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羟基喜树碱抗癌谱的实验研究 被引量:18
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作者 任中海 仝运科 +2 位作者 张成辉 程明芝 韩东景 《肿瘤防治杂志》 2002年第1期27-29,共3页
目的 :预测羟基喜树碱 (OPT)的抗癌谱 ,指导临床用药。方法 :收集我院 2 0 0 0年 6月~ 2 0 0 0年 11月 96例手术切除的肿瘤标本 ,行肿瘤细胞原代培养 ,用MTT法对OPT进行体外药敏试验。抑制率≥ 5 0 %为敏感 ,推荐临床使用 ;<30 %为... 目的 :预测羟基喜树碱 (OPT)的抗癌谱 ,指导临床用药。方法 :收集我院 2 0 0 0年 6月~ 2 0 0 0年 11月 96例手术切除的肿瘤标本 ,行肿瘤细胞原代培养 ,用MTT法对OPT进行体外药敏试验。抑制率≥ 5 0 %为敏感 ,推荐临床使用 ;<30 %为耐药。结果 :OPT平均敏感率为 2 5 .5 % ,耐药率为 4 2 .6%。各类肿瘤敏感率为乳腺癌 (5 0 .0 % ) >贲门腺癌 (4 1.7% ) >胃癌、宫颈癌 (33.3% ) >食管癌 (30 .4 % ) >结肠癌、膀胱癌 (2 5 .0 % ) >卵巢癌、肺癌 (16.7% ) >肾癌、甲状腺癌 (0 ) ;耐药率依次为甲状腺癌(10 0 0 % ) >膀胱癌 (75 .0 % ) >食管癌 (5 2 .0 % ) >肺癌、宫颈癌、肾癌 (5 0 .0 % ) >胃癌、卵巢癌 (33.3% )>乳腺癌、贲门腺癌、结肠癌 (2 5 .0 % )。结论 :OPT的抗癌谱为乳腺癌、贲门腺癌、结肠癌、胃癌、卵巢癌、肺癌、宫颈癌。肾癌。 展开更多
关键词 羟基喜树碱 抗癌谱 实验研究
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铂类抗癌药物展望 被引量:29
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作者 刘伟平 张永俐 孙加林 《贵金属》 CAS CSCD 2005年第1期47-52,共6页
在过去的10年里,铂类抗癌药物取得了重要的进展,又有4种新药,奈达铂、奥沙利铂、舒铂和洛铂相继于1995~2001年成功上市,同时也有多个候选药物因疗效低、毒性大,与顺铂、卡铂比较无优势而在临床试验中被淘汰.目前还有另外9种铂化合物仍... 在过去的10年里,铂类抗癌药物取得了重要的进展,又有4种新药,奈达铂、奥沙利铂、舒铂和洛铂相继于1995~2001年成功上市,同时也有多个候选药物因疗效低、毒性大,与顺铂、卡铂比较无优势而在临床试验中被淘汰.目前还有另外9种铂化合物仍在进行临床研究,这些化合物为顺铂和卡铂的类似物、亲脂性配合物、口服铂(Ⅳ)配合物、多核铂配合物以及具有空间位阻的铂配合物.新的铂类抗癌药将在今后10~20年内从那些在临床研究中显示出低毒性、抗癌谱广、与现有药物无交叉耐药性的化合物中产生. 展开更多
关键词 铂类抗癌 药物 卡铂 顺铂 临床研究 奈达铂 抗癌谱 淘汰 交叉耐药性 低毒性
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鸦胆子油乳在肿瘤防治中的意义 被引量:16
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作者 徐颖扉 陈培丰 +1 位作者 朱国猛 林胜友 《实用肿瘤学杂志》 CAS 2005年第3期238-240,共3页
关键词 鸦胆子油乳 肿瘤防治 石油醚提取物 水包油型乳剂 苦木科植物 大豆磷脂 肿瘤细胞 研究发现 肿瘤治疗 乳化剂 亲和力 特异性 抗癌谱
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羟基喜树碱为主联合化疗治疗晚期胃肠道肿瘤临床观察
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作者 王志强 邢健 张健国 《医学研究通讯》 2005年第3期80-80,共1页
近年来研究发现羟基喜树碱抗癌谱广,能选择性地抑制拓扑异构酶,干扰DNA的复制而日益受到重视并广泛用于多种恶性肿瘤的治疗.
