The multiglycosides of Tripterygium uilfordii(TII), a ready-made Chinese herbal medicine used for the treatment of rheumatoid arthritis , have been shown to cause oligospermia in patients. In the present study, the an...The multiglycosides of Tripterygium uilfordii(TII), a ready-made Chinese herbal medicine used for the treatment of rheumatoid arthritis , have been shown to cause oligospermia in patients. In the present study, the antifertility effects of TII and tripchlorolide (T4, isolated from TII) were observed in male rats. In rats fed with TII at a dose of 10mg·kg·d for 7 weeks, the seminiferous tubules were essentially not influenced. However, most of the sperm heads along the surface of the tubular lumen were transformed from the normal sickle-shaped to round shaped. suggesting a possible mutagenic action. There was minimal testicular change but prominent epididymal spermatozoa damage in all rats treated with T4 (0. 05 mg·kg·d) for 7 weeks. The epididymal spermatozoa showed various structural abnormalities, including disrupted connecting pieces and cracked midpieces. and more than 80% of the spermatozoa were decapitated. No significant changes were seen in the main visceral organs. The data suggest that T4 may have good prospects as a male contraceptive.展开更多
Forty four adult male rats weighing about 250 g were divided into 3 groups: Group 1 received GTW at a does of 10 mg/kg/d, Group 2, 20mg/kg/d, and Group 3 was givea 1% carboxymethy! cellulose as control. The rats were ...Forty four adult male rats weighing about 250 g were divided into 3 groups: Group 1 received GTW at a does of 10 mg/kg/d, Group 2, 20mg/kg/d, and Group 3 was givea 1% carboxymethy! cellulose as control. The rats were sacrificed on展开更多
In present study, 37 subjects with local nodules greater than 4mm ( unilateral or bilateral) were selected from 1134 vasectomizcd men, and 42 subjects with small nodules (less than 4ram) were served as controls.
文摘The multiglycosides of Tripterygium uilfordii(TII), a ready-made Chinese herbal medicine used for the treatment of rheumatoid arthritis , have been shown to cause oligospermia in patients. In the present study, the antifertility effects of TII and tripchlorolide (T4, isolated from TII) were observed in male rats. In rats fed with TII at a dose of 10mg·kg·d for 7 weeks, the seminiferous tubules were essentially not influenced. However, most of the sperm heads along the surface of the tubular lumen were transformed from the normal sickle-shaped to round shaped. suggesting a possible mutagenic action. There was minimal testicular change but prominent epididymal spermatozoa damage in all rats treated with T4 (0. 05 mg·kg·d) for 7 weeks. The epididymal spermatozoa showed various structural abnormalities, including disrupted connecting pieces and cracked midpieces. and more than 80% of the spermatozoa were decapitated. No significant changes were seen in the main visceral organs. The data suggest that T4 may have good prospects as a male contraceptive.
文摘Forty four adult male rats weighing about 250 g were divided into 3 groups: Group 1 received GTW at a does of 10 mg/kg/d, Group 2, 20mg/kg/d, and Group 3 was givea 1% carboxymethy! cellulose as control. The rats were sacrificed on
文摘In present study, 37 subjects with local nodules greater than 4mm ( unilateral or bilateral) were selected from 1134 vasectomizcd men, and 42 subjects with small nodules (less than 4ram) were served as controls.
