Hyperimmunoglobulin E syndrome (HIES) is a rare immunode-ficiency associated with elevated serum IgE levels, eczematous skin, recurrent cutaneous infections, and distinctive musculoskeletal features. We report two cas...Hyperimmunoglobulin E syndrome (HIES) is a rare immunode-ficiency associated with elevated serum IgE levels, eczematous skin, recurrent cutaneous infections, and distinctive musculoskeletal features. We report two cases seen at our institution and review the current literature. Patient 1 was an 18-month old African American boy with recurrent staphylococcal cold abscesses, pneumonia, and bacteremia. He had severely eczematous skin, ultimately complicated by eczema herpeticum. After treatment of systemic infections with culture-directed antibiotics, a brief course of cyclosporine, 5 mg/kg, improved the dermatitis and allowed transition to long-term therapy with oral trimethoprim-sulfamethoxazole. Patient 2 was a 15-year-old Caucasian boy with long-standing HIES. He has been maintained on a regimen of interferon gamma injections given 3 times weekly and monthly intravenous immunoglobulin since the age of 3 years, prophylactic antibiotics, and low-dose fluconazole. He has occasional episodes of cold abscesses and sinusitis, but has had excellent control since institution of this regimen and has not experienced any adverse effects.展开更多
Six patients infected with Cydospora cayetanensis who sought medical care at three different hospitals in Turkey are herein presented.Four patients were male and the others were female and their ages ranged from 7 to ...Six patients infected with Cydospora cayetanensis who sought medical care at three different hospitals in Turkey are herein presented.Four patients were male and the others were female and their ages ranged from 7 to 62 years.The first patient was HIV-positive and presented with watery diarrhea with a frequency of up to 18 times a day for more than ten months and diagnosed as cyclosporiosis in Kayseri,1996. The second patient was also HIV positive and diagnosed as cyclosporiosis in Kayseri,2000.The third patient was an acute myeloblastic leukemia(AML)patient and diagnosed in Istanbul,2000.The fourth patient was idiopathic hepatic cirrhosis complaining of diarrhea and weakness and diagnosed in Kayseri,2001.The fifth and sixth patients were immunocompetent patients complaining of diarrhea and diagnosed in Izmir and Kayseri,2002.Diarrhea occurring from one to ten times a day conlJnued for 7 to 70 d in the last 5 patients.Treatment with a trimethoprim/sulfamethoxazole compound was done for all patients.Both symptomatic and parasitologic improvements were quickly observed.In summary,C.cayetanensis infection is rare in Turkey and most patients infected with this pathogen tend to be immunosuppressive individuals at present.展开更多
文摘Hyperimmunoglobulin E syndrome (HIES) is a rare immunode-ficiency associated with elevated serum IgE levels, eczematous skin, recurrent cutaneous infections, and distinctive musculoskeletal features. We report two cases seen at our institution and review the current literature. Patient 1 was an 18-month old African American boy with recurrent staphylococcal cold abscesses, pneumonia, and bacteremia. He had severely eczematous skin, ultimately complicated by eczema herpeticum. After treatment of systemic infections with culture-directed antibiotics, a brief course of cyclosporine, 5 mg/kg, improved the dermatitis and allowed transition to long-term therapy with oral trimethoprim-sulfamethoxazole. Patient 2 was a 15-year-old Caucasian boy with long-standing HIES. He has been maintained on a regimen of interferon gamma injections given 3 times weekly and monthly intravenous immunoglobulin since the age of 3 years, prophylactic antibiotics, and low-dose fluconazole. He has occasional episodes of cold abscesses and sinusitis, but has had excellent control since institution of this regimen and has not experienced any adverse effects.
文摘Six patients infected with Cydospora cayetanensis who sought medical care at three different hospitals in Turkey are herein presented.Four patients were male and the others were female and their ages ranged from 7 to 62 years.The first patient was HIV-positive and presented with watery diarrhea with a frequency of up to 18 times a day for more than ten months and diagnosed as cyclosporiosis in Kayseri,1996. The second patient was also HIV positive and diagnosed as cyclosporiosis in Kayseri,2000.The third patient was an acute myeloblastic leukemia(AML)patient and diagnosed in Istanbul,2000.The fourth patient was idiopathic hepatic cirrhosis complaining of diarrhea and weakness and diagnosed in Kayseri,2001.The fifth and sixth patients were immunocompetent patients complaining of diarrhea and diagnosed in Izmir and Kayseri,2002.Diarrhea occurring from one to ten times a day conlJnued for 7 to 70 d in the last 5 patients.Treatment with a trimethoprim/sulfamethoxazole compound was done for all patients.Both symptomatic and parasitologic improvements were quickly observed.In summary,C.cayetanensis infection is rare in Turkey and most patients infected with this pathogen tend to be immunosuppressive individuals at present.