关键词 治疗 晚期胃肠道肿瘤 羟基喜树碱 联合化疗 临床观察 HCPT 抗癌谱 DNA 选择性 CF
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“九旭杯”鸦胆子油乳注射液有奖征文活动
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《重庆医学》 CAS CSCD 北大核心 2014年第1期32-32,共1页
九旭鸦胆子油乳注射液具有低毒、高效和抗癌谱广等诸多优点,已广泛应用于肺癌、肺癌脑转移、消化道肿瘤、肝癌、恶性胸水等肿瘤治疗领域。为进一步探索九旭鸦胆子油乳注射液的疗效和安全性,造福患者,浙江九旭药业有限公司与《重庆医... 九旭鸦胆子油乳注射液具有低毒、高效和抗癌谱广等诸多优点,已广泛应用于肺癌、肺癌脑转移、消化道肿瘤、肝癌、恶性胸水等肿瘤治疗领域。为进一步探索九旭鸦胆子油乳注射液的疗效和安全性,造福患者,浙江九旭药业有限公司与《重庆医学》联合举办“九旭杯”鸦胆子油乳注射液有奖征文活动,有关征文内容及要求通知见《重庆医学》杂志网站首页: 展开更多
关键词 鸦胆子油乳注射液 征文活动 《重庆医学》 肺癌脑转移 消化道肿瘤 恶性胸水 征文内容 抗癌谱
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Curcumin: A putative chemopreventive agent 被引量:1
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作者 Loganathan Palanikumar Natarajan Panneerselvam 《Journal of Life Sciences》 2009年第5期47-53,共7页
Curcumin (diferuloylmethane), the main yellow bioactive component of turmeric has been shown to have a wide spectrum of biological actions. It is anti-inflammatory, antioxidant, anticarcinogenic, antimutagenic, anti... Curcumin (diferuloylmethane), the main yellow bioactive component of turmeric has been shown to have a wide spectrum of biological actions. It is anti-inflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral, antifibrotic, antivenom, anti-ulcer and hypocholesteremic. Its anticancer effect is mainly mediated through induction of apoptosis. Its anti-inflammatory, anticancer and antioxidant roles may be clinically exploited to control rheumatism, carcinogenesis and oxidative stress-related pathogenesis. Clinically, curcumin has already been used to reduce post-operative inflammation, Thus, curcumin has the potential of chemopreventive action and has been used in the development of modern medicine to treat various diseases. 展开更多
关键词 CURCUMIN anticancer and chemo-preventive AGENT
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超声心动图观察阿霉素化疗病人左心功能变化
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作者 王黎静 韩子文 +2 位作者 张秀泉 刘威 李东明 《沈阳部队医药》 1998年第3期275-276,共2页
阿霉索(ADM)是强效广谱抗癌药,为用于恶性肿瘤联合化疗的主药之一.但它对心脏可产生毒性反应。为此,我们应用超声心动图对48例肿瘤化疗病人进行用药前、后的左心功能变化观察,现报告如下.
关键词 超声心动图 阿霉素 化疗病人 左心功能 抗癌
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Colorectal carcinoma-associated antigen Ca-Hb3 detected by one-dimensional SDS-polyacrylamide gel electrophoresis and liquid chromatography-tandem mass spectrometry
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作者 Shuo Sun Feng-Jie Guo Yong-Qing Tong Jian-Gao Zhu Guan-Cheng Li 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第10期1588-1591,共4页
AIM: To comprehensively identify the proteins of tumor relative antigen Ca-Hb3 recognized by colorectal carcinoma monoclonal antibody Hb3. METHODS: Ca-Hb3 was isolated by SDS-polyacrylamide gel electrophoresis (PAGE) ... AIM: To comprehensively identify the proteins of tumor relative antigen Ca-Hb3 recognized by colorectal carcinoma monoclonal antibody Hb3. METHODS: Ca-Hb3 was isolated by SDS-polyacrylamide gel electrophoresis (PAGE) followed by digestion with trypsin. Trypsin peptides were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/ MS). The proteins identified by mass spectrometry were analyzed using bioinformatics. RESULTS: Ca-Hb3 was identified as a CKAP4-like protein by Nano HPLC tandem mass spectrometry analysis. The molecular weight of CKAP4-like protein was 62.02 kDa, including one hydrophobic region, one transmembrane domain, five coiled coils, four glycosylation sites and forty-nine phosphorylation sites. CKAP4-like protein had a high homogeneity with DeltaNp63α. The characteristic expression of DeltaNp63α that is considered a potential oncogene in the isoforms of p63 was similar to that of Ca-Hb3. CONCLUSION: Ca-Hb3 is probably a CKAP4-like protein, belonging to DeltaNp63α isoform of p63 family. 展开更多
关键词 Colorectal neoplasm Monoclonal antibody ANTIGEN Mass spectrometry P63
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Observation of Cell-Size Variation under Environmental Stress by Fluorescence Correlation Spectroscopy without Objective Image Magnification
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作者 Kitao Fujiwara Keishiro Horiuchi Sayuri Goryoda Yasuhiro Hashidume Naoko Horiguchi Takeshi Miyakawa Masako Takasu Motohide Aoki 《Journal of Environmental Science and Engineering(A)》 2012年第3期364-370,共7页
Fluorescence correlation spectroscopy (FCS) without objective image magnification (without using con-focal microscope) was applied to observe the variation in cell size of Escherichia coli (E. coli) induced by t... Fluorescence correlation spectroscopy (FCS) without objective image magnification (without using con-focal microscope) was applied to observe the variation in cell size of Escherichia coli (E. coli) induced by the anti-cancer agent MitomycinC (MMC). In the system without image magnification followed in this study, the suspension of E. coli cells was stirred, and the difference in movement due to the different cell sizes induced by the compulsive solution flow was detected. The addition of 0.1-0.4 pg/L of MMC elongated the E. coli cell length from about 3.6 to 7.8μm. The flow cell (i.d. = about 1 mm) also produced a size-dependent correlation curve, The present system is not based on single molecular FCS but is inexpensive and effective at observing the variation in cell size induced by environmental changes. 展开更多
关键词 Cell size fluorescence correlation spectroscopy environmental stress GFP E. coli.
