5 and 4.0 μl/L NO2 showed insignificant effects on the growth of C. camphora seedlings. However, exposure to 0.5 and 4.0 pilL NO2 for 15 d significantly reduced their chlorophyll content （P〈0.05）, enhanced their malondialdehyde （MDA） content and superoxide dismutase （SOD） activity （P〈0.05）, and also significantly reduced the maximal quantum yield of PSII in the dark [the ratio of variable fluorescence to maximal fluorescence （Fv/Fm）] （P〈0.05）. In the latter 30 d, 0.5μl/L NO2 showed a positive effect on the vitality of the seedlings, which was reflected by a recovery in the ratio of Fv/Fm and chlorophyll content, and obviously enhanced growth, SOD activity, ascorbate （AsA） content and glutathione reductase （GR） activity （P〈0.05）; 4.0 pilL NO2 then showed a negative effect, indicated by significant reductions in chlorophyll content and the ratio of Fv/Fm, and inhibited growth （P〈0.05）. Conclusion： The results suggest adaptation of C. camphora seedlings to 60-d exposure to 0.1 and 0.5 μl/L NO2, but not to 60-d exposure to 4.0 pilL NO2 C. camphora seedlings may protect themselves from injury by strengthening their antioxidant system in response to NO2-induced oxidative stress.