支气管哮喘的抗炎症疗法

支气管哮喘是一种较常见的疾病,发病率约占人口的2％,儿童与成年人都可发病。早期治疗支气管哮喘,可选用拟肾上腺素类药物兴奋支气管平滑肌细胞β受体,提高细胞内的cAMP含量;或选用含黄嘌呤基团的茶碱类药物抑制磷酸二酯酶活性,阻止cAMP转变为5′AMP,以保持细胞内的cAMP含量;或选用阿托品等M受体阻断剂减少细胞内cGMP,以提高cAMP/cGMP比值。但是这些缓解剂只能暂时缓解哮喘症状,难以达到治愈目的。

角膜神经性疼痛诊治进展

角膜神经性疼痛是一种定义不明的疾病。针对角膜神经性疼痛患者的临床建议、检测方法和治疗方法十分缺乏。目前基于对神经性疼痛病理生理学上的研究,临床上已有一些可行的检测方法和治疗方法,其中检测方法包括使用活性染料的裂隙灯检查法、触觉测量计、丙美卡因挑战测试法、体内共焦距显微镜检测。治疗方法包括抗炎症疗法、神经再生性疗法、系统用药、使用保护性隐形眼镜和一些辅助疗法。本文旨在总结针对其可行的检测方法和治疗方法。

Common carotid arterial thrombosis associated with ulcerative colitis

A 26-year-old woman with ulcerative colitis was transferred to our hospital with left hemiparesis due to cerebral infarction. Cervical ultrasonography and magnetic resonance imaging angiography revealed thrombosis at the right common carotid artery and the right internal carotid artery. Antithrombotic and anticoagulant therapies were commenced. After about 2 wk of the treatment, the frequency of her diarrhea increased. She underwent emergency subtotal colectomy, but 10 d later an abundant hemorrhage from the remnant rectum occurred, so the remnant rectum was resected and an ileal pouch anal anastomosis was performed. Antithrombotic and anticoagulant therapies were continued, but neither her neurological status nor magnetic resonance imaging angiography findings showed subsequent changes. She was discharged 3 mon after operation. This is a rare case of common carotid arterial thrombosis occurring as a complication of ulcerative colitis, in which antithrombotic and anticoagulant therapies are considered to provoke a deterioration of the patient’s bowel disease.