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Changes in tumor-antigen expression profile as human small-cell lung cancers progress
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作者 Li-Sheng Ge Neil T. Hoa +4 位作者 Nils Lambrecht Maria Dacosta-Iyer Yi Ouyang Amir Abolhoda Martin R. Jadus 《Cancer Biology & Medicine》 SCIE CAS CSCD 2015年第2期96-105,共10页
Objective: Our group has previously observed that in patients with small-cell lung cancers (SCLCs), the expression of a tumor antigen, glioma big potassium (gBK) ion channel, is higher at the time of death than w... Objective: Our group has previously observed that in patients with small-cell lung cancers (SCLCs), the expression of a tumor antigen, glioma big potassium (gBK) ion channel, is higher at the time of death than when the cancer is first treated by surgical resection. This study aimed to determine whether this dichotomy was common in other potential lung tumor antigens by examining the same patient samples using our more extensive profile analysis of tumor-antigen precursor protein (TAPP). We then tested the hypothesis that therapeutic intervention may inadvertently cause this increased gBK production. Methods: SCLC samples (eight surgical resections and three autopsy samples) and three control lungs were examined by quantitative real-time polymerase chain reaction for 42 potential TAPPs that represent potential T-cell-mediated immunological targets. Results: Twenty-two TAPP mRNAs displayed the same profile as gBK, i.e., more mRNAs were expressed at autopsy than in their surgical counterparts. B-cyclin and mouse double minute 2, human homolog of PS3-binding protein were elevated in both autopsy and surgical specimens above the normal-lung controls. When HTB119 cells were incubated with doxorubicin, gBK was strongly induced, as confirmed by intracellular flow cytometry with a gBK-specific antibody. Conclusion: Our findings suggested that more immunological targets became available as the tumor responded to chemotherapy and proceeded toward its terminal stages. 展开更多
关键词 Small-cell lung cancer (SCLC) glioma big potassium (gBK) ion channel tumor antigens immunoprevention real-timepolymerase chain reaction T-LYMPHOCYTES
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榄香烯对小鼠移植瘤U14放疗增敏的实验研究 被引量:11
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作者 邹丽娟 孙秀华 +2 位作者 徐晓颖 邓涛 陈英海 《中华放射医学与防护杂志》 CAS CSCD 北大核心 2004年第3期254-255,共2页
关键词 榄香烯 小鼠 移植瘤 U14放疗增敏 抗癌谱 毒副作用
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Determination of 8,2′-diprenylquercetin 3-methyl ether in plasma by UPLC-MS-MS and its pharmacokinetic application in rats
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作者 刘焕 范珊珊 +6 位作者 张雯 张驿帆 李腾 尚明英 刘广学 徐风 蔡少青 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2017年第10期747-753,共7页
8,2'-Diprenylquercetin 3-methyl ether with significant anti-breast cancer activity is the main constituent of Tibetan medicine Sinopodophylli Fructus. In the present study, we developed and validated a rapid and sens... 8,2'-Diprenylquercetin 3-methyl ether with significant anti-breast cancer activity is the main constituent of Tibetan medicine Sinopodophylli Fructus. In the present study, we developed and validated a rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of 8,2'-diprenylquercetin 3-methyl ether in rat plasma. 8-Prenylkaempferol was used as the internal standard. The separation was carried out using Waters ACQUITY UPLC BEH C18 column (2.1 mm×100 ram, 1.7 μm) with a mobile phase consisting of acetonitrile and 0.1% formic acid in water on a gradient program at a flow rate of 0.4 mL'min-1 and temperature of 30 ℃. Triple quadrupole mass spectrometric detection in negative ion mode was used for multiple-reaction monitoring of the transitions at m/z 451.30→177.25 and m/z 353.25→298.15 for 8,2'-diprenylquercetin 3-methyl ether and 8-prenylkaempferol, respectively. The calibration curves were linear within the concentration range 0.1-2000 ng/mL (r = 0.9954). The recoveries were 103%-115%, and the results were consistent across low, middle and high concentration levels. The intra- and inter-day precisions were within 15%, and the bias was between --6%-15%. This method was simple, rapid and sensitive, which could be applied to the determination of 8,2'-diprenylquercetin 3-methyl ether in plasma and pharmacokinetic study in rats. Pharmacokinetic test indicated that the peak plasma concentration occurred in 2 h after the female rats were intragastrically administered with 8,2'-diprenylquercetin 3-methyl ether at the dose of 100 mg/kg, and the biological half-life was 6.79 h. The blood drug concentration maintained equal amount for 20 h, which was conducive to the in vivo effects of drugs. 展开更多
关键词 8 2'-Diprenylquercetin 3-methyl ether UPLC-MS/MS Blood concentration Anti-breast cancer PHARMACOKINETIC
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